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ICCVAM Biennial Report 2018-2019

Biennial Progress Report 2018-2019 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/892746

Reassessment of Dog Testing Requirements for Food and Color Additive Safety Assessments

As FDA advances its Predictive Toxicology Roadmap, its Center for Food Safety and Applied Nutrition will reevaluate traditional approaches to toxicity testing to refine testing recommendations and include accurate predictive models of toxicity that are appropriate to use in evaluating the safe use of food additives or color additives. As part of this effort, the Center reviewed all dog studies previously submitted as part of the approval for food additive or color additive petitions. These findings may enable the Center to determine when a toxicity study in dogs could provide toxicological information not otherwise available using other experimental model systems and may help to identify endpoints for potential evaluation using modern in vitro or in silico techniques. A report on the findings of the review is in preparation.

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