TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Benign Tumors Total 581/1074(54.1%) 537/1077(49.9%) Mean(sd) 54.5%(10.6) 50.1%(9.6) Range 18/55 - 36/50 16/50 - 33/50 Males 29/50 27/59 29/50 21/60 18/55 24/50 36/50 31/50 30/50 28/50 30/50 36/50 27/50 24/50 30/50 31/50 31/50 20/50 22/50 27/50 30/50 Females 16/50 27/58 23/49 27/60 20/60 29/49 28/50 22/50 25/50 25/50 22/50 21/50 32/50 27/51 31/50 31/50 23/50 20/50 26/50 33/50 29/50 --------------------------------------------------------------------------- Malignant Tumors Total 460/1074(42.8%) 491/1077(45.6%) Mean(sd) 43.1%(12.7) 45.6%(9.6) Range 11/50 - 34/50 13/50 - 31/50 Males 16/50 20/59 11/50 20/60 14/55 18/50 19/50 34/50 33/50 20/50 23/50 24/50 33/50 16/50 19/50 22/50 23/50 21/50 28/50 25/50 21/50 Females 16/50 26/58 21/49 26/60 30/60 23/49 15/50 20/50 27/50 28/50 26/50 21/50 24/50 17/51 27/50 26/50 20/50 13/50 25/50 31/50 29/50 --------------------------------------------------------------------------- Malignant and Benign Total 834/1074(77.7%) 788/1077(73.2%) Tumors Mean(sd) 78.0%(12.1) 73.3%(9.7) Range 28/55 - 49/50 27/50 - 47/50 Males 37/50 39/59 35/50 37/60 28/55 32/50 44/50 48/50 49/50 40/50 40/50 47/50 44/50 33/50 42/50 40/50 43/50 35/50 40/50 40/50 41/50 Females 27/50 42/58 34/49 41/60 36/60 35/49 35/50 34/50 42/50 40/50 36/50 34/50 41/50 37/51 43/50 38/50 36/50 29/50 38/50 47/50 43/50 --------------------------------------------------------------------------- Hemangioma Total 10/1074(0.9%) 15/1077(1.4%) Mean(sd) 0.9%(1.3) 1.4%(2.1) Range 0/50 - 2/50 0/50 - 3/50 Males 0/50 1/59 0/50 0/60 0/55 1/50 1/50 0/50 2/50 0/50 2/50 1/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 1/58 1/49 0/60 0/60 2/49 2/50 0/50 0/50 0/50 0/50 1/50 0/50 2/51 3/50 3/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 30/1074(2.8%) 39/1077(3.6%) Mean(sd) 2.8%(2.0) 3.6%(2.6) Range 0/50 - 3/50 0/50 - 4/50 Males 0/50 1/59 0/50 2/60 2/55 2/50 1/50 3/50 3/50 1/50 3/50 1/50 3/50 2/50 1/50 1/50 1/50 0/50 2/50 0/50 1/50 Females 0/50 3/58 0/49 1/60 3/60 3/49 3/50 4/50 1/50 0/50 1/50 1/50 3/50 1/51 2/50 4/50 2/50 0/50 2/50 2/50 3/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 40/1074(3.7%) 54/1077(5%) Hemangioma Mean(sd) 3.7%(2.8) 5.0%(3.8) Range 0/50 - 5/50 0/50 - 7/50 Males 0/50 2/59 0/50 2/60 2/55 3/50 2/50 3/50 5/50 1/50 5/50 2/50 3/50 3/50 1/50 1/50 1/50 1/50 2/50 0/50 1/50 Females 0/50 4/58 1/49 1/60 3/60 5/49 5/50 4/50 1/50 0/50 1/50 2/50 3/50 3/51 5/50 7/50 2/50 0/50 2/50 2/50 3/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 19/1074(1.8%) 39/1077(3.6%) Mean(sd) 1.8%(2.4) 3.6%(2.5) Range 0/50 - 3/50 0/50 - 5/50 Males 0/50 0/59 0/50 1/60 0/55 0/50 0/50 3/50 1/50 2/50 3/50 1/50 3/50 0/50 1/50 3/50 0/50 0/50 0/50 0/50 1/50 Females 5/50 2/58 4/49 1/60 2/60 2/49 3/50 1/50 3/50 1/50 1/50 3/50 1/50 2/51 1/50 2/50 2/50 0/50 1/50 0/50 2/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/1074(0%) 0/1077(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 47/1074(4.4%) 162/1077(15%) Histiocytic, Mean(sd) 4.4%(2.2) 15.1%(7.4) Lymphocytic, Mixed, NOS, Range 1/59 - 4/50 3/50 - 16/50 or Undifferentiated Cell Type Males 2/50 1/59 2/50 2/60 2/55 3/50 4/50 2/50 1/50 2/50 1/50 2/50 4/50 1/50 1/50 3/50 3/50 2/50 1/50 4/50 4/50 Females 4/50 5/58 13/49 7/60 13/60 11/49 6/50 7/50 4/50 3/50 3/50 7/50 12/50 7/51 7/50 9/50 6/50 3/50 12/50 7/50 16/50 --------------------------------------------------------------------------- Osteoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1074(0%) 5/1077(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.1) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 2/50 0/50 1/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/1074(0%) 5/1077(0.5%) Mean(sd) 0.0%(0.0) 0.5%(1.1) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 2/50 0/50 1/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 37/1058(3.5%) 5/1071(0.5%) Mean(sd) 3.5%(3.3) 0.4%(0.8) Range 0/49 - 6/50 0/50 - 1/50 Males 1/49 2/59 0/49 1/60 4/55 2/48 2/50 1/50 0/49 1/50 0/50 3/48 2/47 0/49 2/50 5/49 6/50 1/47 2/50 0/50 2/49 Females 0/50 1/58 0/49 1/59 0/60 0/49 1/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/47 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/1058(0%) 