NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:36:22 14 WEEK SSAC FINAL #1; REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 01/13/00 - 01/14/00 Treatment Groups: Include 001 0 NG TEQ/KG Include 002 7 NG TEQ/KG Include 003 22 NG TEQ/KG Include 004 72 NG TEQ/KG Include 005 216 NG TEQ/KG Include 006 360 NG TEQ/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:36:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 98 86 98 86 98 86 Scheduled Sacrifice 16 10 16 10 16 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:36:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (1) Nephroblastoma 1 (100%) Page 3 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:36:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 1 Total Primary Neoplasms 1 Total Animals with Benign Neoplasms Total Benign Neoplasms Total Animals with Malignant Neoplasms 1 Total Malignant Neoplasms 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------