NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 CORE + STOP STUDY FINAL #1; REVISION #1 RATS Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| DAY ON TEST | 7| 1| 6| 8| 3| 3| 4| 5| 6| 6| 8| 8| 2| 2| 2| 3| 3| 4| 5| 6| 7| 8| 8| 8| 0| | 5| 3| 2| 2| 4| 4| 8| 5| 4| 7| 2| 6| 3| 8| 8| 9| 9| 9| 1| 5| 2| 7| 7| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 8| 9| 6| 3| 6| 9| 2| 6| 3| 1| 2| 0| 5| 2| 9| 4| 6| 5| 6| 4| 2| 0| 9| 4| 1| TEQ/KG | 8| 1| 2| 1| 1| 3| 7| 7| 5| 4| 3| 3| 4| 1| 5| 3| 8| 5| 5| 5| 4| 2| 6| 8| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| DAY ON TEST | 7| 1| 6| 8| 3| 3| 4| 5| 6| 6| 8| 8| 2| 2| 2| 3| 3| 4| 5| 6| 7| 8| 8| 8| 0| | 5| 3| 2| 2| 4| 4| 8| 5| 4| 7| 2| 6| 3| 8| 8| 9| 9| 9| 1| 5| 2| 7| 7| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 8| 9| 6| 3| 6| 9| 2| 6| 3| 1| 2| 0| 5| 2| 9| 4| 6| 5| 6| 4| 2| 0| 9| 4| 1| TEQ/KG | 8| 1| 2| 1| 1| 3| 7| 7| 5| 4| 3| 3| 4| 1| 5| 3| 8| 5| 5| 5| 4| 2| 6| 8| 2| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X| Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | Bilateral, C-Cell, Carcinoma | X | C-Cell, Adenoma | X X X| C-Cell, Carcinoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| DAY ON TEST | 7| 1| 6| 8| 3| 3| 4| 5| 6| 6| 8| 8| 2| 2| 2| 3| 3| 4| 5| 6| 7| 8| 8| 8| 0| | 5| 3| 2| 2| 4| 4| 8| 5| 4| 7| 2| 6| 3| 8| 8| 9| 9| 9| 1| 5| 2| 7| 7| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 8| 9| 6| 3| 6| 9| 2| 6| 3| 1| 2| 0| 5| 2| 9| 4| 6| 5| 6| 4| 2| 0| 9| 4| 1| TEQ/KG | 8| 1| 2| 1| 1| 3| 7| 7| 5| 4| 3| 3| 4| 1| 5| 3| 8| 5| 5| 5| 4| 2| 6| 8| 2| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granulosa Cell Tumor Malignant | X | Luteoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Polyp Stromal | X X X X X X| Bilateral, Polyp Stromal | X | Cervix, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + M M M + + M M + + M M + + M + + + M M + + +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Fibroma | | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| DAY ON TEST | 7| 1| 6| 8| 3| 3| 4| 5| 6| 6| 8| 8| 2| 2| 2| 3| 3| 4| 5| 6| 7| 8| 8| 8| 0| | 5| 3| 2| 2| 4| 4| 8| 5| 4| 7| 2| 6| 3| 8| 8| 9| 9| 9| 1| 5| 2| 7| 7| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 8| 9| 6| 3| 6| 9| 2| 6| 3| 1| 2| 0| 5| 2| 9| 4| 6| 5| 6| 4| 2| 0| 9| 4| 1| TEQ/KG | 8| 1| 2| 1| 1| 3| 7| 7| 5| 4| 3| 3| 4| 1| 5| 3| 8| 5| 5| 5| 4| 2| 6| 8| 2| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Medulloblastoma Mal | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 0| 1| 2| 2| 3| 3| 3| 4| 4| 5| 5| 6| 7| 7| 7| 7| 7| 0| 1| 2| 3| 4| 4| 6| TEQ/KG | 1| 5| 5| 0| 8| 0| 2| 4| 4| 9| 0| 2| 6| 0| 6| 7| 8| 9| 4| 3| 9| 3| 6| 7| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 0| 1| 2| 2| 3| 3| 3| 4| 4| 5| 5| 6| 7| 7| 7| 7| 7| 0| 1| 2| 3| 4| 4| 6| TEQ/KG | 1| 5| 5| 0| 8| 0| 2| 4| 4| 9| 0| 2| 6| 0| 6| 7| 8| 9| 4| 3| 9| 3| 6| 7| 4| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X| Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | Bilateral, C-Cell, Carcinoma | | C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | X X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 0| 1| 2| 2| 3| 3| 3| 4| 4| 5| 5| 6| 7| 7| 7| 7| 7| 0| 1| 2| 3| 4| 4| 6| TEQ/KG | 1| 5| 5| 0| 8| 0| 2| 4| 4| 9| 0| 2| 6| 0| 6| 7| 8| 9| 4| 3| 9| 3| 6| 7| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Granulosa Cell Tumor Malignant | | Luteoma | X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Polyp Stromal | X X | Bilateral, Polyp Stromal | X X | Cervix, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + M M M M M + + + + M M + + + M + + + M M M M M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Thymoma Benign | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Fibroma | X| __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 0| 1| 2| 2| 3| 3| 3| 4| 4| 5| 5| 6| 7| 7| 7| 7| 7| 0| 1| 2| 3| 4| 4| 6| TEQ/KG | 1| 5| 5| 0| 8| 0| 2| 4| 4| 9| 0| 2| 6| 0| 6| 7| 8| 9| 4| 3| 9| 3| 6| 7| 4| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Medulloblastoma Mal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X | |__________________________________________________________________________| Ureter | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 6| 8| 9| | L | TEQ/KG | 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Hepatocellular Adenoma | | 2 | |__________________________________________________________________________|____________| Mesentery | + + + | 53 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tooth | + | 29 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 6| 8| 9| | L | TEQ/KG | 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Adenoma | | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | X X X | 30 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | Bilateral, C-Cell, Adenoma | | 1 | Bilateral, C-Cell, Carcinoma | | 1 | C-Cell, Adenoma | X | 8 | C-Cell, Carcinoma | | 3 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 6| 8| 9| | L | TEQ/KG | 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Granulosa Cell Tumor Malignant | | 1 | Luteoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Carcinoma | | 1 | Polyp Stromal | | 8 | Bilateral, Polyp Stromal | | 3 | Cervix, Schwannoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | M M + | 28 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 53 | Thymoma Benign | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenoma | | 2 | Carcinoma | | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 6| 8| 9| | L | TEQ/KG | 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Carcinoma, Multiple | | 1 | Fibroadenoma | X X | 27 | Fibroadenoma, Multiple | | 15 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Basal Cell Adenoma | | 1 | Fibroma | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Medulloblastoma Mal | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Carcinoma, Metastatic, Thyroid Gland | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 6| 8| 9| | L | TEQ/KG | 9| 0| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 2| 4| 6| 7| 0| 3| 4| 8| 8| 9| 2| 2| 3| 3| 4| 6| 9| 1| 1| 2| 3| 3| | 0| 8| 5| 8| 7| 4| 4| 0| 6| 3| 4| 5| 8| 5| 5| 4| 4| 1| 7| 4| 1| 6| 3| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 5| 4| 3| 1| 6| 7| 3| 4| 2| 5| 4| 3| 2| 1| 5| 2| 6| 2| 1| 1| 3| 2| 3| 3| 1| TEQ/KG | 8| 3| 0| 2| 2| 7| 7| 6| 6| 2| 1| 8| 1| 1| 6| 4| 4| 7| 6| 3| 4| 0| 3| 1| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | |__________________________________________________________________________| Mesentery | + M M + + + M + M + + + M + M M + M M M + + M + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Uterus | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Skin | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 2| 4| 6| 7| 0| 3| 4| 8| 8| 9| 2| 2| 3| 3| 4| 6| 9| 1| 1| 2| 3| 3| | 0| 8| 5| 8| 7| 4| 4| 0| 6| 3| 4| 5| 8| 5| 5| 4| 4| 1| 7| 4| 1| 6| 3| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 5| 4| 3| 1| 6| 7| 3| 4| 2| 5| 4| 3| 2| 1| 5| 2| 6| 2| 1| 1| 3| 2| 3| 3| 1| TEQ/KG | 8| 3| 0| 2| 2| 7| 7| 6| 6| 2| 1| 8| 1| 1| 6| 4| 4| 7| 6| 3| 4| 0| 3| 1| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 2| 4| 6| 7| 0| 3| 4| 8| 8| 9| 2| 2| 3| 3| 4| 6| 9| 1| 1| 2| 3| 3| | 0| 8| 5| 8| 7| 4| 4| 0| 6| 3| 4| 5| 8| 5| 5| 4| 4| 1| 7| 4| 1| 6| 3| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 5| 4| 3| 1| 6| 7| 3| 4| 2| 5| 4| 3| 2| 1| 5| 2| 6| 2| 1| 1| 3| 2| 3| 3| 1| TEQ/KG | 8| 3| 0| 2| 2| 7| 7| 6| 6| 2| 1| 8| 1| 1| 6| 4| 4| 7| 6| 3| 4| 0| 3| 1| 7| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | X| Hemangiosarcoma | | Polyp Stromal | X | Schwannoma Malignant | X | Bilateral, Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M M + M M + M M M M + M M + M M M + M M M + + + M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Skin | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | Fibroadenoma | X X X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 2| 4| 6| 7| 0| 3| 4| 8| 8| 9| 2| 2| 3| 3| 4| 6| 9| 1| 1| 2| 3| 3| | 0| 8| 5| 8| 7| 4| 4| 0| 6| 3| 4| 5| 8| 5| 5| 4| 4| 1| 7| 4| 1| 6| 3| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 5| 4| 3| 1| 6| 7| 3| 4| 2| 5| 4| 3| 2| 1| 5| 2| 6| 2| 1| 1| 3| 2| 3| 3| 1| TEQ/KG | 8| 3| 0| 2| 2| 7| 7| 6| 6| 2| 1| 8| 1| 1| 6| 4| 4| 7| 6| 3| 4| 0| 3| 1| 7| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Schwannoma Malignant, Metastatic, | | Uterus | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranial Nerve, Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Carcinoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Brain | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | | Renal Tubule, Carcinoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| DAY ON TEST | 7| 7| 7| 2| 4| 6| 7| 0| 3| 4| 8| 8| 9| 2| 2| 3| 3| 4| 6| 9| 1| 1| 2| 3| 3| | 0| 8| 5| 8| 7| 4| 4| 0| 6| 3| 4| 5| 8| 5| 5| 4| 4| 1| 7| 4| 1| 6| 3| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 5| 4| 3| 1| 6| 7| 3| 4| 2| 5| 4| 3| 2| 1| 5| 2| 6| 2| 1| 1| 3| 2| 3| 3| 1| TEQ/KG | 8| 3| 0| 2| 2| 7| 7| 6| 6| 2| 1| 8| 1| 1| 6| 4| 4| 7| 6| 3| 4| 0| 3| 1| 7| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Uterus | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 5| 5| 8| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 2| 1| 9| 9| 3| 1| 0| 5| 4| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 4| 2| 1| 2| 6| 5| 4| 3| 3| 1| 1| 2| 2| 3| 4| 4| 1| 3| 4| 4| 4| 5| 5| 5| 5| TEQ/KG | 8| 3| 5| 5| 0| 1| 0| 5| 2| 4| 9| 2| 9| 6| 2| 4| 8| 9| 5| 7| 9| 0| 3| 4| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + M + + + + M M + + + + + + + + M M| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Uterus | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Skin | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 5| 5| 8| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 2| 1| 9| 9| 3| 1| 0| 5| 4| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 4| 2| 1| 2| 6| 5| 4| 3| 3| 1| 1| 2| 2| 3| 4| 4| 1| 3| 4| 4| 4| 5| 5| 5| 5| TEQ/KG | 8| 3| 5| 5| 0| 1| 0| 5| 2| 4| 9| 2| 9| 6| 2| 4| 8| 9| 5| 7| 9| 0| 3| 4| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tooth | + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + M + + + + + + + + + + M + + M M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 5| 5| 8| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 2| 1| 9| 9| 3| 1| 0| 5| 4| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 4| 2| 1| 2| 6| 5| 4| 3| 3| 1| 1| 2| 2| 3| 4| 4| 1| 3| 4| 4| 4| 5| 5| 5| 5| TEQ/KG | 8| 3| 5| 5| 0| 1| 0| 5| 2| 4| 9| 2| 9| 6| 2| 4| 8| 9| 5| 7| 9| 0| 3| 4| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | | Hemangiosarcoma | X | Polyp Stromal | X X X | Schwannoma Malignant | | Bilateral, Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M + + M M M + + M M M M + M M M M + + M + M M M M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Skin | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | Fibroadenoma | X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 5| 5| 8| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 2| 1| 9| 9| 3| 1| 0| 5| 4| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 4| 2| 1| 2| 6| 5| 4| 3| 3| 1| 1| 2| 2| 3| 4| 4| 1| 3| 4| 4| 4| 5| 5| 5| 5| TEQ/KG | 8| 3| 5| 5| 0| 1| 0| 5| 2| 4| 9| 2| 9| 6| 2| 4| 8| 9| 5| 7| 9| 0| 3| 4| 9| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Schwannoma Malignant, Metastatic, | | Uterus | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranial Nerve, Schwannoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Carcinoma, Metastatic, Uncertain | | Primary Site | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Brain | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Papilloma | X | Renal Tubule, Carcinoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 5| 5| 8| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 2| 1| 9| 9| 3| 1| 0| 5| 4| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 4| 2| 1| 2| 6| 5| 4| 3| 3| 1| 1| 2| 2| 3| 4| 4| 1| 3| 4| 4| 4| 5| 5| 5| 5| TEQ/KG | 8| 3| 5| 5| 0| 1| 0| 5| 2| 4| 9| 2| 9| 6| 2| 4| 8| 9| 5| 7| 9| 0| 3| 4| 9| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant, Metastatic, | | Uterus | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 6| | L | TEQ/KG | 3| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 51 | |__________________________________________________________________________|____________| Intestine Large, Colon | + | 51 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + | 51 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + | 51 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + | 51 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + | 51 | Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + | 51 | |__________________________________________________________________________|____________| Liver | + | 51 | Hepatocellular Adenoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 35 | |__________________________________________________________________________|____________| Oral Mucosa | + | 51 | Gingival, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + | 51 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + | 51 | Schwannoma Malignant, Metastatic, | | | Skin | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 6| | L | TEQ/KG | 3| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + | 51 | |__________________________________________________________________________|____________| Tooth | + | 26 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 51 | |__________________________________________________________________________|____________| Heart | + | 51 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + | 51 | |__________________________________________________________________________|____________| Adrenal Medulla | + | 51 | Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + | 51 | |__________________________________________________________________________|____________| Parathyroid Gland | + | 45 | |__________________________________________________________________________|____________| Pituitary Gland | + | 51 | Pars Distalis, Adenoma | X | 11 | |__________________________________________________________________________|____________| Thyroid Gland | + | 51 | C-Cell, Adenoma | | 5 | C-Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 6| | L | TEQ/KG | 3| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + | 51 | |__________________________________________________________________________|____________| Ovary | + | 51 | |__________________________________________________________________________|____________| Uterus | + | 51 | Carcinoma | | 1 | Hemangiosarcoma | | 1 | Polyp Stromal | | 4 | Schwannoma Malignant | | 1 | Bilateral, Polyp Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + | 51 | |__________________________________________________________________________|____________| Lymph Node | M | 16 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + | 51 | Schwannoma Malignant, Metastatic, | | | Skin | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 51 | |__________________________________________________________________________|____________| Spleen | + | 51 | |__________________________________________________________________________|____________| Thymus | + | 51 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 51 | Adenoma | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 6| | L | TEQ/KG | 3| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Fibroadenoma | | 23 | Fibroadenoma, Multiple | | 15 | |__________________________________________________________________________|____________| Skin | + | 51 | Fibroma | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 51 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + | 51 | Cranial Nerve, Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + | 51 | Carcinoma, Metastatic, Mammary Gland | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Nose | + | 51 | Schwannoma Malignant, Metastatic, | | | Brain | | 1 | |__________________________________________________________________________|____________| Trachea | + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| | | DAY ON TEST | 2| | | | 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 6| | L | TEQ/KG | 3| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 51 | |__________________________________________________________________________|____________| Harderian Gland | + | 51 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + | 51 | Papilloma | | 1 | Renal Tubule, Carcinoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + | 51 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + | 51 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 9| 0| 2| 4| 4| 5| 7| 7| 0| 2| 4| 5| 6| 6| 6| 7| 7| 8| 0| 1| 3| 3| 5| 5| | 3| 9| 8| 6| 3| 3| 5| 1| 4| 4| 3| 8| 8| 5| 7| 7| 2| 2| 6| 8| 1| 2| 9| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 5| 3| 8| 3| 2| 7| 5| 3| 4| 0| 9| 9| 4| 2| 0| 3| 1| 3| 2| 7| 1| 8| 7| 5| 4| TEQ/KG | 8| 5| 5| 0| 7| 9| 2| 4| 1| 3| 1| 3| 3| 0| 4| 8| 7| 3| 6| 7| 9| 2| 8| 6| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | Cholangiocarcinoma | | Cholangiocarcinoma, Multiple | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + M + + + + + + M + + + + + M M| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Acinus, Adenoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 9| 0| 2| 4| 4| 5| 7| 7| 0| 2| 4| 5| 6| 6| 6| 7| 7| 8| 0| 1| 3| 3| 5| 5| | 3| 9| 8| 6| 3| 3| 5| 1| 4| 4| 3| 8| 8| 5| 7| 7| 2| 2| 6| 8| 1| 2| 9| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 5| 3| 8| 3| 2| 7| 5| 3| 4| 0| 9| 9| 4| 2| 0| 3| 1| 3| 2| 7| 1| 8| 7| 5| 4| TEQ/KG | 8| 5| 5| 0| 7| 9| 2| 4| 1| 3| 1| 3| 3| 0| 4| 8| 7| 3| 6| 7| 9| 2| 8| 6| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | Pars Distalis, Carcinoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X| C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 9| 0| 2| 4| 4| 5| 7| 7| 0| 2| 4| 5| 6| 6| 6| 7| 7| 8| 0| 1| 3| 3| 5| 5| | 3| 9| 8| 6| 3| 3| 5| 1| 4| 4| 3| 8| 8| 5| 7| 7| 2| 2| 6| 8| 1| 2| 9| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 5| 3| 8| 3| 2| 7| 5| 3| 4| 0| 9| 9| 4| 2| 0| 3| 1| 3| 2| 7| 1| 8| 7| 5| 4| TEQ/KG | 8| 5| 5| 0| 7| 9| 2| 4| 1| 3| 1| 3| 3| 0| 4| 8| 7| 3| 6| 7| 9| 2| 8| 6| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Periovarian Tissue, Carcinoma, | | Metastatic, Pancreas | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | Leiomyoma | | Polyp Stromal | X X X | Schwannoma Malignant, Metastatic, | | Vagina | X | Bilateral, Polyp Stromal | X | Cervix, Schwannoma Malignant, | | Metastatic, Vagina | | |__________________________________________________________________________| Vagina | + | Schwannoma Malignant | X | Schwannoma Malignant, Metastatic, | | Skin | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + M M M + M M M M + M + + M + + M M M + M M M M M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 9| 0| 2| 4| 4| 5| 7| 7| 0| 2| 4| 5| 6| 6| 6| 7| 7| 8| 0| 1| 3| 3| 5| 5| | 3| 9| 8| 6| 3| 3| 5| 1| 4| 4| 3| 8| 8| 5| 7| 7| 2| 2| 6| 8| 1| 2| 9| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 5| 3| 8| 3| 2| 7| 5| 3| 4| 0| 9| 9| 4| 2| 0| 3| 1| 3| 2| 7| 1| 8| 7| 5| 4| TEQ/KG | 8| 5| 5| 0| 7| 9| 2| 4| 1| 3| 1| 3| 3| 0| 4| 8| 7| 3| 6| 7| 9| 2| 8| 6| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Fibrosarcoma | | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Carcinoma, Metastatic, Pancreas | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | Carcinoma, Metastatic, Oral Mucosa | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | X | Carcinoma, Metastatic, Pancreas | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| DAY ON TEST | 6| 9| 0| 2| 4| 4| 5| 7| 7| 0| 2| 4| 5| 6| 6| 6| 7| 7| 8| 0| 1| 3| 3| 5| 5| | 3| 9| 8| 6| 3| 3| 5| 1| 4| 4| 3| 8| 8| 5| 7| 7| 2| 2| 6| 8| 1| 2| 9| 1| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 5| 3| 8| 3| 2| 7| 5| 3| 4| 0| 9| 9| 4| 2| 0| 3| 1| 3| 2| 7| 1| 8| 7| 5| 4| TEQ/KG | 8| 5| 5| 0| 