1/1071(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/49 - 0/49 0/50 - 1/49 Males 0/49 0/59 0/49 0/60 0/55 0/48 0/50 0/50 0/49 0/50 0/50 0/48 0/47 0/49 0/50 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 1/49 0/59 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/47 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1058(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/59 0/49 0/60 0/55 0/48 0/50 0/50 0/49 0/50 0/50 0/48 0/47 0/49 0/50 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/47 0/50 0/50 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1058(0%) 0/1071(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/59 0/49 0/60 0/55 0/48 0/50 0/50 0/49 0/50 0/50 0/48 0/47 0/49 0/50 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/47 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1008(0%) 0/1021(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/59 0/49 0/60 0/55 0/48 0/50 0/50 0/49 0/50 0/0 0/48 0/47 0/49 0/50 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/50 0/50 0/50 0/50 0/0 0/50 0/50 0/50 0/50 0/50 0/50 0/47 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Pheochromocytoma Benign Total 4/1056(0.4%) 19/1062(1.8%) Mean(sd) 0.4%(0.8) 1.8%(2.2) Range 0/49 - 1/48 0/49 - 4/50 Males 0/49 0/58 0/49 0/60 0/55 1/49 0/50 0/50 1/48 0/50 1/50 1/48 0/47 0/49 0/49 0/49 0/50 0/47 0/50 0/50 0/49 Females 1/50 1/58 0/49 1/59 1/60 2/48 0/50 1/50 0/49 1/50 0/50 0/49 4/50 0/47 3/50 0/50 1/48 0/47 1/50 2/50 0/48 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 1/1056(0.1%) 0/1062(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/49 - 1/58 0/50 - 0/50 Males 0/49 1/58 0/49 0/60 0/55 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/49 0/49 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 0/49 0/59 0/60 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/47 0/50 0/50 0/48 0/47 0/50 0/50 0/48 --------------------------------------------------------------------------- Pheochromocytoma Total 1/1056(0.1%) 3/1062(0.3%) Malignant Mean(sd) 0.1%(0.4) 0.3%(0.8) Range 0/49 - 1/50 0/50 - 2/60 Males 0/49 0/58 0/49 0/60 0/55 0/49 0/50 1/50 0/48 0/50 0/50 0/48 0/47 0/49 0/49 0/49 0/50 0/47 0/50 0/50 0/49 Females 0/50 0/58 0/49 0/59 2/60 1/48 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/47 0/50 0/50 0/48 0/47 0/50 0/50 0/48 --------------------------------------------------------------------------- Pheochromocytoma: Total 6/1056(0.6%) 22/1062(2.1%) Benign, Complex, Mean(sd) 0.6%(0.9) 2.0%(2.4) Malignant, NOS Range 0/49 - 1/48 0/49 - 4/50 Males 0/49 1/58 0/49 0/60 0/55 1/49 0/50 1/50 1/48 0/50 1/50 1/48 0/47 0/49 0/49 0/49 0/50 0/47 0/50 0/50 0/49 Females 1/50 1/58 0/49 1/59 3/60 3/48 0/50 1/50 0/49 1/50 0/50 0/49 4/50 0/47 3/50 0/50 1/48 0/47 1/50 2/50 0/48 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1065(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/49 0/50 0/49 0/49 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/48 0/50 0/50 0/48 --------------------------------------------------------------------------- Hemangioma Total 0/1065(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/49 0/50 0/49 0/49 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/48 0/50 0/50 0/48 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/1065(0.3%) 10/1071(0.9%) Mean(sd) 0.3%(0.7) 1.0%(1.2) Range 0/50 - 1/48 0/50 - 2/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/49 0/50 0/49 0/49 1/48 0/50 0/50 1/49 0/50 0/50 1/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 1/49 0/50 0/50 0/50 0/50 1/50 1/49 1/50 0/51 1/50 1/50 2/50 0/48 0/50 1/50 1/48 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/1065(0%) 1/1071(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/49 0/50 0/49 0/49 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 1/50 0/50 0/48 0/50 0/50 0/48 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 1/1065(0.1%) 0/1071(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 1/50 0/50 0/49 0/50 0/49 0/49 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/48 0/50 0/50 0/48 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1065(0%) 0/1071(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/49 0/50 0/49 0/49 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/57 