NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 CORE + STOP STUDY FINAL #1; REVISION #1 RATS Facility: Battelle Columbus Laboratory Chemical CAS #: TEFPCBMIX Lock Date: 11/04/02 Cage Range: All Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X | Basophilic Focus, Multiple | X X X X X X | Cholangiofibrosis | | Clear Cell Focus | X | Clear Cell Focus, Multiple | | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X X | Fatty Change, Diffuse | | Fatty Change, Focal | 2 1 1 1 2 2| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1| Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X | Necrosis | 1 1| Pigmentation | 1 1 1 | Bile Duct, Cyst | 3 3 1 | Bile Duct, Fibrosis | 1 1 2 2| Bile Duct, Hyperplasia | 1 1 | __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Centrilobular, Degeneration | 2 | Oval Cell, Hyperplasia | 1 1 | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Fat, Necrosis | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 1 1 1 2| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | 1 | Acinus, Hyperplasia, Focal | | Acinus, Hyperplasia | 2 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 1 2 1 | Inflammation | 3 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 2 1 1 1 1 | |__________________________________________________________________________| Tooth | + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 1 1 1 2 1 2 1 1 2 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 2 1 1 | Coronary Artery, Inflammation, | | Chronic Active | 1 | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Epicardium, Inflammation | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 2 1 2 2 2 1 1 2 2 1 2 3 2 2 2 1 2 1 2 1| Atrophy | | Degeneration, Cystic | 2 2 2 2 3 2 2 | Hematopoietic Cell Proliferation | 1| Hyperplasia | 2 2 2 2 2 2 2 2 2| Hypertrophy | 2 2 2 2 2 2 3 3 1 2 2 1 2 1 3 2 2 2 1 3 1 2 1| Necrosis | | Vacuolization Cytoplasmic | 1 3 1 1 1 1 2 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 1 3 1 1 2 3 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + M + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 2 2 3 3 2 2 2 2 2 2 1 | Cyst | 2 | Vacuolization Cytoplasmic | 2 | Pars Distalis, Hyperplasia | 3 3 3 3 1 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | Follicle, Cyst | | Follicular Cell, Hypertrophy | 1 1 2 1 1 1 2 1 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation | 2 1 1 2 3 2 3 1 1 3 3 1 2 3 2 2 2 2 2 3 1 1 3| Duct, Cyst | 1 3 2 3 3 2 3 3 3 3 2 2 2 2 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4| Cyst | 2 2 2 3 2 2 2 2 3 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hyperplasia, Cystic | 1 | Inflammation, Chronic Active | | Inflammation, Suppurative | 1 | Metaplasia, Squamous | 2 1 2 1 2 1 2 1 2 2 | Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 2 2 1 1 3 2 2 2 4 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 3 2 3 3 4 4 3 2 4 4| |__________________________________________________________________________| Lymph Node | M + + + + + M M M M + M + M M M M M M + M + + + +| Deep Cervical, Hyperplasia, Plasma | | Cell | | Lumbar, Hemorrhage | 2 | Mediastinal, Ectasia | 1 1 2 1 | Mediastinal, Hemorrhage | 1 2| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 | Hyperplasia, Plasma Cell | 2 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 3 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hyperplasia, Histiocytic | | Hyperplasia, Plasma Cell | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 1 1 2 3 2 2 2 3 1 2 2 2 3 2 4| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pigmentation | 1 1 2 1 1 1 1 1 2 2 3 3 1 1 1 2 1 2 1 1 2 2 1 2 1| Capsule, Fibrosis | | Lymphoid Follicle, Atrophy | 2 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 4 2 2 3 4 2 4 2 4 3 4 4 2 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 2 2 1 2 1 2 1 1 2 1 1 1 2 2 1 | Inflammation, Granulomatous | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 1 2 2 2 2 1 2 2 1 2 1 2 2 2 2| Inflammation | 1 4 | Alveolar Epithelium, Hyperplasia | 1 3 1 1 1 1 1 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 | Serosa, Fibrosis | 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 5| 7| 7| 6| 5| 6| 5| 7| 7| 7| 4| 7| 7| 7| 5| 7| 6| 7| 6| DAY ON TEST | 8| 8| 2| 2| 0| 2| 6| 2| 2| 2| 8| 7| 4| 2| 2| 2| 8| 2| 2| 2| 6| 0| 3| 2| 6| | 7| 6| 7| 6| 7| 7| 7| 6| 6| 8| 2| 2| 8| 6| 7| 6| 2| 6| 7| 6| 4| 7| 9| 6| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| TEQ/KG | 2| 3| 4| 5| 2| 3| 4| 5| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 3 | Iris, Inflammation | 2 | Retina, Atrophy | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X X X | Infarct | | Inflammation, Chronic Active | 3 | Mineralization | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 3 1 1 1 2 1 2 1 1 1 1 1 2 1 | Pelvis, Inflammation | 2 3 | Renal Tubule, Hyperplasia | 2 1 | Transitional Epithelium, Hyperplasia | 2 3 | |__________________________________________________________________________| Ureter | + | Transitional Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | X | Edema | | Inflammation | 2 2 2 | Transitional Epithelium, Hyperplasia | 2 3 | __________________________________________|__________________________________________________________________________ Page 7 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 3 2| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Basophilic Focus, Multiple | X X X X X X X | Cholangiofibrosis | 3 | Clear Cell Focus | X X X | Clear Cell Focus, Multiple | X | Eosinophilic Focus | X X | Eosinophilic Focus, Multiple | X X | Fatty Change, Diffuse | 1 2 1 | Fatty Change, Focal | 1 1 1 1 | Hematopoietic Cell Proliferation | 1 1 2 2 1 2 1 1 1 1 2 1 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X X X| Necrosis | 2 | Pigmentation | 1 1 | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 2 2 | Bile Duct, Hyperplasia | 1 1 | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Centrilobular, Degeneration | 3 | Oval Cell, Hyperplasia | 1 1 | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 1 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Acinus, Atrophy | | Acinus, Hyperplasia, Focal | 2 | Acinus, Hyperplasia | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Inflammation | 3 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 2 2 1 1 1 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 1 1 2 2 1 2 1 2 1 2 1 2 3 2 1 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 1 1 1 2 | Coronary Artery, Inflammation, | | Chronic Active | | __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Epicardium, Inflammation | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 1 2 2 1 1 1 2 2 1 1 1 1 1 2 2 2 1 1 1| Atrophy | 3 3 | Degeneration, Cystic | 2 1 3 2 | Hematopoietic Cell Proliferation | | Hyperplasia | 2 2 2 2 | Hypertrophy | 3 3 3 3 2 1 2 1 2 2 2 2 2 2 3 2 2 2 1 1 | Necrosis | | Vacuolization Cytoplasmic | 2 2 2 1 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 1 3 2 2 2 2 | Cyst | | Vacuolization Cytoplasmic | 2 | Pars Distalis, Hyperplasia | 3 2 2 2 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 2 1 1 | Follicle, Cyst | 3 | Follicular Cell, Hypertrophy | 1 1 1 1 1 2 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation | 3 2 2 2 2 2 1 1 2 1 1 1 1 2 1 3 1 2 2 1 1 2 2| Duct, Cyst | 3 2 3 2 2 2 2 2 1 1 2 3 1 2 3 3 2 2 2 3 1| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Cyst | 3 2 2 2 2 2 2 2 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 1 | Hyperplasia, Cystic | | Inflammation, Chronic Active | 1 1 | Inflammation, Suppurative | 2 1 | Metaplasia, Squamous | 2 1 2 1 2 4 1 1 2 1 4 1 | Endometrium, Hyperplasia, Cystic | 3 1 2 1 1 4 2 2 1 3 3 2 1 2 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 3 3 3 3 3 3 2 3 3 2 3 4 4 2| |__________________________________________________________________________| Lymph Node | M M + + + M M + M + M + M + M M + + + M + M + + M| Deep Cervical, Hyperplasia, Plasma | | Cell | | Lumbar, Hemorrhage | | Mediastinal, Ectasia | 2 1 1 | Mediastinal, Hemorrhage | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 3 2 2 2 2 3 3 2 2 3 2 2 2 2 3 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Histiocytic | 2 2 | Hyperplasia, Plasma Cell | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 2 3 2 3 2 2 3 2 3 1 2 2 2 2 2 1 3 4 2| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pigmentation | 1 2 2 2 2 2 1 1 1 2 2 1 2 3 1 2 2 2 2 2 2 1 1 2| Capsule, Fibrosis | 3 | Lymphoid Follicle, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 1 1 2 4 3 2 2 3 2 3 3 2 2 3 2 4 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hyperplasia | 1 2 1 2 2 1 4 1 1 1 1| Inflammation, Granulomatous | 2 3 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 2 1 1 1 1 2 1 2 2 2 2 2 1 1 2 2 2 2 1 2| Inflammation | 1 1 1| Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 1| Alveolar Epithelium, Metaplasia, | | Bronchiolar | | Serosa, Fibrosis | 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 | Respiratory Epithelium, Hyperplasia | 1 1 1 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 6| 6| 5| 3| 7| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 2| 3| 5| DAY ON TEST | 2| 2| 8| 2| 2| 2| 2| 4| 3| 6| 2| 5| 2| 5| 3| 2| 2| 2| 2| 2| 2| 2| 7| 1| 3| | 7| 7| 8| 6| 6| 6| 3| 9| 4| 2| 7| 1| 6| 5| 9| 7| 6| 6| 6| 6| 6| 7| 5| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 NG | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| TEQ/KG | 6| 7| 8| 9| 0| 2| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 8| 1| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | | Iris, Inflammation | | Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 2 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X | Infarct | 3 4 | Inflammation, Chronic Active | | Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pelvis, Inflammation | 3 3 | Renal Tubule, Hyperplasia | | Transitional Epithelium, Hyperplasia | 2 2 | |__________________________________________________________________________| Ureter | | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | | Edema | 3 | Inflammation | 2 2 2 | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 13 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 3 2.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | M + + | 52 | Parasite Metazoan | | 3 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Basophilic Focus | X | 14 | Basophilic Focus, Multiple | | 13 | Cholangiofibrosis | | 1 3.0| Clear Cell Focus | | 4 | Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | X | 5 | Eosinophilic Focus, Multiple | | 5 | Fatty Change, Diffuse | | 3 1.3| Fatty Change, Focal | | 10 1.3| Hematopoietic Cell Proliferation | 1 1 | 27 1.1| Hepatodiaphragmatic Nodule | | 2 | Inflammation | 1 1 1 | 49 1.0| Mixed Cell Focus | X | 5 | Mixed Cell Focus, Multiple | | 33 | Necrosis | | 3 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Pigmentation | | 5 1.0| Bile Duct, Cyst | | 4 2.3| Bile Duct, Fibrosis | | 6 1.7| Bile Duct, Hyperplasia | 1 | 5 1.0| Centrilobular, Degeneration | | 2 2.5| Oval Cell, Hyperplasia | | 4 1.0| |__________________________________________________________________________|____________| Mesentery | + + + | 53 | Fat, Necrosis | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Hyperplasia, Squamous | | 11 1.1| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Inflammation, Chronic Active | | 1 1.0| Acinus, Atrophy | | 1 1.0| Acinus, Hyperplasia, Focal | | 1 2.0| Acinus, Hyperplasia | | 2 1.5| |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Hyperplasia, Squamous | | 4 1.5| Inflammation | | 2 3.0| Ulcer | | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Mineralization | | 12 1.3| |__________________________________________________________________________|____________| Tooth | + | 29 | Peridontal Tissue, Inflammation | 4 | 29 1.6| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Mineralization | | 1 1.0| |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 1 1 1 | 20 1.2| Coronary Artery, Inflammation, | | | Chronic Active | | 1 1.0| Epicardium, Inflammation | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | | 42 1.6| Atrophy | | 2 3.0| Degeneration, Cystic | 3 | 12 2.2| Hematopoietic Cell Proliferation | | 1 1.0| Hyperplasia | | 13 2.0| Hypertrophy | 1 3 | 45 2.0| Necrosis | 4 | 1 4.0| Vacuolization Cytoplasmic | | 14 1.6| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Hyperplasia | 2 | 13 1.8| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | 3 | 23 2.2| Cyst | | 1 2.0| Vacuolization Cytoplasmic | | 2 2.0| Pars Distalis, Hyperplasia | 1 | 11 2.4| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | C-Cell, Hyperplasia | | 7 1.4| Follicle, Cyst | | 1 3.0| Follicular Cell, Hypertrophy | 2 | 22 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 53 | Inflammation | 2 2 3 | 49 1.9| Duct, Cyst | 2 1 2 | 40 2.2| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 3 3 3 | 46 3.0| Cyst | | 19 2.2| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Congestion | | 1 1.0| Hyperplasia, Cystic | | 1 1.0| Inflammation, Chronic Active | | 2 1.0| Inflammation, Suppurative | 2 | 4 1.5| Metaplasia, Squamous | 1 | 23 1.7| Endometrium, Hyperplasia, Cystic | 1 | 32 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 2 4 4 | 37 2.8| |__________________________________________________________________________|____________| Lymph Node | + + + | 28 | Deep Cervical, Hyperplasia, Plasma | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Cell | 3 | 1 3.0| Lumbar, Hemorrhage | | 1 2.0| Mediastinal, Ectasia | | 7 1.3| Mediastinal, Hemorrhage | | 2 1.5| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | Ectasia | | 3 2.7| Hyperplasia, Plasma Cell | 2 4 3 | 45 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Ectasia | | 1 2.0| Hyperplasia, Histiocytic | | 2 2.0| Hyperplasia, Plasma Cell | | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 3 4 | 49 2.2| Pigmentation | 2 2 1 | 52 1.6| Capsule, Fibrosis | | 1 3.0| Lymphoid Follicle, Atrophy | 3 | 4 2.5| |__________________________________________________________________________|____________| Thymus | + + + | 53 | Atrophy | 4 2 | 40 2.