7| 9| 2| 4| 1| 3| 1| 3| 3| 0| 4| 8| 7| 3| 6| 7| 9| 2| 8| 6| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Oral Mucosa | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 0| 3| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 8| 8| 9| 9| 0| 0| 0| 3| 3| 3| 4| 5| 5| 8| 8| 9| 9| 9| 0| 0| 1| 1| 4| 5| 6| TEQ/KG | 4| 7| 8| 2| 1| 6| 7| 2| 6| 9| 0| 5| 7| 0| 8| 4| 5| 6| 5| 9| 0| 6| 4| 1| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Cholangiocarcinoma | X X X X | Cholangiocarcinoma, Multiple | X | |__________________________________________________________________________| Mesentery | + + + + + + M + + + M + + M + + + + + + + M + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 0| 3| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 8| 8| 9| 9| 0| 0| 0| 3| 3| 3| 4| 5| 5| 8| 8| 9| 9| 9| 0| 0| 1| 1| 4| 5| 6| TEQ/KG | 4| 7| 8| 2| 1| 6| 7| 2| 6| 9| 0| 5| 7| 0| 8| 4| 5| 6| 5| 9| 0| 6| 4| 1| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X| Pars Distalis, Carcinoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 0| 3| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 8| 8| 9| 9| 0| 0| 0| 3| 3| 3| 4| 5| 5| 8| 8| 9| 9| 9| 0| 0| 1| 1| 4| 5| 6| TEQ/KG | 4| 7| 8| 2| 1| 6| 7| 2| 6| 9| 0| 5| 7| 0| 8| 4| 5| 6| 5| 9| 0| 6| 4| 1| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Periovarian Tissue, Carcinoma, | | Metastatic, Pancreas | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Leiomyoma | X | Polyp Stromal | X X | Schwannoma Malignant, Metastatic, | | Vagina | | Bilateral, Polyp Stromal | | Cervix, Schwannoma Malignant, | | Metastatic, Vagina | X | |__________________________________________________________________________| Vagina | + | Schwannoma Malignant | | Schwannoma Malignant, Metastatic, | | Skin | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M M M + M M M M + + M + M M + M + M M + M M + M M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + M + +| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 0| 3| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 8| 8| 9| 9| 0| 0| 0| 3| 3| 3| 4| 5| 5| 8| 8| 9| 9| 9| 0| 0| 1| 1| 4| 5| 6| TEQ/KG | 4| 7| 8| 2| 1| 6| 7| 2| 6| 9| 0| 5| 7| 0| 8| 4| 5| 6| 5| 9| 0| 6| 4| 1| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | Carcinoma, Multiple | | Fibroadenoma | X X X X X X X X X| Fibroadenoma, Multiple | X X X X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Fibrosarcoma | X | Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Carcinoma, Metastatic, Pancreas | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | Carcinoma, Metastatic, Oral Mucosa | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mammary Gland | | Carcinoma, Metastatic, Pancreas | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 0| 3| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 8| 8| 9| 9| 0| 0| 0| 3| 3| 3| 4| 5| 5| 8| 8| 9| 9| 9| 0| 0| 1| 1| 4| 5| 6| TEQ/KG | 4| 7| 8| 2| 1| 6| 7| 2| 6| 9| 0| 5| 7| 0| 8| 4| 5| 6| 5| 9| 0| 6| 4| 1| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Oral Mucosa | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 7| 8| 9| | L | TEQ/KG | 6| 6| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Carcinoma, Metastatic, Pancreas | | 1 | Cholangiocarcinoma | | 4 | Cholangiocarcinoma, Multiple | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 45 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Squamous Cell Carcinoma | | 2 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Carcinoma | | 1 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 7| 8| 9| | L | TEQ/KG | 6| 6| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tongue | | 1 | |__________________________________________________________________________|____________| Tooth | + + + | 33 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 53 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Subcapsular, Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | Pars Distalis, Adenoma | | 16 | Pars Distalis, Carcinoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | Bilateral, C-Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 7| 8| 9| | L | TEQ/KG | 6| 6| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Adenoma | | 7 | C-Cell, Carcinoma | | 2 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 51 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | Periovarian Tissue, Carcinoma, | | | Metastatic, Pancreas | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Carcinoma, Metastatic, Pancreas | | 1 | Leiomyoma | | 1 | Polyp Stromal | X | 6 | Schwannoma Malignant, Metastatic, | | | Vagina | | 1 | Bilateral, Polyp Stromal | | 1 | Cervix, Schwannoma Malignant, | | | Metastatic, Vagina | | 1 | |__________________________________________________________________________|____________| Vagina | | 2 | Schwannoma Malignant | | 1 | Schwannoma Malignant, Metastatic, | | | Skin | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 7| 8| 9| | L | TEQ/KG | 6| 6| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | M M M | 16 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 51 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Carcinoma | | 3 | Carcinoma, Multiple | | 1 | Fibroadenoma | X | 21 | Fibroadenoma, Multiple | | 15 | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 1 | Fibrosarcoma | | 1 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Carcinoma, Metastatic, Pancreas | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 7| 8| 9| | L | TEQ/KG | 6| 6| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Carcinoma, Metastatic, Oral Mucosa | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Carcinoma, Metastatic, Mammary Gland | | 1 | Carcinoma, Metastatic, Pancreas | | 1 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Carcinoma, Metastatic, Oral Mucosa | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Carcinoma, Metastatic, Pancreas | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 4| 7| 6| 6| 9| 8| 3| 3| 3| 4| 4| 5| 5| 6| 6| 7| 9| 0| 0| 1| 2| 3| 5| 5| 5| | 1| 8| 1| 7| 0| 0| 4| 7| 9| 1| 8| 2| 5| 5| 7| 0| 4| 2| 4| 9| 8| 6| 1| 3| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 8| 0| 3| 3| 4| 1| 4| 1| 8| 2| 3| 7| 8| 6| 5| 4| 1| 5| 2| 1| 8| 6| 6| 4| 1| TEQ/KG | 1| 9| 8| 3| 3| 2| 5| 4| 5| 0| 4| 7| 4| 1| 9| 9| 3| 6| 7| 8| 2| 2| 0| 7| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Cholangiocarcinoma, Multiple | X X X | Cholangioma | X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | + + + M M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Neuroendocrine Tumor, Malignant | X | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 4| 7| 6| 6| 9| 8| 3| 3| 3| 4| 4| 5| 5| 6| 6| 7| 9| 0| 0| 1| 