TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Benign Tumors Total 86/150(57.3%) 88/150(58.7%) Mean(sd) 57.3%(21.9) 58.7%(16.2) Range 16/50 - 35/50 20/50 - 34/50 Males 35/50 16/50 35/50 Females 34/50 20/50 34/50 --------------------------------------------------------------------------- Malignant Tumors Total 60/150(40%) 59/150(39.3%) Mean(sd) 40.0%(3.5) 39.3%(20.5) Range 19/50 - 22/50 11/50 - 31/50 Males 22/50 19/50 19/50 Females 31/50 17/50 11/50 --------------------------------------------------------------------------- Malignant and Benign Total 108/150(72%) 114/150(76%) Tumors Mean(sd) 72.0%(15.9) 76.0%(15.1) Range 27/50 - 42/50 31/50 - 46/50 Males 42/50 27/50 39/50 Females 46/50 31/50 37/50 --------------------------------------------------------------------------- Hemangioma Total 3/150(2%) 1/150(0.7%) Mean(sd) 2.0%(2.0) 0.7%(1.2) Range 0/50 - 2/50 0/50 - 1/50 Males 2/50 0/50 1/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 16/150(10.7%) 9/150(6%) Mean(sd) 10.7%(8.3) 6.0%(3.5) Range 2/50 - 10/50 1/50 - 4/50 Males 4/50 10/50 2/50 Females 4/50 1/50 4/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 19/150(12.7%) 10/150(6.7%) Hemangioma Mean(sd) 12.7%(7.0) 6.7%(2.3) Range 3/50 - 10/50 2/50 - 4/50 Males 6/50 10/50 3/50 Females 4/50 2/50 4/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 1/150(0.7%) 4/150(2.7%) Mean(sd) 0.7%(1.2) 2.7%(4.6) Range 0/50 - 1/50 0/50 - 4/50 Males 1/50 0/50 0/50 Females 4/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/150(0%) 1/150(0.7%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.7%(1.2) or Undifferentiated Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 10/150(6.7%) 22/150(14.7%) Histiocytic, Mean(sd) 6.7%(1.2) 14.7%(4.6) Lymphocytic, Mixed, NOS, Range 3/50 - 4/50 6/50 - 10/50 or Undifferentiated Cell Type Males 3/50 3/50 4/50 Females 10/50 6/50 6/50 --------------------------------------------------------------------------- Osteoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 9/149(6%) 5/148(3.4%) Mean(sd) 6.0%(8.7) 3.4%(1.2) Range 0/49 - 8/50 1/50 - 2/48 Males 0/49 8/50 1/50 Females 2/48 2/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/149(0%) 0/148(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/48 - 0/48 Males 0/49 0/50 0/50 Females 0/48 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/99(0%) 0/136(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/48 - 0/48 Males 0/49 0/0 0/50 Females 0/48 0/38 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/99(0%) 0/136(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/48 - 0/48 Males 0/49 0/0 0/50 Females 0/48 0/38 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/149(0%) 0/148(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/48 - 0/48 Males 0/49 0/50 0/50 Females 0/48 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Pheochromocytoma Benign Total 2/148(1.4%) 5/148(3.4%) Mean(sd) 1.4%(1.2) 3.4%(4.1) Range 0/50 - 1/48 0/50 - 4/50 Males 1/48 0/50 1/50 Females 1/48 4/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/148(0%) 0/148(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 0/50 0/50 Females 0/48 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 0/148(0%) 1/148(0.7%) Malignant Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/48 - 0/48 0/50 - 1/48 Males 0/48 0/50 0/50 Females 1/48 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 2/148(1.4%) 6/148(4.1%) Benign, Complex, Mean(sd) 1.4%(1.2) 4.1%(4.0) Malignant, NOS Range 0/50 - 1/48 0/50 - 4/50 Males 1/48 0/50 1/50 Females 2/48 4/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/149(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/149(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/149(1.3%) 2/150(1.3%) Mean(sd) 1.4%(2.4) 1.3%(1.2) Range 0/50 - 2/49 0/50 - 1/50 Males 2/49 0/50 0/50 Females 1/50 0/50 1/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/149(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/149(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/149(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Astrocytoma Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/150(0%) 0/150(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/150(0%) 0/150(0%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Basosquamous Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/149(0.7%) Mean(sd) 0.7%(1.2) Range 0/49 - 1/50 Males 0/49 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/140(0%) 0/140(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/46 - 0/46 0/43 - 0/43 Males 0/46 0/44 0/50 Females 0/43 0/47 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 7/150(4.7%) 2/150(1.3%) Mean(sd) 4.7%(4.2) 1.3%(1.2) Range 0/50 - 4/50 0/50 - 1/50 Males 3/50 0/50 4/50 Females 0/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/150(4.7%) 2/150(1.3%) Mean(sd) 4.7%(4.2) 