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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/884494

Alternative Criteria for Classification of Corrosive Materials

DOT proposed an amendment to the Hazardous Materials Regulation in November 2018 (83 FR 60970). The amendment would enable non-testing alternatives that use existing data on chemical properties to be considered for classifying corrosive mixtures. Currently, the regulation requires offerors to classify Class 8 corrosive material and assign a packing group based on test data. The regulation authorizes a skin corrosion test and various in vitro test methods that do not involve animal testing. However, only data obtained from testing are currently acceptable for classification and assignment to a packing group. These alternatives would afford offerors the ability to make a classification and packing group assignment without the need to conduct physical tests.

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