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 1 3.0| Hyperplasia | | 26 1.5| Inflammation, Granulomatous | | 3 2.3| |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 2 1 3 | 40 1.7| Inflammation | | 5 1.6| Alveolar Epithelium, Hyperplasia | 1 | 18 1.2| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | | 1 1.0| Serosa, Fibrosis | | 3 1.3| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 4 | 17 1.2| Respiratory Epithelium, Hyperplasia | | 8 1.6| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Cataract | | 1 3.0| Iris, Inflammation | | 1 2.0| Retina, Atrophy | | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | 3 | 24 1.1| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 6| 6| 7| | | DAY ON TEST | 2| 8| 2| | | | 8| 7| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| | A | 0 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | + + + | 53 | Calculus Micro Observation Only | | 6 | Infarct | | 2 3.5| Inflammation, Chronic Active | | 1 3.0| Mineralization | 1 | 46 1.0| Nephropathy | 1 1 1 | 41 1.1| Pelvis, Inflammation | | 4 2.8| Renal Tubule, Hyperplasia | | 2 1.5| Transitional Epithelium, Hyperplasia | | 4 2.3| |__________________________________________________________________________|____________| Ureter | | 1 | Transitional Epithelium, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Calculus Gross Observation | | 1 | Edema | | 1 3.0| Inflammation | 2 1 | 8 1.9| Transitional Epithelium, Hyperplasia | 2 | 4 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X | Basophilic Focus, Multiple | X X X | Cholangiofibrosis | | Clear Cell Focus | X | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X | Fatty Change, Diffuse | 1 1 1 1 1 1 1 1 1| Fatty Change, Focal | 1 1 1 2 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 2 1 | Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 1 1 1 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X| Necrosis | 1 2 2 3 2 2 2 | Pigmentation | 1 2 1 2 1 1 2 1 1 2| Toxic Hepatopathy | 2 1 1 1 | Artery, Inflammation | | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | 3 3 3 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 2 1 | Centrilobular, Degeneration | 1 2 | Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 2 1 | Hepatocyte, Multinucleated | 1 2 2 2| Oval Cell, Hyperplasia | 1 1 | Serosa, Inflammation | 3 2 | |__________________________________________________________________________| Mesentery | + + M + + M + + + + M + + M + M M + M + M M + + M| Inflammation | | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 1 3 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 | Lipomatosis | 2 | Acinus, Atrophy | 2 3 | Acinus, Vacuolization Cytoplasmic | 1 | Artery, Inflammation, Chronic Active | 3 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Hyperplasia, Squamous | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Mineralization | 1 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 1 1 1 1 1 1 4 1 2 1 1 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 | Coronary Artery, Inflammation, | | Chronic Active | 2 | Epicardium, Inflammation | 2 | Pericardium, Inflammation, Chronic | | Active | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 1 1 1 2 2 2 1 1 1 1 1 2 2 2 1| Atrophy | | Degeneration, Cystic | 2 2 3 2 2 2 3| Hyperplasia | 2 2 2 2 2 2 | Hypertrophy | 1 2 2 2 4 2 2 3 1 3 1 3 2 1 2 2 2 2 3 3| Vacuolization Cytoplasmic | 1 2 1 2 3 2 2 1 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 3 2 1 2 | Cytoplasmic Alteration | | Vacuolization Cytoplasmic | 1 | Pars Distalis, Hyperplasia | 2 4 1 3 3 3 2 2| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 3 3 2 3 | Follicular Cell, Hypertrophy | 1 2 2 1 1 1 1 1 2 1 2 1 2 1 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 1 3 1 2 2 2 2 1 2 2 2 1 2 2 1 1 2 1 2| Duct, Cyst | 2 1 2 3 2 3 2 2 3 2 2 1 1 3 3 1 3 1 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3| Cyst | 2 2 3 2 2 2 2 | Inflammation, Chronic Active | 3 | Periovarian Tissue, Inflammation, | | Chronic Active | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | 3 | Inflammation, Chronic Active | 1 | Inflammation, Suppurative | 4 | Metaplasia, Squamous | 1 1 2 2 2 1 4 2 2| Endometrium, Hyperplasia, Cystic | 1 3 2 4 2 1 2 1 2 2 4 1| Serosa, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 3 2 2 3 4 2 3 2 2 3 3 3 3 2 2 3 4 3 2 2 | |__________________________________________________________________________| Lymph Node | + M M M + M M M M + M M + M M M + + + + M + M + M| Lumbar, Ectasia | 3 | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Ectasia | 2 1 1 2 2 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Plasma Cell| 2 2 2 | Renal, Ectasia | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Hemorrhage | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 3 2 2 2 3 3 2 2 2 3 2 4 1 3 1 3 1| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 2 3 1 1 1 3 1 1 1 1 1 1 1 1| Lymphoid Follicle, Atrophy | 2 2 2 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 2 4 2 4 2 4 3 2 2 1 4 2 4 2| Artery, Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 | Hyperplasia | 1 2 1 1 2 1 2 1 1 1 | Inflammation, Granulomatous | 2 2 | Inflammation | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 5| 3| 5| 7| 6| 5| 6| 7| 7| 6| 4| 7| 6| 5| 6| 4| 5| 7| 2| 6| 7| 6| 6| 7| 7| DAY ON TEST | 2| 2| 9| 2| 5| 6| 3| 2| 2| 1| 9| 2| 5| 3| 5| 3| 4| 2| 7| 3| 1| 2| 1| 0| 2| | 5| 8| 4| 6| 9| 7| 9| 7| 6| 6| 8| 6| 1| 4| 9| 6| 1| 6| 5| 1| 4| 3| 1| 5| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Infiltration Cellular, Histiocyte | 2 2 2 1 2 2 2 2 2 1 2 2 1 2 3 1 2 1 | Inflammation | 1 1 1 1 2 | Metaplasia, Squamous | 1 | Alveolar Epithelium, Hyperplasia | 1 1 2 2 1 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 2 1 1 2 1 1 1 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 2 2 2 2 1 1 1 1 | Olfactory Epithelium, Metaplasia | 2 2 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 3 2 1 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 2 3 | Cornea, Inflammation | | Retina, Atrophy | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1 3 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X X | Cyst | 2 | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1| Nephropathy | 1 2 1 1 1 2 1 1 1 1 2 1 1 1 1 4 1 1 1 1 1| Pelvis, Inflammation | 2 2 1 | Transitional Epithelium, Hyperplasia | 2 1 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 1 | Transitional Epithelium, Hyperplasia | 2 1 | __________________________________________|__________________________________________________________________________ Page 26 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration | 3 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X | Basophilic Focus, Multiple | X X X X X| Cholangiofibrosis | 1 1 | Clear Cell Focus | | Eosinophilic Focus | X X X X | Eosinophilic Focus, Multiple | X X X X X X | Fatty Change, Diffuse | 1 1 1 1 1 | Fatty Change, Focal | 2 1 2 1 2 1| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1| Hepatodiaphragmatic Nodule | X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 3 1| Mixed Cell Focus | X X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X| Necrosis | 2 2 3 3 2 | Pigmentation | 1 1 1 1 1 2 2 3 | Toxic Hepatopathy | 1 1 1 1 | Artery, Inflammation | 1 | __________________________________________|__________________________________________________________________________| Page 27 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 1 1 1 | Centrilobular, Degeneration | 3 | Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1| Hepatocyte, Multinucleated | 1 1 1 1 1 | Oval Cell, Hyperplasia | 1 1 | Serosa, Inflammation | | |__________________________________________________________________________| Mesentery | M + + + + M M + + + + + + + + + + M M + M + + + +| Inflammation | 3 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 1 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 1 | Lipomatosis | | Acinus, Atrophy | 2 1 1 | Acinus, Vacuolization Cytoplasmic | | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Hyperplasia, Squamous | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Mineralization | 1 1 2 1 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 1 1 1 2 1 2 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 2 1 1 1 | Coronary Artery, Inflammation, | | Chronic Active | | Epicardium, Inflammation | | Pericardium, Inflammation, Chronic | | Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 1 1 1 2 1 2 1 2 3 1 1 1 2 1 1| Atrophy | 4 | Degeneration, Cystic | 1 3 3 3 2 | Hyperplasia | 3 | Hypertrophy | 1 1 2 2 2 3 1 3 1 1 3 3 2 2 2 2 1 2 3 2| Vacuolization Cytoplasmic | 3 1 1 1 1 2 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + M + + M + + M + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 2 2 3 4 | Cytoplasmic Alteration | 1 | Vacuolization Cytoplasmic | | Pars Distalis, Hyperplasia | 2 3 3 3 3 2| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 1 2 2 2 | Follicular Cell, Hypertrophy | 2 2 1 1 1 2 1 2 2 1 2 1 1 1 1 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 2 1 2 2 1 2 2 1 1 2 2 2 1 1 1 1 2 2 2 1| Duct, Cyst | 3 1 2 1 3 3 2 3 1 2 3 2 3 3 3 2 2 2 1 2 3 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3| Cyst | 2 2 4 2 2 | Inflammation, Chronic Active | | Periovarian Tissue, Inflammation, | | Chronic Active | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Inflammation, Chronic Active | 2 2 2 2 | Inflammation, Suppurative | 1 2 | Metaplasia, Squamous | 4 4 1 4 2 2 2 3 4 4 2 1 2 4 | Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 1 3 3 2 2 2| Serosa, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 3 4 3 2 2 3 4 2 4 4 2 1 3 3 2 3| |__________________________________________________________________________| Lymph Node | M M + + + M M M + M M M + M M M M M M M M M M M M| Lumbar, Ectasia | | Lumbar, Hyperplasia, Plasma Cell | | Mediastinal, Ectasia | 1 1 | Mediastinal, Hemorrhage | 2 | Mediastinal, Hyperplasia, Plasma Cell| | Renal, Ectasia | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2 3 3 2 2 3 2 2 2 2 2 3 2 2 2 2 2 2 2 2| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 1 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 3 4 2 1 2 2 2 2 2 2 3 3 2 1 1 2 2 3 2 2| Pigmentation | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 3 2 2 2 1 1 1| Lymphoid Follicle, Atrophy | 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 4 3 2 2 2 2 2 2 2 2 3 1 2 3 3 3 2 2 2| Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 2 1 2 2 1 3 | Inflammation, Granulomatous | | Inflammation | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 4| 7| 7| 4| 7| 0| 7| 7| 4| 7| 6| 7| 7| 6| 4| 7| 7| 5| 0| 7| 6| 3| 7| 5| DAY ON TEST | 7| 8| 2| 0| 8| 2| 7| 2| 2| 0| 2| 4| 2| 2| 9| 4| 2| 2| 2| 7| 2| 8| 4| 2| 3| | 4| 5| 7| 0| 4| 6| 8| 6| 7| 0| 7| 2| 7| 7| 1| 3| 7| 7| 5| 0| 7| 3| 7| 7| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7 NG | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| TEQ/KG | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| 2| 3| 4| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Infiltration Cellular, Histiocyte | 1 2 2 3 1 1 2 2 1 1 2 1 1 1 1 | Inflammation | 2 1 1 3 | Metaplasia, Squamous | | Alveolar Epithelium, Hyperplasia | 1 1 1 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 2 1 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 | Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Hyperplasia | 1 1 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cataract | 4 | Cornea, Inflammation | 2 | Retina, Atrophy | 2 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X X | Cyst | 3 | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 1 1 1 1 1 1 1 1 3 1 1 1 1 1 1| Pelvis, Inflammation | 2 2 1| Transitional Epithelium, Hyperplasia | 2 2 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 32 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 51 | Degeneration | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + | 51 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + | 51 | Parasite Metazoan | | 2 | Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + | 51 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + | 51 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + | 51 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + | 51 | |__________________________________________________________________________|____________| Liver | + | 51 | Angiectasis | | 1 2.0| Basophilic Focus | X | 8 | Basophilic Focus, Multiple | | 8 | Cholangiofibrosis | | 2 1.0| Clear Cell Focus | | 1 | Eosinophilic Focus | | 5 | Eosinophilic Focus, Multiple | | 16 | Fatty Change, Diffuse | | 14 1.0| Fatty Change, Focal | | 10 1.4| Hematopoietic Cell Proliferation | 1 | 27 1.0| Hepatodiaphragmatic Nodule | | 2 | Inflammation | 2 | 47 1.2| Mixed Cell Focus | | 5 | Mixed Cell Focus, Multiple | | 23 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Necrosis | 2 | 13 2.2| Pigmentation | | 18 1.4| Toxic Hepatopathy | | 8 1.1| Artery, Inflammation | | 1 1.0| Bile Duct, Cyst | | 3 3.0| Bile Duct, Fibrosis | | 2 1.0| Bile Duct, Hyperplasia | | 5 1.2| Centrilobular, Degeneration | | 3 2.0| Hepatocyte, Hypertrophy | | 16 1.1| Hepatocyte, Multinucleated | | 9 1.3| Oval Cell, Hyperplasia | | 4 1.0| Serosa, Inflammation | | 2 2.5| |__________________________________________________________________________|____________| Mesentery | + | 35 | Inflammation | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Oral Mucosa | + | 51 | Gingival, Hyperplasia, Squamous | | 10 1.2| |__________________________________________________________________________|____________| Pancreas | + | 51 | Inflammation, Chronic Active | | 5 1.8| Lipomatosis | | 1 2.0| Acinus, Atrophy | | 5 1.8| Acinus, Vacuolization Cytoplasmic | | 1 1.0| Artery, Inflammation, Chronic Active | | 2 3.0| |__________________________________________________________________________|____________| Salivary Glands | + | 51 | |__________________________________________________________________________|____________| Stomach, Forestomach | + | 51 | Erosion | | 1 2.0| Hyperplasia, Squamous | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Erosion | 2 | 1 2.0| Mineralization | | 6 1.3| |__________________________________________________________________________|____________| Tooth | | 26 | Peridontal Tissue, Inflammation | | 26 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 51 | |__________________________________________________________________________|____________| Heart | + | 51 | Cardiomyopathy | | 13 1.1| Coronary Artery, Inflammation, | | | Chronic Active | | 1 2.0| Epicardium, Inflammation | | 1 2.0| Pericardium, Inflammation, Chronic | | | Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + | 51 | Angiectasis | | 35 1.4| Atrophy | | 1 4.0| Degeneration, Cystic | | 12 2.3| Hyperplasia | | 7 2.1| Hypertrophy | | 40 2.1| Vacuolization Cytoplasmic | | 16 1.6| |__________________________________________________________________________|____________| Adrenal Medulla | + | 51 | Hyperplasia | | 4 2.5| |__________________________________________________________________________|____________| Islets, Pancreatic | + | 51 | |__________________________________________________________________________|____________| Parathyroid Gland | + | 45 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Pituitary Gland | + | 51 | Angiectasis | | 13 2.2| Cytoplasmic Alteration | | 1 1.0| Vacuolization Cytoplasmic | | 1 1.0| Pars Distalis, Hyperplasia | | 14 2.6| |__________________________________________________________________________|____________| Thyroid Gland | + | 51 | C-Cell, Hyperplasia | | 11 2.3| Follicular Cell, Hypertrophy | 3 | 35 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + | 51 | Inflammation | 1 | 44 1.6| Duct, Cyst | 2 | 41 2.2| |__________________________________________________________________________|____________| Ovary | + | 51 | Atrophy | 3 | 34 3.1| Cyst | | 12 2.3| Inflammation, Chronic Active | | 1 3.0| Periovarian Tissue, Inflammation, | | | Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Uterus | + | 51 | Adenomyosis | | 1 3.0| Inflammation, Chronic Active | | 5 1.8| Inflammation, Suppurative | | 3 2.3| Metaplasia, Squamous | 1 | 24 2.4| Endometrium, Hyperplasia, Cystic | | 23 2.0| Serosa, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + | 51 | Hyperplasia | 4 | 41 2.8| |__________________________________________________________________________|____________| Lymph Node | + | 16 | Lumbar, Ectasia | | 1 3.0| Lumbar, Hyperplasia, Plasma Cell | 3 | 1 3.0| Mediastinal, Ectasia | | 7 1.4| Mediastinal, Hemorrhage | | 2 2.0| Mediastinal, Hyperplasia, Plasma Cell| | 3 2.0| Renal, Ectasia | | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + | 51 | Ectasia | | 2 2.0| Hyperplasia, Lymphoid | | 1 3.0| Hyperplasia, Plasma Cell | | 35 2.1| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 51 | Ectasia | | 1 3.0| Hemorrhage | | 2 1.5| |__________________________________________________________________________|____________| Spleen | + | 51 | Hematopoietic Cell Proliferation | 4 | 44 2.3| Pigmentation | 1 | 50 1.3| Lymphoid Follicle, Atrophy | | 5 2.0| |__________________________________________________________________________|____________| Thymus | + | 51 | Atrophy | 3 | 44 2.5| Artery, Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 51 | Cyst | | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Hyperplasia | | 17 1.5| Inflammation, Granulomatous | | 2 2.0| Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Skin | + | 51 | Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 51 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + | 51 | Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + | 51 | Infiltration Cellular, Histiocyte | | 33 1.6| Inflammation | | 9 1.4| Metaplasia, Squamous | | 1 1.0| Alveolar Epithelium, Hyperplasia | | 10 1.2| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | | 14 1.3| |__________________________________________________________________________|____________| Nose | + | 51 | Inflammation | 1 | 15 1.4| Olfactory Epithelium, Metaplasia | | 2 2.0| Respiratory Epithelium, Hyperplasia | | 11 1.8| |__________________________________________________________________________|____________| Trachea | + | 51 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| | | DAY ON TEST | 6| | | | 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| | T | ANIMAL ID | 1| | A | 7 NG | 7| | L | TEQ/KG | 7| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 51 | Cataract | | 3 3.0| Cornea, Inflammation | | 1 2.0| Retina, Atrophy | | 3 2.7| |__________________________________________________________________________|____________| Harderian Gland | + | 51 | Inflammation | | 7 1.4| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + | 51 | Calculus Micro Observation Only | | 