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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods
https://ntp.niehs.nih.gov/go/928031

CompTox Chemicals Dashboard

The CompTox Chemicals Dashboard is the primary web-based application that provides access to data and algorithms from the EPA Center for Computational Toxicology and Exposure. Since April 2017, a total of 10 releases have increased the data available from an initial release of 560k data points to a total of 906k data points with the December 2021 release. There are now over 310 individual chemical lists available that include substances such as pesticides, disinfectant byproducts, and PFAS. The latest release represents a major architecture and design update, with data management based on a datamart-datahub technology, a rich API, and fresh user interface design. With this architecture, new applications using the same underpinning data and API will be easier to build and maintain long-term. The update also supported significant improvements in performance. For example, batch searches and downloads for 5000 chemicals now generally take less than 5 seconds compared with over a minute in the previous version. Both Generalized Read-Across (GenRA) and Abstract Sifter are now separate modules, allowing their use for querying chemicals beyond those present in the underlying database. The next release of data, planned for 2022, will expand the number of substances to over 1.2 million chemicals and will include updates to many of the existing chemical lists.

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