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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/928416

Abstracts

A searchable list of NICEATM and ICCVAM abstracts is available on the NTP website.

Abedini J, Bell S, Chang X, Choksi N, Cook B, Daniel AB, Hines D, Karmaus AL, Mansouri K, Allen D, Kleinstreuer N. 2021. NICEATM computational tools and data resources [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Abedini JA, Bell S, Chang X, Cook BT, Karmaus AL, Mansouri K, Allen DG, Kleinstreuer NC. 2021. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract 2542]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Abedini J, Bell S, Mansouri K, McAfee E, Phillips J, Chang X, Karmaus AL, Cook B, Allen D, Casey W, Kleinstreuer N. 2020. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Abedini J, Cook B, McAfee E, Phillips J, Bell S, Rooney J, Allen D, Casey W, Kleinstreuer N. 2021. Utilizing ICE tools to expand chemical knowledge: Chemical Quest [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Adams VH, Reinke EN, Holden LA, LaScala JJ. 2020. In silico and in vitro analysis of 4-4'-methylenedianiline replacements [Abstract 3393]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Allen DG. 2020. Regulatory landscape and key considerations for establishing inhalation reference data [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Allen DG. 2021. Retrospective analysis of dermal triple pack data [Abstract P225]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Allen DG, Rooney JP, Choksi N, Ceger P, Daniel A, Karmaus A, Strickland J, To K, Truax J, Casey W, Kleinstreuer N. 2021. Establishing confidence in NAMs: considering variability in reference test methods [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Allen DG, Rooney JP, Kleinstreuer NC, Lowit A, Perron M. 2021. Retrospective analysis of dermal absorption triple pack data [Abstract 2757]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Bell S. 2020. Integrated Chemical Environment [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Bell S. 2021. Improving alternative method adoption through tools and resources to support community knowledge [Abstract 1008]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Bell S, Abedini J, Ceger P, Karmaus A, Daniel A, Choksi N, Rooney J, Allen D, Kleinstreuer N. 2020. Providing insight into chemical activity through data curation and assay annotation [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Bell S, Ceger P, Fostel J, Holmgren S, Masci AM, Allen D, Casey W, Kleinstreuer N. 2021. Accelerating adoption of NAMs with FAIR principles [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC. 2020. NICEATM computational tools and resources supporting alternative test method development and evaluation [Abstract 2976]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Bishop P, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2021. Acute oral toxicity predictions for environmental risk assessment [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Borba J, Braga R, Alves V, Muratov E, Kleinstreuer N, Tropsha A, Andrade C. 2020. Pred-Skin: a web portal for accurate prediction of human skin sensitizers [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Britton K, Korest D, Judson R, Jarema K, Coutros K, Wetmore B, Hill B, Hunter D, Olin J, Padilla S. 2020. Developmental toxicity assessment of a library of per- and polyfluoroalkyl substances in zebrafish (Danio rerio) embryos/larvae [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Casey W. 2020. Modernizing the NTP carcinogenicity testing program [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Casey W. 2021. Incorporating NAMs into the DNTP carcinogenicity testing program [Abstract 1196]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Casey W. 2021. Modernizing the NTP’s carcinogenicity testing program [Abstract 11]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Casey W. 2021. Organ-on-a-chip validation efforts: challenges and lessons learned [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Ceger P. 2021. Retrospective evaluation of the acute fish toxicity test for pesticide registration [Abstract P268]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Ceger P, Allen DG, Choksi N, Daniel A, Eckel W, Hamm J, Johnson T, Kleinstreuer NC, Lowit M, Sprankle C, Truax J, Odenkirchen E. 2021. Retrospective evaluation of the acute fish toxicity test for pesticide registration [Abstract 2324]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Ceger P, Garcia-Reyero N, Allen D, Arnold E, Bloom R, Brennan JC, Clarke C, Eisenreich K, Fay K, Hamm J, Henry PFP, Horak K, Hunter W, Judkins D, Klein P, Kleinstreuer N, Koehrn K, LaLone CA, Laurenson JP, Leet JK, Lowit A, Lynn SG, Norberg-King T, Perkins EJ, Petersen EJ, Rattner BA, Sprankle CS, Steeger T, Warren JE, Odenkirchen E. 2021. Determination of ecotoxicity testing needs among selected U.S. federal agencies [Abstract]. Presented at SETAC North America 2021; 14-18 November 2021.