6 | Cyst | | 2 2.5| Inflammation, Suppurative | | 1 1.0| Mineralization | 1 | 34 1.1| Nephropathy | | 37 1.2| Pelvis, Inflammation | | 6 1.7| Transitional Epithelium, Hyperplasia | | 6 1.8| |__________________________________________________________________________|____________| Urinary Bladder | + | 51 | Inflammation | | 3 1.3| Transitional Epithelium, Hyperplasia | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Basophilic Focus | X X | Basophilic Focus, Multiple | X | Cholangiofibrosis | 1 | Degeneration, Cystic | | Eosinophilic Focus | X X X X X | Eosinophilic Focus, Multiple | X X X X X X | Fatty Change, Diffuse | 1 2 1 1 1 1 1 2 2 1 1 1 1 | Fatty Change, Focal | 1 1 | Hematopoietic Cell Proliferation | 2 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperplasia, Nodular | X X X X X X | Inflammation | 2 1 2 2 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 2 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X | Necrosis | 3 2 | Pigmentation | 2 1 1 2 3 1 1 2 2 1 1 1 1 1 1 2 1 1 | Toxic Hepatopathy | 3 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 | __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | 3 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 3 3 1 2 1 | Centrilobular, Degeneration | 1 2 2 2 3 | Centrilobular, Fibrosis | 1 1 | Hepatocyte, Hypertrophy | 4 1 2 1 1 2 1 1 2 1 1 | Hepatocyte, Multinucleated | 2 1 1 1 1 1 1 1 1 2 | Oval Cell, Hyperplasia | 3 2 1 1 1 1 1 1 1 1 1 1 | Portal, Fibrosis | 1 | |__________________________________________________________________________| Mesentery | + + + + + M + + M + + + + + + + M + + + + + M + +| Necrosis | | Artery, Inflammation, Chronic Active | 4 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 2 2 1 1 1 2 2 2 2 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation, Chronic Active | 2 1 1 | Lipomatosis | | Acinus, Atrophy | 1 1 | Acinus, Vacuolization Cytoplasmic | 1 1 | Artery, Inflammation, Chronic Active | 3 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 3 | Inflammation | 3 | Ulcer | 3 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | |__________________________________________________________________________| Tongue | + | Cyst | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Tooth | + + + + + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 2 2 1 1 2 1 1 1 2 2 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 | Valve, Hyperplasia | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 3 2 2 2 2 2 2 1 1 1 1 2 1 2 1 1 | Degeneration, Cystic | 2 1 1 2 2 1 2 | Hyperplasia | 2 3 2 2 2 2 2 3 | Hypertrophy | 1 2 2 2 2 1 2 2 3 2 2 1 2 3 3 1 1 1 4 3 2 1 | Necrosis | 2 2 | Vacuolization Cytoplasmic | 1 2 2 2 2 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 3 3 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + M +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Angiectasis | 3 2 3 3 2 2 2 1 | Cytoplasmic Alteration | 1 | Pars Distalis, Hyperplasia | 3 2 2 1 1 2 2 2 1 2| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2 2 2 2 1 | Follicular Cell, Hypertrophy | 3 1 2 2 2 2 2 2 2 2 2 4 1 1 1 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Inflammation | 2 1 1 1 2 2 3 1 2 1 1 2 1 1 2 2 2 2 3 2 1| Duct, Cyst | 1 1 2 3 2 2 1 2 1 3 1 3 2 2 3 3 3 3 2 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Cyst | 2 2 2 2 2 3 2 2 | Inflammation, Chronic Active | 4 4 | Inflammation | 4 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3| Inflammation, Suppurative | 1 1 | Metaplasia, Squamous | 3 4 2 3 4 2 2 2 2 2 1 3 3 2 2 2 2 | Endometrium, Hyperplasia, Cystic | 1 2 1 2 1 3 3 1 3 2 2 2 3 3 4| |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 2 3 3 3 3 3 3 4 2 2 3 3 3 3| |__________________________________________________________________________| Lymph Node | M + + M M M + M M M M M M + M M M M M + + + M M +| Mediastinal, Ectasia | 2 1 1 1 | Mediastinal, Hemorrhage | 2 1 | Mediastinal, Hyperplasia, Lymphoid | 4 4 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 3 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 3 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 | Hyperplasia, Histiocytic | | __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 3 2 1 2 2 2 2 2 2 2 2 2 2 1 3 2 3 1 2 3 | Pigmentation | 1 1 1 2 2 2 2 2 2 3 2 2 1 1 1 2 2 1 1 1 1 1 2 1 1| Lymphoid Follicle, Atrophy | 3 2 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| Atrophy | 4 4 4 3 2 2 2 2 4 2 3 3 3 4 4 2 3 3 3 4| Hemorrhage | 3 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 1 1 | Inflammation, Granulomatous | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 2 2 1 2 2 3 2 2 2 2 2 1 2 2 1 1 1 2 2 2 | Inflammation | 1 | Metaplasia, Squamous | | Necrosis | 3 | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 5| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 5| 4| 4| 7| 5| 4| 3| 7| 5| 7| 7| 4| 5| DAY ON TEST | 2| 0| 6| 2| 2| 2| 2| 2| 2| 7| 1| 6| 8| 4| 2| 2| 7| 7| 9| 2| 6| 2| 2| 7| 5| | 6| 4| 7| 7| 6| 6| 7| 7| 7| 2| 1| 5| 6| 3| 6| 6| 2| 1| 9| 6| 7| 6| 6| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| TEQ/KG | 1| 3| 4| 5| 6| 7| 9| 0| 6| 7| 9| 0| 6| 7| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 2 2 2 2 1 2 1 2 1 1 2 1 1 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | Olfactory Epithelium, Metaplasia | 2 | Respiratory Epithelium, Hyperplasia | 1 | Squamous Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X X | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1| Nephropathy | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 3 2 1 | Pelvis, Dilatation | 2 | Pelvis, Inflammation | | Transitional Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 | __________________________________________|__________________________________________________________________________ Page 45 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X | Basophilic Focus, Multiple | X X X | Cholangiofibrosis | 1 1 | Degeneration, Cystic | 1 | Eosinophilic Focus | X X X X X X | Eosinophilic Focus, Multiple | X X X X X | Fatty Change, Diffuse | 1 1 1 1 2 2 1 1 1 1 1 1| Fatty Change, Focal | 2 2 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperplasia, Nodular | X X X X | Inflammation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| Mixed Cell Focus | X X | Mixed Cell Focus, Multiple | X X X X X X X X X X X X X X X| Necrosis | 3 2 1 | Pigmentation | 1 1 1 2 2 2 1 2 1 2 2 1 1 2 2 2 2 2| Toxic Hepatopathy | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 1 | Bile Duct, Hyperplasia | 2 | Centrilobular, Degeneration | 1 2 | Centrilobular, Fibrosis | 1 1 1 1| Hepatocyte, Hypertrophy | 2 1 2 1 1 1 1 1 2 1 | Hepatocyte, Multinucleated | 1 1 1 1 1 2 1 1 1| Oval Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 | Portal, Fibrosis | 1 | |__________________________________________________________________________| Mesentery | + M + + + M + + + + + + + M + + + + + + + M + + +| Necrosis | 3 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 2 1 1 1 1 1 2 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation, Chronic Active | 2 | Lipomatosis | 2| Acinus, Atrophy | 2| Acinus, Vacuolization Cytoplasmic | 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | 2 | Inflammation | 2 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 2 2 1 | |__________________________________________________________________________| Tongue | | Cyst | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Tooth | + + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1| Valve, Hyperplasia | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 1 2 2 1 2 1 1 2 2 1 1 2 1 1 2 2| Degeneration, Cystic | 2 1 3 3 2| Hyperplasia | 2 2 1 2 2| Hypertrophy | 4 2 1 2 2 1 2 2 1 3 1 1 3 3 3 3 2 2 2 2 3 3| Necrosis | | Vacuolization Cytoplasmic | 1 1 2 1 1 2 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 2 3 2 2 2 3 2| Cytoplasmic Alteration | | Pars Distalis, Hyperplasia | 2 3 1 2 4 3 3 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 3 2 1 1 2 | Follicular Cell, Hypertrophy | 2 2 2 2 1 1 2 2 2 2 2 1 1 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| Inflammation | 1 1 2 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 | Duct, Cyst | 2 2 3 2 2 2 3 3 2 2 2 2 2 3 2 2 1 2 2 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3| Cyst | 2 3 2 2 4 2 3 | Inflammation, Chronic Active | 4 | Inflammation | 4 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 1 1 3 | Metaplasia, Squamous | 2 1 1 2 2 2 3 4 4 2 3| Endometrium, Hyperplasia, Cystic | 2 2 1 4 4 2 2 1 2 1 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 3 1 3 2 2 3 3 2 4 4 4 2 2 3 3 4 2| |__________________________________________________________________________| Lymph Node | + M M M + M M + M M + M M M M M M M M + M M + + M| Mediastinal, Ectasia | 2 1 | Mediastinal, Hemorrhage | 2 1 | Mediastinal, Hyperplasia, Lymphoid | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | | Hyperplasia, Lymphoid | 2 3 | Hyperplasia, Plasma Cell | 2 3 2 2 2 2 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Histiocytic | 2 | __________________________________________|__________________________________________________________________________| Page 49 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 1 3 3 2 1 2 1 2 2 2 2 2 2 2 1| Pigmentation | 1 1 1 1 2 1 2 2 2 1 2 1 1 3 1 2 1 1 1 1 1 1 1 1| Lymphoid Follicle, Atrophy | | |__________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 3 2 4 2 4 3 4 2 3 4 3 2 2 3 2 2 2 4 4| Hemorrhage | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | Hyperplasia | 1 2 2 1 1 1 2 1 2 | Inflammation, Granulomatous | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrocephalus | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 2 2 2 1 1 2 1 1 2 2 3 2 2 2 2 1 1| Inflammation | 1 1 1 2 1 1 | Metaplasia, Squamous | 1 2 | Necrosis | | __________________________________________|__________________________________________________________________________| Page 50 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 6| 7| 0| 7| 7| 6| 6| 4| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 5| 7| DAY ON TEST | 2| 5| 2| 5| 2| 5| 2| 6| 2| 2| 0| 3| 4| 2| 3| 5| 0| 2| 0| 2| 2| 2| 0| 4| 2| | 7| 9| 7| 5| 6| 1| 6| 3| 7| 7| 8| 9| 3| 6| 2| 9| 8| 7| 0| 6| 7| 3| 7| 8| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 22 NG | 4| 4| 5| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 4| 5| 1| 2| 5| 6| 7| 8| 0| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 1 2 1 2 2 1 1 1 1 1 2 2 3 2 2 1 1| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 3 1 2 1 1 1 | Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Hyperplasia | 2 1 2 1 | Squamous Epithelium, Hyperplasia | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | X X | Inflammation, Suppurative | 1 2 2 2 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1| Pelvis, Dilatation | | Pelvis, Inflammation | 2 | Transitional Epithelium, Hyperplasia | 3 1 1 1 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | __________________________________________|__________________________________________________________________________ Page 51 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 2 2.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Artery, Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Parasite Metazoan | | 2 | Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | Artery, Inflammation, Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 2 1.0| Basophilic Focus | | 6 | Basophilic Focus, Multiple | | 4 | Cholangiofibrosis | | 3 1.0| Degeneration, Cystic | | 1 1.0| Eosinophilic Focus | | 11 | Eosinophilic Focus, Multiple | X | 12 | Fatty Change, Diffuse | 1 1 | 27 1.2| Fatty Change, Focal | 2 2 | 6 1.7| Hematopoietic Cell Proliferation | 1 1 | 30 1.0| Hyperplasia, Nodular | | 10 | Inflammation | 1 1 1 | 50 1.1| Mixed Cell Focus | | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mixed Cell Focus, Multiple | X | 28 | Necrosis | 1 | 6 2.0| Pigmentation | 3 2 | 38 1.6| Toxic Hepatopathy | 1 1 | 32 1.2| Bile Duct, Cyst | | 3 2.3| Bile Duct, Fibrosis | 2 | 3 1.3| Bile Duct, Hyperplasia | 1 | 7 1.9| Centrilobular, Degeneration | 2 | 8 1.9| Centrilobular, Fibrosis | 1 | 7 1.0| Hepatocyte, Hypertrophy | 1 | 22 1.4| Hepatocyte, Multinucleated | 1 2 | 21 1.2| Oval Cell, Hyperplasia | 1 1 | 23 1.2| Portal, Fibrosis | | 2 1.0| |__________________________________________________________________________|____________| Mesentery | + + + | 45 | Necrosis | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Hyperplasia, Squamous | | 20 1.4| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Edema | | 1 2.0| Inflammation, Chronic Active | | 4 1.5| Lipomatosis | | 1 2.0| Acinus, Atrophy | | 3 1.3| Acinus, Vacuolization Cytoplasmic | | 8 1.0| Artery, Inflammation, Chronic Active | | 2 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 53 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Hyperplasia, Squamous | 2 | 3 2.3| Inflammation | | 2 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Ulcer | | 1 3.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Mineralization | | 6 1.5| |__________________________________________________________________________|____________| Tongue | | 1 | Cyst | | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + | 33 | Peridontal Tissue, Inflammation | 1 1 | 33 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 52 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | | 17 1.0| Valve, Hyperplasia | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 2 | 39 1.6| Degeneration, Cystic | 2 | 13 1.8| Hyperplasia | | 13 2.1| Hypertrophy | 3 2 2 | 47 2.1| Necrosis | | 2 2.0| Vacuolization Cytoplasmic | | 13 1.5| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Hyperplasia | | 9 2.3| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 52 | Angiectasis | 3 | 19 2.3| Cytoplasmic Alteration | | 1 1.0| Pars Distalis, Hyperplasia | 1 | 19 2.1| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 53 | C-Cell, Hyperplasia | | 13 1.8| Follicular Cell, Hypertrophy | 1 | 34 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 51 | Inflammation | 1 1 1 | 46 1.4| Duct, Cyst | 2 2 | 43 2.1| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 3 | 43 3.0| Cyst | | 15 2.3| Inflammation, Chronic Active | | 3 4.0| Inflammation | | 3 3.3| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Inflammation, Chronic Active | | 2 3.0| Inflammation, Suppurative | | 5 1.4| Metaplasia, Squamous | | 28 2.4| Endometrium, Hyperplasia, Cystic | | 25 2.2| |__________________________________________________________________________|____________| Vagina | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 2 3 | 36 2.8| |__________________________________________________________________________|____________| Lymph Node | + M M | 16 | Mediastinal, Ectasia | 1 | 7 1.3| Mediastinal, Hemorrhage | | 4 1.5| Mediastinal, Hyperplasia, Lymphoid | | 2 4.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 53 | Ectasia | | 3 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | 3 | 3 2.7| Hyperplasia, Plasma Cell | 1 | 34 2.1| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Hemorrhage | | 2 2.0| Hyperplasia, Histiocytic | | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 1 3 | 49 2.0| Pigmentation | 1 2 1 | 52 1.4| Lymphoid Follicle, Atrophy | | 2 2.5| |__________________________________________________________________________|____________| Thymus | + + + | 51 | Atrophy | 2 4 4 | 44 3.0| Hemorrhage | | 2 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 2 3.0| Hyperplasia | 2 1 | 13 1.4| Inflammation, Granulomatous | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Skin | + + + | 53 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hemorrhage | | 1 1.0| Hydrocephalus | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Infiltration Cellular, Histiocyte | 1 2 | 46 1.7| Inflammation | | 7 1.1| Metaplasia, Squamous | | 2 1.5| Necrosis | | 1 3.0| Alveolar Epithelium, Hyperplasia | | 2 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 | 39 1.4| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 3 | 16 1.3| Olfactory Epithelium, Metaplasia | | 1 2.0| Respiratory Epithelium, Hyperplasia | | 5 1.4| Squamous Epithelium, Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 7| 7| 7| | | DAY ON TEST | 2| 2| 0| | | | 6| 6| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| | A | 22 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 8| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 20 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Calculus Micro Observation Only | X | 6 | Inflammation, Suppurative | | 4 1.8| Mineralization | 1 1 | 38 1.1| Nephropathy | 1 1 | 37 1.2| Pelvis, Dilatation | | 1 2.0| Pelvis, Inflammation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 6 1.