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/48 0/50 0/50 0/48 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/1074(0.3%) 3/1077(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 1/60 0/55 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1074(0%) 4/1077(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 1/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/1074(0%) 4/1077(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 1/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Astrocytoma Benign Total 0/1073(0%) 1/1075(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/49 --------------------------------------------------------------------------- Meningioma Malignant Total 0/1073(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/1073(0%) 0/1075(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/1073(0%) 1/1075(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Oligodendroglioma Total 0/1073(0%) 0/1075(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/1073(0%) 2/1075(0.2%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 1/49 --------------------------------------------------------------------------- Sarcoma Total 0/1073(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Basosquamous Tumor Total 0/1074(0%) 1/1077(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1074(0.1%) 1/1077(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/60 0/50 - 1/60 Males 0/50 0/59 0/50 1/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 1/1068(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/59 Males 0/50 1/59 0/50 0/60 0/54 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1068(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/1068(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/54 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1068(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/54 Males 0/50 0/59 0/50 0/60 1/54 0/50 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/927(0%) 0/974(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/44 - 0/44 0/46 - 0/46 Males 0/44 0/56 0/48 0/55 0/45 0/45 0/44 0/41 0/37 0/43 0/42 0/42 0/42 0/41 0/42 0/43 0/45 0/33 0/47 0/46 0/46 Females 0/46 0/53 0/48 0/59 0/57 0/42 0/46 0/45 0/43 0/40 0/47 0/45 0/45 0/46 0/43 0/40 0/43 0/44 0/46 0/50 0/46 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 48/974(4.9%) 34/977(3.5%) Mean(sd) 4.6%(4.1) 31.8%(94.7) Range 0/60 - 7/50 0/60 - 0/0 Males 2/50 1/59 7/50 0/60 0/55 5/50 6/50 2/50 4/50 1/50 0/0 1/50 3/50 4/50 3/50 0/0 3/50 1/50 1/50 1/50 3/50 Females 1/50 1/58 4/49 0/60 0/60 3/49 8/50 1/50 2/50 2/50 0/0 2/50 1/50 0/51 4/50 0/0 2/50 0/50 1/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 10/974(1%) 11/977(1.1%) Mean(sd) 1.0%(1.7) 1.0%(1.4) Range 0/50 - 3/50 0/50 - 2/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 2/50 0/0 3/50 1/50 0/50 0/50 0/0 1/50 0/50 2/50 0/50 1/50 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 1/50 0/50 1/50 0/0 0/50 2/50 0/51 1/50 0/0 0/50 1/50 1/50 2/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 58/974(6%) 45/977(4.6%) Mean(sd) 24.6%(86.1) 4.3%(4.0) Range 0/60 - 0/0 0/60 - 8/50 Males 2/50 1/59 7/50 0/60 0/55 5/50 6/50 2/50 4/50 3/50 0/0 4/50 4/50 4/50 3/50 0/0 4/50 1/50 3/50 1/50 4/50 Females 1/50 1/58 5/49 0/60 0/60 3/49 8/50 2/50 2/50 3/50 0/0 2/50 3/50 0/51 5/50 0/0 2/50 1/50 2/50 3/50 2/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1072(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1072(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1072(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1072(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 2/1074(0.2%) 0/1077(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 2/1074(0.2%) 0/1077(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1074(0%) 4/1077(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 6/1074(0.6%) 1/1077(0.1%) Mean(sd) 0.6%(1.1) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/59 1/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 2/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 2/1074(0.2%) 0/1077(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 6/1074(0.6%) 1/1077(0.1%) Mean(sd) 0.6%(1.1) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/59 