Seminal Vesicle - Amyloid

Image of amyloid in the seminal vesicle from a male B6C3F1 mouse in an chronic study
Seminal Vesicle - Amyloid. Arrow indicates amyloid deposits in a male B6C3F1 mouse from a chronic study.
Figure 1 of 2
Image of amyloid in the seminal vesicle from a male B6C3F1 mouse in an chronic study
Seminal Vesicle - Amyloid. Higher magnification of Figure 1. Arrows indicate amyloid deposits in a male B6C3F1 mouse from a chronic study.
Figure 2 of 2
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comment:

Amyloidosis in the seminal vesicle is characterized by deposition of homogeneous eosinophilic to amphophilic amorphous material that expands the subepithelial stroma (arrows, Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Since it is a systemic condition, amyloid deposits should be present in other tissues, such as spleen, liver, kidney, and intestine, particularly in vascular and perivascular sites. Amyloidosis is an age-related change that occurs primarily in mice, with variable mouse strain susceptibility.

recommendation:

Amyloidosis should be diagnosed and graded and should be described in the pathology narrative when it is exacerbated by treatment. If both seminal vesicles are involved, the diagnosis should be qualified as bilateral and severity based on the more affected seminal vesicle

references:

Boorman GA, Elwell MR, Mitsumori K. 1990. Male accessory sex glands, penis, and scrotum. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 419-428.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563

Creasy D, Bube A, de Rijk E, Kandori H, Kuwahara M, Masson R, Nolte T, Reams R, Regan K, Rehm S, Rogerson P, Whitney K. 2012. Proliferative and nonproliferative lesions of the rat and mouse male reproductive system. Toxicol Pathol 40:40S-121S.
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22949412

Gordon LR, Majka JA, Boorman GA. 1996. Spontaneous nonneoplastic and neoplastic lesions and experimentally induced neoplasms of the testes and accessory sex glands. In: Pathobiology of the Aging Mouse, Vol 1 (Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM, eds). ILSI Press, Washington, DC, 421-441.
Abstract: http://catalog.hathitrust.org/Record/008994685

Radovsky A, Mitsumori K, Chapin RE. 1999. Male reproductive tract. In: Pathology of the Mouse: Reference and Atlas (Maronpot RR, Boorman GA, Gaul BW, eds). Cache River Press, Vienna, IL, 381-407.
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm