TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Benign Tumors Total 120/199(60.3%) 118/200(59%) Mean(sd) 60.3%(7.5) 59.0%(10.6) Range 26/50 - 33/49 23/50 - 36/50 Males 33/49 26/50 28/50 33/50 Females 29/50 23/50 36/50 30/50 --------------------------------------------------------------------------- Malignant Tumors Total 109/199(54.8%) 108/200(54%) Mean(sd) 54.7%(5.5) 54.0%(7.5) Range 23/49 - 30/50 23/50 - 32/50 Males 23/49 30/50 28/50 28/50 Females 27/50 23/50 32/50 26/50 --------------------------------------------------------------------------- Malignant and Benign Total 165/199(82.9%) 161/200(80.5%) Tumors Mean(sd) 82.9%(2.5) 80.5%(7.5) Range 40/50 - 43/50 35/50 - 44/50 Males 41/49 40/50 41/50 43/50 Females 41/50 35/50 44/50 41/50 --------------------------------------------------------------------------- Hemangioma Total 2/199(1%) 3/200(1.5%) Mean(sd) 1.0%(2.0) 1.5%(1.9) Range 0/49 - 2/50 0/50 - 2/50 Males 0/49 0/50 0/50 2/50 Females 0/50 1/50 2/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 19/199(9.5%) 6/200(3%) Mean(sd) 9.6%(3.4) 3.0%(4.8) Range 3/50 - 7/50 0/50 - 5/50 Males 4/49 3/50 5/50 7/50 Females 0/50 0/50 5/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 21/199(10.6%) 9/200(4.5%) Hemangioma Mean(sd) 10.6%(5.2) 4.5%(6.4) Range 3/50 - 9/50 0/50 - 7/50 Males 4/49 3/50 5/50 9/50 Females 0/50 1/50 7/50 1/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 3/199(1.5%) 8/200(4%) Mean(sd) 1.5%(1.9) 4.0%(1.6) Range 0/49 - 2/50 1/50 - 3/50 Males 0/49 2/50 1/50 0/50 Females 1/50 3/50 2/50 2/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/199(0%) 0/200(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 13/199(6.5%) 41/200(20.5%) Histiocytic, Mean(sd) 6.5%(5.3) 20.5%(9.1) Lymphocytic, Mixed, NOS, Range 1/50 - 7/50 5/50 - 15/50 or Undifferentiated Cell Type Males 3/49 7/50 2/50 1/50 Females 15/50 13/50 8/50 5/50 --------------------------------------------------------------------------- Osteoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 7/198(3.5%) 1/199(0.5%) Mean(sd) 3.5%(4.7) 0.5%(1.0) Range 0/49 - 5/50 0/50 - 1/49 Males 0/49 0/50 2/49 5/50 Females 0/50 1/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/198(0%) 1/199(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/50 0/49 0/50 Females 1/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Pheochromocytoma Benign Total 1/197(0.5%) 2/199(1%) Mean(sd) 0.5%(1.1) 1.0%(2.0) Range 0/49 - 1/48 0/50 - 2/50 Males 0/49 0/50 1/48 0/50 Females 0/50 0/49 2/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/197(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 1/197(0.5%) 1/199(0.5%) Malignant Mean(sd) 0.5%(1.0) 0.5%(1.0) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 1/50 0/48 0/50 Females 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 2/197(1%) 3/199(1.5%) Benign, Complex, Mean(sd) 1.0%(1.2) 1.5%(3.0) Malignant, NOS Range 0/49 - 1/48 0/50 - 3/50 Males 0/49 1/50 1/48 0/50 Females 0/50 0/49 3/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/199(1%) 1/200(0.5%) Mean(sd) 1.0%(1.2) 0.5%(1.0) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 1/50 0/50 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/199(0%) 1/200(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/199(0%) 1/200(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Astrocytoma Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/199(0%) 0/200(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/199(0%) 0/200(0%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Basosquamous Tumor Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/183(0%) 0/181(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/38 - 0/38 Males 0/48 0/50 0/44 0/41 Females 0/38 0/48 0/47 0/48 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 13/199(6.5%) 7/200(3.5%) Mean(sd) 6.6%(1.1) 3.5%(4.1) Range 3/50 - 4/49 0/50 - 4/50 Males 4/49 3/50 3/50 3/50 Females 0/50 0/50 3/50 4/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 7/200(3.5%) Mean(sd) 0.0%(0.0) 3.5%(4.4) Range 0/49 - 0/49 0/50 - 5/50 Males 0/49 0/50 0/50 0/50 Females 5/50 0/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 13/199(6.5%) 14/200(7%) Mean(sd) 6.6%(1.1) 7.0%(4.8) Range 3/50 - 4/49 0/50 - 5/50 Males 4/49 3/50 3/50 3/50 Females 5/50 0/50 4/50 5/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/199(0.5%) 0/199(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/50 1/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/197(0%) 2/196(1%) Mean(sd) 0.0%(0.0) 1.0%(1.2) Range 0/49 - 0/49 0/49 - 1/48 Males 0/49 0/50 0/48 0/50 Females 0/49 1/50 1/48 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/197(0%) 0/196(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/197(0%) 2/196(1%) Mean(sd) 0.0%(0.0) 1.0%(1.2) Range 0/49 - 0/49 0/49 - 1/48 Males 0/49 0/50 0/48 0/50 Females 0/49 1/50 1/48 