1/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 2/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 8/1074(0.7%) 1/1077(0.1%) Mean(sd) 0.7%(1.3) 0.1%(0.4) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 1/59 1/50 0/60 0/55 2/50 0/50 0/50 0/50 0/50 2/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1074(0%) 4/1077(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 9/1057(0.9%) 10/1066(0.9%) Mean(sd) 0.8%(1.5) 0.9%(1.3) Range 0/50 - 2/50 0/50 - 2/50 Males 0/50 1/59 0/49 0/60 0/52 0/47 0/50 0/50 0/48 0/50 0/50 0/48 0/47 2/50 2/50 1/49 2/50 0/49 1/50 0/49 0/50 Females 0/50 0/58 0/49 2/59 0/59 0/49 0/49 0/49 1/50 1/50 1/50 0/48 0/50 0/51 2/50 0/50 1/49 0/50 1/50 0/49 1/47 --------------------------------------------------------------------------- Carcinoma Total 0/1057(0%) 1/1066(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/58 Males 0/50 0/59 0/49 0/60 0/52 0/47 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 1/58 0/49 0/59 0/59 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 0/49 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 9/1057(0.9%) 11/1066(1%) Mean(sd) 0.8%(1.5) 1.0%(1.3) Range 0/50 - 2/50 0/50 - 2/50 Males 0/50 1/59 0/49 0/60 0/52 0/47 0/50 0/50 0/48 0/50 0/50 0/48 0/47 2/50 2/50 1/49 2/50 0/49 1/50 0/49 0/50 Females 0/50 1/58 0/49 2/59 0/59 0/49 0/49 0/49 1/50 1/50 1/50 0/48 0/50 0/51 2/50 0/50 1/49 0/50 1/50 0/49 1/47 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1068(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1068(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 1/1068(0.1%) 0/1075(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 1/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1068(0.1%) 0/1075(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/59 0/50 - 0/50 Males 0/50 1/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 3/1068(0.3%) 1/1075(0.1%) Mean(sd) 0.3%(0.7) 0.1%(0.4) Range 0/50 - 1/49 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 1/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 Females 0/50 0/58 0/49 0/60 0/60 1/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 1/1068(0.1%) 2/1075(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 1/49 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/1068(0.4%) 2/1075(0.2%) Mean(sd) 0.4%(1.0) 0.2%(0.6) Range 0/50 - 2/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 1/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 2/50 1/50 Females 0/50 0/58 0/49 0/60 0/60 1/49 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1068(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1068(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/1068(0%) 1/1075(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/49 0/50 0/50 0/49 0/49 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Cholangiocarcinoma Total 0/1072(0%) 0/1072(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Cholangioma Total 1/1072(0.1%) 0/1072(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 1/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/1072(0.1%) 0/1072(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/59 0/50 - 0/50 Males 0/50 1/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Hemangioma Total 1/1072(0.1%) 0/1072(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Hemangiosarcoma Total 16/1072(1.5%) 8/1072(0.7%) Mean(sd) 1.5%(1.5) 0.7%(1.3) Range 0/50 - 2/49 0/50 - 2/50 Males 0/50 0/59 0/50 1/60 1/55 1/50 0/50 2/50 2/50 0/50 1/50 1/50 2/49 2/50 0/50 1/50 0/50 0/50 1/49 0/50 1/50 Females 0/50 2/58 0/49 0/60 0/60 0/49 1/49 1/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 2/50 0/50 0/50 1/49 0/50 0/47 --------------------------------------------------------------------------- Hepatoblastoma Total 6/1072(0.6%) 0/1072(0%) Mean(sd) 0.6%(1.8) 0.0%(0.0) Range 0/59 - 4/50 0/50 - 0/50 Males 1/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 4/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 1/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 356/1072(33.2%) 224/1072(20.9%) Mean(sd) 33.4%(9.3) 21.0%(9.8) Range 8/55 - 24/50 4/49 - 20/47 Males 17/50 13/59 19/50 17/60 8/55 13/50 13/50 22/50 22/50 20/50 16/50 24/50 19/49 14/50 22/50 17/50 13/50 12/50 12/49 23/50 20/50 Females 6/50 13/58 5/49 13/60 6/60 4/49 11/49 17/50 8/50 9/50 11/50 12/50 11/50 6/51 16/50 14/50 7/50 6/50 9/49 20/50 20/47 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 279/1072(26%) 168/1072(15.7%) Mean(sd) 26.3%(9.6) 15.7%(8.1) Range 6/55 - 24/50 4/51 - 19/50 Males 14/50 10/59 7/50 11/60 6/55 7/50 11/50 24/50 23/50 12/50 13/50 14/50 15/49 12/50 10/50 16/50 15/50 17/50 17/49 12/50 13/50 Females 4/50 11/58 4/49 7/60 8/60 7/49 4/49 4/50 12/50 19/50 12/50 6/50 4/50 4/51 10/50 10/50 9/50 7/50 6/49 15/50 5/47 --------------------------------------------------------------------------- Hepatocellular Total 283/1072(26.4%) 168/1072(15.7%) Carcinoma or Mean(sd) 26.6%(10.5) 15.7%(8.1) Hepatoblastoma Range 6/55 - 27/50 4/51 - 19/50 Males 14/50 10/59 7/50 11/60 6/55 7/50 11/50 24/50 27/50 12/50 13/50 14/50 15/49 12/50 10/50 16/50 15/50 17/50 17/49 12/50 13/50 Females 4/50 11/58 4/49 7/60 8/60 7/49 4/49 4/50 12/50 19/50 12/50 6/50 4/50 4/51 10/50 10/50 9/50 7/50 6/49 15/50 5/47 --------------------------------------------------------------------------- Hepatocellular Total 582/1072(54.3%) 348/1072(32.5%) Carcinoma or Mean(sd) 54.7%(14.0) 32.6%(10.5) Hepatocellular Adenoma Range 12/55 - 43/50 9/49 - 27/50 Males 28/50 23/59 24/50 26/60 12/55 19/50 21/50 43/50 38/50 30/50 26/50 35/50 32/49 24/50 30/50 29/50 28/50 27/50 27/49 30/50 30/50 Females 10/50 20/58 9/49 18/60 14/60 9/49 15/49 20/50 18/50 23/50 21/50 17/50 14/50 10/51 22/50 19/50 14/50 13/50 12/49 27/50 23/47 --------------------------------------------------------------------------- Hepatocellular Total 584/1072(54.5%) 348/1072(32.5%) Carcinoma, Mean(sd) 54.9%(14.3) 32.6%(10.5) Hepatocellular Adenoma, Range 12/55 - 43/50 9/49 - 27/50 or Hepatoblastoma Males 28/50 23/59 24/50 26/60 12/55 19/50 21/50 43/50 40/50 30/50 26/50 35/50 32/49 24/50 30/50 29/50 28/50 27/50 27/49 30/50 30/50 Females 10/50 20/58 9/49 18/60 14/60 9/49 15/49 20/50 18/50 23/50 21/50 17/50 14/50 10/51 22/50 19/50 14/50 13/50 12/49 27/50 23/47 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 9/1072(0.8%) 13/1072(1.2%) Mean(sd) 0.8%(1.5) 1.2%(1.6) Range 0/50 - 3/50 0/50 - 2/49 Males 0/50 1/59 0/50 0/60 0/55 0/50 1/50 0/50 1/50 0/50 0/50 3/50 0/49 0/50 1/50 1/50 0/50 1/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 2/50 1/50 0/50 2/50 0/50 1/51 2/50 1/50 0/50 0/50 2/49 1/50 1/47 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 1/1072(0.1%) 0/1072(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/59 - 1/50 0/50 - 0/50 Males 1/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/1072(0%) 0/1072(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/1072(0%) 0/1072(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/1072(0%) 0/1072(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1072(0%) 0/1072(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- Sarcoma Total 0/1072(0%) 0/1072(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/49 0/50 0/47 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1071(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 201/1071(18.8%) 67/1075(6.2%) Adenoma Mean(sd) 19.0%(8.4) 6.3%(3.7) Range 5/60 - 18/50 0/50 - 7/49 Males 12/50 6/59 11/49 5/60 7/55 6/50 18/50 8/50 9/50 9/50 13/50 18/50 8/48 7/50 9/50 11/50 16/50 5/50 5/50 6/50 12/50 Females 3/50 3/58 4/48 3/60 2/60 7/49 4/50 2/50 3/50 1/50 6/50 1/50 2/50 4/51 7/50 3/50 2/50 4/50 0/50 4/50 2/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 97/1071(9.1%) 43/1075(4%) Carcinoma Mean(sd) 9.0%(5.2) 3.9%(3.2) Range 0/49 - 10/48 0/50 - 7/58 Males 2/50 7/59 0/49 9/60 4/55 4/50 5/50 6/50 4/50 2/50 3/50 6/50 10/48 1/50 5/50 2/50 4/50 2/50 7/50 8/50 6/50 Females 1/50 7/58 3/48 4/60 4/60 1/49 0/50 2/50 1/50 2/50 1/50 1/50 1/50 2/51 0/50 0/50 4/50 0/50 3/50 2/50 4/49 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 285/1071(26.6%) 109/1075(10.1%) Carcinoma or Mean(sd) 26.8%(8.3) 10.1%(3.6) Alveolar/Bronchiolar Range 7/50 - 21/50 2/50 - 8/49 Adenoma Males 14/50 13/59 11/49 13/60 9/55 10/50 21/50 13/50 11/50 11/50 15/50 21/50 18/48 8/50 14/50 13/50 20/50 7/50 12/50 14/50 17/50 Females 4/50 9/58 7/48 7/60 6/60 8/49 4/50 4/50 4/50 3/50 7/50 2/50 3/50 6/51 7/50 3/50 6/50 4/50 3/50 6/50 6/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1071(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/1071(0%) 