NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 53 WEEK SSAC FINAL #1; REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/12/00 - 10/13/00 Treatment Groups: Include 001 0 NG TEQ/KG Include 002 7 NG TEQ/KG Include 003 22 NG TEQ/KG Include 004 72 NG TEQ/KG Include 005 216 NG TEQ/KG Include 006 360 NG TEQ/KG Page 1 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9| | L | TEQ/KG | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Basophilic Focus | X X | 2 | Eosinophilic Focus | X | 1 | Fatty Change, Focal | 1 | 1 1.0| Inflammation | 1 1 1 1 1 1 1 | 7 1.0| Mixed Cell Focus | X X | 2 | Mixed Cell Focus, Multiple | X X X X X | 5 | Necrosis | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Hypertrophy | 1 1 1 1 1 | 5 1.0| Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Hyperplasia | 1 | 1 1.0| Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9| | L | TEQ/KG | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | Atrophy | 3 3 3 3 3 3 3 | 7 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Metaplasia, Squamous | 2 2 2 2 1 2 | 6 1.8| Endometrium, Hyperplasia, Cystic | 2 2 2 3 1 2 | 6 2.0| |__________________________________________________________________________|____________| Vagina | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Pigmentation | 2 1 2 2 1 2 1 1 | 8 1.5| |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Atrophy | 2 2 2 2 2 | 5 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | Cyst | 3 | 1 3.0| Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 NG | 0| 2| 4| 6| 8| 8| 8| 8| 8| 8| 8| 9| 9| | L | TEQ/KG | 1| 2| 2| 3| 1| 2| 3| 4| 6| 7| 9| 0| 4| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 | 7 1.1| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 7 NG | 2| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 8| | L | TEQ/KG | 8| 5| 7| 1| 5| 6| 8| 9| 0| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + | 7 | Basophilic Focus | X X X | 3 | Inflammation | 2 1 1 1 1 1 1 | 7 1.1| Mixed Cell Focus | X X | 2 | Mixed Cell Focus, Multiple | X X X | 3 | Necrosis | 1 | 1 1.0| Pigmentation | 1 1 1 1 1 | 5 1.0| Hepatocyte, Hypertrophy | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + | 7 | Acinus, Atrophy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + | 7 | Angiectasis | 1 1 | 2 1.0| Hypertrophy | 2 1 3 | 3 2.0| Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 7 | Follicular Cell, Hypertrophy | 1 1 1 3 | 4 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + | 7 | Atrophy | 3 2 3 3 3 3 | 6 2.8| Cyst | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 7 NG | 2| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 8| | L | TEQ/KG | 8| 5| 7| 1| 5| 6| 8| 9| 0| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Uterus | + + + + + + + | 7 | Metaplasia, Squamous | 2 2 2 1 1 | 5 1.6| Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 2 | 6 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + | 7 | Atrophy | 2 2 2 2 3 1 2 | 7 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + | 7 | Infiltration Cellular, Histiocyte | 1 2 1 1 1 | 5 1.2| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 22 NG | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5| | L | TEQ/KG | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Basophilic Focus | X | 1 | Clear Cell Focus, Multiple | X | 1 | Eosinophilic Focus | X | 1 | Inflammation | 1 2 2 1 1 1 2 1 | 8 1.4| Mixed Cell Focus | X X | 2 | Mixed Cell Focus, Multiple | X X X X X | 5 | Necrosis | 1 1 1 | 3 1.0| Pigmentation | 1 1 1 2 1 1 1 1 | 8 1.1| Toxic Hepatopathy | 1 1 | 2 1.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Hepatocyte, Hypertrophy | 2 1 | 2 1.5| Hepatocyte, Multinucleated | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | Inflammation, Chronic Active | 2 | 1 2.0| Acinus, Atrophy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Angiectasis | 1 1 1 | 3 1.0| Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 2 2 2 2 2 | 6 1.8| Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 22 NG | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5| | L | TEQ/KG | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Follicular Cell, Hypertrophy | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | Atrophy | 3 3 3 3 3 3 | 6 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Inflammation, Suppurative | 2 1 | 2 1.5| Metaplasia, Squamous | 1 2 3 2 2 | 5 2.0| Endometrium, Hyperplasia, Cystic | 4 3 4 1 3 | 5 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Atrophy | 2 3 2 2 2 2 2 | 7 2.1| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 7 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 6| 6| 5| 5| 5| 5| 5| 6| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 22 NG | 0| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 5| 5| | L | TEQ/KG | 2| 8| 1| 2| 3| 4| 5| 2| 6| 7| 9| 4| 9| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 2 1 | 3 1.