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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods

Alternative Criteria for Classification of Corrosive Materials

DOT proposed an amendment to the Hazardous Materials Regulation in November 2018 (83 FR 60970). The amendment would enable non-testing alternatives that use existing data on chemical properties to be considered for classifying corrosive mixtures. Currently, the regulation requires offerors to classify Class 8 corrosive material and assign a packing group based on test data. The regulation authorizes a skin corrosion test and various in vitro test methods that do not involve animal testing. However, only data obtained from testing are currently acceptable for classification and assignment to a packing group. These alternatives would afford offerors the ability to make a classification and packing group assignment without the need to conduct physical tests.