NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:43:22 53 WEEK SSAC FINAL #1; REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/12/00 - 10/13/00 Treatment Groups: Include 001 0 NG TEQ/KG Include 002 7 NG TEQ/KG Include 003 22 NG TEQ/KG Include 004 72 NG TEQ/KG Include 005 216 NG TEQ/KG Include 006 360 NG TEQ/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:43:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 86 98 86 Scheduled Sacrifice 13 12 13 13 13 Early Deaths Survivors Animals Examined Microscopically 8 7 8 8 8 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (8) (7) (8) (8) (8) Angiectasis 1 (13%) Basophilic Focus 2 (25%) 3 (43%) 1 (13%) 1 (13%) 1 (13%) Cholangiofibrosis 2 (25%) 5 (63%) Clear Cell Focus, Multiple 1 (13%) Eosinophilic Focus 1 (13%) 1 (13%) Fatty Change, Diffuse 4 (50%) 8 (100%) Fatty Change, Focal 1 (13%) Hepatodiaphragmatic Nodule 1 (13%) Hyperplasia, Nodular 1 (13%) 8 (100%) Inflammation 7 (88%) 7 (100%) 8 (100%) 8 (100%) 8 (100%) Mixed Cell Focus 2 (25%) 2 (29%) 2 (25%) Mixed Cell Focus, Multiple 5 (63%) 3 (43%) 5 (63%) 7 (88%) Necrosis 1 (13%) 1 (14%) 3 (38%) 2 (25%) 2 (25%) Pigmentation 5 (71%) 8 (100%) 8 (100%) 8 (100%) Toxic Hepatopathy 2 (25%) 8 (100%) 8 (100%) Bile Duct, Cyst 1 (13%) Bile Duct, Fibrosis 1 (13%) Bile Duct, Hyperplasia 1 (13%) 1 (13%) 8 (100%) Centrilobular, Fibrosis 5 (63%) 8 (100%) Hepatocyte, Hypertrophy 1 (14%) 2 (25%) 8 (100%) 8 (100%) Hepatocyte, Multinucleated 3 (38%) 8 (100%) 8 (100%) Oval Cell, Hyperplasia 8 (100%) Portal, Fibrosis 8 (100%) Pancreas (8) (7) (8) (8) (8) Inflammation, Chronic Active 1 (13%) 2 (25%) 1 (13%) Acinus, Atrophy 1 (14%) 1 (13%) 1 (13%) 1 (13%) Acinus, Vacuolization Cytoplasmic 6 (75%) 8 (100%) Stomach, Forestomach (8) (8) Edema 1 (13%) Stomach, Glandular (8) (8) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:43:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Erosion 2 (25%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (8) (7) (8) (8) (8) Angiectasis 2 (29%) 3 (38%) 4 (50%) 1 (13%) Atrophy 5 (63%) Degeneration, Cystic 1 (13%) 2 (25%) Hyperplasia 1 (13%) 1 (13%) 1 (13%) Hypertrophy 5 (63%) 3 (43%) 6 (75%) 7 (88%) 5 (63%) Vacuolization Cytoplasmic 1 (13%) 1 (14%) 1 (13%) 1 (13%) Pituitary Gland (8) (8) Cyst 1 (13%) Thyroid Gland (8) (7) (8) (8) (8) C-Cell, Hyperplasia 1 (13%) 1 (13%) Follicular Cell, Hypertrophy 3 (38%) 4 (57%) 6 (75%) 7 (88%) 7 (88%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (8) (7) (8) (8) (8) Atrophy 7 (88%) 6 (86%) 6 (75%) 5 (63%) Cyst 1 (14%) Uterus (8) (7) (8) (8) (8) Inflammation, Suppurative 2 (25%) Metaplasia, Squamous 6 (75%) 5 (71%) 5 (63%) 5 (63%) Endometrium, Hyperplasia, Cystic 6 (75%) 6 (86%) 5 (63%) 5 (63%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (8) (8) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:43:22 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 1 (13%) Pigmentation 8 (100%) 8 (100%) Thymus (8) (7) (8) (8) (6) Atrophy 5 (63%) 7 (100%) 7 (88%) 8 (100%) 6 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (1) (1) (8) Cyst 1 (13%) Hyperplasia 1 (13%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (8) (7) (8) (8) (8) Infiltration Cellular, Histiocyte 7 (88%) 5 (71%) 7 (88%) 6 (75%) 8 (100%) Inflammation 1 (13%) Pigmentation 1 (13%) Alveolar Epithelium, Hyperplasia 1 (13%) Alveolar Epithelium, Metaplasia, Bronchiolar 3 (38%) 3 (38%) 6 (75%) Interstitium, Fibrosis 1 (13%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------