Chang X. 2021. Toxicokinetic models for QIVIVE and consideration of uncertainty [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Chang X. 2021. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract 442]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Chang X, Lumen A, Palmer J, Lee U, Ceger P, Donley B, Bell S, Allen D, Casey W, Kleinstreuer NC. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproate analogues [Abstract P15]. Presented at the 60th Annual Meeting of the Society for Birth Defects Research and Prevention; 25 June-2 July 2020.

Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Kleinstreuer N. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Chang X, Lumen A, Palmer J, Lee UJ, Ceger P, Donley E, Bell S, Allen D, Casey W, Kleinstreuer N. 2020. In vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues [Abstract 1612]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Chang X, Palmer J, Donley E, Allen D, Casey W, Kleinstreuer N. 2021. In vitro to in vivo extrapolation for developmental toxicity potency of selected Tox21 chemicals [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Choksi N. 2021. Developing a defined approach for eye irritation testing [Abstract P505]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen DG. 2020. Developing a defined approach for eye irritation testing [Abstract 2198]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Choksi N, Clippinger AJ, Gehen S, Corvaro M, Kolle SN, Bentley K, Hofstra A, Inforzato M, Ryan N, Webb E, Casey W, Allen D. 2020. Testing of agrochemical formulations using in vitro and ex vivo eye irritation test methods [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2021. Chemical exploration: providing biological context for NAMs [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Cook B, Abedini J, Bell S, McAfee E, Phillips J, Allen D, Kleinstreuer N. 2020. Chemical exploration: identifying bioactivity with the use of structural features [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Cook B, Abedini JA, Bell S, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC. 2021. Providing context for chemical effects through bioactivity and consumer use [Abstract 2541]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Daniel AB, Abedini JA, Bell S, Chang X, Cook B, Karmaus AL, Hines DE, McAfee E, Phillips J, Rooney JP, Allen DG, Kleinstreuer NC. 2021. Updates to the Integrated Chemical Environment: expanding tools and data to support toxicity assessments [Abstract 2958]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Farcas MT, Stefaniak AB, McKinney W, Knepp AK, Bowers L, Mandler WK, Kashon M, Battelli L, Stueckle TA, Orandle M, Winn A, Friend SA, Jackson SR, Qi C, Hammond DR, Mercer R, LeBeouf R, Burns D, Ranpara A, Thomas TA, Matheson J, Castranova V, Qian Y. 2020. Toxicological evaluation of acrylonitrile butdiene styrene (ABS) 3D printer emissions [Abstract 1679]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Fitzpatrick S. 2020. In vitro microphysiological systems: advancing regulatory science through innovation [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Fitzpatrick S. 2021. Developing performance based qualification criteria for organs on a chip [Abstract 946]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Fitzpatrick S. 2021. Implementing new testing approaches at the US Food and Drug Administration [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Foster C. 2021. Standardizing developmental toxicology study extractions using automated application of ontologies [Abstract P576]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Foster C, Wignall J, Kovach S, Trgovcich J, Varghese A, Rochester J, Stout M, Kleinstreuer NC. 2020. Automated applications of ontologies to standardize developmental toxicology study extraction [Abstract 25]. Presented at the 60th Annual Meeting of the Society for Birth Defects Research and Prevention; 25 June-2 July 2020.

