NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 31 WEEK SSAC FINAL #1; REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 05/16/00 - 05/17/00 Treatment Groups: Include 001 0 NG TEQ/KG Include 002 7 NG TEQ/KG Include 003 22 NG TEQ/KG Include 004 72 NG TEQ/KG Include 005 216 NG TEQ/KG Include 006 360 NG TEQ/KG Page 1 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Basophilic Focus | X | 1 | Cholangiofibrosis | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X | 1 | Inflammation | 1 1 1 1 2 2 1 1 1 1 | 10 1.2| Mixed Cell Focus | X X X | 3 | Mixed Cell Focus, Multiple | X X | 2 | Necrosis | 1 | 1 1.0| Pigmentation | 1 1 | 2 1.0| Bile Duct, Fibrosis | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Hypertrophy | 1 2 1 1 1 | 5 1.2| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Follicular Cell, Hypertrophy | 2 1 1 | 3 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 3 3 | 6 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Inflammation, Suppurative | 3 | 1 3.0| Metaplasia, Squamous | 1 2 1 2 2 | 5 1.6| Endometrium, Hyperplasia, Cystic | 1 2 1 2 2 | 5 1.6| |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Pigmentation | 1 1 1 2 1 1 2 1 1 1 | 10 1.2| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 1 1 2 | 3 1.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | Hyperplasia | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 1| 1| 1| 1| 2| 3| 3| 3| 3| 4| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 6| 7| 8| 9| 5| 6| 7| 8| 9| 0| 3| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 2 | 2 2.0| Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 7 NG | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| | L | TEQ/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation | 1 1 1 1 1 1 1 1 1 2 | 10 1.1| Mixed Cell Focus | X X X X X | 5 | Mixed Cell Focus, Multiple | X X X | 3 | Necrosis | 1 | 1 1.0| Pigmentation | 1 1 1 1 | 4 1.0| Hepatocyte, Hypertrophy | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Angiectasis | 1 1 1 1 1 1 | 6 1.0| Degeneration, Cystic | 2 | 1 2.0| Hypertrophy | 2 2 1 2 | 4 1.8| |__________________________________________________________________________|____________| Pituitary Gland | + | 1 | Angiectasis | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 3 3 3 | 7 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 7 NG | 0| 0| 0| 0| 0| 7| 7| 7| 7| 7| | L | TEQ/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Metaplasia, Squamous | 2 1 1 2 2 2 | 6 1.7| Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 | 5 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Infiltration Cellular, Histiocyte | 1 1 | 2 1.0| Inflammation | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 22 NG | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| | L | TEQ/KG | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation | 2 1 2 1 1 1 1 1 1 1 | 10 1.2| Mixed Cell Focus | X | 1 | Mixed Cell Focus, Multiple | X | 1 | Necrosis | 2 | 1 2.0| Pigmentation | 2 1 1 1 1 1 1 1 1 | 9 1.1| Hepatocyte, Hypertrophy | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | Serosa, Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Angiectasis | 1 1 | 2 1.0| Hypertrophy | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicular Cell, Hypertrophy | 1 1 1 2 2 1 1 | 7 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 3 2 3 | 7 2.9| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 22 NG | 2| 3| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 9| | L | TEQ/KG | 8| 7| 8| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Uterus | + + + + + + + + + + | 10 | Decidual Reaction | X | 1 | Metaplasia, Squamous | 2 2 1 1 2 2 | 6 1.7| Endometrium, Hyperplasia, Cystic | 2 2 1 1 3 1 | 6 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 1 2 2 1 2 | 5 1.6| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cholangiofibrosis | 2 1 | 2 1.5| Fatty Change, Diffuse | 2 1 2 | 3 1.7| Hepatodiaphragmatic Nodule | X | 1 | Inflammation | 2 2 1 2 2 2 1 3 2 1 | 10 1.8| Mixed Cell Focus, Multiple | X X X X X X | 6 | Pigmentation | 1 1 1 2 1 1 1 2 1 1 | 10 1.2| Toxic Hepatopathy | 1 1 1 | 3 1.0| Bile Duct, Fibrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Fibrosis | 1 1 1 | 3 1.0| Hepatocyte, Hypertrophy | 2 1 1 1 1 1 1 1 | 8 1.1| Hepatocyte, Multinucleated | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Vacuolization Cytoplasmic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Hypertrophy | 2 1 2 | 3 1.7| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicular Cell, Hypertrophy | 1 2 1 2 2 1 1 | 7 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Ovary | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 | 4 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Metaplasia, Squamous | 2 2 1 2 | 4 1.8| Endometrium, Hyperplasia, Cystic | 2 1 1 | 3 1.