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 2 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Erosion | | Hyperplasia | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X | Basophilic Focus, Multiple | X | Cholangiofibrosis | 1 2 1 3 1 1 3 3 4| Clear Cell Focus, Multiple | | Eosinophilic Focus | | Eosinophilic Focus, Multiple | X X X X X X X X | Fatty Change, Diffuse | 2 1 2 1 2 1 1 2 2 2 2 2 1 1 2 1 2 1 1 2 1| Fatty Change, Focal | 2 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Hepatodiaphragmatic Nodule | X | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X| Inflammation | 2 2 2 1 1 1 2 2 1 1 1 1 2 1 1 1 3 1 1 1 1 1 3 2 1| Mixed Cell Focus, Multiple | X X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Necrosis | 3 1 1 1 3 1 2 3 2 2 2 2 2 3 | Pigmentation | 2 2 2 2 2 1 2 2 2 1 2 3 2 2 2 3 2 2 2 2 2 2 2 2 2| Toxic Hepatopathy | 3 3 2 3 2 2 3 2 2 2 2 3 3 3 3 3 3 3 3 3 2 3 2 3| Artery, Inflammation | | Bile Duct, Cyst | 1 2 3 2 2 2 | Bile Duct, Fibrosis | 2 2 1 2 1 | Bile Duct, Hyperplasia | 1 2 2 3 4 2 3 2 2 1 2 2 2 1 1 3 1 2 2| Centrilobular, Degeneration | 3 2 1 | Centrilobular, Fibrosis | 1 1 1 2 2 2 2 1 2 2 1 1 1 1 2 2 1 | Hepatocyte, Glandular Structures | | Hepatocyte, Hypertrophy | 3 3 2 3 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 2 3 3| Hepatocyte, Multinucleated | 2 2 2 2 1 2 2 2 2 2 2 2 1 2 3 2 2 1 2 1 2 2 2 2| Oval Cell, Hyperplasia | 2 2 2 2 1 1 1 2 2 2 3 2 2 3 2 2 2 3 3 2 2 3| Portal, Fibrosis | 1 1 2 2 2 1 3 1 2 2 1 1 1 1 3 2 2| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + M + + +| Necrosis | | Artery, Inflammation, Chronic Active | 3 3 1 3| Fat, Necrosis | 2 2 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 2 2 1 2 3 2 1 3 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 | Acinus, Atrophy | 2 2 2 | Acinus, Vacuolization Cytoplasmic | 2 2 2 1 2 1 2 2 1 1 1 2 2 1 2 1 2| Artery, Inflammation, Chronic Active | 3 2 2 2 3 4 2 3 2 1 3| Duct, Dilatation | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Erosion | 2 | Hyperplasia, Squamous | 1 2 2 1 | Inflammation | | Mineralization | 1 | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Ulcer | | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 1 3 2 1 1 2 2 1 1 1 4 4 1 2 3 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 | Coronary Artery, Inflammation, | | Chronic Active | 3 3 2 1| Endocardium, Hyperplasia | 3 | Epicardium, Inflammation | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1 3 1 1 1 2 3 1 1 1| Atrophy | 2 2 2| Degeneration, Cystic | 2 1 1 3 | Hyperplasia | 2 2 2 3 2| Hypertrophy | 1 2 3 3 2 1 2 2 2 1 3 2 3 2 2 3 2 2 3 | Inflammation | 3 | Necrosis | 3 2 | Vacuolization Cytoplasmic | 1 2 1 1 1 2 2 1 3 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + M M + + + + + + + + + + + + M + + +| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 3 | Vacuolization Cytoplasmic | 1 1 1 1 1 | Pars Distalis, Hyperplasia | 2 1 2 3 3 2 3 2 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 | Follicular Cell, Hypertrophy | 2 2 2 1 2 3 1 1 1 1 3 2 1 2 1 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| Inflammation | 1 1 1 2 1 1 1 1 2 1 1 2| Artery, Inflammation, Chronic Active | 3| Duct, Cyst | 3 2 2 3 3 1 3 2 3 2 3 2 2 2 2 3 2 3 1 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 3 3 3 3 3 3| Cyst | 3 2 3 2 2 2| Inflammation, Chronic Active | 4 | Inflammation | 4 | Artery, Inflammation | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Hemorrhage | 4 | Inflammation, Chronic Active | 3 | Inflammation, Suppurative | 2 3 3 4 | Metaplasia, Squamous | 2 2 2 3 3 3 4 3 | Endometrium, Hyperplasia, Cystic | 2 2 3 4 2 3 4 3 4 1 1 3 2 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia | 2 3 2 3 3 2 4 2 2 2 3 3 4 3 2 3 4 3 3 3 4 3| |__________________________________________________________________________| Lymph Node | + M M + M M M + + M M + + M + + + M M + M M + + +| Hemorrhage | 2 | Deep Cervical, Congestion | 2 | Deep Cervical, Ectasia | 1 | Deep Cervical, Hemorrhage | 2 | Deep Cervical, Hyperplasia, | | Histiocytic | 2 | Lumbar, Ectasia | | Mediastinal, Congestion | 2 | Mediastinal, Ectasia | 2 2 1 1 | Mediastinal, Hemorrhage | 2 2 2 2 2 1 | Mediastinal, Hyperplasia, Histiocytic| 2 | Mediastinal, Hyperplasia, Plasma Cell| | Pancreatic, Hyperplasia, Histiocytic | | Pancreatic, Hyperplasia, Lymphoid | 3 | Renal, Ectasia | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 | Hyperplasia, Histiocytic | 2 | Hyperplasia, Plasma Cell | 3 2 2 2 2 2 2 2 2 2 2 3 2 2| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 2 | Hyperplasia, Histiocytic | 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 2 2 1 2 1 2 2 1 3 1 1 2 1 2 3 2 3 2 3 3 2| Pigmentation | 1 2 2 1 1 1 2 2 2 2 1 2 3 1 1 2 1 1 1 1 1 1 1| Lymphoid Follicle, Atrophy | 2 2 1 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3| Necrosis | | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 1 2 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 1 1 1 | Inflammation | 1 3 | Necrosis | 3 3 | Cerebrum, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 2 2 1 2 2 1 2 1 1 2 1 1 1 2 2 2 2 1 2 1 1| Inflammation | 3 3 | Metaplasia, Squamous | 2 2 2 3 2 2 2| Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 2 2 2 2 3 1 1 2 3 2 1 1 1 1 2 1 2 2 1 1 2| Serosa, Fibrosis | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 1 2 3 1 | Olfactory Epithelium, Degeneration | 2 | Olfactory Epithelium, Metaplasia | 2 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 | __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 0| 7| 4| 5| 5| 7| 6| 6| 6| 5| 6| 6| 6| 7| 7| 7| 3| 5| 2| 7| DAY ON TEST | 2| 1| 2| 5| 2| 7| 2| 8| 9| 3| 2| 5| 1| 7| 4| 6| 0| 8| 2| 0| 0| 6| 4| 6| 2| | 7| 0| 6| 9| 7| 8| 6| 0| 4| 7| 7| 6| 9| 8| 1| 2| 4| 6| 7| 7| 7| 7| 8| 1| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| TEQ/KG | 1| 2| 3| 4| 5| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 6| 7| 8| 9| 1| 2| 3| 4| 8| 2| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cornea, Inflammation | 3 | Retina, Atrophy | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 2 3 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 3 3 1 1 1 1 1 1 3 2 1 1 3 2 3 2 3 4 2 1 2| Artery, Inflammation, Chronic Active | | Pelvis, Inflammation | 2 | Transitional Epithelium, Hyperplasia | 4 1 3 2 1 2 4 3 | Transitional Epithelium, Metaplasia, | | Squamous | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Metaplasia, Squamous | | Artery, Inflammation, Chronic Active | | Transitional Epithelium, Hyperplasia | 2 | __________________________________________|__________________________________________________________________________ Page 65 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | Artery, Inflammation, Chronic Active | 3 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 3 3 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Erosion | 2 | Hyperplasia | 3 | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X | Basophilic Focus, Multiple | X | Cholangiofibrosis | 1 3 2 3 3 3 3 3 3 1| Clear Cell Focus, Multiple | X | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X | Fatty Change, Diffuse | 1 2 2 1 1 2 2 1 1 2 1 2 1 2 2 1 2 1 1 2 2| Fatty Change, Focal | | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Hepatodiaphragmatic Nodule | | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 1 2 2 2 2 1 1 2 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1| Mixed Cell Focus, Multiple | X X X X X X| __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Necrosis | 2 1 3 2 2 2 2 1 2 1 2 3 | Pigmentation | 2 2 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2| Toxic Hepatopathy | 1 3 2 3 3 2 2 3 2 4 2 2 3 2 3 3 3 4 2 3 2 3 4 2| Artery, Inflammation | | Bile Duct, Cyst | 3 3 2 1 3 2 2 2 | Bile Duct, Fibrosis | 2 2 2 2 | Bile Duct, Hyperplasia | 1 1 1 3 2 2 1 2 1 2 2 2 2 1 2 3 2 2 2 1 1 2 2 1| Centrilobular, Degeneration | 2 2 2 2 2 | Centrilobular, Fibrosis | 2 2 2 1 2 1 2 2 1 2 1 1 1 1 2 2 | Hepatocyte, Glandular Structures | 1 | Hepatocyte, Hypertrophy | 2 2 2 2 3 3 2 2 2 3 3 2 3 3 3 2 3 3 2 2 3 4 | Hepatocyte, Multinucleated | 1 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2 1 1| Oval Cell, Hyperplasia | 1 2 2 3 2 1 2 2 2 3 3 2 3 2 2 3 2 3 1 2 3 3 3 1| Portal, Fibrosis | 2 1 2 2 1 2 1 3 2 2 2 2 1 2 2 3 3 3 2| |__________________________________________________________________________| Mesentery | M + + + + M + + + + + + + + + + + M + + + + + + +| Necrosis | 3 | Artery, Inflammation, Chronic Active | 2 2 3 4 3 | Fat, Necrosis | 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 2 1 1 2 3 2 1 1 1 2 2 3 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 | Acinus, Atrophy | 2 1 | Acinus, Vacuolization Cytoplasmic | 3 1 1 2 2 1 2 1 1 1 2 2 2 2 1 2 2 2 1 2| Artery, Inflammation, Chronic Active | 4 2 3 3 1 2 2 2 2 | Duct, Dilatation | 2 | |__________________________________________________________________________| Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 2 | Erosion | | Hyperplasia, Squamous | 3 3 2 1 2 1 4 | Inflammation | 3 2 1 1 | Mineralization | | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Ulcer | 2 | Artery, Inflammation, Chronic Active | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 1 2 1 1 2 1 4 1 1 1 1 1 4 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 | Coronary Artery, Inflammation, | | Chronic Active | 3 1 | Endocardium, Hyperplasia | | Epicardium, Inflammation | 2 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 1 1 1 2 1 1 1 1| Atrophy | 4 2 2 2 3 2 2 2 2 3 3 3 | Degeneration, Cystic | 2 2 2 3 3 1 3 | Hyperplasia | 1 3 2 1 2 2 3 | Hypertrophy | 1 3 3 2 3 2 3 2 3 3 2 2 1 3 3 3 3 3 2 1 1 3 2| Inflammation | | Necrosis | 3 1 | Vacuolization Cytoplasmic | 2 2 3 2 1 2 1 2 2 1 2 2| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 2 2 3 2 2 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 2 2 3 | Vacuolization Cytoplasmic | | Pars Distalis, Hyperplasia | 3 4 2 2 1 3 2 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2| Follicular Cell, Hypertrophy | 1 2 1 2 3 2 2 1 2 2 1 2 2 2 2 3 2 1 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 1 1 1 1 1 1 2 1 1 1 2 2 1 1 1 1| Artery, Inflammation, Chronic Active | | Duct, Cyst | 2 2 1 2 2 1 3 3 2 2 2 1 2 3 3 3 2 3 3 3 3 1 3 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Cyst | 3 2 2 2 2 3 2 2 2 2 2 3 | Inflammation, Chronic Active | 4 | Inflammation | 4 2 | Artery, Inflammation | 4 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | 2 3 3 | Hemorrhage | 3 | Inflammation, Chronic Active | 3 4 3 | Inflammation, Suppurative | 2 4 | Metaplasia, Squamous | 3 3 2 2 1 1 2 2 4 4 4 2 3 2| Endometrium, Hyperplasia, Cystic | 1 3 3 1 1 2 3 3 1 1 2 1 1 2 3 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia | 2 3 3 3 2 3 3 2 4 4 3 4 4 3 3 3 3 2 3 3 3 3 2| |__________________________________________________________________________| Lymph Node | + + + + + + + M + + M M + M M M + M M M M M M M M| Hemorrhage | | Deep Cervical, Congestion | | Deep Cervical, Ectasia | | Deep Cervical, Hemorrhage | | Deep Cervical, Hyperplasia, | | Histiocytic | | Lumbar, Ectasia | 3 | Mediastinal, Congestion | | Mediastinal, Ectasia | 2 1 1 | Mediastinal, Hemorrhage | 1 2 2 1 2 3 2 2 2 | Mediastinal, Hyperplasia, Histiocytic| 2 | Mediastinal, Hyperplasia, Plasma Cell| 3 | Pancreatic, Hyperplasia, Histiocytic | 2 | Pancreatic, Hyperplasia, Lymphoid | 3 | Renal, Ectasia | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 | Hyperplasia, Histiocytic | | Hyperplasia, Plasma Cell | 2 3 2 3 2 2 2 2 2 2 2 3 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 | Hemorrhage | | Hyperplasia, Histiocytic | 2 1 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 1 2 2 2 2 2 1 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2| Pigmentation | 1 1 2 2 1 2 1 2 1 1 1 1 1 1 1 2 1 2 2 2 1 1 1 1| Lymphoid Follicle, Atrophy | 3 | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| Atrophy | 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4| Necrosis | 3 | __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Hyperplasia | 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation | | Necrosis | | Cerebrum, Degeneration | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 3 | Hemorrhage | 3 | Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 1 1 2 1 1 1 2 1 2 1 2 1 2 2 2 2| Inflammation | | Metaplasia, Squamous | 2 1 2 3 2 2 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 2 2 1 1 1 2 1 1 1 2 2 1 2 1 2 2 3 3 2| Serosa, Fibrosis | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 2 1 2 | Olfactory Epithelium, Degeneration | | Olfactory Epithelium, Metaplasia | 3 2 | Respiratory Epithelium, Hyperplasia | 1 3 2 2 | __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 3| 7| 5| 7| 6| 6| 5| 7| 6| 6| 6| 5| 6| 5| 6| 6| 7| 7| 5| 7| 6| 7| 0| 6| 7| DAY ON TEST | 9| 2| 3| 2| 5| 6| 7| 2| 0| 6| 9| 6| 5| 6| 3| 8| 2| 1| 5| 2| 5| 2| 4| 2| 2| | 0| 6| 4| 7| 3| 7| 0| 6| 2| 3| 8| 7| 1| 5| 6| 7| 7| 4| 2| 7| 9| 7| 1| 8| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 72 NG | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| TEQ/KG | 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cornea, Inflammation | | Retina, Atrophy | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 4 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 3 2 1 2 1 3 3 2 3 4 3 1 3 3 2 4 1 1 2 3 1 3 1| Artery, Inflammation, Chronic Active | | Pelvis, Inflammation | 4 2 3 2 2 | Transitional Epithelium, Hyperplasia | 1 1 4 1 2 3 3 2 | Transitional Epithelium, Metaplasia, | | Squamous | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 3 1 3 | Metaplasia, Squamous | 3 | Artery, Inflammation, Chronic Active | 3 | Transitional Epithelium, Hyperplasia | 3 2 2 | __________________________________________|__________________________________________________________________________ Page 72 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 3 1.3| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 53 | Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 53 | Parasite Metazoan | | 2 | Artery, Inflammation, Chronic Active | 3 | 3 3.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 53 | Artery, Inflammation, Chronic Active | | 2 3.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | Dilatation | | 1 3.0| Erosion | | 1 2.0| Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 53 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | | 1 2.0| Basophilic Focus | | 5 | Basophilic Focus, Multiple | X | 3 | Cholangiofibrosis | 1 1 | 21 2.2| Clear Cell Focus, Multiple | | 1 | Eosinophilic Focus | | 1 | Eosinophilic Focus, Multiple | | 14 | Fatty Change, Diffuse | 2 2 1 | 45 1.5| Fatty Change, Focal | | 1 2.0| Hematopoietic Cell Proliferation | 1 | 32 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia, Nodular | X X X | 45 | Inflammation | 1 1 | 52 1.4| Mixed Cell Focus, Multiple | X | 16 | Necrosis | | 26 2.0| Pigmentation | 2 2 2 | 52 2.1| Toxic Hepatopathy | 2 2 1 | 51 2.6| Artery, Inflammation | 3 | 1 3.0| Bile Duct, Cyst | | 14 2.1| Bile Duct, Fibrosis | 1 | 10 1.7| Bile Duct, Hyperplasia | 2 2 2 | 46 1.8| Centrilobular, Degeneration | | 8 2.0| Centrilobular, Fibrosis | 2 2 2 | 36 1.6| Hepatocyte, Glandular Structures | | 1 1.0| Hepatocyte, Hypertrophy | 3 2 3 | 47 2.6| Hepatocyte, Multinucleated | 2 1 1 | 48 1.8| Oval Cell, Hyperplasia | 2 1 2 | 49 2.1| Portal, Fibrosis | 2 | 37 1.8| |__________________________________________________________________________|____________| Mesentery | + + + | 49 | Necrosis | | 1 3.0| Artery, Inflammation, Chronic Active | | 9 2.7| Fat, Necrosis | | 3 2.3| |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Hyperplasia, Squamous | 2 | 24 1.8| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Inflammation, Chronic Active | | 3 1.3| Acinus, Atrophy | | 5 1.8| Acinus, Vacuolization Cytoplasmic | 2 1 | 39 1.6| Artery, Inflammation, Chronic Active | 1 | 21 2.3| Duct, Dilatation | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Edema | | 2 2.5| Erosion | | 1 2.0| Hyperplasia, Squamous | | 11 2.0| Inflammation | | 4 1.8| Mineralization | | 1 1.0| Ulcer | | 1 2.0| Artery, Inflammation, Chronic Active | | 2 2.5| |__________________________________________________________________________|____________| Stomach, Glandular | + + + | 53 | Mineralization | | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + + | 34 | Peridontal Tissue, Inflammation | 3 3 2 | 34 1.8| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 1 1 2 | 34 1.1| Coronary Artery, Inflammation, | | | Chronic Active | 1 | 7 2.0| Endocardium, Hyperplasia | | 1 3.0| Epicardium, Inflammation | | 6 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | 1 | 25 1.3| Atrophy | | 15 2.4| Degeneration, Cystic | | 11 2.