1.3%(1.2) Range 0/50 - 4/50 0/50 - 1/50 Males 3/50 0/50 4/50 Females 0/50 1/50 1/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 1/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 1/149(0.7%) 1/149(0.7%) Mean(sd) 0.7%(1.2) 0.7%(1.2) Range 0/49 - 1/50 0/50 - 1/49 Males 0/49 0/50 1/50 Females 1/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/149(0%) 2/149(1.3%) Mean(sd) 0.0%(0.0) 1.3%(2.3) Range 0/49 - 0/49 0/49 - 2/50 Males 0/49 0/50 0/50 Females 0/49 2/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/149(0.7%) 3/149(2%) Mean(sd) 0.7%(1.2) 2.0%(2.0) Range 0/49 - 1/50 0/50 - 2/50 Males 0/49 0/50 1/50 Females 1/49 2/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/150(0.7%) 1/150(0.7%) Mean(sd) 0.7%(1.2) 0.7%(1.2) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 0/50 Females 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/150(1.3%) 1/150(0.7%) Mean(sd) 1.3%(1.2) 0.7%(1.2) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 1/50 Females 1/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Cholangiocarcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 6/150(4%) 2/150(1.3%) Mean(sd) 4.0%(2.0) 1.3%(2.3) Range 1/50 - 3/50 0/50 - 2/50 Males 3/50 1/50 2/50 Females 2/50 0/50 0/50 --------------------------------------------------------------------------- Hepatoblastoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 57/150(38%) 56/150(37.3%) Mean(sd) 38.0%(22.7) 37.3%(26.6) Range 6/50 - 27/50 4/50 - 30/50 Males 24/50 6/50 27/50 Females 30/50 4/50 22/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 27/150(18%) 18/150(12%) Mean(sd) 18.0%(11.1) 12.0%(12.5) Range 4/50 - 15/50 1/50 - 13/50 Males 8/50 4/50 15/50 Females 13/50 4/50 1/50 --------------------------------------------------------------------------- Hepatocellular Total 27/150(18%) 18/150(12%) Carcinoma or Mean(sd) 18.0%(11.1) 12.0%(12.5) Hepatoblastoma Range 4/50 - 15/50 1/50 - 13/50 Males 8/50 4/50 15/50 Females 13/50 4/50 1/50 --------------------------------------------------------------------------- Hepatocellular Total 67/150(44.7%) 63/150(42%) Carcinoma or Mean(sd) 44.7%(23.4) 42.0%(26.2) Hepatocellular Adenoma Range 9/50 - 31/50 7/50 - 33/50 Males 27/50 9/50 31/50 Females 33/50 7/50 23/50 --------------------------------------------------------------------------- Hepatocellular Total 67/150(44.7%) 63/150(42%) Carcinoma, Mean(sd) 44.7%(23.4) 42.0%(26.2) Hepatocellular Adenoma, Range 9/50 - 31/50 7/50 - 33/50 or Hepatoblastoma Males 27/50 9/50 31/50 Females 33/50 7/50 23/50 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 32/150(21.3%) 5/150(3.3%) Adenoma Mean(sd) 21.3%(10.3) 3.3%(1.2) Range 5/50 - 15/50 1/50 - 2/50 Males 12/50 5/50 15/50 Females 1/50 2/50 2/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 14/150(9.3%) 5/150(3.3%) Carcinoma Mean(sd) 9.3%(5.0) 3.3%(3.1) Range 2/50 - 7/50 0/50 - 3/50 Males 7/50 5/50 2/50 Females 3/50 2/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 42/150(28%) 10/150(6.7%) Carcinoma or Mean(sd) 28.0%(10.6) 6.7%(2.3) Alveolar/Bronchiolar Range 8/50 - 18/50 2/50 - 4/50 Adenoma Males 18/50 8/50 16/50 Females 4/50 4/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/150(0%) 0/150(0%) or Adenoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/150(0%) 1/150(0.7%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 0/50 1/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Papilloma Squamous or Total 0/150(0%) 0/150(0%) Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/150(0%) 0/150(0%) Carcinoma, Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous, or Papilloma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/149(0.7%) Mean(sd) 0.7%(1.2) Range 0/49 - 1/50 Females 1/50 0/49 0/50 --------------------------------------------------------------------------- Cystadenoma Total 9/149(6%) Mean(sd) 6.0%(4.0) Range 1/50 - 5/50 Females 1/50 3/49 5/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/149(0.7%) Benign Mean(sd) 0.7%(1.2) Range 0/50 - 1/50 Females 0/50 0/49 1/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/149(0.7%) Malignant Mean(sd) 0.7%(1.2) Range 0/50 - 1/49 Females 0/50 1/49 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 2/149(1.3%) Benign, Malignant, NOS Mean(sd) 1.3%(1.2) Range 0/50 - 1/49 Females 0/50 1/49 1/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/149(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/149(0.7%) Mean(sd) 0.7%(1.2) Range 0/50 - 1/50 Females 0/50 0/49 1/50 --------------------------------------------------------------------------- Liposarcoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Luteoma Total 3/149(2%) Mean(sd) 2.0%(3.5) Range 0/50 - 3/50 Females 0/50 0/49 3/50 --------------------------------------------------------------------------- Teratoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Teratoma