Eye, Anterior chamber - Proteinaceous fluid

Image of anterior chamber proteinaceous fluid in the eye from a female F344/N rat in a chronic study
Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. Anterior chamber proteinaceous fluid (arrow) is characterized by accumulations of homogeneous pale eosinophilic material that contains few if any inflammatory cells.
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Image of anterior chamber proteinaceous fluid in the eye from a female F344/N rat in a chronic study
Eye, Anterior chamber - Proteinaceous fluid in a female F344/N rat from a chronic study. There are accumulations of homogeneous pale eosinophilic material in the anterior chamber (arrow) that contains few if any inflammatory cells.
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comment:

Anterior chamber proteinaceous fluid is characterized by intracameral accumulations of homogeneous pale eosinophilic material (often including fibrin) that contains few if any inflammatory cells ( Figure 1image opens in a pop-up window and Figure 2image opens in a pop-up window ). Anterior chamber proteinaceous fluid can compress the iridocorneal filtration angle channels and/or the adjacent trabecular meshwork, impeding normal drainage of aqueous humor with resultant elevations in intraocular pressure. (Other ocular lesions in Figure 1image opens in a pop-up window and/or Figure 2image opens in a pop-up window include posterior synechiae, lens cataract with mineralization, and/or iridial inflammation.)

recommendation:

Proteinaceous fluid in the anterior chamber should be diagnosed as "Eye, Anterior chamber - Proteinaceous fluid" and assigned a severity grade. If anterior chamber proteinaceous fluid is part of a more dispersed inflammatory process in the eye, it need not be diagnosed separately but should be described in the pathology narrative.

references:

National Toxicology Program. 1997. NTP TR-450. Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies). NTP, Research Triangle Park, NC.
Abstract: http://ntp.niehs.nih.gov/go/6044

Smith RS, Sundberg JP, John SWM. 2002. The anterior segment. In: Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods (Smith RS, John SWM, Nishina PM, Sundberg JP, eds). CRC Press, Boca Raton, FL, 111-159.