2| 3| 5| 5| 5| | 1| 8| 1| 7| 0| 0| 4| 7| 9| 1| 8| 2| 5| 5| 7| 0| 4| 2| 4| 9| 8| 6| 1| 3| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 8| 0| 3| 3| 4| 1| 4| 1| 8| 2| 3| 7| 8| 6| 5| 4| 1| 5| 2| 1| 8| 6| 6| 4| 1| TEQ/KG | 1| 9| 8| 3| 3| 2| 5| 4| 5| 0| 4| 7| 4| 1| 9| 9| 3| 6| 7| 8| 2| 2| 0| 7| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Benign | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + M + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 4| 7| 6| 6| 9| 8| 3| 3| 3| 4| 4| 5| 5| 6| 6| 7| 9| 0| 0| 1| 2| 3| 5| 5| 5| | 1| 8| 1| 7| 0| 0| 4| 7| 9| 1| 8| 2| 5| 5| 7| 0| 4| 2| 4| 9| 8| 6| 1| 3| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 8| 0| 3| 3| 4| 1| 4| 1| 8| 2| 3| 7| 8| 6| 5| 4| 1| 5| 2| 1| 8| 6| 6| 4| 1| TEQ/KG | 1| 9| 8| 3| 3| 2| 5| 4| 5| 0| 4| 7| 4| 1| 9| 9| 3| 6| 7| 8| 2| 2| 0| 7| 7| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | | Fibrosarcoma | | Polyp Stromal | X X | Squamous Cell Carcinoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M M + M + + + M + + + M M M M + + + + + M M + + +| Pancreatic, Carcinoma, Metastatic, | | Stomach, Glandular | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + M + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenolipoma | X | Fibroadenoma | X X X X X X| Fibroadenoma, Multiple | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 2| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 4| 7| 6| 6| 9| 8| 3| 3| 3| 4| 4| 5| 5| 6| 6| 7| 9| 0| 0| 1| 2| 3| 5| 5| 5| | 1| 8| 1| 7| 0| 0| 4| 7| 9| 1| 8| 2| 5| 5| 7| 0| 4| 2| 4| 9| 8| 6| 1| 3| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 8| 0| 3| 3| 4| 1| 4| 1| 8| 2| 3| 7| 8| 6| 5| 4| 1| 5| 2| 1| 8| 6| 6| 4| 1| TEQ/KG | 1| 9| 8| 3| 3| 2| 5| 4| 5| 0| 4| 7| 4| 1| 9| 9| 3| 6| 7| 8| 2| 2| 0| 7| 7| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X | Cystic Keratinizing Epithelioma, | | Multiple | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenolipoma | X | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 6| 6| 6| 7| 8| 8| 9| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 9| 2| 3| 7| 8| 6| 7| 8| 7| 7| 0| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 7| 2| 5| 4| 1| 2| 6| 5| 3| 3| 0| 7| 0| 1| 4| 4| 5| 0| 0| 1| 2| 4| 6| 7| TEQ/KG | 4| 9| 6| 7| 8| 9| 8| 3| 8| 1| 2| 2| 6| 3| 1| 2| 4| 0| 1| 5| 6| 9| 6| 4| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X X X X | Cholangiocarcinoma, Multiple | X X X X X X X X | Cholangioma | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Hepatocholangioma | X | |__________________________________________________________________________| Mesentery | + + + + M + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Neuroendocrine Tumor, Malignant | | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 6| 6| 6| 7| 8| 8| 9| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 9| 2| 3| 7| 8| 6| 7| 8| 7| 7| 0| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 7| 2| 5| 4| 1| 2| 6| 5| 3| 3| 0| 7| 0| 1| 4| 4| 5| 0| 0| 1| 2| 4| 6| 7| TEQ/KG | 4| 9| 6| 7| 8| 9| 8| 3| 8| 1| 2| 2| 6| 3| 1| 2| 4| 0| 1| 5| 6| 9| 6| 4| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Benign | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 6| 6| 6| 7| 8| 8| 9| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 9| 2| 3| 7| 8| 6| 7| 8| 7| 7| 0| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 7| 2| 5| 4| 1| 2| 6| 5| 3| 3| 0| 7| 0| 1| 4| 4| 5| 0| 0| 1| 2| 4| 6| 7| TEQ/KG | 4| 9| 6| 7| 8| 9| 8| 3| 8| 1| 2| 2| 6| 3| 1| 2| 4| 0| 1| 5| 6| 9| 6| 4| 8| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | X | Fibrosarcoma | X | Polyp Stromal | X X X X X | Squamous Cell Carcinoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + M + + + M M M M + M M M M M + + M + M M M + + M| Pancreatic, Carcinoma, Metastatic, | | Stomach, Glandular | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenolipoma | | Fibroadenoma | X X X X X X X X| Fibroadenoma, Multiple | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 5| 6| 6| 6| 7| 8| 8| 9| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | 9| 9| 2| 3| 7| 8| 6| 7| 8| 7| 7| 0| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 7| 2| 5| 4| 1| 2| 6| 5| 3| 3| 0| 7| 0| 1| 4| 4| 5| 0| 0| 1| 2| 4| 6| 7| TEQ/KG | 4| 9| 6| 7| 8| 9| 8| 3| 8| 1| 2| 2| 6| 3| 1| 2| 4| 0| 1| 5| 6| 9| 6| 4| 8| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X X X| Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenolipoma | | __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 0| 3| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Cholangiocarcinoma | | 7 | Cholangiocarcinoma, Multiple | X | 12 | Cholangioma | | 1 | Hepatocellular Adenoma | | 2 | Hepatocellular Adenoma, Multiple | | 2 | Hepatocholangioma | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 49 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Squamous Cell Carcinoma | | 4 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 0| 3| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Carcinoma | | 1 | Neuroendocrine Tumor, Malignant | | 1 | |__________________________________________________________________________|____________| Tooth | + | 34 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Schwannoma Benign | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Adenoma | X | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Adenoma | X | 8 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 0| 3| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Carcinoma | | 1 | Fibrosarcoma | | 1 | Polyp Stromal | X | 8 | Squamous Cell Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | M M M | 25 | Pancreatic, Carcinoma, Metastatic, | | | Stomach, Glandular | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 51 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Adenolipoma | | 1 | Fibroadenoma | | 14 | Fibroadenoma, Multiple | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 0| 3| 6| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + | 53 | Fibroma | | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Cystic Keratinizing Epithelioma | | 6 | Cystic Keratinizing Epithelioma, | | | Multiple | X | 14 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 2| | | | 7| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 0| 3| 6| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | Adenolipoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 6| 6| 1| 3| 4| 7| 8| 9| 4| 4| 5| 5| 7| 7| 7| 8| 9| 0| 2| 2| 2| 2| 3| 3| 3| | 6| 7| 3| 7| 9| 3| 3| 7| 6| 7| 0| 0| 4| 4| 9| 2| 6| 4| 0| 3| 5| 7| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 7| 1| 4| 5| 4| 9| 1| 1| 3| 1| 6| 0| 7| 9| 0| 5| 9| 6| 2| 8| 9| 4| 5| 1| TEQ/KG | 9| 3| 9| 6| 8| 