0/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/198(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Cholangiocarcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 2/199(1%) 0/200(0%) Mean(sd) 1.0%(2.0) 0.0%(0.0) Range 0/49 - 2/50 0/50 - 0/50 Males 0/49 0/50 0/50 2/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 11/199(5.5%) 1/200(0.5%) Mean(sd) 5.5%(5.0) 0.5%(1.0) Range 0/49 - 6/50 0/50 - 1/50 Males 0/49 3/50 2/50 6/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Hepatoblastoma Total 3/199(1.5%) 1/200(0.5%) Mean(sd) 1.5%(1.0) 0.5%(1.0) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 1/50 1/50 1/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 86/199(43.2%) 70/200(35%) Mean(sd) 43.3%(9.9) 35.0%(8.7) Range 16/50 - 26/49 11/50 - 20/50 Males 26/49 16/50 19/50 25/50 Females 20/50 11/50 19/50 20/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 63/199(31.7%) 46/200(23%) Mean(sd) 31.6%(10.1) 23.0%(6.2) Range 10/49 - 21/50 7/50 - 14/50 Males 10/49 13/50 19/50 21/50 Females 7/50 13/50 14/50 12/50 --------------------------------------------------------------------------- Hepatocellular Total 64/199(32.2%) 47/200(23.5%) Carcinoma or Mean(sd) 32.1%(10.6) 23.5%(6.4) Hepatoblastoma Range 10/49 - 21/50 7/50 - 14/50 Males 10/49 13/50 20/50 21/50 Females 7/50 13/50 14/50 13/50 --------------------------------------------------------------------------- Hepatocellular Total 126/199(63.3%) 96/200(48%) Carcinoma or Mean(sd) 63.3%(10.9) 48.0%(5.9) Hepatocellular Adenoma Range 24/50 - 36/50 20/50 - 27/50 Males 31/49 24/50 35/50 36/50 Females 25/50 20/50 24/50 27/50 --------------------------------------------------------------------------- Hepatocellular Total 127/199(63.8%) 96/200(48%) Carcinoma, Mean(sd) 63.8%(11.3) 48.0%(5.9) Hepatocellular Adenoma, Range 24/50 - 36/50 20/50 - 27/50 or Hepatoblastoma Males 31/49 24/50 36/50 36/50 Females 25/50 20/50 24/50 27/50 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/199(0%) 1/200(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/199(0%) 1/200(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 39/198(19.7%) 14/199(7%) Adenoma Mean(sd) 19.7%(5.3) 7.0%(4.2) Range 6/50 - 12/50 1/50 - 6/50 Males 11/49 10/49 6/50 12/50 Females 6/50 1/50 4/50 3/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 17/198(8.6%) 6/199(3%) Carcinoma Mean(sd) 8.6%(3.5) 3.0%(2.6) Range 2/50 - 6/49 0/50 - 3/49 Males 5/49 6/49 2/50 4/50 Females 1/50 0/50 2/50 3/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 53/198(26.8%) 20/199(10.1%) Carcinoma or Mean(sd) 26.8%(7.5) 10.1%(5.4) Alveolar/Bronchiolar Range 8/50 - 16/49 1/50 - 7/50 Adenoma Males 15/49 16/49 8/50 14/50 Females 7/50 1/50 6/50 6/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/198(0%) 0/199(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/198(0%) 0/199(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/49 0/50 0/50 Females 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/50 0/50 1/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/199(0%) 2/200(1%) Mean(sd) 0.0%(0.0) 1.0%(2.0) Range 0/49 - 0/49 0/50 - 2/50 Males 0/49 0/50 0/50 0/50 Females 2/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/199(0%) 1/200(0.5%) or Adenoma Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/199(0%) 2/200(1%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 1.0%(2.0) Range 0/49 - 0/49 0/50 - 2/50 Males 0/49 0/50 0/50 0/50 Females 2/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 2/200(1%) Mean(sd) 0.0%(0.0) 1.0%(2.0) Range 0/49 - 0/49 0/50 - 2/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 2/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Papilloma Squamous or Total 0/199(0%) 0/200(0%) Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 1/200(0.5%) Carcinoma, Papilloma Mean(sd) 0.0%(0.0) 0.5%(1.0) Squamous, or Papilloma Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Squamous Cell Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Cystadenoma Total 8/199(4%) Mean(sd) 4.0%(2.8) Range 0/49 - 3/50 Females 3/50 0/49 3/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/199(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/199(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 0/199(0%) Benign, Malignant, NOS Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/199(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/199(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/199(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 1/199(0.5%) Mean(sd) 0.5%(1.0) Range 0/49 - 1/50 Females 1/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Teratoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Teratoma Benign Total 1/199(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/49 0/50 1/50 --------------------------------------------------------------------------- Teratoma Malignant Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Teratoma NOS Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Thecoma Benign Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/197(0%) 1/197(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/197(0%) 1/197(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 1/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/197(0%) 0/197(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/48 0/50 Females 0/49 0/50 0/48 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 0/187(0%) 0/171(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/36 - 0/36 Males 0/43 0/48 0/50 0/46 Females 0/36 0/45 0/43 0/47 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Squamous Cell Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/180(0%) 22/193(11.4%) Mean(sd) 0.0%(0.0) 11.3%(5.2) Range 0/45 - 0/45 2/46 - 8/49 Males 0/45 0/48 0/47 0/40 Females 5/48 7/50 8/49 2/46 --------------------------------------------------------------------------- Carcinoma Total 0/180(0%) 1/193(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/45 - 0/45 0/48 - 1/50 Males 0/45 0/48 0/47 0/40 Females 0/48 1/50 0/49 0/46 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/180(0%) 23/193(11.9%) Mean(sd) 0.0%(0.0) 11.8%(5.7) Range 0/45 - 0/45 2/46 - 8/49 Males 0/45 0/48 0/47 0/40 Females 5/48 8/50 8/49 2/46 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 1/180(0.6%) 2/193(1%) Mean(sd) 0.5%(1.1) 1.0%(2.1) Range 0/45 - 1/48 0/48 - 2/49 Males 0/45 1/48 0/47 0/40 Females 0/48 0/50 2/49 0/46 --------------------------------------------------------------------------- Carcinoma Total 0/180(0%) 0/193(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/48 - 0/48 Males 0/45 0/48 0/47 0/40 Females 0/48 0/50 0/49 0/46 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/180(0.6%) 2/193(1%) Mean(sd) 0.5%(1.1) 1.0%(2.1) Range 0/45 - 1/48 0/48 - 2/49 Males 0/45 1/48 0/47 0/40 Females 0/48 0/50 2/49 0/46 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma Total 1/198(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/49 Males 1/49 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/198(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/49 Males 1/49 0/50 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/198(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Hemangioma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrosarcoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/199(0.5%) 0/200(0%) Mean(sd) 0.5%(1.0) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 1/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/199(0%) 0/200(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Basal Cell Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/199(0%) 0/200(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/199(0%) 1/200(0.5%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.5%(1.0) Benign, or Range 0/49 - 0/49 0/50 - 1/50 Trichoepithelioma Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/199(0%) 0/200(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/199(0%) 1/200(0.5%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.5%(1.0) Basosquamous Tumor Range 0/49 - 0/49 0/50 - 1/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 0/199(0%) 1/200(0.5%) Carcinoma, Carcinoma, Mean(sd) 0.0%(0.0) 0.5%(1.0) Basosq. Tumor (M or B), Range 0/49 - 0/49 0/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/199(0%) 0/200(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/199(1%) 3/200(1.5%) Mean(sd) 1.0%(1.2) 1.5%(3.0) Range 0/49 - 1/50 0/50 - 3/50 Males 0/49 0/50 1/50 1/50 Females 0/50 0/50 3/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/199(0%) 0/200(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 0/200(0%) Carcinoma, Basal Cell Mean(sd) 0.0%(0.0) 0.0%(0.0) Carcinoma, Basosquamous Range 0/49 - 0/49 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 0/200(0%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 0/200(0%) Papilloma, Papilloma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Cell Carcinoma Range 0/49 - 0/49 0/50 - 0/50 or Keratoacanthoma Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 0/200(0%) Papilloma, Papilloma, or Mean(sd) 0.0%(0.0) 0.0%(0.0) Keratoacanthoma Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibroma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 3/199(1.5%) 3/200(1.5%) Sarcoma, Myxoma, Mean(sd) 1.5%(1.9) 1.5%(1.9) Myxosarcoma, or Fibrous Range 0/49 - 2/50 0/50 - 2/50 Histiocytoma Males 0/49 1/50 0/50 2/50 Females 0/50 1/50 2/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/199(0.5%) 2/200(1%) Mean(sd) 0.5%(1.0) 1.0%(1.2) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 0/50 0/50 1/50 Females 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 3/199(1.5%) 3/200(1.5%) Myxosarcoma, or Fibrous Mean(sd) 1.5%(1.9) 1.5%(1.9) Histiocytoma Range 0/49 - 2/50 0/50 - 2/50 Males 0/49 1/50 0/50 2/50 Females 0/50 1/50 2/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/199(0%) 1/200(0.5%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.5%(1.0) NOS) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/199(0%) 