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hyperplasia | | 12 2.1| Hypertrophy | 2 3 | 44 2.3| Inflammation | | 1 3.0| Necrosis | | 4 2.3| Vacuolization Cytoplasmic | 1 2 | 24 1.7| |__________________________________________________________________________|____________| Adrenal Medulla | + + + | 53 | Hyperplasia | 2 | 12 2.1| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Angiectasis | | 7 2.4| Vacuolization Cytoplasmic | | 5 1.0| Pars Distalis, Hyperplasia | | 18 2.3| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | C-Cell, Hyperplasia | 2 | 10 2.0| Follicular Cell, Hypertrophy | 2 2 | 38 1.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | Inflammation | 1 2 | 34 1.2| Artery, Inflammation, Chronic Active | | 1 3.0| Duct, Cyst | 2 | 45 2.3| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 3 3 | 42 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Cyst | 2 | 19 2.3| Inflammation, Chronic Active | 4 | 3 4.0| Inflammation | | 3 3.3| Artery, Inflammation | | 1 4.0| |__________________________________________________________________________|____________| Uterus | + + + | 53 | Adenomyosis | | 3 2.7| Hemorrhage | | 2 3.5| Inflammation, Chronic Active | 3 | 5 3.2| Inflammation, Suppurative | 3 | 7 3.0| Metaplasia, Squamous | 1 2 | 24 2.5| Endometrium, Hyperplasia, Cystic | | 30 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Hyperplasia | 4 3 3 | 48 2.9| |__________________________________________________________________________|____________| Lymph Node | M + M | 25 | Hemorrhage | | 1 2.0| Deep Cervical, Congestion | | 1 2.0| Deep Cervical, Ectasia | | 1 1.0| Deep Cervical, Hemorrhage | | 1 2.0| Deep Cervical, Hyperplasia, | | | Histiocytic | | 1 2.0| Lumbar, Ectasia | | 1 3.0| Mediastinal, Congestion | | 1 2.0| Mediastinal, Ectasia | | 7 1.4| Mediastinal, Hemorrhage | | 15 1.9| Mediastinal, Hyperplasia, Histiocytic| | 2 2.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0| Pancreatic, Hyperplasia, Histiocytic | | 1 2.0| Pancreatic, Hyperplasia, Lymphoid | | 2 3.0| Renal, Ectasia | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 77 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | Ectasia | | 4 2.3| Hyperplasia, Histiocytic | | 1 2.0| Hyperplasia, Plasma Cell | 2 | 27 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 53 | Ectasia | | 2 2.0| Hemorrhage | | 2 2.0| Hyperplasia, Histiocytic | | 6 1.8| |__________________________________________________________________________|____________| Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 2 2 2 | 52 2.0| Pigmentation | 1 2 1 | 50 1.4| Lymphoid Follicle, Atrophy | | 5 2.2| |__________________________________________________________________________|____________| Thymus | + M + | 51 | Atrophy | 3 3 | 49 3.9| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Cyst | | 2 2.0| Hyperplasia | 3 | 6 1.8| |__________________________________________________________________________|____________| Skin | + + + | 53 | Cyst Epithelial Inclusion | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 78 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hemorrhage | | 4 1.3| Inflammation | | 2 2.0| Necrosis | | 2 3.0| Cerebrum, Degeneration | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Congestion | | 2 2.5| Hemorrhage | | 1 3.0| Infiltration Cellular, Histiocyte | 1 2 1 | 48 1.5| Inflammation | 4 | 3 3.3| Metaplasia, Squamous | 2 | 14 2.1| Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 1 | 46 1.6| Serosa, Fibrosis | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | | 10 1.7| Olfactory Epithelium, Degeneration | | 1 2.0| Olfactory Epithelium, Metaplasia | | 3 2.3| Respiratory Epithelium, Hyperplasia | | 8 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Cornea, Inflammation | | 1 3.0| Retina, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 5| 5| 7| | | DAY ON TEST | 5| 3| 2| | | | 5| 9| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| | A | 72 NG | 8| 8| 8| | L | TEQ/KG | 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Harderian Gland | + + + | 53 | Inflammation | | 13 1.2| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Inflammation, Suppurative | | 3 2.3| Mineralization | 1 1 | 44 1.0| Nephropathy | 1 1 2 | 48 2.0| Artery, Inflammation, Chronic Active | 3 | 1 3.0| Pelvis, Inflammation | | 6 2.5| Transitional Epithelium, Hyperplasia | | 16 2.3| Transitional Epithelium, Metaplasia, | | | Squamous | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 53 | Inflammation | | 4 2.3| Metaplasia, Squamous | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 3.0| Transitional Epithelium, Hyperplasia | | 4 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 2 2| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | | Cholangiofibrosis | 3 4 4 3 4 4 3 4 4 4 2 4 4 4 4 2 4 4| Degeneration, Cystic | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X | Fatty Change, Diffuse | 2 1 2 3 2 3 2 1 1 2 1 3 2 2 2 2 2 2 2 1 1 3 2 1| Fatty Change, Focal | 3 | Hematopoietic Cell Proliferation | 1 1 1 2 1 2 1 1 | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 2 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Metaplasia | 1 1 | Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X | Necrosis | 2 3 2 2 2 | Pigmentation | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2| Toxic Hepatopathy | 3 4 4 4 4 3 4 4 3 3 4 3 3 4 4 4 4 4 4 3 4 2 3 4 3| Bile Duct, Cyst | 2 2 3 2 2 3 2 2 2 2 2 | __________________________________________|__________________________________________________________________________| Page 81 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 2 2 | Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 2 1 2 2 2 3 2 2 2 2 2 2 1 3 1| Centrilobular, Degeneration | 2 2 | Centrilobular, Fibrosis | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2| Hepatocyte, Glandular Structures | 2 | Hepatocyte, Hypertrophy | 3 3 3 3 3 4 3 4 3 3 3 3 3 3 3 3 3 4 3 3 3 3 3 4 3| Hepatocyte, Multinucleated | 3 2 1 2 1 2 2 1 3 2 2 3 2 2 1 1 2 2 2 3 2 2 3 3| Oval Cell, Hyperplasia | 3 3 3 3 3 3 3 4 2 3 3 2 3 3 3 4 3 3 3 2 3 3 3 4 3| Portal, Fibrosis | 2 3 3 3 3 1 3 3 3 2 2 2 3 3 3 3 3 3 3 2 3 2 2 3 3| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + M + + + + +| Artery, Inflammation, Chronic Active | 3 2 1 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 2 1 2 1 1 3 2 1 3 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation, Chronic Active | 1 2 | Acinus, Atrophy | 1 1 1 1 | Acinus, Vacuolization Cytoplasmic | 2 2 1 1 3 2 1 2 2 2 2 1 2 2 2 2 2 2 2 1 1 2 1| Artery, Inflammation, Chronic Active | 3 3 3 2 | Duct, Dilatation | 3 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia, Squamous | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Erosion | 2 | Hemorrhage | 2 | Mineralization | 1 1 1 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + +| Peridontal Tissue, Inflammation | 2 1 4 1 1 1 1 1 1 2 3 1 1| __________________________________________|__________________________________________________________________________| Page 82 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Adventitia, Hemorrhage | | Aorta, Adventitia, Inflammation | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 1 | Coronary Artery, Inflammation, | | Chronic Active | 3 4 3 3 | Coronary Artery, Thrombosis | | Epicardium, Inflammation | 3 2 2 1 1 2 1 1 1 | Valve, Fibrosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Atrophy | 2 3 2 2 2 2 2 2 3 3 2 3 2 2 2 2 2 2 2 3 | Degeneration, Cystic | 2 2 3 2 2 | Hyperplasia | 3 2 2 | Hypertrophy | 3 1 1 2 2 3 2 2 2 1 3 4 3 2 1 2 3 1 3 2 1 1 1| Necrosis | 2 | Vacuolization Cytoplasmic | 1 2 2 1 2 1 1 2 1 1 2 1 2 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Artery, Inflammation, Chronic Active | | C-Cell, Hyperplasia | 1 3 2 3 2 1 3| __________________________________________|__________________________________________________________________________| Page 83 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 3 2 1 1 1 2 2 2 3 1 2 2 2 2 1 2 2 2 2 1 2 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 1 1 1 2| Duct, Cyst | 2 2 2 3 2 2 2 2 2 3 2 3 2 4 3 3 3 3 3 4 3 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 | Cyst | 1 2 2 2 2 2 | |__________________________________________________________________________| Oviduct | | Cyst | | Inflammation | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | 3 2 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia | 3 2 3 3 3 3 3 3 3 3 2 4 3 3 3 2 3 3 2 2 2| |__________________________________________________________________________| Lymph Node | + M M M + M M + M + M + M + M M M M + + M M + + +| Mediastinal, Ectasia | 2 2 1 | Mediastinal, Hemorrhage | 2 2 1 2 2 | Mediastinal, Hyperplasia, Histiocytic| 2 | Pancreatic, Ectasia | | Pancreatic, Hemorrhage | | Pancreatic, Hyperplasia, Histiocytic | 2 | Renal, Ectasia | | Renal, Hemorrhage | | __________________________________________|__________________________________________________________________________| Page 84 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Renal, Hyperplasia, Histiocytic | 3 | Renal, Hyperplasia | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Ectasia | 2 | Hemorrhage | 2 | Hyperplasia, Lymphoid | 4 | Hyperplasia, Plasma Cell | 2 2 3 2 3 2 2 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| Ectasia | | Hemorrhage | 2 1 | Hyperplasia, Histiocytic | 2 2 | Hyperplasia, Lymphoid | 4 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 2 1 2 2 1 1 2 | Pigmentation | 1 1 1 1 2 2 2 1 2 2 1 2 1 2 1 1 2 1 1 1 1 2 1 1 1| Lymphoid Follicle, Atrophy | 2 3 | Red Pulp, Atrophy | 2| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Atrophy | 4 3 4 2 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 3 4| Artery, Inflammation, Chronic Active | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Inflammation | 3 | Ulcer | 3 | Subcutaneous Tissue, Inflammation, | | Chronic Active | 3 | __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 2 2 | Inflammation | 3 | Necrosis | 3 | Artery, Inflammation, Chronic Active | 2 | Meninges, Inflammation | 3 | Meninges, Vein, Thrombosis | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Inflammation | 2 | Metaplasia, Squamous | 2 2 2 2 1 4 2 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1| Mediastinum, Inflammation | 3 | Serosa, Fibrosis | 1 2 1 2 2 1 1 1 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 4 2 3 1 1 1 1 2 | Necrosis | 4 | Ulcer | | Glands, Hyperplasia | | Olfactory Epithelium, Metaplasia | 3 2 2 | Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 3 2 2 3 | Squamous Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 4| 7| 6| 6| 5| 4| 6| 3| 4| 5| 3| 5| 6| 6| 4| 5| 5| 5| 5| 6| 5| 3| 6| 3| DAY ON TEST | 8| 7| 0| 1| 8| 6| 4| 2| 9| 5| 3| 1| 2| 4| 6| 4| 7| 7| 4| 3| 3| 5| 3| 7| 7| | 2| 4| 9| 1| 6| 5| 6| 3| 7| 0| 4| 3| 3| 9| 7| 7| 9| 5| 8| 0| 9| 5| 7| 4| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| TEQ/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cornea, Inflammation | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 2 1 3 3 3 3 1 1 1 2 2 1 1 3 3 2 3 2 3 3 1 1 3 1| Pigmentation | | Transitional Epithelium, Hyperplasia | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation | 2 | Transitional Epithelium, Hyperplasia | 3 | __________________________________________|__________________________________________________________________________ Page 87 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 1 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X | Cholangiofibrosis | 4 3 2 4 2 4 4 3 3 4 3 4 3 3 4 3 3 3 3 2 3| Degeneration, Cystic | 2 | Eosinophilic Focus | | Eosinophilic Focus, Multiple | X X X| Fatty Change, Diffuse | 1 1 2 2 1 1 2 2 2 1 1 1 2 1 2 2 2 2 2 2 1 2| Fatty Change, Focal | 2 3 4 3 2 2 2 2 | Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2 1 1| Metaplasia | 1 1 | Mixed Cell Focus | | Mixed Cell Focus, Multiple | | Necrosis | 2 3 2 3 3 2 3 2 2 3 2| Pigmentation | 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2| Toxic Hepatopathy | 4 4 4 3 4 3 3 4 3 3 3 3 3 4 4 4 4 3 3 3 3 4 3 4| Bile Duct, Cyst | 2 2 2 2 2 2 3 3 3 2 2 2 | __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 2 | Bile Duct, Hyperplasia | 3 1 2 3 2 1 1 2 2 2 2 2 2 2 2 2 3 2 2 3 2 3 2 2| Centrilobular, Degeneration | 3 | Centrilobular, Fibrosis | 2 2 2 2 2 2 1 1 1 1 1 2 2 2 3 2 2 2 2 3 2 4 2 2| Hepatocyte, Glandular Structures | 1 1 1 | Hepatocyte, Hypertrophy | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 4 3 3| Hepatocyte, Multinucleated | 2 2 2 2 1 3 2 3 2 2 2 2 1 3 2 1 1 1 1 1 1 3 1 2 2| Oval Cell, Hyperplasia | 3 3 4 3 3 3 3 3 3 3 3 3 2 3 4 3 3 3 3 3 3 4 3 3| Portal, Fibrosis | 3 3 3 2 3 2 3 3 3 3 3 3 2 3 3 2 2 3 3 3 2 4 2 2| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 2 3 1 2 2 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 2 2 3 2 1 1 1 3 2 1 1 2 2 2 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 1 | Inflammation, Chronic Active | | Acinus, Atrophy | 1 2 1 | Acinus, Vacuolization Cytoplasmic | 1 1 1 2 2 2 2 1 2 2 2 2 1 2 2 3 2 2 2 3 3 2 3 | Artery, Inflammation, Chronic Active | 4 3 4 2 3 2 1 2 3 | Duct, Dilatation | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperplasia, Squamous | 2 2 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Erosion | | Hemorrhage | | Mineralization | 1 2 | |__________________________________________________________________________| Tooth | + + + + + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 2 1 1 1 1 1 1 1 2 1 1 2 | __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Adventitia, Hemorrhage | 2 | Aorta, Adventitia, Inflammation | 3 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 | Coronary Artery, Inflammation, | | Chronic Active | 2 2 3 3 2 | Coronary Artery, Thrombosis | | Epicardium, Inflammation | 1 2 2 1 | Valve, Fibrosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 | Atrophy | 3 3 2 2 2 2 3 3 3 3 4 2 2 3 2 3 4 3 2 2 3 | Degeneration, Cystic | 2 | Hyperplasia | 2 2 3 2 2 2 | Hypertrophy | 2 3 2 3 2 1 1 1 3 3 2 2 2 1 3 1 2 3 2| Necrosis | | Vacuolization Cytoplasmic | 2 1 1 2 2 2 2 3 3 1 3 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation | 3 | Artery, Inflammation, Chronic Active | 3 | C-Cell, Hyperplasia | 1 1 1 1 2 2 | __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Follicular Cell, Hyperplasia | 2 3 | Follicular Cell, Hypertrophy | 1 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 1 2 1 1 | Duct, Cyst | 3 1 3 2 2 2 1 2 1 3 3 3 2 2 2 3 2 1 2 3 3 2 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 2 | Cyst | 2 2 | |__________________________________________________________________________| Oviduct | + | Cyst | 3 | Inflammation | 3 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | 1 2 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Hyperplasia | 3 3 4 3 3 4 3 2 3 2 3 3 3 3 3 3 3 3 3 3 3 2 2 3| |__________________________________________________________________________| Lymph Node | + M + M M M M M + M M M M M + + M + M + M M + M M| Mediastinal, Ectasia | 2 1 2 2 | Mediastinal, Hemorrhage | 2 2 | Mediastinal, Hyperplasia, Histiocytic| 2 | Pancreatic, Ectasia | 2 | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Histiocytic | 3 2 3 | Renal, Ectasia | | Renal, Hemorrhage | | __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Renal, Hyperplasia, Histiocytic | | Renal, Hyperplasia | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| Atrophy | | Ectasia | 2 2 | Hemorrhage | | Hyperplasia, Lymphoid | 3 | Hyperplasia, Plasma Cell | 2 2 2 2 2 3 2 2 2 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 1 2 | Hyperplasia, Histiocytic | 2 2 3 | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 1 3 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 3 2 2| Pigmentation | 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 2 2 1 2 1| Lymphoid Follicle, Atrophy | 2 | Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Atrophy | 4 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3 4 4 2 4 4 4 