8| 5| 6| 4| 9| 7| 2| 8| 1| 4| 7| 4| 3| 1| 0| 9| 0| 3| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X| Cholangiocarcinoma, Multiple | X X | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Hepatocholangioma, Multiple | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 6| 6| 1| 3| 4| 7| 8| 9| 4| 4| 5| 5| 7| 7| 7| 8| 9| 0| 2| 2| 2| 2| 3| 3| 3| | 6| 7| 3| 7| 9| 3| 3| 7| 6| 7| 0| 0| 4| 4| 9| 2| 6| 4| 0| 3| 5| 7| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 7| 1| 4| 5| 4| 9| 1| 1| 3| 1| 6| 0| 7| 9| 0| 5| 9| 6| 2| 8| 9| 4| 5| 1| TEQ/KG | 9| 3| 9| 6| 8| 8| 5| 6| 4| 9| 7| 2| 8| 1| 4| 7| 4| 3| 1| 0| 9| 0| 3| 7| 8| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X | Bilateral, Polyp Stromal | | __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 6| 6| 1| 3| 4| 7| 8| 9| 4| 4| 5| 5| 7| 7| 7| 8| 9| 0| 2| 2| 2| 2| 3| 3| 3| | 6| 7| 3| 7| 9| 3| 3| 7| 6| 7| 0| 0| 4| 4| 9| 2| 6| 4| 0| 3| 5| 7| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 7| 1| 4| 5| 4| 9| 1| 1| 3| 1| 6| 0| 7| 9| 0| 5| 9| 6| 2| 8| 9| 4| 5| 1| TEQ/KG | 9| 3| 9| 6| 8| 8| 5| 6| 4| 9| 7| 2| 8| 1| 4| 7| 4| 3| 1| 0| 9| 0| 3| 7| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M M + + M + M M M M + + M M M + M M M M + M + M M| |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 1| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| DAY ON TEST | 6| 6| 1| 3| 4| 7| 8| 9| 4| 4| 5| 5| 7| 7| 7| 8| 9| 0| 2| 2| 2| 2| 3| 3| 3| | 6| 7| 3| 7| 9| 3| 3| 7| 6| 7| 0| 0| 4| 4| 9| 2| 6| 4| 0| 3| 5| 7| 0| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 7| 1| 4| 5| 4| 9| 1| 1| 3| 1| 6| 0| 7| 9| 0| 5| 9| 6| 2| 8| 9| 4| 5| 1| TEQ/KG | 9| 3| 9| 6| 8| 8| 5| 6| 4| 9| 7| 2| 8| 1| 4| 7| 4| 3| 1| 0| 9| 0| 3| 7| 8| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 3| 4| 5| 5| 6| 6| 6| 7| 7| 7| 8| 0| 1| 2| 3| 3| 3| 3| 3| 4| 6| 7| 7| 7| 7| | 6| 8| 5| 5| 5| 5| 7| 2| 5| 9| 2| 2| 1| 3| 2| 9| 9| 9| 9| 9| 7| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 4| 4| 5| 1| 9| 6| 9| 4| 4| 9| 8| 1| 1| 9| 4| 7| 7| 7| 3| 3| 4| 4| 7| 8| TEQ/KG | 0| 2| 5| 1| 3| 7| 3| 1| 1| 0| 2| 0| 0| 5| 6| 4| 2| 6| 7| 6| 7| 9| 7| 5| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X X X | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X | Hepatocholangioma, Multiple | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 3| 4| 5| 5| 6| 6| 6| 7| 7| 7| 8| 0| 1| 2| 3| 3| 3| 3| 3| 4| 6| 7| 7| 7| 7| | 6| 8| 5| 5| 5| 5| 7| 2| 5| 9| 2| 2| 1| 3| 2| 9| 9| 9| 9| 9| 7| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 4| 4| 5| 1| 9| 6| 9| 4| 4| 9| 8| 1| 1| 9| 4| 7| 7| 7| 3| 3| 4| 4| 7| 8| TEQ/KG | 0| 2| 5| 1| 3| 7| 3| 1| 1| 0| 2| 0| 0| 5| 6| 4| 2| 6| 7| 6| 7| 9| 7| 5| 8| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oviduct | +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X X | Bilateral, Polyp Stromal | | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 3| 4| 5| 5| 6| 6| 6| 7| 7| 7| 8| 0| 1| 2| 3| 3| 3| 3| 3| 4| 6| 7| 7| 7| 7| | 6| 8| 5| 5| 5| 5| 7| 2| 5| 9| 2| 2| 1| 3| 2| 9| 9| 9| 9| 9| 7| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 4| 4| 5| 1| 9| 6| 9| 4| 4| 9| 8| 1| 1| 9| 4| 7| 7| 7| 3| 3| 4| 4| 7| 8| TEQ/KG | 0| 2| 5| 1| 3| 7| 3| 1| 1| 0| 2| 0| 0| 5| 6| 4| 2| 6| 7| 6| 7| 9| 7| 5| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | M + M + M M M M M M + + M + + M M + M + M + + + M| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X X X X X X X X X X X X X| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| DAY ON TEST | 3| 4| 5| 5| 6| 6| 6| 7| 7| 7| 8| 0| 1| 2| 3| 3| 3| 3| 3| 4| 6| 7| 7| 7| 7| | 6| 8| 5| 5| 5| 5| 7| 2| 5| 9| 2| 2| 1| 3| 2| 9| 9| 9| 9| 9| 7| 2| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 5| 4| 4| 5| 1| 9| 6| 9| 4| 4| 9| 8| 1| 1| 9| 4| 7| 7| 7| 3| 3| 4| 4| 7| 8| TEQ/KG | 0| 2| 5| 1| 3| 7| 3| 1| 1| 0| 2| 0| 0| 5| 6| 4| 2| 6| 7| 6| 7| 9| 7| 5| 8| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 6| 7| 7| | | DAY ON TEST | 8| 0| 0| | | | 6| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 1| 0| 6| | L | TEQ/KG | 2| 9| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Cholangiocarcinoma | X | 7 | Cholangiocarcinoma, Multiple | X X | 21 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma | | 7 | Hepatocellular Adenoma, Multiple | X | 10 | Hepatocholangioma, Multiple | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 52 | |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | |__________________________________________________________________________|____________| Pancreas | + + + | 53 | |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 6| 7| 7| | | DAY ON TEST | 8| 0| 0| | | | 6| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 1| 0| 6| | L | TEQ/KG | 2| 9| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + | 53 | |__________________________________________________________________________|____________| Tooth | | 29 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Adenoma | X | 4 | Follicular Cell, Adenoma | X | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 6| 7| 7| | | DAY ON TEST | 8| 0| 0| | | | 6| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 1| 0| 6| | L | TEQ/KG | 2| 9| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | |__________________________________________________________________________|____________| Ovary | + + + | 53 | |__________________________________________________________________________|____________| Oviduct | | 1 | |__________________________________________________________________________|____________| Uterus | + + + | 53 | Polyp Stromal | | 6 | Bilateral, Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | |__________________________________________________________________________|____________| Lymph Node | + M M | 20 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | |__________________________________________________________________________|____________| Spleen | + + + | 53 | |__________________________________________________________________________|____________| Thymus | + + + | 51 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Fibroadenoma | | 4 | |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 6| 7| 7| | | DAY ON TEST | 8| 0| 0| | | | 6| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 1| 0| 6| | L | TEQ/KG | 2| 9| 5| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Cystic Keratinizing Epithelioma | X | 1 | Cystic Keratinizing Epithelioma, | | | Multiple | X X | 48 | |__________________________________________________________________________|____________| Nose | + + + | 53 | |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| DAY ON TEST | 5| 9| 7| 0| 0| 1| 2| 2| 3| 3| 3| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| | 