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6| | L | TEQ/KG | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Basophilic Focus | X | 1 | Cholangiofibrosis | 1 2 | 2 1.5| Fatty Change, Diffuse | 1 1 1 1 | 4 1.0| Hepatodiaphragmatic Nodule | X | 1 | Hyperplasia, Nodular | X | 1 | Inflammation | 2 2 2 2 2 2 2 1 | 8 1.9| Mixed Cell Focus, Multiple | X X X X X X X | 7 | Necrosis | 1 1 | 2 1.0| Pigmentation | 2 2 2 2 2 2 2 2 | 8 2.0| Toxic Hepatopathy | 1 1 1 1 1 1 2 2 | 8 1.3| Bile Duct, Hyperplasia | 1 | 1 1.0| Centrilobular, Fibrosis | 1 1 1 1 2 | 5 1.2| Hepatocyte, Hypertrophy | 1 2 1 1 2 1 3 2 | 8 1.6| Hepatocyte, Multinucleated | 1 2 2 1 1 1 2 1 | 8 1.4| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | Inflammation, Chronic Active | 1 1 | 2 1.0| Acinus, Atrophy | 1 | 1 1.0| Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Angiectasis | 1 2 1 1 | 4 1.3| Degeneration, Cystic | 1 2 | 2 1.5| Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 3 2 3 3 2 1 | 7 2.1| Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6| | L | TEQ/KG | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Thyroid Gland | + + + + + + + + | 8 | Follicular Cell, Hypertrophy | 2 1 1 2 1 2 1 | 7 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | Atrophy | 3 3 3 3 3 | 5 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | Metaplasia, Squamous | 2 2 2 2 1 | 5 1.8| Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 | 5 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + | 8 | Atrophy | 3 3 3 2 3 4 3 3 | 8 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 | 6 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 6| 6| 6| 5| 5| 5| 5| 6| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 72 NG | 0| 0| 0| 1| 1| 3| 3| 3| 3| 3| 4| 4| 6| | L | TEQ/KG | 6| 7| 8| 0| 5| 0| 5| 6| 7| 9| 0| 1| 5| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Inflammation | 2 | 1 2.0| Pigmentation | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 3 3 | 3 2.3| Interstitium, Fibrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8| | L | TEQ/KG | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + | 8 | Angiectasis | 2 | 1 2.0| Basophilic Focus | X | 1 | Cholangiofibrosis | 3 2 3 3 1 | 5 2.4| Fatty Change, Diffuse | 2 2 2 3 2 2 2 2 | 8 2.1| Hyperplasia, Nodular | X X X X X X X X | 8 | Inflammation | 2 1 1 1 2 1 1 2 | 8 1.4| Necrosis | 1 1 | 2 1.0| Pigmentation | 2 3 2 3 3 2 3 2 | 8 2.5| Toxic Hepatopathy | 3 4 3 3 3 3 3 3 | 8 3.1| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Fibrosis | 1 | 1 1.0| Bile Duct, Hyperplasia | 2 2 3 2 2 2 2 2 | 8 2.1| Centrilobular, Fibrosis | 2 2 2 2 2 2 2 2 | 8 2.0| Hepatocyte, Hypertrophy | 4 4 4 4 3 4 4 3 | 8 3.8| Hepatocyte, Multinucleated | 3 3 2 3 3 2 3 2 | 8 2.6| Oval Cell, Hyperplasia | 3 3 3 3 2 2 2 3 | 8 2.6| Portal, Fibrosis | 2 2 2 2 2 2 2 2 | 8 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + | 8 | Inflammation, Chronic Active | 1 | 1 1.0| Acinus, Atrophy | 1 | 1 1.0| Acinus, Vacuolization Cytoplasmic | 2 2 1 2 2 2 2 1 | 8 1.8| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 8 | Edema | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 8 | Erosion | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8| | L | TEQ/KG | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + | 8 | Angiectasis | 1 | 1 1.0| Atrophy | 2 3 2 2 2 | 5 2.2| Hyperplasia | 2 | 1 2.0| Hypertrophy | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 8 | Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 8 | C-Cell, Hyperplasia | 1 | 1 1.0| Follicular Cell, Hypertrophy | 1 3 2 1 1 1 2 | 7 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + | 8 | |__________________________________________________________________________|____________| Vagina | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + | 8 | Pigmentation | 1 1 1 1 2 1 2 1 | 8 1.3| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 10:50:35 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 216 NG | 2| 2| 2| 2| 3| 3| 5| 6| 7| 8| 8| 8| 8| | L | TEQ/KG | 6| 7| 8| 9| 0| 8| 3| 0| 9| 1| 2| 5| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Thymus | + + + M + M + + | 6 | Atrophy | 4 3 4 4 4 4 | 6 3.8| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 8 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + | 8 | Infiltration Cellular, Histiocyte | 1 1 3 1 1 1 1 2 | 8 1.4| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 2 1 2 2 1 2 | 6 1.7| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------