NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/15/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 11:01:31 53 WEEK SSAC FINAL #1; REVISION #1 Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 10/12/00 - 10/13/00 Treatment Groups: Include 001 0 NG TEQ/KG Include 002 7 NG TEQ/KG Include 003 22 NG TEQ/KG Include 004 72 NG TEQ/KG Include 005 216 NG TEQ/KG Include 006 360 NG TEQ/KG a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/15/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 11:01:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 86 98 86 Scheduled Sacrifice 13 12 13 13 13 Early Deaths Survivors Animals Examined Microscopically 8 7 8 8 8 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (8) (7) (8) (8) (8) Angiectasis 1 [2.0] Basophilic Focus 2 3 1 1 1 Cholangiofibrosis 2 [1.5] 5 [2.4] Clear Cell Focus, Multiple 1 Eosinophilic Focus 1 1 Fatty Change, Diffuse 4 [1.0] 8 [2.1] Fatty Change, Focal 1 [1.0] Hepatodiaphragmatic Nodule 1 Hyperplasia, Nodular 1 8 Inflammation 7 [1.0] 7 [1.1] 8 [1.4] 8 [1.9] 8 [1.4] Mixed Cell Focus 2 2 2 Mixed Cell Focus, Multiple 5 3 5 7 Necrosis 1 [1.0] 1 [1.0] 3 [1.0] 2 [1.0] 2 [1.0] Pigmentation 5 [1.0] 8 [1.1] 8 [2.0] 8 [2.5] Toxic Hepatopathy 2 [1.0] 8 [1.3] 8 [3.1] Bile Duct, Cyst 1 [2.0] Bile Duct, Fibrosis 1 [1.0] Bile Duct, Hyperplasia 1 [1.0] 1 [1.0] 8 [2.1] Centrilobular, Fibrosis 5 [1.2] 8 [2.0] Hepatocyte, Hypertrophy 1 [1.0] 2 [1.5] 8 [1.6] 8 [3.8] Hepatocyte, Multinucleated 3 [1.0] 8 [1.4] 8 [2.6] Oval Cell, Hyperplasia 8 [2.6] Portal, Fibrosis 8 [2.0] Pancreas (8) (7) (8) (8) (8) Inflammation, Chronic Active 1 [2.0] 2 [1.0] 1 [1.0] Acinus, Atrophy 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0] Acinus, Vacuolization Cytoplasmic 6 [1.0] 8 [1.8] Stomach, Forestomach (8) (8) Edema 1 [2.0] Stomach, Glandular (8) (8) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/15/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 11:01:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Erosion 2 [1.5] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (8) (7) (8) (8) (8) Angiectasis 2 [1.0] 3 [1.0] 4 [1.3] 1 [1.0] Atrophy 5 [2.2] Degeneration, Cystic 1 [2.0] 2 [1.5] Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0] Hypertrophy 5 [1.0] 3 [2.0] 6 [1.8] 7 [2.1] 5 [1.0] Vacuolization Cytoplasmic 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0] Pituitary Gland (8) (8) Cyst 1 [1.0] Thyroid Gland (8) (7) (8) (8) (8) C-Cell, Hyperplasia 1 [1.0] 1 [1.0] Follicular Cell, Hypertrophy 3 [1.0] 4 [1.5] 6 [1.0] 7 [1.4] 7 [1.6] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (8) (7) (8) (8) (8) Atrophy 7 [3.0] 6 [2.8] 6 [3.0] 5 [3.0] Cyst 1 [2.0] Uterus (8) (7) (8) (8) (8) Inflammation, Suppurative 2 [1.5] Metaplasia, Squamous 6 [1.8] 5 [1.6] 5 [2.0] 5 [1.8] Endometrium, Hyperplasia, Cystic 6 [2.0] 6 [1.7] 5 [3.0] 5 [1.8] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (8) (8) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96022-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 11/15/04 Route: GAVAGE TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Time: 11:01:31 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 NG 7 NG 22 NG 72 NG 216 NG 360 NG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG TEQ/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hematopoietic Cell Proliferation 1 [1.0] Pigmentation 8 [1.5] 8 [1.3] Thymus (8) (7) (8) (8) (6) Atrophy 5 [2.0] 7 [2.0] 7 [2.1] 8 [3.0] 6 [3.8] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (8) (2) (1) (1) (8) Cyst 1 [3.0] Hyperplasia 1 [1.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (8) (7) (8) (8) (8) Infiltration Cellular, Histiocyte 7 [1.1] 5 [1.2] 7 [1.0] 6 [1.3] 8 [1.4] Inflammation 1 [2.0] Pigmentation 1 [2.0] Alveolar Epithelium, Hyperplasia 1 [2.0] Alveolar Epithelium, Metaplasia, Bronchiolar 3 [1.3] 3 [2.3] 6 [1.7] Interstitium, Fibrosis 1 [3.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------