1| 1| 4| 3| 9| 7| 2| 6| 3| 6| 7| 3| 3| 5| 4| 0| 7| 7| 7| 7| 5| 8| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 8| 7| 0| 2| 4| 6| 2| 4| 3| 6| 6| 3| 7| 0| 5| 7| 1| 1| 3| 6| 7| 3| 5| 0| 5| TEQ/KG | 5| 9| 3| 5| 6| 5| 6| 7| 3| 9| 8| 1| 2| 5| 3| 6| 1| 3| 2| 3| 1| 0| 5| 4| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + M + + + + + + + + +| Cholangiocarcinoma | | Cholangiocarcinoma, Multiple | | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + +| _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| DAY ON TEST | 5| 9| 7| 0| 0| 1| 2| 2| 3| 3| 3| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| | 1| 1| 4| 3| 9| 7| 2| 6| 3| 6| 7| 3| 3| 5| 4| 0| 7| 7| 7| 7| 5| 8| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 8| 7| 0| 2| 4| 6| 2| 4| 3| 6| 6| 3| 7| 0| 5| 7| 1| 1| 3| 6| 7| 3| 5| 0| 5| TEQ/KG | 5| 9| 3| 5| 6| 5| 6| 7| 3| 9| 8| 1| 2| 5| 3| 6| 1| 3| 2| 3| 1| 0| 5| 4| 2| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + M + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + M + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| DAY ON TEST | 5| 9| 7| 0| 0| 1| 2| 2| 3| 3| 3| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| | 1| 1| 4| 3| 9| 7| 2| 6| 3| 6| 7| 3| 3| 5| 4| 0| 7| 7| 7| 7| 5| 8| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 8| 7| 0| 2| 4| 6| 2| 4| 3| 6| 6| 3| 7| 0| 5| 7| 1| 1| 3| 6| 7| 3| 5| 0| 5| TEQ/KG | 5| 9| 3| 5| 6| 5| 6| 7| 3| 9| 8| 1| 2| 5| 3| 6| 1| 3| 2| 3| 1| 0| 5| 4| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node | M + + + + + + + M + + + M + + M + M + + M + + M +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + M M + + + + M + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X X | Cystic Keratinizing Epithelioma, | | Multiple | X | __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| DAY ON TEST | 5| 9| 7| 0| 0| 1| 2| 2| 3| 3| 3| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 7| 7| 8| 8| | 1| 1| 4| 3| 9| 7| 2| 6| 3| 6| 7| 3| 3| 5| 4| 0| 7| 7| 7| 7| 5| 8| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 8| 7| 0| 2| 4| 6| 2| 4| 3| 6| 6| 3| 7| 0| 5| 7| 1| 1| 3| 6| 7| 3| 5| 0| 5| TEQ/KG | 5| 9| 3| 5| 6| 5| 6| 7| 3| 9| 8| 1| 2| 5| 3| 6| 1| 3| 2| 3| 1| 0| 5| 4| 2| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + M + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| DAY ON TEST | 8| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 5| 6| 6| 8| 8| 0| 1| 1| 2| 2| | 9| 4| 4| 0| 3| 3| 3| 1| 9| 9| 6| 7| 8| 2| 9| 6| 2| 2| 3| 3| 6| 0| 5| 3| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 7| 6| 8| 2| 8| 0| 7| 6| 8| 8| 1| 7| 3| 0| 7| 2| 1| 1| 2| 7| 3| 0| 8| 5| 0| TEQ/KG | 5| 1| 4| 4| 0| 8| 8| 2| 1| 3| 2| 3| 5| 9| 4| 2| 0| 4| 1| 0| 4| 1| 2| 0| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Cholangiocarcinoma, Multiple | X X X| Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | M + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| DAY ON TEST | 8| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 5| 6| 6| 8| 8| 0| 1| 1| 2| 2| | 9| 4| 4| 0| 3| 3| 3| 1| 9| 9| 6| 7| 8| 2| 9| 6| 2| 2| 3| 3| 6| 0| 5| 3| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 7| 6| 8| 2| 8| 0| 7| 6| 8| 8| 1| 7| 3| 0| 7| 2| 1| 1| 2| 7| 3| 0| 8| 5| 0| TEQ/KG | 5| 1| 4| 4| 0| 8| 8| 2| 1| 3| 2| 3| 5| 9| 4| 2| 0| 4| 1| 0| 4| 1| 2| 0| 6| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| DAY ON TEST | 8| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 5| 6| 6| 8| 8| 0| 1| 1| 2| 2| | 9| 4| 4| 0| 3| 3| 3| 1| 9| 9| 6| 7| 8| 2| 9| 6| 2| 2| 3| 3| 6| 0| 5| 3| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 7| 6| 8| 2| 8| 0| 7| 6| 8| 8| 1| 7| 3| 0| 7| 2| 1| 1| 2| 7| 3| 0| 8| 5| 0| TEQ/KG | 5| 1| 4| 4| 0| 8| 8| 2| 1| 3| 2| 3| 5| 9| 4| 2| 0| 4| 1| 0| 4| 1| 2| 0| 6| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node | + + M + + + + + M M + + + + M M + + M M M + M M +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X X X X X X X X X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| DAY ON TEST | 8| 9| 9| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 4| 5| 6| 6| 8| 8| 0| 1| 1| 2| 2| | 9| 4| 4| 0| 3| 3| 3| 1| 9| 9| 6| 7| 8| 2| 9| 6| 2| 2| 3| 3| 6| 0| 5| 3| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 7| 6| 8| 2| 8| 0| 7| 6| 8| 8| 1| 7| 3| 0| 7| 2| 1| 1| 2| 7| 3| 0| 8| 5| 0| TEQ/KG | 5| 1| 4| 4| 0| 8| 8| 2| 1| 3| 2| 3| 5| 9| 4| 2| 0| 4| 1| 0| 4| 1| 2| 0| 6| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Granulocytic | X | __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| | | DAY ON TEST | 4| 5| 5| 5| 6| 7| 8| 8| 9| 0| 0| 1| 2| 4| 1| 3| | | | 6| 2| 3| 6| 1| 8| 2| 2| 1| 4| 4| 3| 4| 5| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 8| 2| 2| 5| 6| 6| 5| 7| 6| 1| 2| 2| 0| 0| 4| 4| | L | TEQ/KG | 6| 7| 3| 4| 6| 4| 1| 7| 7| 5| 9| 8| 2| 7| 9| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + | 65 | Cholangiocarcinoma | X X X X | 5 | Cholangiocarcinoma, Multiple | X X X X | 7 | Hepatocellular Adenoma | | 3 | Hepatocellular Adenoma, Multiple | X X | 2 | Hepatocholangioma | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + | 63 | |__________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + | 66 | Gingival, Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| | | DAY ON TEST | 4| 5| 5| 5| 6| 7| 8| 8| 9| 0| 0| 1| 2| 4| 1| 3| | | | 6| 2| 3| 6| 1| 8| 2| 2| 1| 4| 4| 3| 4| 5| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 8| 2| 2| 5| 6| 6| 5| 7| 6| 1| 2| 2| 0| 0| 4| 4| | L | TEQ/KG | 6| 7| 3| 4| 6| 4| 1| 7| 7| 5| 9| 8| 2| 7| 9| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + | 25 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + | 65 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + | 65 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + | 64 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + | 62 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + | 66 | C-Cell, Adenoma | X | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| | | DAY ON TEST | 4| 5| 5| 5| 6| 7| 8| 8| 9| 0| 0| 1| 2| 4| 1| 3| | | | 6| 2| 3| 6| 1| 8| 2| 2| 1| 4| 4| 3| 4| 5| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 8| 2| 2| 5| 6| 6| 5| 7| 6| 1| 2| 2| 0| 0| 4| 4| | L | TEQ/KG | 6| 7| 3| 4| 6| 4| 1| 7| 7| 5| 9| 8| 2| 7| 9| 8| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Clitoral Gland | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + | 66 | Polyp Stromal | X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Lymph Node | M + + + + + M M + + M + + + + + | 45 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Thymus | + M M + + + + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + | 66 | Fibroadenoma | X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| | | DAY