NTP Experiment-Test: 96014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 06/20/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 10:13:08 FINAL/MICE Facility: Southern Research Institute Chemical CAS #: 71133-14-7 Lock Date: 06/29/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 06/20/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 10:13:08 ____________________________________________________________________________________________________________________________________ MICE:B6C3F1 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Depletion Glycogen 1 [1.0] 1 [1.0] 2 [1.0] 1 [1.0] 6 [1.0] Hematopoietic Cell Proliferation 2 [1.0] Inflammation, Acute, Focal 1 [1.0] Inflammation, Chronic, Focal 3 [1.0] 3 [1.0] 2 [1.0] 1 [1.0] 3 [1.0] 6 [1.2] Necrosis, Focal 1 [2.0] Tension Lipidosis, Focal 1 [2.0] Stomach, Glandular (10) (10) Epithelium, Cyst 1 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) Zona Reticularis, Vacuolization Cytoplasmic 8 [1.0] 10 [1.1] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) Cyst 1 [2.0] ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 06/20/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 10:13:08 ____________________________________________________________________________________________________________________________________ MICE:B6C3F1 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) Hematopoietic Cell Proliferation 1 [2.0] 2 [1.5] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Inflammation, Chronic, Focal 1 [1.0] 1 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 06/20/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 10:13:08 ____________________________________________________________________________________________________________________________________ MICE:B6C3F1 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 [1.0] 1 [1.0] Inflammation, Chronic, Focal 5 [1.2] 5 [1.0] 3 [1.0] 5 [1.2] 5 [1.0] 4 [1.0] Salivary Glands (10) (10) Parotid Gland, Inflammation, Chronic, Focal 1 [1.0] Stomach, Forestomach (10) (10) Edema, Focal 1 [2.0] Erosion, Focal 1 [2.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 96014-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 06/20/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 10:13:08 ____________________________________________________________________________________________________________________________________ MICE:B6C3F1 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Spleen (10) (10) Pigmentation, Hemosiderin 1 [2.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) (10) (10) Inflammation, Chronic, Focal 3 [1.3] 1 [1.0] Renal Tubule, Vacuolization Cytoplasmic 10 [2.0] 10 [1.8] 10 [2.0] 10 [2.0] 10 [1.2] 6 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------