Harderian Gland - Infiltration Cellular, Mononuclear Cell
comment:Small focal clusters of inflammatory cells in the interstitium are common incidental findings in the Harderian gland of rats and mice. These infiltrates are most commonly mononuclear cells (lymphocytes) ( Figure 1 and Figure 2 ), but other inflammatory cells may also be present. Increased incidences and severity of such infiltrates can also be associated with various pathologic conditions. Cellular infiltrates can be distinguished from inflammation by the presence of other features of inflammation, such as tissue destruction, hemorrhage, fibrosis, edema, or additional types of leukocytes.
recommendation:Harderian gland infiltrates should be diagnosed and assigned a severity grade, especially when there are treatment-related increases in incidence and/or severity. The predominant type of cell present should be indicated in the diagnosis as a modifier (e.g., Harderian gland - Infiltration cellular, Mononuclear cell). If there is an even mix of cell types (i.e., no one cell type predominates), the modifier "mixed" may be used.
related links:Harderian Gland - Inflammation
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