ON TEST | 4| 5| 5| 5| 6| 7| 8| 8| 9| 0| 0| 1| 2| 4| 1| 3| | | | 6| 2| 3| 6| 1| 8| 2| 2| 1| 4| 4| 3| 4| 5| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 8| 2| 2| 5| 6| 6| 5| 7| 6| 1| 2| 2| 0| 0| 4| 4| | L | TEQ/KG | 6| 7| 3| 4| 6| 4| 1| 7| 7| 5| 9| 8| 2| 7| 9| 8| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + | 66 | Cystic Keratinizing Epithelioma | X | 6 | Cystic Keratinizing Epithelioma, | | | Multiple | X X X X X X X X X X X X X X | 35 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + | 66 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + | 66 | Leukemia Granulocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| DAY ON TEST | 0| 0| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 8| 0| 8| 0| 5| 7| 9| | 1| 9| 6| 6| 6| 0| 2| 0| 1| 7| 4| 8| 8| 7| 2| 3| 5| 9| 2| 3| 3| 1| 1| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 1| 0| 0| 2| 3| 1| 2| 1| 1| 2| 4| 4| 4| 3| 3| 5| 2| 1| 2| 4| 2| 0| 3| 0| 2| TEQKG ST | 5| 1| 8| 6| 0| 4| 1| 7| 3| 5| 8| 4| 7| 6| 3| 0| 0| 9| 4| 2| 3| 2| 2| 5| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Cholangiocarcinoma, Multiple | X | Hepatocellular Adenoma | X | Hepatocholangioma | | |__________________________________________________________________________| Mesentery | + + M + + + + M M + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Squamous Cell Carcinoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| DAY ON TEST | 0| 0| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 8| 0| 8| 0| 5| 7| 9| | 1| 9| 6| 6| 6| 0| 2| 0| 1| 7| 4| 8| 8| 7| 2| 3| 5| 9| 2| 3| 3| 1| 1| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 1| 0| 0| 2| 3| 1| 2| 1| 1| 2| 4| 4| 4| 3| 3| 5| 2| 1| 2| 4| 2| 0| 3| 0| 2| TEQKG ST | 5| 1| 8| 6| 0| 4| 1| 7| 3| 5| 8| 4| 7| 6| 3| 0| 0| 9| 4| 2| 3| 2| 2| 5| 9| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M M + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | | Bilateral, Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| DAY ON TEST | 0| 0| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 8| 0| 8| 0| 5| 7| 9| | 1| 9| 6| 6| 6| 0| 2| 0| 1| 7| 4| 8| 8| 7| 2| 3| 5| 9| 2| 3| 3| 1| 1| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 1| 0| 0| 2| 3| 1| 2| 1| 1| 2| 4| 4| 4| 3| 3| 5| 2| 1| 2| 4| 2| 0| 3| 0| 2| TEQKG ST | 5| 1| 8| 6| 0| 4| 1| 7| 3| 5| 8| 4| 7| 6| 3| 0| 0| 9| 4| 2| 3| 2| 2| 5| 9| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node | M + M + M + M M M M + + + M M M M M + + M M + M +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + M M + + M + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | | Fibroadenoma, Multiple | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranial Nerve, Squamous Cell | | Carcinoma, Metastatic, Oral | | Mucosa | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystic Keratinizing Epithelioma | X X X | Cystic Keratinizing Epithelioma, | | Multiple | X X X X | __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 _____________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| DAY ON TEST | 0| 0| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| 5| 6| 7| 7| 7| 7| 8| 0| 8| 0| 5| 7| 9| | 1| 9| 6| 6| 6| 0| 2| 0| 1| 7| 4| 8| 8| 7| 2| 3| 5| 9| 2| 3| 3| 1| 1| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 1| 0| 0| 2| 3| 1| 2| 1| 1| 2| 4| 4| 4| 3| 3| 5| 2| 1| 2| 4| 2| 0| 3| 0| 2| TEQKG ST | 5| 1| 8| 6| 0| 4| 1| 7| 3| 5| 8| 4| 7| 6| 3| 0| 0| 9| 4| 2| 3| 2| 2| 5| 9| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 4| 6| 9| 9| 0| 0| 0| 3| 3| 5| 6| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | 4| 5| 1| 1| 3| 4| 1| 2| 7| 6| 8| 9| 3| 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 1| 1| 1| 4| 2| 4| 4| 0| 3| 2| 1| 2| 3| 3| 3| 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| L | TEQKG ST | 0| 8| 2| 5| 8| 9| 1| 6| 7| 7| 6| 2| 1| 5| 4| 3| 4| 7| 9| 1| 8| 9| 0| 3| 6| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X X X X X X X| 7 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X | 12 | Hepatocellular Adenoma | | 1 | Hepatocholangioma | X | 1 | |__________________________________________________________________________|____________| Mesentery | + M M + + + M + + + + + + + + + + M + + + + + + +| 43 | |__________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Gingival, Squamous Cell Carcinoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 86 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 4| 6| 9| 9| 0| 0| 0| 3| 3| 5| 6| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | 4| 5| 1| 1| 3| 4| 1| 2| 7| 6| 8| 9| 3| 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 1| 1| 1| 4| 2| 4| 4| 0| 3| 2| 1| 2| 3| 3| 3| 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| L | TEQKG ST | 0| 8| 2| 5| 8| 9| 1| 6| 7| 7| 6| 2| 1| 5| 4| 3| 4| 7| 9| 1| 8| 9| 0| 3| 6| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + + + + + +| 23 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 | C-Cell, Adenoma | X X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 4| 6| 9| 9| 0| 0| 0| 3| 3| 5| 6| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | 4| 5| 1| 1| 3| 4| 1| 2| 7| 6| 8| 9| 3| 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 1| 1| 1| 4| 2| 4| 4| 0| 3| 2| 1| 2| 3| 3| 3| 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| L | TEQKG ST | 0| 8| 2| 5| 8| 9| 1| 6| 7| 7| 6| 2| 1| 5| 4| 3| 4| 7| 9| 1| 8| 9| 0| 3| 6| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Polyp Stromal | X X X X X X X | 7 | Bilateral, Polyp Stromal | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | M + M + + + + M + + + + + M M M M M M M M + M M +| 22 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | Fibroadenoma | X X X X X X X X X X X| 11 | Fibroadenoma, Multiple | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 88 NTP Experiment-Test: 96022-02 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:23:08 __________________________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 2| 4| 6| 9| 9| 0| 0| 0| 3| 3| 5| 6| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | 4| 5| 1| 1| 3| 4| 1| 2| 7| 6| 8| 9| 3| 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 1| 1| 1| 4| 2| 4| 4| 0| 3| 2| 1| 2| 3| 3| 3| 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| L | TEQKG ST | 0| 8| 2| 5| 8| 9| 1| 6| 7| 7| 6| 2| 1| 5| 4| 3| 4| 7| 9| 1| 8| 9| 0| 3| 6| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranial Nerve, Squamous Cell | | | Carcinoma, Metastatic, Oral | | | Mucosa | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystic Keratinizing Epithelioma | X X X X | 7 | Cystic Keratinizing Epithelioma, | | | Multiple | X | 5 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------