Gombar V, Sedykh A, Ross A, Casey W, Shah R. 2021. OrbiTox: a translational discovery platform for concerted view and analysis of big data [Abstract 2802]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Gombar V, Sedykh A, Ross A, Witt K, Shah R, Casey W. 2021. OrbiTox: a translational discovery platform for concerted view and analysis of multi-domain data [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Gordon JD, Uhl R, Toman B, Elliot J, Petersen E. 2020. Using a measurement science approach to increase confidence in the EASA skin sensitization assay [Abstract 1417]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Gordon JD, Uhl R, Toman B, Elliot J, Petersen E. 2020. EASA skin sensitization assay development: using a measurement science approach to increase confidence [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Guo X, Seo J, Wu Q, Manjanatha MG, Mei N. 2021. Performance of metabolically competent HepaRG cells for genotoxicity testing: a comparison between three human hepatic cells using the high-throughput micronucleus and comet assays [Abstract 2806]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Hamm J. 2021. Performance of the GHS mixtures equations for predicting acute oral toxicity [Abstract P572]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Hamm J, Allen DG, Ceger P, Flint T, Kleinstreuer NC, O'Dell L, Tao JJ, Lowit A. 2021. Predicting oral acute toxicity using the GHS additivity equation [Abstract 2345]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Henry TR, Salazar KD, Hayes MP, Kennedy W, Keene AM, Jarabek AM, Price OT, Moors S, Jovanovich L, Rose JL, Tveit A, Tremblay RT, Becker RA, Osman-Sypher S, McMullen PD, Slattery SD, Irwin W, Odin M, Melia J, Sharma M, Clippinger AJ, Stucki A, Stedeford T. 2021. Surfactants category: an integrated approach to testing and assessment (IATA) including new approach methods (NAMs) for assessing inhalation risks under the Toxic Substances Control Act (TSCA) [Abstract 2583]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Hill BN, Hunter DL, Padilla S. 2020. Zebrafish larval locomotor activity is depressed by lack of swim bladder inflation or dimethyl sulfoxide [Abstract 1461]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Hilton GM, Akerman G, Baldassari J, Battalora M, Buesen R, Clippinger AJ, Geter D, Lowit A, Melching-Kollmuss S, Kormos T, Papineni S, Peffer RC, Williamson Riffle B, Ryan N, Visconti N, Wolf DC. 2020. Rethinking carcinogenicity assessment for agrochemicals [Abstract 2200]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Hines D, Bell S, Chang X, Mansouri K, Allen D, Casey W, Kleinstreuer N. 2021. Computational support of pharmacokinetic models and in vitro to in vivo extrapolation [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Jarabek AM, Stedeford T, Ladics GS, Price OT, Tveit A, Hayes MP, Tremblay RT, Snyder SA, Salazar KD, Osman-Sypher S, Irwin W, Odin M, Melia J, Carlson-Lynch H, Sharma M, Clippinger AJ, Stucki AO, Henry TR. 2021. Poorly soluble, low toxicity (PSLT) polymer category: an integrated approach to testing and assessment (IATA) including new approach methods (NAMs) under the Toxic Substances Control Act (TSCA) [Abstract 2593]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kaldhone P, Yan J, Chen T, Manjanatha M. 2020. Glyphosate safety assessment through Ames test [Abstract 1668]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kang JC, Valerio L. 2020. Investigating DNA adduct formation by flavor chemicals and tobacco byproducts in electronic nicotine delivery system (ENDS) using in silico approaches [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Karmaus AL 2021. Comparing and interpreting Tox21 data analysis approaches [Abstract 1000]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Karmaus AL. 2021. Interpreting the Tox21 data analysis methods toward a consensus [Continuing Education course presentation]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Karmaus AL. 2021. Rat acute systemic toxicity testing: evaluating reproducibility and inherent variability [Abstract P232]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Karmaus A, Rooney J, Ceger P, Abedini J, Phillips J, Bell S, Allen D, Kleinstreuer N. 2021. Annotating and visualizing in vitro data to gain context [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Kleinstreuer NC. 2020. Computational crowdsourcing: leveraging global expertise to predict toxicity [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2020. What do computational toxicology tools offer? [Continuing Education course presentation]. Presented as part of the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2020. Establishing international test guidelines for skin sensitization: predictive capacity and applicability domain of nonanimal-defined approaches [Abstract]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Kleinstreuer NC. 2021. Automated approaches to anchoring alternatives [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. Applying in vitro to in vivo extrapolation to NAM-derived PODs [Abstract 49]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. Building an AOP-driven defined approach guideline [Abstract 47]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. High-throughput screening to predict HERG inhibition [Abstract P577]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. International regulatory progress on nonanimal approaches for skin sensitization [Abstract 1283]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. The intersection of scientific advances and regulatory needs [Abstract]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Kleinstreuer NC. 2021. Introduction to skin sensitisation NAMs and defined approaches [Abstract]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. A North American regulatory perspective on skin sensitization risk assessment [Abstract 48]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. "Proof in animals": has journal editorial policy fallen behind advances in human-based approaches [Abstract]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Kleinstreuer NC. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract P578]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Krishna S, Berridge BR, Kleinstreuer N. 2020. Predicting putative cardiotoxic chemicals using Tox21 qHTS data [Abstract 3131]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract 2791]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Krishna S, Beverley B, Walker V, Kleinstreuer N, Rooney A. 2021. Systematic evidence mapping of research on environmental exposures and cardiovascular disease [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N. 2021. High-throughput screening to predict hERG inhibition [Abstract 2561]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Krishna S, Borrel A, Huang R, Zhao J, Xia M, Kleinstreuer N. 2021. High-throughput screening to predict hERG inhibition [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Lavrich K, Ramiahgari S, Urbano N, Merrick BA, Ferguson S. 2020. Modeling inter-individual susceptibility in toxicological screening using 3D spheroid primary human hepatocyte cultures [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Li X, He X, Chen S, Guo X, Bryant MS, Guo L, Manjanatha MG, Mei N. 2021. The genotoxicity of pyrrolizidine alkaloids is mediated by CYP3A in metabolically competent TK6 cell lines [Abstract 2804]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Lowit A. 2021. Recent progress toward reducing animal use and adopting new approach methods [Abstract 1134]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Lowit M, Ceger P, Allen D, Arnold E, Choksi N, Daniel A, Hamm J, Judkins D, Kleinstreuer N, Montague B, Sprankle C, Truax J, Odenkirchen E. 2020. Exploring ways to reduce animal testing in support of the registration of pesticides by the U.S. Environmental Protection Agency [Abstract]. Presented at SETAC North America 2020; 15-19 November 2020.