1/200(0.5%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.5%(1.0) Schwannoma (benign, Range 0/49 - 0/49 0/50 - 1/50 malignant or NOS) Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 2/199(1%) 1/200(0.5%) Mean(sd) 1.0%(1.2) 0.5%(1.0) Range 0/49 - 1/50 0/50 - 1/50 Males 0/49 1/50 0/50 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrosarcoma Total 0/197(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/197(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/197(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/48 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 5/197(2.5%) 4/198(2%) Mean(sd) 2.6%(1.9) 2.0%(2.9) Range 0/50 - 2/49 0/50 - 3/49 Males 2/49 0/50 1/48 2/50 Females 0/50 0/50 3/49 1/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/197(0%) 1/198(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/48 0/50 Females 1/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/197(0%) 1/198(0.5%) Malignant Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/48 0/50 Females 1/50 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/199(0.5%) 5/200(2.5%) Carcinoma or Papilloma Mean(sd) 0.5%(1.0) 2.5%(2.5) Squamous Range 0/49 - 1/50 0/50 - 3/50 Males 0/49 1/50 0/50 0/50 Females 1/50 1/50 0/50 3/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/199(0.5%) 4/200(2%) Mean(sd) 0.5%(1.0) 2.0%(2.8) Range 0/49 - 1/50 0/50 - 3/50 Males 0/49 1/50 0/50 0/50 Females 0/50 1/50 0/50 3/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 2/199(1%) Mean(sd) 1.0%(1.2) Range 0/50 - 1/49 Males 1/49 1/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Males 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrosarcoma Total 1/165(0.6%) 0/187(0%) Mean(sd) 0.6%(1.1) 0.0%(0.0) Range 0/37 - 1/45 0/45 - 0/45 Males 0/37 1/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Hemangioma Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/165(0%) 0/187(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Sarcoma Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Thymoma Benign Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Thymoma Malignant Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Thymoma NOS Total 0/165(0%) 0/187(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/165(0%) 0/187(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/37 - 0/37 0/45 - 0/45 Males 0/37 0/45 0/42 0/41 Females 0/45 0/47 0/47 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/199(0%) 0/198(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 13/199(6.5%) 8/198(4%) Mean(sd) 6.5%(4.4) 4.1%(1.7) Range 1/49 - 6/50 1/50 - 3/49 Males 1/49 4/50 6/50 2/50 Females 2/50 1/50 2/49 3/49 --------------------------------------------------------------------------- Carcinoma Total 1/199(0.5%) 1/198(0.5%) Mean(sd) 0.5%(1.0) 0.5%(1.0) Range 0/50 - 1/49 0/50 - 1/49 Males 1/49 0/50 0/50 0/50 Females 0/50 0/50 0/49 1/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 14/199(7%) 9/198(4.5%) Mean(sd) 7.0%(3.8) 4.6%(2.6) Range 2/50 - 6/50 1/50 - 4/49 Males 2/49 4/50 6/50 2/50 Females 2/50 1/50 2/49 4/49 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Fibrosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Squamous Cell Carcinoma Total 0/199(0%) 1/200(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.0) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/199(0%) 1/200(0.5%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.5%(1.0) Squamous Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adamantinoma Benign Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 1/199(0.5%) 1/200(0.5%) Mean(sd) 0.5%(1.0) 0.5%(1.0) Range 0/50 - 1/49 0/50 - 1/50 Males 1/49 0/50 0/50 0/50 Females 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Carcinoma or Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/200(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/200(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/200(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/200(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 5/200(2.5%) Mean(sd) 2.5%(3.8) Range 0/50 - 4/50 Females 0/50 4/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 5/200(2.5%) Polyp Stromal Mean(sd) 2.5%(3.8) Range 0/50 - 4/50 Females 0/50 4/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Leiomyosarcoma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/200(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/200(0.5%) Mean(sd) 0.5%(1.0) Range 0/50 - 1/50 Females 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE GAVAGE METHYL CELLULOSE (Updated 12/99) Males(4 studies) Females(4 studies) =========================================================================== Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/199(0%) 0/200(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/50 0/50 ---------------------------------------------------------------------------