1/1075(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1071(0.1%) 2/1075(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/49 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 1/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/1071(0%) 1/1075(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/1071(0%) 0/1075(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/48 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/59 0/50 - 0/50 Males 0/50 1/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1074(0%) 0/1077(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 2/1077(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/58 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1074(0%) 0/1077(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1074(0%) 25/1077(2.3%) Mean(sd) 0.0%(0.0) 2.3%(2.0) Range 0/50 - 0/50 0/50 - 3/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 1/58 1/49 2/60 2/60 3/49 0/50 3/50 1/50 0/50 1/50 0/50 3/50 0/51 0/50 2/50 0/50 1/50 1/50 1/50 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1074(0%) 25/1077(2.3%) Mean(sd) 0.0%(0.0) 2.3%(2.0) Range 0/50 - 0/50 0/50 - 3/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 1/58 1/49 2/60 2/60 3/49 0/50 3/50 1/50 0/50 1/50 0/50 3/50 0/51 0/50 2/50 0/50 1/50 1/50 1/50 2/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/1074(0%) 0/1077(0%) or Adenoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/1074(0%) 25/1077(2.3%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 2.3%(2.0) Range 0/50 - 0/50 0/50 - 3/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 1/58 1/49 2/60 2/60 3/49 0/50 3/50 1/50 0/50 1/50 0/50 3/50 0/51 0/50 2/50 0/50 1/50 1/50 1/50 2/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) 1/1077(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/1074(0.2%) 3/1077(0.3%) Mean(sd) 0.2%(0.9) 0.3%(0.7) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Lipoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/55 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 1/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 2/1077(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1067(0.1%) 0/1071(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/53 0/50 0/50 0/50 0/50 0/50 0/49 0/48 0/48 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/59 0/49 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/47 --------------------------------------------------------------------------- Carcinoma Total 0/1067(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/53 0/50 0/50 0/50 0/50 0/50 0/49 0/48 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/59 0/49 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/47 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1067(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/53 0/50 0/50 0/50 0/50 0/50 0/49 0/48 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/59 0/49 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/47 --------------------------------------------------------------------------- Sarcoma Total 1/1067(0.1%) 0/1071(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/53 0/50 0/50 0/50 0/50 0/50 0/49 0/48 0/48 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/59 0/49 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/49 0/50 0/50 0/47 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Papilloma Squamous or Total 0/1074(0%) 1/1077(0.1%) Papilloma Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1074(0.1%) 1/1077(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/1074(0.1%) 2/1077(0.2%) Carcinoma, Papilloma Mean(sd) 0.1%(0.4) 0.2%(0.6) Squamous, or Papilloma Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Squamous Cell Carcinoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 3/1055(0.3%) Mean(sd) 0.3%(1.0) Range 0/50 - 2/49 Females 0/50 0/58 1/49 0/58 0/57 0/48 2/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 1/1055(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/48 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 1/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 1/1055(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/48 Females 0/50 0/58 0/49 0/58 0/57 