Pituitary Gland, Rathke's Cleft - Dilation

Image of Rathke's cleft dilation in the pituitary gland from a female F344/N rat in a chronic study
Pituitary, Rathke�s cleft - Dilation in a female F344/N rat from a chronic study. The dilated Rathke�s cleft is filled with intensely eosinophilic proteinaceous material with cholesterol clefts (arrow) present at the edge of the dilated cleft.
Figure 1 of 3
Image of Rathke's cleft dilation in the pituitary gland from a female F344/N rat in a chronic study
Pituitary, Rathke�s cleft - Dilation in a female F344/N rat from a chronic study. Higher magnification of Figure 1 shows the dilated Rathke�s cleft filled with intensely eosinophilic proteinaceous material and the cholesterol clefts (arrow) at the edge of the dilated cleft in greater detail.
Figure 2 of 3
Image of Rathke's cleft dilation in the pituitary gland from a female F344/N rat in a chronic study
Pituitary, Rathke�s cleft - Dilation in a female F344/N rat from a chronic study. The dilated Rathke�s cleft contains pale eosinophilic proteinaceous material and erythrocytes (hemorrhage).
Figure 3 of 3
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comment:

Dilated persistent Rathke’s clefts are relatively common in rats and typically contain eosinophilic colloid-like proteinaceous material. Cholesterol clefts (arrow, Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ), as well as free erythrocytes ( Figure 3image opens in a pop-up window ), may be present. Pituitary cysts may also be present (see Pituitary Gland - Cyst).

recommendation:

Since chronic studies may incorporate in utero exposure, developmental alterations potentially related to treatment could influence the ultimate presence and appearance of Rathke’s cleft. Thus, this change should be documented when present. A severity grade is appropriate if there is a potential treatment-related effect on the occurrence or severity of this change. Hemorrhage or cholesterol clefts within the dilated Rathke’s cleft should not be diagnosed separately unless warranted by severity.

related links:

Pituitary Gland - Cyst

references:

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Capen CC, DeLellis RA, Yarrington JT. 1991. Endocrine system. In: Handbook of Toxicologic Pathology (Haschek WM, Rousseaux CG, eds). Academic Press, New York, 697-705.
Abstract: http://www.sciencedirect.com/science/book/9780123302151

Carlton WW, Gries CL. 1983. Cysts, pituitary; rat, mouse, and hamster. In: Endocrine System (Jones TC, Mohr U, Hunt RD, eds). Springer, New York, 161-163.
Abstract: http://www.springer.com/medicine/pathology/book/978-3-642-96722-1

Gon G, Nakamura F, Ishikawa H. 1987. Cystlike structures derived from the marginal cells of Rathke's cleft in rat pituitary grafts. Cell Tissue Res 250:29-33.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/3652164

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Abstract: http://www.jstor.org/stable/3625875

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Abstract: http://www.ncbi.nlm.nih.gov/pubmed/10930044

Kouki T, Imai H, Aoto K, Eto K, Shioda S, Kawamura K, Kikuyama S. 2001. Developmental origin of the rat adenohypophysis prior to the formation of Rathke's pouch. Development 128:959-963.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11222149

Lansdown AB, Grasso P 1971. Histological observations on a Rathke's cleft abnormality in a laboratory rat. J Comp Pathol 81:141-144.
Abstract: http://www.sciencedirect.com/science/article/pii/0021997571900661

MacKenzie WF, Boorman GA. 1991. Pituitary gland. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman G, Eustis S, Elwell M, Montgomery CA, MacKenzie W, eds). Academic Press, San Diego, 485-500.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Morton D, Tekeli S. 1997. "Have you seen this?" Pituitary cysts in a mouse. Toxicol Pathol 25:333.
Full Text: http://tpx.sagepub.com/content/25/3/333.long

Quintanar-Stephano A, Munoz Fernandez L, Quintanar JL, Kovacs K. 2001. Cysts in the rat adenohypophysis: Incidence and histology. Endocr Pathol 12:63-71.
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