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ICCVAM Biennial Report 2020-2021

Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods

EPA List of NAMs for TSCA Information Requirements

A 2016 update of the Toxic Substances Control Act (TSCA) required EPA to issue a list of methods and approaches that do not use vertebrate animals (i.e., NAMs) to develop new data or information required under TSCA. In February 2021, EPA updated the list of NAMs that the agency will consider for the purpose of satisfying information requirements under TSCA. Some updates reflected changes made to OECD test guidelines, while other updates considered guidance on acute systemic toxicity testing waivers issued by the EPA Office of Pesticide Programs and availability of a new expert system to predict carcinogenicity of organic chemicals, fibers, metals, and polymers.

The NAMs list is an element of EPA’s 2018 “Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Within the TSCA Program.” Information about the NAMs list and the Strategic Plan is available on the EPA website.