Respiratory System

Nose - Foreign Material

    Narrative
    Nose - Foreign material in a female F344/NTac rat from an acute study. Free dark brown particulate material is present in the nasal cavity (arrows).
    Nose - Foreign material in a female F344/NTac rat from an acute study (higher magnification of Figure 1). The dark brown particulate material (arrows) is associated with proteinaceous material.
    Nose, Nasopharyngeal duct - Foreign material in a female F344/NTac rat from an acute study. Dark brown particulate material is present at the base of the nasopharyngeal duct (arrow).
    Nose, Nasopharyngeal duct - Foreign material in a female F344/NTac rat from an acute study (higher magnification of Figure 3). The dark brown particulate material is within macrophages.
    Lung - Foreign material in a female F344/NTac rat from a subchronic study. The appearance of the dark brown particulate material in the lungs from a longer-duration study of the same material is similar to that shown in Figures 1-4.

    Authors

    Rodney A. Miller, DVM, PhD, DACVP
    NC Pathology Group Manager
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Mark F. Cesta, DVM, PhD, DACVP
    Staff Scientist, NTP Pathologist
    Cellular and Molecular Pathology Branch
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC

    Reviewers

    Robert R. Maronpot, DVM, MS, MPH, DACVP, DABT, FIATP
    Senior Pathologist
    Experimental Pathology Laboratories, Inc.
    Research Triangle Park, NC

    Ronald Herbert, DVM, PhD
    NTP Pathologist
    Group Leader, Pathology Support Group
    Division of the National Toxicology Program
    National Institute of Environmental Health Sciences
    Research Triangle Park, NC