4| Artery, Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Inflammation | | Ulcer | | Subcutaneous Tissue, Inflammation, | | Chronic Active | | __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation | | Necrosis | | Artery, Inflammation, Chronic Active | | Meninges, Inflammation | | Meninges, Vein, Thrombosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 2 1 1 2 1 1 1 1| Inflammation | 4 | Metaplasia, Squamous | 3 2 2 2 2 2 2 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 | Mediastinum, Inflammation | | Serosa, Fibrosis | 2 1 2 3 2 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 2 1 2 1 1 3 2 1| Necrosis | | Ulcer | | Glands, Hyperplasia | 3 3 | Olfactory Epithelium, Metaplasia | 1 3 3 2 | Respiratory Epithelium, Hyperplasia | 2 2 3 3 3 | Squamous Epithelium, Hyperplasia | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 6| 5| 5| 4| 5| 3| 1| 5| 4| 5| 7| 4| 6| 2| 6| 6| 6| 6| 6| 5| 5| 5| 5| 5| 4| DAY ON TEST | 7| 3| 5| 9| 3| 4| 6| 2| 5| 6| 0| 7| 3| 6| 7| 3| 3| 0| 7| 2| 2| 7| 8| 0| 7| | 2| 6| 5| 6| 0| 9| 6| 0| 0| 7| 9| 4| 9| 7| 4| 9| 9| 2| 4| 5| 7| 2| 2| 4| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 216 NG | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 9| 9| 9| 9| 9| TEQ/KG | 9| 0| 1| 4| 7| 8| 9| 1| 2| 3| 5| 1| 2| 3| 5| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Cornea, Inflammation | 3 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 3 1 2 3 2 1 1 2 2 2 2 3 1 3 1 2 3 2 2 3 1 1 1 | Pigmentation | 2 | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | Transitional Epithelium, Hyperplasia | | __________________________________________|__________________________________________________________________________ Page 94 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + | 53 | Muscularis, Inflammation | | 3 1.7| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 52 | Parasite Metazoan | | 1 | Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + | 52 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 52 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Liver | + + + | 53 | Angiectasis | 2 | 3 2.0| Basophilic Focus | | 4 | Cholangiofibrosis | 4 4 4 | 42 3.4| Degeneration, Cystic | | 1 2.0| Eosinophilic Focus | X | 2 | Eosinophilic Focus, Multiple | | 4 | Fatty Change, Diffuse | 2 1 2 | 49 1.7| Fatty Change, Focal | 3 | 10 2.6| Hematopoietic Cell Proliferation | 1 1 | 22 1.1| Hyperplasia, Nodular | X X X | 50 | Inflammation | 1 1 | 51 1.2| Metaplasia | | 4 1.0| Mixed Cell Focus | | 1 | Mixed Cell Focus, Multiple | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 95 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Necrosis | 2 | 17 2.4| Pigmentation | 3 2 2 | 53 2.0| Toxic Hepatopathy | 4 4 4 | 52 3.5| Bile Duct, Cyst | 2 3 | 25 2.2| Bile Duct, Fibrosis | | 3 2.0| Bile Duct, Hyperplasia | 2 3 2 | 52 1.9| Centrilobular, Degeneration | | 3 2.3| Centrilobular, Fibrosis | 3 2 3 | 52 1.9| Hepatocyte, Glandular Structures | 1 | 5 1.2| Hepatocyte, Hypertrophy | 3 4 3 | 52 3.2| Hepatocyte, Multinucleated | 2 1 2 | 52 1.9| Oval Cell, Hyperplasia | 3 3 3 | 52 3.0| Portal, Fibrosis | 3 3 3 | 52 2.7| |__________________________________________________________________________|____________| Mesentery | + + + | 52 | Artery, Inflammation, Chronic Active | | 9 2.1| |__________________________________________________________________________|____________| Oral Mucosa | + + + | 53 | Gingival, Hyperplasia, Squamous | 1 | 27 1.7| |__________________________________________________________________________|____________| Pancreas | + + + | 53 | Edema | 2 | 4 1.8| Inflammation, Chronic Active | | 2 1.5| Acinus, Atrophy | 2 1 | 9 1.2| Acinus, Vacuolization Cytoplasmic | 1 2 3 | 49 1.9| Artery, Inflammation, Chronic Active | 2 | 14 2.6| Duct, Dilatation | | 3 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 52 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + | 53 | Edema | | 1 2.0| Hyperplasia, Squamous | 1 | 4 1.8| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Glandular | + + + | 53 | Cyst | | 1 2.0| Erosion | | 1 2.0| Hemorrhage | | 1 2.0| Mineralization | 1 | 6 1.2| |__________________________________________________________________________|____________| Tooth | + + | 29 | Peridontal Tissue, Inflammation | 1 1 | 29 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + | 53 | Aorta, Adventitia, Hemorrhage | | 1 2.0| Aorta, Adventitia, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Heart | + + + | 53 | Cardiomyopathy | 1 | 14 1.0| Coronary Artery, Inflammation, | | | Chronic Active | 2 | 10 2.7| Coronary Artery, Thrombosis | 2 | 1 2.0| Epicardium, Inflammation | | 13 1.5| Valve, Fibrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + | 53 | Angiectasis | | 4 1.0| Atrophy | 2 2 2 | 44 2.4| Degeneration, Cystic | | 6 2.2| Hyperplasia | 2 | 10 2.2| Hypertrophy | 2 1 1 | 45 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 1 | 27 1.7| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Medulla | + + + | 53 | Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + | 53 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + | 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + | 53 | Pars Distalis, Hyperplasia | 3 | 4 2.3| |__________________________________________________________________________|____________| Thyroid Gland | + + + | 52 | Inflammation | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 3.0| C-Cell, Hyperplasia | 2 2 | 15 1.8| Follicular Cell, Hyperplasia | | 2 2.5| Follicular Cell, Hypertrophy | 1 3 1 | 44 1.9| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + | 52 | Inflammation | | 21 1.1| Duct, Cyst | 2 3 2 | 48 2.4| |__________________________________________________________________________|____________| Ovary | + + + | 53 | Atrophy | 3 | 7 3.0| Cyst | | 8 1.9| |__________________________________________________________________________|____________| Oviduct | | 1 | Cyst | | 1 3.0| Inflammation | | 1 3.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 98 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Uterus | + + + | 53 | Endometrium, Hyperplasia, Cystic | | 7 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + | 53 | Atrophy | 3 | 2 2.5| Hyperplasia | 4 2 | 47 2.9| |__________________________________________________________________________|____________| Lymph Node | M + M | 20 | Mediastinal, Ectasia | | 7 1.7| Mediastinal, Hemorrhage | | 7 1.9| Mediastinal, Hyperplasia, Histiocytic| | 2 2.0| Pancreatic, Ectasia | | 1 2.0| Pancreatic, Hemorrhage | | 1 2.0| Pancreatic, Hyperplasia, Histiocytic | | 4 2.5| Renal, Ectasia | 2 | 1 2.0| Renal, Hemorrhage | 2 | 1 2.0| Renal, Hyperplasia, Histiocytic | | 1 3.0| Renal, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 52 | Atrophy | | 1 4.0| Ectasia | 2 | 4 2.0| Hemorrhage | 1 | 2 1.5| Hyperplasia, Lymphoid | | 2 3.5| Hyperplasia, Plasma Cell | 3 | 22 2.2| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 52 | Ectasia | | 1 2.0| Hemorrhage | | 4 1.5| Hyperplasia, Histiocytic | | 5 2.2| Hyperplasia, Lymphoid | | 1 4.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 99 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Spleen | + + + | 53 | Hematopoietic Cell Proliferation | 3 2 2 | 50 1.9| Pigmentation | 1 1 2 | 50 1.3| Lymphoid Follicle, Atrophy | | 3 2.3| Red Pulp, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + | 51 | Atrophy | 4 4 4 | 50 3.8| Artery, Inflammation, Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + | 53 | Hyperplasia | | 6 1.2| |__________________________________________________________________________|____________| Skin | + + + | 53 | Cyst Epithelial Inclusion | | 1 | Inflammation | | 1 3.0| Ulcer | | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + | 53 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + | 53 | Hemorrhage | 2 | 5 2.0| Inflammation | | 1 3.0| Necrosis | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 2.0| Meninges, Inflammation | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 100 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Meninges, Vein, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + | 53 | Hemorrhage | | 2 1.0| Infiltration Cellular, Histiocyte | 1 1 | 46 1.1| Inflammation | | 2 3.0| Metaplasia, Squamous | 2 4 | 16 2.3| Alveolar Epithelium, Hyperplasia | | 1 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 | 35 1.1| Mediastinum, Inflammation | | 1 3.0| Serosa, Fibrosis | 2 | 16 1.6| |__________________________________________________________________________|____________| Nose | + + + | 53 | Inflammation | 1 3 | 22 1.7| Necrosis | | 1 4.0| Ulcer | 2 | 1 2.0| Glands, Hyperplasia | | 2 3.0| Olfactory Epithelium, Metaplasia | 2 | 8 2.3| Respiratory Epithelium, Hyperplasia | 2 3 | 16 2.4| Squamous Epithelium, Hyperplasia | | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + | 53 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + | 53 | Cornea, Inflammation | | 1 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + | 53 | Inflammation | | 7 1.0| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 101 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 3| 6| 5| | | DAY ON TEST | 8| 3| 6| | | | 3| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| | A | 216 NG | 9| 9| 9| | L | TEQ/KG | 5| 6| 7| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + | 53 | Mineralization | 1 1 | 34 1.1| Nephropathy | 1 3 3 | 50 2.0| Pigmentation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + | 52 | Inflammation | | 1 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cholangiofibrosis | 4 4 3 2 4 3 4 3 4 3 | Eosinophilic Focus, Multiple | X X X X | Fatty Change, Diffuse | 2 1 2 2 1 2 1 2 1 1 2 1 3 2 2 2 1 2 1 1 2 | Fatty Change, Focal | 2 3 2 | Hematopoietic Cell Proliferation | 1 1 | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 1 2 2 2 1 1 2 1 1 2 2 2 1 1 2 2 1 1 1 1 1 2 1 1| Metaplasia | 2 2 | Mineralization | 2 | Mixed Cell Focus | X X | Necrosis | 3 3 3 2 2 3 3 3 | Pigmentation | 1 2 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1| Thrombosis | | Toxic Hepatopathy | 4 4 2 4 4 4 4 4 4 3 4 3 4 3 4 4 4 4 4 3 3 4 4 4 4| Bile Duct, Cyst | 2 2 2 1 2 2 2 2 | Bile Duct, Dilatation | 2 | __________________________________________|__________________________________________________________________________| Page 103 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 2 | Bile Duct, Hyperplasia | 3 3 1 3 3 3 3 3 3 1 3 1 3 1 3 3 2 2 2 1 3 2 2 3| Centrilobular, Degeneration | 2 | Centrilobular, Fibrosis | 2 2 2 2 2 2 2 2 2 3 2 3 2 3 2 2 2 2 2 2 2 2| Hepatocyte, Glandular Structures | 2 3 1 1 3 4 1 2 1 2 3| Hepatocyte, Hypertrophy | 4 4 2 4 4 3 4 3 4 3 4 2 4 3 4 4 3 3 3 4 4 4 4 4 4| Hepatocyte, Multinucleated | 1 1 2 1 1 2 1 1 3 2 3 3 1 1 2 2 2 2 2 1 | Oval Cell, Hyperplasia | 3 4 1 4 3 4 4 4 4 2 3 2 3 2 4 4 3 4 2 2 2 4 3 3 3| Portal, Fibrosis | 3 3 4 3 3 3 3 3 3 2 4 2 3 3 3 3 2 3 3 4 3 3 4| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | | Fat, Necrosis | 3 3 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Gingival, Hyperplasia, Squamous | 2 2 1 1 1 1 1 4 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 1 2 2 2| Hemorrhage | | Inflammation, Chronic Active | 3 1| Acinus, Atrophy | 1 3 2| Acinus, Vacuolization Cytoplasmic | 2 1 2 2 2 1 2 1 1 3 3 1 1 3 1 1 3 1 | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Squamous | 2 1 2 | Inflammation | | Mineralization | 1 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + M + + + + + + + + + + + + + + + + +| Erosion | | Hemorrhage | 2 | __________________________________________|__________________________________________________________________________| Page 104 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Inflammation | | Mineralization | 2 2| Glands, Cyst | | |__________________________________________________________________________| Tooth | + + + + + + + + + + | Peridontal Tissue, Inflammation | 2 1 2 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Adventitia, Hemorrhage | | Aorta, Adventitia, Inflammation | 2 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 1 1 1 | Atrium, Thrombosis | 3 | Coronary Artery, Inflammation, | | Chronic Active | 3 3 2 3 | Epicardium, Hemorrhage | 2 | Epicardium, Inflammation | 2 2 1 | Myocardium, Hemorrhage | 2 | Myocardium, Inflammation | | Myocardium, Necrosis | 3 | Ventricle, Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 1 1 | Atrophy | 2 3 2 2 3 2 2 2 2 2 2 2 4 3 2 2 2 3 | Degeneration, Cystic | 1 2 | Hyperplasia | 2 | Hypertrophy | 2 3 1 1 2 1 1 1 2 3 2 1 2 1 3 | Necrosis | 2 | Vacuolization Cytoplasmic | 1 1 1 1 1 2 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 105 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| Necrosis | 2 | Pars Distalis, Hyperplasia | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3| C-Cell, Hyperplasia | 2 | Follicular Cell, Hyperplasia | 2 | Follicular Cell, Hypertrophy | 2 2 1 1 2 1 1 1 1 1 1 2 1 3 2 4| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 2 1 1 1 2 | Duct, Cyst | 3 2 2 3 3 3 3 2 2 2 1 2 2 2 3 3 2 3 2 3 2 3 2 3 3| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 3 4 | Cyst | 2 2 1 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Hemorrhage | | Inflammation, Suppurative | | Thrombosis | | Endometrium, Hyperplasia, Cystic | 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | __________________________________________|__________________________________________________________________________| Page 106 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia | 2 3 2 2 3 3 3 3 3 2 2 2 2 3 2 2 3 2 2 3| |__________________________________________________________________________| Lymph Node | + + + M + + + + + + + + M + + M M + + + + + + M +| Mediastinal, Ectasia | 2 1 1 2 2 1 1 2 2 2 1 2 | Mediastinal, Hemorrhage | 2 1 1 1 2 2 1| Mediastinal, Hyperplasia, Histiocytic| | Mediastinal, Pigmentation | 2 | Pancreatic, Ectasia | | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Histiocytic | 3 2 2 | Pancreatic, Hyperplasia, Lymphoid | | Renal, Hyperplasia, Histiocytic | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 2 | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 | Necrosis, Lymphoid | | Necrosis | | Pigmentation | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 2 3 2 2 2 3| Hyperplasia, Lymphoid | 3 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 1 2 1 1 2 2 1 2 1 2 1 2 1| Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | | Lymphoid Follicle, Atrophy | 3 | Red Pulp, Atrophy | | |__________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +| Atrophy | 4 4 4 4 4 4 4 4 4 3 3 4 3 4 4 4 4 4 4 4 4| Artery, Inflammation, Chronic Active | | __________________________________________|__________________________________________________________________________| Page 107 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Inflammation | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Mineralization | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Inflammation | | Metaplasia, Squamous | 2 2 2 2 | Alveolar Epithelium, Hyperplasia | 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 | Artery, Thrombosis | 2 | Artery, Mediastinum, Inflammation, | | Chronic Active | | Serosa, Fibrosis | 2 2 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 2 2 1 1 | __________________________________________|__________________________________________________________________________| Page 108 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 4| 5| 1| 2| 2| 4| 5| 3| 3| 3| 2| 3| 2| 3| 5| 3| 3| 4| 3| 2| 2| 4| 5| 5| 2| DAY ON TEST | 1| 2| 7| 8| 4| 2| 4| 1| 4| 6| 6| 3| 6| 6| 0| 8| 5| 5| 0| 0| 2| 5| 1| 0| 7| | 0| 4| 4| 9| 5| 9| 5| 3| 2| 2| 7| 6| 7| 2| 4| 3| 6| 3| 0| 3| 2| 2| 3| 4| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Olfactory Epithelium, Metaplasia | | Respiratory Epithelium, Hyperplasia | 3 1 2 1 | Squamous Epithelium, Hyperplasia | 1 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | | Retina, Degeneration | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 3 | Inflammation, Suppurative | 1 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Necrosis | | Nephropathy | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 109 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Muscularis, Inflammation | 3 2 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 | Inflammation | 2 2 | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 2 | Cholangiofibrosis | 3 1 3 3 4 3 4 3 3 2 4 4| Eosinophilic Focus, Multiple | X X X| Fatty Change, Diffuse | 1 2 2 1 