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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods

Accelerating the Pace of Chemical Risk Assessment

The advent of NAMs for generating safety information on chemicals provides an opportunity to assess what chemical risk assessment should look like in the 21st century. EPA played a leadership role in Accelerating the Pace of Chemical Risk Assessment (Kavlock et al. 2018), an international activity designed to bring together regulators from key international regulatory agencies such as the European Chemicals Agency and Health Canada to discuss progress in applying the new tools to prioritization, screening, and application to quantitative risk assessment of differing levels of complexity. During 2020 and 2021, the collaboration developed case studies on the development and applications of NAMs for chemical risk assessment, one of which was described in a paper published by EPA scientists and collaborators (Paul Friedman et al. 2020). These collaborations examined how NAMs might transform regulatory evaluation of chemicals and help overcome barriers to acceptance by increasing confidence in the use and acceptance of NAMs in regulatory chemical risk assessment.