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + | 9 | Atrophy | 2 2 2 2 3 2 2 4 2 | 9 2.3| Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 | 2 1.0| Inflammation, Granulomatous | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| | L | TEQ/KG | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cholangiofibrosis | 1 2 | 2 1.5| Eosinophilic Focus | X X X | 3 | Eosinophilic Focus, Multiple | X X X X | 4 | Fatty Change, Diffuse | 1 2 1 2 1 2 1 1 | 8 1.4| Hyperplasia, Nodular | X | 1 | Infarct | 3 | 1 3.0| Inflammation | 2 2 2 2 1 1 1 2 2 1 | 10 1.6| Necrosis | 1 1 | 2 1.0| Pigmentation | 2 2 2 2 3 2 2 2 2 2 | 10 2.1| Toxic Hepatopathy | 2 2 2 2 2 2 2 2 2 3 | 10 2.1| Bile Duct, Hyperplasia | 2 2 2 1 2 1 1 1 1 2 | 10 1.5| Centrilobular, Fibrosis | 2 2 2 2 2 2 2 1 2 1 | 10 1.8| Hepatocyte, Hypertrophy | 3 3 2 3 3 3 3 2 3 3 | 10 2.8| Hepatocyte, Multinucleated | 3 2 2 2 2 2 2 2 2 3 | 10 2.2| Oval Cell, Hyperplasia | 1 2 2 1 1 1 1 1 | 8 1.3| Portal, Fibrosis | 2 | 1 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Acinus, Atrophy | 1 | 1 1.0| Acinus, Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 1 1 | 10 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Angiectasis | 1 | 1 1.0| Atrophy | 1 1 | 2 1.0| Hypertrophy | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Follicular Cell, Hypertrophy | 2 2 2 2 1 2 1 2 2 | 9 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Metaplasia, Squamous | 2 | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 2 4 4 4 4 3 3 3 | 9 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 1 | 1 1.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 5 1.0| Inflammation, Granulomatous | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 5| 5| 7| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 1| 2| 3| 4| 5| 5| 6| 8| 3| 6| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 1 1 | 3 1.3| Interstitium, Fibrosis, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cholangiofibrosis | 1 | 1 1.0| Eosinophilic Focus | X X | 2 | Eosinophilic Focus, Multiple | X X X | 3 | Fatty Change, Diffuse | 1 1 2 1 1 1 2 1 3 | 9 1.4| Hyperplasia, Nodular | X X X X | 4 | Inflammation | 2 2 1 2 2 1 1 1 1 1 | 10 1.4| Pigmentation | 2 3 2 3 3 3 3 2 3 2 | 10 2.6| Toxic Hepatopathy | 3 3 2 2 3 3 3 3 3 3 | 10 2.8| Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 1 1 | 10 1.2| Centrilobular, Fibrosis | 3 3 2 2 2 3 2 2 2 2 | 10 2.3| Hepatocyte, Hypertrophy | 4 4 4 3 3 3 3 3 3 4 | 10 3.4| Hepatocyte, Multinucleated | 2 3 2 3 3 2 3 3 3 2 | 10 2.6| Oval Cell, Hyperplasia | 2 2 1 1 1 2 1 1 1 1 | 10 1.3| Portal, Fibrosis | 3 2 2 2 | 4 2.3| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 | 2 1.0| Acinus, Atrophy | 1 1 | 2 1.0| Acinus, Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 1 1 | 10 1.1| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Angiectasis | 1 | 1 1.0| Atrophy | 2 2 2 2 2 2 1 1 | 8 1.8| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hypertrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Cytoplasmic Alteration | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 3 | 1 3.0| Follicular Cell, Hypertrophy | 1 1 2 2 1 1 4 | 7 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 2 | 1 2.0| |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Pigmentation | 1 1 2 1 1 1 1 2 2 1 | 10 1.3| |__________________________________________________________________________|____________| Thymus | + + + + + M M + M M | 6 | Atrophy | 4 4 4 3 3 4 | 6 3.7| _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:29:27 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Infiltration Cellular, Histiocyte | 1 1 | 2 1.0| Inflammation, Granulomatous | 1 2 | 2 1.5| Metaplasia, Squamous | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 1 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 2 | 3 1.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------