3 2 2 2 2 2 2 1 3 1 2 2 2 2 2 1 2 | Fatty Change, Focal | 2 2| Hematopoietic Cell Proliferation | 1 1 1 1 1 1| Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X X X X X X X X| Inflammation | 1 1 2 1 2 1 1 1 2 2 2 1 1 1 2 2 1 1 2 1 2 2 1 1 2| Metaplasia | 2 2 | Mineralization | | Mixed Cell Focus | X | Necrosis | 1 2 1 2 3 2 3 2 2 2 1 | Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| Thrombosis | 2 | Toxic Hepatopathy | 4 3 4 4 4 3 3 4 4 4 4 3 4 4 3 4 4 4 4 3 4 4 4 4 4| Bile Duct, Cyst | 1 2 1 2 | Bile Duct, Dilatation | | __________________________________________|__________________________________________________________________________| Page 110 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Bile Duct, Fibrosis | 2 1 | Bile Duct, Hyperplasia | 2 2 3 2 3 1 2 4 3 2 1 3 2 1 2 2 3 3 1 3 4 3 3 2| Centrilobular, Degeneration | 2 2 3 1 2 | Centrilobular, Fibrosis | 2 2 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2| Hepatocyte, Glandular Structures | 3 4 3 2 2 2 1 3 2 2 3 2 | Hepatocyte, Hypertrophy | 3 3 4 4 4 3 3 3 4 4 4 4 4 4 4 4 4 4 4 4 3 4 4 4 3| Hepatocyte, Multinucleated | 1 1 2 2 1 1 1 2 2 1 1 1 1 1 1 2| Oval Cell, Hyperplasia | 3 3 4 3 3 1 3 4 3 3 2 3 3 3 3 4 3 4 2 4 4 3 3 3| Portal, Fibrosis | 2 2 3 3 4 3 4 3 3 2 3 3 2 3 3 3 4 2 4 3 3 3 3| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic Active | 1 1 3 | Fat, Necrosis | 2 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Gingival, Hyperplasia, Squamous | 2 1 2 1 2 1 1| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 2 1 2 2 2 2 2 2 1 | Hemorrhage | 3 | Inflammation, Chronic Active | 2 1 2 | Acinus, Atrophy | 1 1 1 3 | Acinus, Vacuolization Cytoplasmic | 1 2 3 2 2 1 1 2 1 1 1 1 1 1 2| Artery, Inflammation, Chronic Active | 2 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Squamous | 2 2 2 2 | Inflammation | | Mineralization | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 2 | Hemorrhage | 1 2 | __________________________________________|__________________________________________________________________________| Page 111 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Inflammation | | Mineralization | 2 1 | Glands, Cyst | 3 | |__________________________________________________________________________| Tooth | + + + + + + + + + +| Peridontal Tissue, Inflammation | 2 1 1 2 1 1 2 2 2 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Adventitia, Hemorrhage | 2 | Aorta, Adventitia, Inflammation | 2 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 1 1 1 2 1 2 1 | Atrium, Thrombosis | | Coronary Artery, Inflammation, | | Chronic Active | 2 3 3 1 | Epicardium, Hemorrhage | | Epicardium, Inflammation | 2 1 1| Myocardium, Hemorrhage | 2 2 | Myocardium, Inflammation | 2 | Myocardium, Necrosis | 2 | Ventricle, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Atrophy | 2 3 2 3 3 2 3 2 2 2 2| Degeneration, Cystic | | Hyperplasia | 3 2 1 | Hypertrophy | 1 1 3 1 1 1 1 2 1 2| Necrosis | 2 2 | Vacuolization Cytoplasmic | 1 1 2 3 1 | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 112 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + M M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Pars Distalis, Hyperplasia | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | C-Cell, Hyperplasia | 2 | Follicular Cell, Hyperplasia | | Follicular Cell, Hypertrophy | 1 2 2 1 1 2 1 2 1 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 2 1 1 1 | Duct, Cyst | 2 2 3 2 3 3 3 3 2 2 3 3 2 3 3 3 2 3 2 2 3 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 | Cyst | 2 2 3 3 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenomyosis | | Hemorrhage | 3 | Inflammation, Suppurative | 2 | Thrombosis | 2 | Endometrium, Hyperplasia, Cystic | 1 3 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 2 2 3 3 2 3 | __________________________________________|__________________________________________________________________________| Page 113 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Hyperplasia | 2 3 2 2 3 3 3 2 3 3 3 2 3 3 3 4 3| |__________________________________________________________________________| Lymph Node | + + M M + + + + + M M + + + + + + + + + + + + + M| Mediastinal, Ectasia | 1 2 1 2 2 2 1 2 1 1 | Mediastinal, Hemorrhage | 2 2 2 2 3 3 2 3 3 1 2 2 1 1 2 | Mediastinal, Hyperplasia, Histiocytic| 3 2 | Mediastinal, Pigmentation | | Pancreatic, Ectasia | | Pancreatic, Hemorrhage | 2 2 | Pancreatic, Hyperplasia, Histiocytic | | Pancreatic, Hyperplasia, Lymphoid | 2 | Renal, Hyperplasia, Histiocytic | 3 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 2 2 2 | Hyperplasia, Lymphoid | | Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 | Necrosis, Lymphoid | 1 | Necrosis | | Pigmentation | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 2 1 3 2 2 2 | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 2 1 1 1 1 1 1 1 1 3 1 2 2 1 2| Pigmentation | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Artery, Inflammation, Chronic Active | 3 | Lymphoid Follicle, Atrophy | 3 3 2 3 2 | Red Pulp, Atrophy | 2 2 | |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + M M +| Atrophy | 3 4 4 4 4 4 4 3 4 4 4 3 4 4 4 4 4 4 4 3 4 3| Artery, Inflammation, Chronic Active | 2 | __________________________________________|__________________________________________________________________________| Page 114 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 3 2 1 2 3 2 1 3 | Mineralization | 1 | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 1 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 | Inflammation | 1 2 | Metaplasia, Squamous | 4 3 | Alveolar Epithelium, Hyperplasia | 1 1 | Alveolar Epithelium, Metaplasia, | | Bronchiolar | 1 1 | Artery, Thrombosis | | Artery, Mediastinum, Inflammation, | | Chronic Active | 3 | Serosa, Fibrosis | 2| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 | __________________________________________|__________________________________________________________________________| Page 115 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 2| 2| 4| 3| 2| 2| 6| 6| 4| 4| 2| 2| 4| 2| 2| 3| 2| 4| 2| 4| 4| 2| 2| 3| DAY ON TEST | 4| 6| 3| 0| 3| 0| 2| 3| 1| 2| 8| 8| 5| 5| 7| 9| 2| 6| 7| 1| 6| 9| 3| 3| 8| | 3| 7| 3| 6| 8| 9| 6| 6| 1| 3| 2| 9| 4| 6| 9| 4| 1| 7| 8| 7| 1| 1| 7| 6| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 360 NG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Olfactory Epithelium, Metaplasia | 2 | Respiratory Epithelium, Hyperplasia | 2 2 | Squamous Epithelium, Hyperplasia | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 | Retina, Degeneration | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Inflammation, Suppurative | | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1| Necrosis | 3 | Nephropathy | 1 1 3 2 1 2 1 2 1 1 1 1 1 1 2 2 2| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 116 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + | 66 | Muscularis, Inflammation | | 2 2.5| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + M + + + + + + + + + + | 65 | Parasite Metazoan | | 2 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 66 | Hyperplasia, Cystic | | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + M + + + + + + + + + + | 65 | Edema | | 2 2.0| Inflammation | | 2 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + M + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Liver | + + + + + M + + + + + + + + + + | 65 | Angiectasis | | 2 2.5| Cholangiofibrosis | 4 3 4 2 3 2 4 | 29 3.2| Eosinophilic Focus, Multiple | X X X | 10 | Fatty Change, Diffuse | 1 3 2 1 3 2 2 1 1 1 1 3 2 2 | 56 1.8| Fatty Change, Focal | 2 | 6 2.2| Hematopoietic Cell Proliferation | 1 1 1 | 11 1.0| Hyperplasia, Nodular | X X X X X X X X X X X X X | 61 | Inflammation | 1 1 2 1 1 1 1 2 1 2 2 1 1 1 1 | 64 1.4| Metaplasia | | 4 2.0| Mineralization | | 1 2.0| Mixed Cell Focus | | 3 | Necrosis | 2 2 3 3 1 2 2 2 | 27 2.2| Pigmentation | 2 2 2 2 3 2 2 1 2 2 1 3 2 2 | 60 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 117 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Thrombosis | | 1 2.0| Toxic Hepatopathy | 4 3 4 3 4 4 4 1 2 3 3 3 3 4 | 64 3.6| Bile Duct, Cyst | 2 3 | 14 1.9| Bile Duct, Dilatation | | 1 2.0| Bile Duct, Fibrosis | 1 | 4 1.5| Bile Duct, Hyperplasia | 3 2 2 2 2 3 3 1 2 2 2 3 | 60 2.4| Centrilobular, Degeneration | 2 1 | 8 1.9| Centrilobular, Fibrosis | 2 2 2 2 2 2 2 1 2 2 2 2 | 57 2.1| Hepatocyte, Glandular Structures | 2 2 | 25 2.2| Hepatocyte, Hypertrophy | 4 3 3 3 3 4 4 2 3 3 4 3 3 2 4 | 65 3.5| Hepatocyte, Multinucleated | 1 2 2 2 2 2 3 1 2 2 3 3 | 48 1.7| Oval Cell, Hyperplasia | 3 2 3 3 3 4 4 2 3 3 3 2 3 | 62 3.0| Portal, Fibrosis | 3 2 3 2 3 3 3 3 3 2 2 3 | 58 2.9| |__________________________________________________________________________|____________| Mesentery | + + M + M M + + + + + + + + + + | 63 | Artery, Inflammation, Chronic Active | | 3 1.7| Fat, Necrosis | | 3 2.7| |__________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + | 66 | Cyst | 2 | 1 2.0| Gingival, Hyperplasia, Squamous | 2 2 | 18 1.6| |__________________________________________________________________________|____________| Pancreas | + + + + + M + + + + + + + + + + | 65 | Edema | 2 2 1 | 19 1.8| Hemorrhage | 2 | 2 2.5| Inflammation, Chronic Active | 2 | 6 1.8| Acinus, Atrophy | 2 | 8 1.8| Acinus, Vacuolization Cytoplasmic | 1 1 2 1 3 1 2 2 2 1 | 43 1.6| Artery, Inflammation, Chronic Active | 3 | 4 2.3| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + | 65 | Hemorrhage | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 118 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hyperplasia, Squamous | 2 2 | 9 1.9| Inflammation | 1 | 1 1.0| Mineralization | 1 | 2 1.0| Ulcer | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + | 65 | Erosion | 2 | 2 2.0| Hemorrhage | | 3 1.7| Inflammation | 1 | 1 1.0| Mineralization | 1 | 5 1.6| Glands, Cyst | | 1 3.0| |__________________________________________________________________________|____________| Tooth | + + + + + | 25 | Peridontal Tissue, Inflammation | 1 4 2 1 1 | 25 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + | 66 | Aorta, Adventitia, Hemorrhage | | 1 2.0| Aorta, Adventitia, Inflammation | | 2 2.0| |__________________________________________________________________________|____________| Heart | + + + + + M + + + + + + + + + + | 65 | Cardiomyopathy | 1 1 1 1 1 1 | 19 1.3| Atrium, Thrombosis | | 1 3.0| Coronary Artery, Inflammation, | | | Chronic Active | 2 | 9 2.4| Epicardium, Hemorrhage | | 1 2.0| Epicardium, Inflammation | | 6 1.5| Myocardium, Hemorrhage | | 3 2.0| Myocardium, Inflammation | | 1 2.0| Myocardium, Necrosis | | 2 2.5| Ventricle, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 119 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + M + + + + + + + + + + | 65 | Angiectasis | 1 1 1 | 6 1.0| Atrophy | 2 2 2 3 2 2 2 2 3 2 4 | 40 2.4| Degeneration, Cystic | | 2 1.5| Hyperplasia | 2 | 5 2.0| Hypertrophy | 2 1 | 27 1.6| Necrosis | 2 | 4 2.0| Vacuolization Cytoplasmic | 3 | 12 1.5| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + M + + + + + + + + + + | 64 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + M + + + + + + + + + + | 65 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + | 62 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + | 65 | Necrosis | | 1 2.0| Pars Distalis, Hyperplasia | | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + | 66 | Hemorrhage | | 1 3.0| C-Cell, Hyperplasia | 2 | 3 2.0| Follicular Cell, Hyperplasia | | 1 2.0| Follicular Cell, Hypertrophy | 2 2 1 2 2 1 2 2 2 3 2 | 37 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + | 66 | Inflammation | 1 1 1 1 2 1 1 1 1 1 | 31 1.1| Duct, Cyst | 2 2 2 3 2 2 2 1 2 3 3 3 2 3 | 61 2.4| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 120 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Ovary | + + + + + M + + + + + + + + + + | 65 | Atrophy | 3 3 | 9 3.0| Cyst | 2 2 2 2 | 13 2.1| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + | 66 | Adenomyosis | 2 | 1 2.0| Hemorrhage | | 1 3.0| Inflammation, Suppurative | 3 | 2 2.5| Thrombosis | | 1 2.0| Endometrium, Hyperplasia, Cystic | 1 3 | 8 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + | 66 | Atrophy | 2 2 2 2 | 12 2.3| Hyperplasia | 3 3 3 2 2 3 2 4 3 2 2 3 | 49 2.6| |__________________________________________________________________________|____________| Lymph Node | M M + M + M M + + + M M M M M M | 45 | Mediastinal, Ectasia | 1 3 2 1 2 | 27 1.6| Mediastinal, Hemorrhage | 2 1 1 | 25 1.8| Mediastinal, Hyperplasia, Histiocytic| | 2 2.5| Mediastinal, Pigmentation | 2 | 2 2.0| Pancreatic, Ectasia | 2 | 1 2.0| Pancreatic, Hemorrhage | 1 | 4 1.8| Pancreatic, Hyperplasia, Histiocytic | | 3 2.3| Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| Renal, Hyperplasia, Histiocytic | | 2 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 66 | Ectasia | 2 | 1 2.0| Hemorrhage | 2 | 7 2.0| Hyperplasia, Lymphoid | | 1 2.0| Hyperplasia, Plasma Cell | 2 3 2 3 | 20 2.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 121 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Necrosis, Lymphoid | | 1 1.0| Necrosis | 1 | 1 1.0| Pigmentation | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + | 65 | Ectasia | 2 | 2 2.0| Hemorrhage | 1 | 14 2.1| Hyperplasia, Lymphoid | | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + M + + + + + + + + + + | 65 | Hematopoietic Cell Proliferation | 2 2 1 1 3 1 1 1 2 2 1 | 43 1.5| Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 | 59 1.1| Artery, Inflammation, Chronic Active | | 1 3.0| Lymphoid Follicle, Atrophy | 3 2 2 | 9 2.6| Red Pulp, Atrophy | | 2 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + | 59 | Atrophy | 4 4 4 4 4 4 4 2 4 4 3 4 4 4 | 57 3.8| Artery, Inflammation, Chronic Active | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + | 66 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + | 66 | Hemorrhage | | 1 2.0| Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 122 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Brain | + + + + + + + + + + + + + + + + | 66 | Hemorrhage | 3 1 2 2 | 14 2.2| Mineralization | | 1 1.0| |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + | 66 | Hemorrhage | | 4 1.3| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 33 1.0| Inflammation | | 2 1.5| Metaplasia, Squamous | 3 | 7 2.6| Alveolar Epithelium, Hyperplasia | 2 | 4 1.3| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 1 1 | 8 1.0| Artery, Thrombosis | | 1 2.0| Artery, Mediastinum, Inflammation, | | | Chronic Active | | 1 3.0| Serosa, Fibrosis | 2 2 1 1 2 | 8 1.8| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + | 66 | Inflammation | 2 1 1 | 11 1.4| Olfactory Epithelium, Metaplasia | | 1 2.0| Respiratory Epithelium, Hyperplasia | 2 2 2 | 9 1.9| Squamous Epithelium, Hyperplasia | | 1 1.