Regulatory Actions for Year 1984

Year	Agency	Title	CASRN

1984	EPA	Certain Polyamino Chemical Substances EPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited NTP bioassay indicated that the dihydrochloride salt of Methylenedianiline is carcinogenic in both sexes of rats and mice. (TR-248) Type: Proposed Rule December 27, 1984 49 FR 50209	13552-44-8
1984	EPA	[(Dinitrophenyl)Azo]-[2,4-Diamino-5-Methoxybenzene] Derivatives; Proposed Determination of Significant New Uses EPA proposed rule promulgating a significant new use rule under TSCA Section 5. NTP Information Cited NTP and others have shown carcinogenic potential of close structural analogues of phenylenediamines. Type: Proposed Rule October 25, 1984 49 FR 42960
1984	EPA	1,1,1-Trichloroethane EPA final rule identifying specific chemical substance and mixture testing requirements. NTP Information Cited EPA did not propose chronic effects or oncogenicity testing because an NTP study is expected to provide sufficient information. (TR-262) Type: Final Rule October 10, 1984 49 FR 39810	71-55-6
1984	OSHA	Ethylene Oxide OSHA final standard on occupational PEL. NTP Information Cited NTP studies show significance of all malignancies rather than increases in only certain types of cancer, in calculating human risk. (TR-326) Type: Other June 22, 1984 49 FR 25734	75-21-8
1984	EPA	Dichloromethane EPA proposed rule to withdraw testing requirements under TSCA. Evaluation of data indicates dichloromethane does not present unreasonable risks. NTP Information Cited EPA expects NTP inhalation bioassay to be sufficient to characterize oncogenic hazards. (TR-306) Type: Proposed Rule June 19, 1984 49 FR 25009	75-09-2
1984	EPA	Nitrobenzene EPA proposed rule to withdraw testing requirements under TSCA. Ongoing government and manufacturers' tests are expected to meet all testing. NTP Information Cited EPA concluded that NTP oncogenicity and subchronic effects testing would be sufficient and so didn't require further testing for these effects. Type: Proposed Rule June 19, 1984 49 FR 25013	98-95-3
1984	EPA	Volatile Synthetic Organic Chemicals EPA proposed rule for National Primary Drinking Water Regulations establishing Recommended Maximum Contaminant Levels for several VOC's. NTP Information Cited NTP studies of trichlorethylene; 1,1,1-trichlorethane; 1,1-dichloroethylene; and p-dichlorobenzene. (TR-319) (TR-228) (TR-243) (TR-273) (TR-262) Type: Proposed Rule June 12, 1984 49 FR 24330	106-46-7 79-01-6 71-55-6 75-35-4
1984	EPA	Fluoroalkenes EPA notice of proposed decision to adopt a negotiated testing program in lieu of required testing. NTP Information Cited NTP planning testing of tetrafluoroethane and vinylidene. (TR-228) Type: Proposed Rule June 04, 1984 49 FR 23112	75-35-4
1984	EPA	Bis(2-Ethylhexyl) Terephthalate EPA notice of decision to adopt negotiated testing program. NTP Information Cited NTP has nominated two chemicals similar to the metabolites of DOTP for genotoxicity testing. Type: Notice June 04, 1984 49 FR 23110	104-76-7 4376-20-9
1984	EPA	Toluene EPA notice of decision not to regulate under CAA based on studies showing toluene not to pose a significant risk to public health. This decision is not relevant to regulation of toluene as a VOC under the air quality standards for ozone. NTP Information Cited NTP is currently conducting a lifetime bioassay on toluene. (TR-371) Type: Notice May 25, 1984 49 FR 22195	108-88-3
1984	EPA	Formaldehyde EPA ANPR announcing decision that TSCA Section 4f priority consideration is applicable in 2 exposure categories, and initiating a regulatory investigation. NTP Information Cited Federal Panel on Formaldehyde, under the aegis of NTP, reviewed CIIT's bioassay methodology from CIIT inhalation study showing nasal cancer in rats. Type: Other May 23, 1984 49 FR 21870	50-00-0
1984	EPA	Calcium, Cobalt, and Lead Napthenates EPA notice of determination not to require testing. NTP Information Cited NTP planning testing of cobalt naphthenate and cobalt sulfate; NTP currently testing naphthenic acid; NTP has completed mutagenicity tests of lead naphthenate. Type: Notice May 21, 1984 49 FR 21411	10124-43-3 61789-51-3
1984	EPA	1,3-Butadiene EPA ANPR and invitation to submit data on controlling exposures, following recent bioassays establishing carcinogenicity. NTP Information Cited NTP chronic oncology studies show carcinogenicity in both sexes of rats and mice; NTP planning further teratology testing. (TR-288) Type: Other May 15, 1984 49 FR 20524	106-99-0
1984	EPA	Cyromazine EPA proposed temporary feed additive regulation. NTP Information Cited NTP bioassay of Melamine, a metabolite of Cyromazine, showed significant increase in bladder carcinomas in male rats. (TR-245) Type: Proposed Rule April 27, 1984 49 FR 18130	108-78-1
1984	EPA	Cyromazine EPA proposed rule to establish feed additive regulation setting temporary maximum permissible residue level in poultry feed. NTP Information Cited NTP bioassay of Melamine, a metabolite of Cyromazine, showed a significant increase in bladder carcinomas in male rats. (TR-245) Type: Notice April 27, 1984 49 FR 18120	108-78-1
1984	EPA	Cyromazine EPA notice of proposed conditional registration under FIFRA for temporary period. NTP Information Cited As a result of the reported oncogenicity of Melamine in the NTP bioassay, the agency stopped the Cyromazine registration process...until it could review the NTP bioassay. (TR-245) Type: Notice April 27, 1984 49 FR 18172	108-78-1
1984	EPA	Isophorone EPA notice of decision to adopt negotiated testing program. NTP Information Cited NTP's initiation of a long-term bioassay, together with CMA proposed testing, make it unnecessary to require TSCA Section 4 testing. (TR-291) Type: Notice January 17, 1984 49 FR 2012	78-59-1
1984	EPA	1,2-Dichloropropane EPA proposed test rule NTP Information Cited NTP 2-year bioassay (TR-263) Type: Proposed Rule January 06, 1984 49 FR 899	78-87-5
1984	EPA	1,2-Butylene Oxide EPA notice of determination not to require testing. NTP Information Cited NTP inhalation bioassay of 1,2-butylene oxide. (TR-329) Type: Notice January 04, 1984 49 FR 503	106-88-7
1984	EPA	Certain Alkyl Epoxides EPA ANPR on testing under TSCA NTP Information Cited NTP subchronic study on 1,2-Epoxyhexadecane applied dermally. Type: Other January 04, 1984 49 FR 449	7320-37-8
1984	EPA	Hydroquinone EPA Proposed test rule under TSCA Section 4. NTP Information Cited EPA is not proposing oncogenicity testing of Hydroquinone since NTP is currently conducting a 2-year bioassay. (TR-366) Type: Proposed Rule January 04, 1984 49 FR 438	123-31-9
1984	EPA	Ethylene Oxide EPA notice of determination not to require testing. NTP Information Cited NTP chronic inhalation bioassay. (TR-326) Type: Notice January 03, 1984 49 FR 200	75-21-8
1984	EPA	Anilines EPA ANPR to require health and environmental effects testing. NTP Information Cited NTP confirmatory study of effects of dietary exposure to 4-Chloroaniline Hydrochloride. (TR-351) Type: Other January 03, 1984 49 FR 108	20265-96-7