Lowit M, Ceger P, Allen D, Choksi N, Daniel A, Eckel, W., Hamm J, Johnson, T., Kleinstreuer N, Sprankle C, Truax J, Odenkirchen E. 2021. Applying the 3Rs to Reduce Animal Testing in Support of the Registration of Pesticides by the U.S. Environmental Protection Agency [Abstract]. Presented at SETAC Europe 2021; 3-6 May 2021.

Lowit M. 2021 Exploring Ways to Reduce Animal Testing in a Regulatory Context. [Abstract]. Presented at SETAC Europe 2021; 3-6 May 2021.

Mansouri K. 2021. OPERA, an open-source and open-data suite of QSAR models [Abstract P508]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Mansouri K, Chang X, Allen D, Casey W, Kleinstreuer N. 2021. QSAR models supporting toxicokinetic modeling and in vitro to in vivo extrapolation [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Mansouri K, Chang X, Judson R, Williams A, Allen DG, Kleinstreuer NC. 2021. OPERA models for ADME properties and toxicity endpoints [Abstract 2543]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Mansouri K, Karmaus AL, Fitzpatrick J, Patlewicz G, Pradeep P, Allen DG, Casey W, Kleinstreuer NC. 2020. Collaborative modeling project for predicting acute oral toxicity [Abstract 2060]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2020. Collaborative modeling project for predicting acute oral toxicity (CATMoS) [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2020. International computational modeling collaborations for predictive toxicology [Abstract]. Presented at SETAC North America 2020; 15-19 November 2020.

Mansouri K, Grulke C, Judson R, Richard A, Williams A, Kleinstreuer N. 2021. Open-source QSAR-ready chemical structure standardization workflow [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Allen D, Casey W, Kleinstreuer N. 2021. Collaborative modeling project for predicting acute oral toxicity (CATMoS) [Abstract]. Presented at the 19th International Workshop on (Quantitative) Structure-Activity Relationships in Environmental Health Sciences; 7-10 June 2021.