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + | 66 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 123 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 2| 3| 3| 2| 2| 4| 3| 0| 3| 3| 4| 3| 2| 0| 4| | | DAY ON TEST | 7| 4| 3| 4| 8| 6| 8| 1| 9| 0| 2| 1| 2| 9| 5| 4| | | | 5| 3| 7| 9| 9| 0| 2| 3| 1| 3| 9| 5| 9| 4| 1| 6| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A | 360 NG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| | L | TEQ/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Retina, Atrophy | | 1 2.0| Retina, Degeneration | 2 | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + | 66 | Inflammation | 1 1 | 9 1.1| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + M + + + + + + + + + + | 65 | Infarct | | 1 3.0| Inflammation, Suppurative | | 1 1.0| Mineralization | 1 1 1 1 1 1 1 | 37 1.1| Necrosis | | 1 3.0| Nephropathy | 1 1 1 1 3 1 1 2 3 1 2 | 43 1.4| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + | 66 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 124 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | Artery, Inflammation, Chronic Active | 3 3 | |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation | 2 | Artery, Inflammation, Chronic Active | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 2 | Basophilic Focus | | Basophilic Focus, Multiple | X | Cholangiofibrosis | 2 2 3 1 4 1 3 2 1 1 1 1 1 1 | Clear Cell Focus | X | Degeneration, Cystic | | Eosinophilic Focus | X | Eosinophilic Focus, Multiple | X X X X X X X X X X | Fatty Change, Diffuse | 2 2 1 1 2 1 1 1 1 1 1 1 3 1 3 1 1 2 1 1 | Fatty Change, Focal | 2 2 2 1 2 1 | Hematopoietic Cell Proliferation | 2 1 2 1 1 1 1 1 1 2 | Hemorrhage | 2 | Hepatodiaphragmatic Nodule | | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X| Inflammation | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________|__________________________________________________________________________| Page 125 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Metaplasia | 2 | Mixed Cell Focus | X | Mixed Cell Focus, Multiple | X X X X X X X X X X | Necrosis | 2 2 2 2 | Pigmentation | 2 2 2 2 2 1 1 2 1 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2| Toxic Hepatopathy | 2 2 2 2 2 2 2 2 2 1 2 2 3 3 3 2 3 2 3 4 3 2 3 2 3| Bile Duct, Cyst | 3 4 2 2 3 4 3 2 3 | Bile Duct, Fibrosis | 2 2 2 2 | Bile Duct, Hyperplasia | 1 1 1 1 1 1 3 1 1 1 3 3 2 2 1 3| Centrilobular, Degeneration | 2 1 2 | Centrilobular, Fibrosis | 2 1 2 1 3 1 2 3 2 3 2 2 1 2 2 2 2 2 2 3| Hepatocyte, Glandular Structures | 3 2 1 2 3| Hepatocyte, Hypertrophy | 4 3 1 4 2 2 3 4 3 4 3 3 3 4 4 1 2 3| Hepatocyte, Multinucleated | 3 2 2 2 2 1 1 1 1 2 1 1 1 1 2 3 1| Oval Cell, Hyperplasia | 2 2 2 2 2 2 1 1 1 2 3 3 2 1 3 3 3 3 2 3 1 3| Portal, Fibrosis | 1 2 3 2 2 1 1 3 3 2 3 2 3 3 3 3 3 1 3| Serosa, Fibrosis | | |__________________________________________________________________________| Mesentery | + + + + + + M M + + + M M + + + M M + + + + + + +| Necrosis | 3 | Artery, Inflammation, Chronic Active | 2 1 2 | |__________________________________________________________________________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| Gingival, Hyperplasia, Squamous | 1 1 1 2 1 2 1 1 | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 2 2 2| Hemorrhage | | Inflammation, Chronic Active | 1 2 3 | Acinus, Atrophy | 2 4 3 | Acinus, Vacuolization Cytoplasmic | 2 2 3 2 3 1 1 1 2 2 2 2 2 1 1 1 1 1| Artery, Inflammation, Chronic Active | 2 2 1 1 1 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Hyperplasia, Squamous | 2 | __________________________________________|__________________________________________________________________________| Page 126 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Inflammation | 1 | Mineralization | 2 | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Artery, Inflammation, Chronic Active | 3 | |__________________________________________________________________________| Tooth | + + + + + + + + + + | Peridontal Tissue, Inflammation | 1 1 2 2 1 2 2 3 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Adventitia, Hemorrhage | 3 | Aorta, Adventitia, Inflammation | 1 2 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 1 1 | Atrium, Thrombosis | 1 | Coronary Artery, Inflammation, | | Chronic Active | 3 | Epicardium, Inflammation | 1 | Myocardium, Hemorrhage | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 2 1 2 1 1 1 1 1 1 1 1 | Atrophy | 2 2 3 2| Degeneration, Cystic | 3 2 2 3 3 | Hyperplasia | 2 2 2 2 | Hypertrophy | 1 3 2 2 3 3 3 2 3 3 2 2 3 1 | Inflammation | 2 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 2 2 2 2 3 1| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 127 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hyperplasia | 2 2 2 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + M + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 2 1 | Cyst | 2 | Cytoplasmic Alteration | | Pars Distalis, Hyperplasia | 2 2 1 | Pars Intermedia, Hyperplasia | 3 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphoid | 3 | C-Cell, Hyperplasia | 2 | Follicular Cell, Hypertrophy | 2 1 2 1 3 2 2 1 2 1 4 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 1 1 1 1 1 1 1 1 1 2 1 | Duct, Cyst | 2 3 3 3 2 2 2 3 1 2 2 1 3 2 2 3 3 2 2| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 3 3 3 3 3 | Cyst | 3 2 2 2 | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage | 2 | Inflammation, Chronic Active | | Inflammation, Suppurative | 2 3 | Metaplasia, Squamous | 2 1 2 | Cervix, Stromal Hyperplasia | | __________________________________________|__________________________________________________________________________| Page 128 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Endometrium, Hyperplasia, Cystic | 2 1 1 2 1 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 2 2 | Hyperplasia | 2 2 3 4 3 3 4 1 2 3 1 3 1 3 3 3 2 3 3| |__________________________________________________________________________| Lymph Node | + M M M M M M M M M M M M + M + M + M M M + M + M| Lumbar, Hemorrhage | 1 | Lumbar, Hyperplasia, Histiocytic | 2 | Mediastinal, Ectasia | 2 | Mediastinal, Hemorrhage | 2 2 3 | Mediastinal, Hyperplasia, Histiocytic| 2 | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Hyperplasia, Plasma Cell| 2 | Pancreatic, Hemorrhage | 2 | Pancreatic, Hyperplasia, Histiocytic | 2 | Pancreatic, Hyperplasia, Lymphoid | | Renal, Ectasia | 3 | Renal, Hemorrhage | | Renal, Hyperplasia, Histiocytic | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 2 2| Hemorrhage | 2 2 1 | Hyperplasia, Plasma Cell | 2 2 3 2 3 3 2 2 3 2 3 2 3 3 2 2| Inflammation | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 2 2 2 3 2 2| Hyperplasia, Histiocytic | | Hyperplasia, Plasma Cell | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 1 1 2 1 2 2 2 2 2 1 2 1 1 1| Pigmentation | 1 2 1 1 1 2 2 2 1 2 1 1 2 2 1 1 1 1 1 1| __________________________________________|__________________________________________________________________________| Page 129 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymphoid Follicle, Atrophy | 2 3 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + + M + + + + +| Atrophy | 4 2 3 2 4 3 2 4 3 2 3 4 4 4 3 4 4 4 4 4 3 4 4| Hemorrhage | 3 | Artery, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 2 2 1 1 | Inflammation, Granulomatous | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Tarsal, Inflammation | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 2 3 1 1 | Mineralization | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 1 1 | Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 1 1 1 1 1 1 2 | Inflammation, Granulomatous | 3 | Inflammation | 2 3 3 | Keratin Cyst | 4 4 | Metaplasia, Squamous | 2 1 2 | Alveolar Epithelium, Hyperplasia | 1 1 1 | Alveolar Epithelium, Metaplasia, | | __________________________________________|__________________________________________________________________________| Page 130 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 _____________________________________________________________________________________________________________________ | 2| 4| 7| 7| 4| 6| 7| 2| 7| 5| 7| 5| 2| 2| 2| 6| 2| 5| 2| 2| 2| 6| 3| 2| 2| DAY ON TEST | 0| 0| 2| 2| 7| 0| 2| 2| 2| 0| 2| 4| 4| 3| 0| 3| 4| 2| 7| 7| 3| 5| 8| 8| 4| | 9| 1| 7| 7| 4| 2| 7| 6| 7| 4| 7| 1| 1| 0| 1| 8| 0| 5| 9| 5| 2| 9| 3| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 360 NG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| TEQKG ST | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Bronchiolar | 2 2 1 1 1 1 1 1 1 | Serosa, Fibrosis | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 2 2 1 1 | Olfactory Epithelium, Metaplasia | 2 | Respiratory Epithelium, Hyperplasia | 2 3 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Retina, Atrophy | 2 | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Accumulation, Hyaline Droplet | | Cyst | 2 | Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Nephropathy | 1 2 3 2 3 1 1 2 2 2 1 2 2 3 1 1 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation | | __________________________________________|__________________________________________________________________________ Page 131 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | Artery, Inflammation, Chronic Active | 2 1 | 4 2.3| |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Inflammation | | 1 2.0| Artery, Inflammation, Chronic Active | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 4 2.3| Basophilic Focus | X X | 2 | Basophilic Focus, Multiple | X X | 3 | Cholangiofibrosis | 3 2 3 2 3 3 1 3 3 3 2 1 2 | 27 2.0| Clear Cell Focus | | 1 | Degeneration, Cystic | 2 | 1 2.0| Eosinophilic Focus | | 1 | Eosinophilic Focus, Multiple | X X X X | 14 | Fatty Change, Diffuse | 2 2 1 1 2 1 1 1 2 1 1 2 1 1 1| 35 1.4| Fatty Change, Focal | 3 2 2 2 2 3 3 3 | 14 2.1| Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 | 22 1.1| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 132 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Hemorrhage | | 1 2.0| Hepatodiaphragmatic Nodule | X | 1 | Hyperplasia, Nodular | X X X X X X X X X X X X X X X X X| 34 | Inflammation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Metaplasia | 1 | 2 1.5| Mixed Cell Focus | | 1 | Mixed Cell Focus, Multiple | X X X X X X X X X | 19 | Necrosis | 2 2 | 6 2.0| Pigmentation | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 50 1.9| Toxic Hepatopathy | 3 3 2 4 3 3 3 3 3 2 3 3 1 3 3 3 2 3 4 3 2 4 3 4 3| 50 2.6| Bile Duct, Cyst | 2 2 3 3 2 3 2 3 4 2 2 3 | 21 2.7| Bile Duct, Fibrosis | 2 2 2 2 2 2 1 2 | 12 1.9| Bile Duct, Hyperplasia | 3 2 1 3 2 1 2 2 2 2 1 1 3 2 2 3 1 2 1 3 1| 37 1.8| Centrilobular, Degeneration | 2 2 3 | 6 2.0| Centrilobular, Fibrosis | 3 1 1 2 2 1 2 2 2 2 2 1 1 1 2 1 2 2 2 3 2 2 2| 43 1.9| Hepatocyte, Glandular Structures | 3 1 3 3 | 9 2.3| Hepatocyte, Hypertrophy | 3 1 2 3 3 3 2 3 2 1 2 1 4 2 3 3 3 3| 36 2.7| Hepatocyte, Multinucleated | 2 1 2 2 1 2 1 1 2 2 2 2 1 1 2 2 1 1 1 2 3| 38 1.6| Oval Cell, Hyperplasia | 3 2 3 4 2 2 2 3 3 2 3 2 2 1 2 2 3 2 3 2 3 | 43 2.3| Portal, Fibrosis | 3 2 3 4 3 1 3 3 2 2 2 1 2 1 2 1 2 3 4 3 2 3 1| 42 2.3| Serosa, Fibrosis | 1 | 1 1.0| |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + M + + + + + + + + +| 43 | Necrosis | | 1 3.0| Artery, Inflammation, Chronic Active | 2 2 1 4 | 7 2.0| |__________________________________________________________________________|____________| Oral Mucosa | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Gingival, Hyperplasia, Squamous | 2 2 2 3 1 1 1 1 1 2 | 18 1.4| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 1 1 1 2 1 2 | 12 1.7| Hemorrhage | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 | 5 1.6| Acinus, Atrophy | 2 2 2 2 2 | 8 2.4| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 133 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Acinus, Vacuolization Cytoplasmic | 2 2 2 2 1 1 1 1 2 1 1 2 2 1 1 2 2 1 1 2 1 1 2| 41 1.6| Artery, Inflammation, Chronic Active | 2 2 2 3 2 | 10 1.8| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Hyperplasia, Squamous | 1 | 2 1.5| Inflammation | 3 | 2 2.0| Mineralization | | 1 2.0| Ulcer | 3 1 | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Artery, Inflammation, Chronic Active | | 1 3.0| |__________________________________________________________________________|____________| Tooth | + + + + + + + + + + + + + | 23 | Peridontal Tissue, Inflammation | 3 3 2 1 1 1 1 2 1 1 1 2 1 | 23 1.6| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Adventitia, Hemorrhage | 2 | 2 2.5| Aorta, Adventitia, Inflammation | | 2 1.5| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 2 1 1 1 1 1 1 | 15 1.1| Atrium, Thrombosis | | 1 1.0| Coronary Artery, Inflammation, | | | Chronic Active | 1 1 1 3 3| 6 2.0| Epicardium, Inflammation | | 1 1.0| Myocardium, Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 134 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 1 1 1 2 1 1 1 | 21 1.2| Atrophy | 2 2 2 4 2 2 2 2 | 12 2.3| Degeneration, Cystic | 2 3 2 2 | 9 2.4| Hyperplasia | 3 2 2 2 2 3 | 10 2.2| Hypertrophy | 2 3 3 1 1 4 3 1 1 1 3 3 2 2 2 | 29 2.2| Inflammation | 2 | 2 2.0| Necrosis | 2 | 2 2.0| Vacuolization Cytoplasmic | 1 1 1 3 1 1 2 1 1 | 16 1.6| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 | Hyperplasia | 2 2 2 2 2 | 8 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + M + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 3 1.3| Cyst | 3 2 | 3 2.3| Cytoplasmic Alteration | 3 2 | 2 2.5| Pars Distalis, Hyperplasia | 3 2 2 2 2 | 8 2.0| Pars Intermedia, Hyperplasia | | 1 3.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infiltration Cellular, Lymphoid | 3 | 2 3.0| C-Cell, Hyperplasia | 2 4 1 1 3 | 6 2.2| Follicular Cell, Hypertrophy | 1 4 2 1 1 1 1 1 1 2 2 3 1 1 1| 29 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 135 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 1 1 1 1 1 2 2 1 2 1 1 2 2 1 1 1 | 30 1.2| Duct, Cyst | 2 1 2 2 1 3 1 1 2 2 2 1 2 3 3 2 2 3 2 2 1| 40 2.1| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 3 3 3 3 2 2 2 | 15 2.7| Cyst | 2 2 3 | 7 2.3| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Hemorrhage | | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Inflammation, Suppurative | 2 2 | 4 2.3| Metaplasia, Squamous | 3 1 1 1 2 | 8 1.6| Cervix, Stromal Hyperplasia | 3 | 1 3.0| Endometrium, Hyperplasia, Cystic | 1 4 4 2 4 4 4 1 3 3 1| 17 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 4 2.0| Hyperplasia | 2 1 3 3 2 2 3 3 2 3 3 2 2 4 3 3 3 2 3 3 3| 40 2.6| |__________________________________________________________________________|____________| Lymph Node | + + + + M + + M M M M + M + M + + M + + + + + + M| 22 | Lumbar, Hemorrhage | | 1 1.0| Lumbar, Hyperplasia, Histiocytic | | 1 2.0| Mediastinal, Ectasia | 2 2 | 3 2.0| Mediastinal, Hemorrhage | 1 2 2 2 2 2 2 2 | 11 2.0| Mediastinal, Hyperplasia, Histiocytic| 3 2 2 | 4 2.3| Mediastinal, Hyperplasia, Lymphoid | 4 | 1 4.0| Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0| Pancreatic, Hemorrhage | 2 2 | 3 2.0| Pancreatic, Hyperplasia, Histiocytic | 2 3 | 3 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 136 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0| Renal, Ectasia | | 1 3.0| Renal, Hemorrhage | 2 2 | 2 2.0| Renal, Hyperplasia, Histiocytic | 2 2 | 3 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 | Ectasia | 3 2 2 2 2 2 3 | 11 2.3| Hemorrhage | 2 | 4 1.8| Hyperplasia, Plasma Cell | 2 2 2 2 2 2 2 2 2 2 2 2 | 28 2.3| Inflammation | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 2.0| Hemorrhage | 1 2 1 2 | 10 1.9| Hyperplasia, Histiocytic | 3 | 1 3.0| Hyperplasia, Plasma Cell | | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 1 2 3 3 2 2 2 1 3 2 2 2 2 2 2 3 2 3 2 1 3 1| 45 1.9| Pigmentation | 1 2 2 1 2 1 1 3 1 1 2 2 2 1 2 1 1 1 1 1 1| 41 1.4| Lymphoid Follicle, Atrophy | 2 | 4 2.5| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + + M + + +| 46 | Atrophy | 4 4 4 3 4 4 3 3 4 4 3 4 3 2 4 2 4 2 2 4 4 4| 45 3.4| Hemorrhage | | 1 3.0| Artery, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Hyperplasia | 2 2 1 2 1 2 2 | 11 1.6| Inflammation, Granulomatous | 2 | 1 2.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 137 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Tarsal, Inflammation | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 1 2 | 8 1.8| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 3 1.3| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 2 1 1 | 24 1.2| Inflammation, Granulomatous | 3 3 3 | 4 3.0| Inflammation | 3 1 1 | 6 2.2| Keratin Cyst | 3 3 4 3 3 3 3 | 9 3.3| Metaplasia, Squamous | 3 1 2 2 2 | 8 1.9| Alveolar Epithelium, Hyperplasia | 1 1 | 5 1.0| Alveolar Epithelium, Metaplasia, | | | Bronchiolar | 1 1 1 2 1 1 | 15 1.2| Serosa, Fibrosis | 1| 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 2 3 2 1 2 2 | 11 1.7| Olfactory Epithelium, Metaplasia | 2 3 2 3 | 5 2.4| Respiratory Epithelium, Hyperplasia | 2 3 2 3 3 3 2 | 10 2.5| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 138 NTP Experiment-Test: 96022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) Date: 11/15/04 Route: GAVAGE Time: 11:12:37 __________________________________________________________________________________________________________________________________ | 2| 6| 5| 4| 2| 6| 4| 2| 7| 7| 2| 6| 7| 7| 7| 6| 3| 7| 2| 5| 7| 2| 2| 5| 2| | DAY ON TEST | 2| 3| 9| 9| 2| 6| 5| 7| 0| 0| 6| 0| 2| 2| 2| 0| 0| 2| 5| 6| 2| 5| 5| 9| 7| | | 6| 6| 3| 4| 6| 3| 1| 2| 3| 0| 7| 7| 7| 7| 7| 1| 3| 7| 8| 1| 7| 8| 4| 4| 3| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A | 360 NG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | TEQKG ST | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Retina, Atrophy | | 1 2.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 1 1 1 1 1 | 12 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accumulation, Hyaline Droplet | 1 | 1 1.0| Cyst | | 1 2.0| Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0| Nephropathy | 3 2 1 3 3 2 3 3 2 2 2 2 2 3 2 1 1 1| 34 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 139 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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