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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Publication of Paper Outlining Agency Testing Needs in Skin and Eye Irritation

Chemical regulation authorities in the United States require or consider eye and skin irritation test data to develop product hazard labeling or to assess risks for exposure to skin- and eye-irritating chemicals. The ICCVAM Ocular and Dermal Irritation Workgroup reviewed U.S. agencies’ data needs for skin and eye irritation (Choksi et al. 2019). Information reviewed included the type of skin and eye irritation data required by each agency and the associated decision context: hazard classification, potency classification, or risk assessment; the preferred tests; and whether alternative or non-animal tests are acceptable. Information on the specific information needed from non-animal test methods was also collected. The review revealed a willingness to consider non-animal or alternative test methods by participating agencies, who encouraged sponsors to consult with the relevant agency to discuss the use and acceptance of alternative methods for local skin and eye irritation testing in designing their testing program.