Martin MM, Baker NC, Boyes WK, Carstens KE, Culbreth ME, Gilbert ME, Harrill JA, Nyffeler J, Padilla S, Paul-Friedman K, Shafer TJ. 2021. An expert-driven literature review of “negative” reference chemicals for developmental neurotoxicity (DNT) assay evaluation [Abstract 2554]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Medlock Kakaley E, Cardon M, Evans N, Bradley P, Iwanowicz L, Gray E, Hartig P, Wilson V. 2020. In vitro bioassay and screening model for pre- and post-distribution for chicago-area treated waters [Abstract 1889]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Mumtaz MM, Pohl HR. 2020. Joint toxicity assessment of perfluoroalkyl substances (PFAS) mixtures [Abstract 2820]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Ooka M, Zhao J, Huang R, Witt K, Ferguson S, Smith-Roe S, Simeonov A, Xia M. 2021. Profiling Tox21 compounds that activate p53 signaling after metabolic activation [Abstract 2761]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Petersen E, Sharma M, Clippinger A, Gordon J, Katz A, Laux P, Leibrock L, Luch A, Matheson J, Stucki A, Tentschert J, Bierkandt F. 2021. Use of cause-and-effect analysis to optimize the reliability of in vitro inhalation toxicity measurements using an air-liquid interface [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Rahman A, Svoboda D, Bushel PR, Berridge BR, Auerbach SS. 2020. Weighted gene coregulation network analysis (wgcna) to decipher temporal dynamics in cardiotoxicity [Abstract 3102]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Rooney JP. 2021. Variability in the rabbit skin irritation assay [Abstract P509]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Rooney J, Abedini J, Bell S, Chang X, Cook B, Ceger P, Hines D, Karmaus A, McAfee E, Phillips J, Allen D, Casey W, Kleinstreuer N. 2021. Building confidence in alternative methods through ICE [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Rooney JP, Choksi N, Ceger P, Daniel A, Truax J, Rai R, Kleinstreuer N, Allen D. 2020. Variability in the rabbit skin irritation assay [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Rooney JP, Choksi N, Ceger P, Daniel AB, Truax J, Allen DG, Kleinstreuer NC. 2021. Variability in the rabbit skin irritation assay [Abstract 2760]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Rooney JP, Choksi N, Rai R, Allen DG, Kleinstreuer NC, Casey W. 2020. Variability in the rabbit skin irritation assay [Abstract 1415]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Rooney J, Lizarraga L, Yamada T, Allen D, Babich M, Daniel A, Fitzpatrick S, Garcia-Reyero N, Gordon J, Hakkinen P, Karmaus A, Kleinstreuer N, Matheson J, Mumtaz M, Rua D, Ruiz P, Scarano L, Volarath P, Patlewicz G. 2020. ICCVAM Read-Across Workgroup: towards guiding principles for read-across applications [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Ruiz P, Boone S, Mumtaz MM. 2020. Advantage of read-across and pharmacokinetics modeling for the exposure assessment of persistent organic pollutants [Abstract 2949]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Sedykh A. 2021. Mixture-based QSAR models of ocular toxicity for regulatory hazard categories [Abstract P230]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Sprankle C. 2021. Effective user support documentation for a toxicological data resource: ICE as a case study [Abstract P513]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J. 2021. Application of defined approaches for skin sensitization to agrochemical products [Abstract P511]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J. 2021. International regulatory needs for acute toxicity data [Abstract P586]. Presented at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; 23 August-2 September 2021.

Strickland J, Allen DG, Api A, Gordon J, Kleinstreuer NC, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2020. Classification of human reference data for skin sensitization [Abstract 1872]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2020. Human reference database for skin sensitization [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.

Strickland J, Allen D, Api AM, Gordon J, Kleinstreuer N, Ko HS, Matheson J, Thierse HJ, Truax J, Herzler M. 2021. Compilation and characterization of a human skin sensitization data set [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Strickland J, Daniel AB, Allen DG, Kleinstreuer NC, Haugabrooks E. 2021. International regulatory needs for acute toxicity data [Abstract 2341]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

Strickland J, Truax J, Corvaro M, Settivari R, Henriquez J, McFadden J, Gulledge T, Johnson V, Gehen S, Germolec D, Allen D, Kleinstreuer N. 2021. Skin sensitization testing of mixtures without animals [Abstract]. Presented at the Tenth Annual Meeting of the American Society for Cellular and Computational Toxicology; 12-14 October 2021.

Tan C, Lowit A, Embry M. 2020. Applications of physiologically based pharmacokinetic (PBPK) modeling in regulatory risk assessment for pesticides [Abstract 1539]. Accepted for presentation at the 2020 Annual Meeting of the Society of Toxicology.

Tandon A, Maharana A, Howard B, Ramaiahgari S, Dunlap P, Rice J, Merrick A, DeVito M, Ferguson S, Shah R. 2021. Toward automation of high-throughput toxicology assay image analysis using deep learning [Abstract 2977]. Presented at the Annual Meeting of the Society of Toxicology; 12-26 March 2021.

You D, Behl M, Choi T, Balik-Meisner M, Mav D, Phadke D, Shah R, Harrill A. 2020. Molecular assessment of interindividual variability in susceptibility to developmental neurotoxicity of methyl mercury using diversity outbred neural progenitor cells [Abstract]. Presented at the Ninth Annual Meeting of the American Society for Cellular and Computational Toxicology; 20-22 October 2020.