Benign Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Teratoma Malignant Total 1/149(0.7%) Mean(sd) 0.7%(1.2) Range 0/50 - 1/49 Females 0/50 1/49 0/50 --------------------------------------------------------------------------- Teratoma NOS Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Thecoma Benign Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/133(0%) 0/130(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/40 - 0/40 Males 0/37 0/49 0/47 Females 0/40 0/47 0/43 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Squamous Cell Papilloma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/141(0%) 15/137(10.9%) Mean(sd) 0.0%(0.0) 10.9%(1.6) Range 0/45 - 0/45 4/44 - 6/49 Males 0/45 0/48 0/48 Females 5/44 6/49 4/44 --------------------------------------------------------------------------- Carcinoma Total 0/141(0%) 0/137(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/44 - 0/44 Males 0/45 0/48 0/48 Females 0/44 0/49 0/44 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/141(0%) 15/137(10.9%) Mean(sd) 0.0%(0.0) 10.9%(1.6) Range 0/45 - 0/45 4/44 - 6/49 Males 0/45 0/48 0/48 Females 5/44 6/49 4/44 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/141(0%) 0/137(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/44 - 0/44 Males 0/45 0/48 0/48 Females 0/44 0/49 0/44 --------------------------------------------------------------------------- Carcinoma Total 0/141(0%) 0/137(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/44 - 0/44 Males 0/45 0/48 0/48 Females 0/44 0/49 0/44 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/141(0%) 0/137(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/44 - 0/44 Males 0/45 0/48 0/48 Females 0/44 0/49 0/44 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/150(0%) 0/150(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Basal Cell Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/150(0%) 0/150(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/150(0%) 0/150(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign, or Range 0/50 - 0/50 0/50 - 0/50 Trichoepithelioma Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 1/150(0.7%) 0/150(0%) or Basosquamous Tumor Mean(sd) 0.7%(1.2) 0.0%(0.0) (malignant or NOS) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 1/150(0.7%) 0/150(0%) Basal Cell Adenoma, Mean(sd) 0.7%(1.2) 0.0%(0.0) Basosquamous Tumor Range 0/50 - 1/50 0/50 - 0/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 1/150(0.7%) 0/150(0%) Carcinoma, Carcinoma, Mean(sd) 0.7%(1.2) 0.0%(0.0) Basosq. Tumor (M or B), Range 0/50 - 1/50 0/50 - 0/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/150(0%) 0/150(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/150(1.3%) 0/150(0%) Mean(sd) 1.3%(2.3) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 2/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/150(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/150(0.7%) 0/150(0%) Carcinoma, Basal Cell Mean(sd) 0.7%(1.2) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 1/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/150(0%) 0/150(0%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/150(0%) 0/150(0%) Papilloma, Papilloma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Cell Carcinoma Range 0/50 - 0/50 0/50 - 0/50 or Keratoacanthoma Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/150(0%) 0/150(0%) Papilloma, Papilloma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Keratoacanthoma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibroma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 0/150(0%) 4/150(2.7%) Sarcoma, Myxoma, Mean(sd) 0.0%(0.0) 2.7%(1.2) Myxosarcoma, or Fibrous Range 0/50 - 0/50 1/50 - 2/50 Histiocytoma Males 0/50 0/50 0/50 Females 2/50 1/50 1/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 0/150(0%) 4/150(2.7%) Myxosarcoma, or Fibrous Mean(sd) 0.0%(0.0) 2.7%(1.2) Histiocytoma Range 0/50 - 0/50 1/50 - 2/50 Males 0/50 0/50 0/50 Females 2/50 1/50 1/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/150(0%) 0/150(0%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.0%(0.0) NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/150(0%) 0/150(0%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 0/50 malignant or NOS) Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 3/150(2%) Mean(sd) 0.0%(0.0) 2.0%(2.0) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/50 0/50 Females 2/50 0/50 1/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Hemangiosarcoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 1/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrosarcoma Total 0/148(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/148(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/148(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 9/148(6.1%) 4/150(2.7%) Mean(sd) 6.1%(5.3) 