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    Image of necrosis in the bone from a male B6C3F1/N mouse in a chronic study
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. This section of a femur demonstrates focal necrosis (arrowhead) associated with marked joint degeneration.
    Image of necrosis in the bone from a male B6C3F1/N mouse in a chronic study
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study (higher magnification of Figure 1). This section of femur illustrates focal necrosis associated with marked joint degeneration.
    Image of necrosis in the bone from a male F344/N rat in a chronic study
    Bone, Femur - Necrosis in a male F344/N rat from a chronic study. Focal necrosis is associated with marked joint degeneration in a section of femur.
    Image of necrosis in the bone from a male B6C3F1/N mouse in a chronic study
    Bone, Femur - Necrosis in a male B6C3F1/N mouse from a chronic study. In this section of femur, focal necrosis is associated with marked joint degeneration.
    Image of necrosis in the bone from a male F344/N rat in a chronic study
    Bone, Vertebra - Necrosis in a male F344/N rat from a chronic study. This section of a vertebra demonstrates marked necrosis characterized by loss of bony architecture, fragmentation, and debris associated with significant fibroplasia and bony remodeling.