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Kidney - Nephropathy, Chronic Progressive - Gallery

Image of nephropathy, chronic progressive in the kidney from a male F344/N rat in a subchronic study
Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. The early cases of chronic progressive nephropathy (CPN) occur as focal to multifocal areas of tubule basophilia with or without hyaline (protein) casts.
Image of nephropathy, chronic progressive in the kidney from a male F344/N rat in a chronic study
Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. This is a more severe case of CPN with prominent hyaline casts.
Image of nephropathy, chronic progressive in the kidney from a male F344/N rat in a chronic study
Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a chronic study. As the severity of CPN progresses, all components of CPN become more prominent, with nearly all of the renal parenchyma involved.
Image of nephropathy, chronic progressive in the kidney from a male F344/N rat in a subchronic study
Kidney - Nephropathy, Chronic progressive in a male F344/N rat from a subchronic study. CPN may become quite severe, leading to an "end-stage" kidney with little normal parenchyma remaining.
Image of nephropathy, chronic progressive in the kidney from a male B6C3F1 mouse in a subchronic study
Kidney - Nephropathy, Chronic progressive in a male B6C3F1 mouse from a subchronic study. Though usually less severe, CPN has a similar appearance in mice.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.