2.7%(3.1) Range 1/50 - 6/50 0/50 - 3/50 Males 2/48 6/50 1/50 Females 1/50 0/50 3/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/148(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/148(0%) 0/150(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/50 - 0/50 Males 0/48 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Hemangioma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 2/150(1.3%) 0/150(0%) Mean(sd) 1.3%(2.3) 0.0%(0.0) Range 0/50 - 2/50 0/50 - 0/50 Males 2/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 2/150(1.3%) 2/150(1.3%) Carcinoma or Papilloma Mean(sd) 1.3%(2.3) 1.3%(1.2) Squamous Range 0/50 - 2/50 0/50 - 1/50 Males 2/50 0/50 0/50 Females 1/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/150(0%) 2/150(1.3%) Mean(sd) 0.0%(0.0) 1.3%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 1/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 1/149(0.7%) Mean(sd) 0.7%(1.2) Range 0/50 - 1/49 Males 1/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/149(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrosarcoma Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Hemangioma Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/112(0.9%) 0/132(0%) Mean(sd) 1.1%(2.0) 0.0%(0.0) Range 0/39 - 1/29 0/45 - 0/45 Males 0/39 1/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/112(0%) 0/132(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Sarcoma Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Thymoma Benign Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Thymoma Malignant Total 0/112(0%) 0/132(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/39 - 0/39 0/45 - 0/45 Males 0/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Thymoma NOS Total 1/112(0.9%) 0/132(0%) Mean(sd) 0.9%(1.5) 0.0%(0.0) Range 0/29 - 1/39 0/45 - 0/45 Males 1/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- Thymoma: Benign, Total 1/112(0.9%) 0/132(0%) Malignant, NOS Mean(sd) 0.9%(1.5) 0.0%(0.0) Range 0/29 - 1/39 0/45 - 0/45 Males 1/39 0/29 0/44 Females 0/45 0/41 0/46 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/149(0%) 1/149(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/49 - 0/49 0/50 - 1/49 Males 0/49 0/50 0/50 Females 1/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/149(0%) 1/149(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/49 - 0/49 0/50 - 1/49 Males 0/49 0/50 0/50 Females 1/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/149(0%) 2/149(1.3%) Mean(sd) 0.0%(0.0) 1.4%(2.4) Range 0/49 - 0/49 0/50 - 2/49 Males 0/49 0/50 0/50 Females 2/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 4/149(2.7%) 5/149(3.4%) Mean(sd) 2.7%(2.3) 3.3%(4.2) Range 0/49 - 2/50 0/49 - 4/50 Males 0/49 2/50 2/50 Females 0/49 1/50 4/50 --------------------------------------------------------------------------- Carcinoma Total 1/149(0.7%) 0/149(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/49 0/49 - 0/49 Males 1/49 0/50 0/50 Females 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/149(3.4%) 5/149(3.4%) Mean(sd) 3.3%(1.2) 3.3%(4.2) Range 1/49 - 2/50 0/49 - 4/50 Males 1/49 2/50 2/50 Females 0/49 1/50 4/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Fibrosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) 1/150(0.7%) Mean(sd) 0.0%(0.0) 0.7%(1.2) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 1/150(0.7%) 0/150(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Squamous Cell Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/150(0%) 0/150(0%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adamantinoma Benign Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Carcinoma or Papilloma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/149(0.7%) 0/149(0%) Mean(sd) 0.7%(1.2) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- Papilloma Total 0/149(0%) 0/149(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 Females 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/150(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 4/150(2.7%) Mean(sd) 2.7%(3.1) Range 0/50 - 3/50 Females 0/50 3/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/150(0.7%) Mean(sd) 0.7%(1.2) Range 0/50 - 1/50 Females 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 5/150(3.3%) Polyp Stromal Mean(sd) 3.3%(4.2) Range 0/50 - 4/50 Females 0/50 4/50 1/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Leiomyosarcoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/150(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE DERMAL ACETONE (Updated 12/99) Males(3 studies) Females(3 studies) =========================================================================== Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/150(0%) 0/150(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 Females 0/50 0/50 0/50 ---------------------------------------------------------------------------