Urinary Bladder - Pigment

Image of pigment in the urinary bladder from a female F344/N rat in a chronic study
Pigment-a focal area of hemosiderin from a female F344/N rat in a chronic study.
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comment:

Pigment is rarely reported in urinary bladders of rodents. The most common pigment is hemosiderin ( Figure 1image opens in a pop-up window ). Pigmentation of urothelium has been observed with administered dye compounds.

recommendation:

Pigment should be diagnosed and given a severity grade. With the exception of Prussian blue staining for hemosiderin, definitive pigment identification is often difficult in histologic sections, even with a battery of special stains. Therefore, it is recommended that a diagnosis of “pigment” (as opposed to diagnosing the type of pigment, e.g., hemosiderin or lipofuscin) is more appropriate. The pathology narrative should describe the morphologic features of the pigment.

references:

Jokinen MP. 1990. Urinary bladder, ureter, and urethra. In: Pathology of the Fischer Rat: Reference and Atlas (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). Academic Press, San Diego, 109-126.
Abstract: http://www.ncbi.nlm.nih.gov/nlmcatalog/9002563