1/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Carcinoma Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Cystadenoma Total 26/1055(2.5%) Mean(sd) 2.5%(1.5) Range 0/49 - 2/47 Females 2/50 2/58 0/49 2/58 1/57 1/48 0/49 1/48 2/48 1/50 2/49 0/49 1/49 1/49 2/50 2/47 2/50 2/49 1/50 1/50 0/48 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 6/1055(0.6%) Benign Mean(sd) 0.6%(0.9) Range 0/50 - 1/48 Females 0/50 0/58 1/49 1/58 0/57 0/48 1/49 0/48 1/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 1/49 0/50 0/50 1/48 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/1055(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 6/1055(0.6%) Benign, Malignant, NOS Mean(sd) 0.6%(0.9) Range 0/50 - 1/48 Females 0/50 0/58 1/49 1/58 0/57 0/48 1/49 0/48 1/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 1/49 0/50 0/50 1/48 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/1055(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Hemangioma Total 3/1055(0.3%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/48 Females 0/50 0/58 0/49 0/58 0/57 1/48 1/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 1/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Liposarcoma Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Luteoma Total 6/1055(0.6%) Mean(sd) 0.6%(1.1) Range 0/50 - 2/49 Females 0/50 0/58 0/49 0/58 0/57 1/48 0/49 0/48 1/48 1/50 0/49 0/49 2/49 0/49 0/50 0/47 1/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Teratoma Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Teratoma Benign Total 4/1055(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/48 Females 0/50 0/58 0/49 0/58 1/57 0/48 0/49 0/48 1/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 1/50 0/50 1/48 --------------------------------------------------------------------------- Teratoma Malignant Total 1/1055(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 1/50 0/50 0/48 --------------------------------------------------------------------------- Teratoma NOS Total 0/1055(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Thecoma Benign Total 2/1055(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/49 Females 0/50 0/58 0/49 0/58 1/57 0/48 1/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 0/50 0/50 0/48 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 2/1055(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/49 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 1/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 1/50 0/50 0/48 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 2/1055(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/48 Females 0/50 0/58 0/49 0/58 0/57 0/48 0/49 0/48 0/48 0/50 0/49 0/49 0/49 0/49 0/50 0/47 0/50 0/49 1/50 0/50 1/48 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1059(0%) 0/1067(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Carcinoma Total 1/1059(0.1%) 2/1067(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/59 - 1/50 0/58 - 1/50 Males 1/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 1/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 1/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1059(0.1%) 2/1067(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/59 - 1/50 0/58 - 1/50 Males 1/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 1/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 1/49 0/47 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1059(0%) 1/1067(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 1/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1059(0%) 0/1067(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Hemangioma Total 0/1059(0%) 0/1067(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1059(0%) 1/1067(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 1/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- Sarcoma Total 0/1059(0%) 0/1067(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/49 0/60 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/48 0/47 0/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/59 0/60 0/49 0/49 0/49 0/50 0/50 0/50 0/48 0/50 0/51 0/49 0/50 0/50 0/50 0/50 0/49 0/47 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/751(0%) 1/737(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.7) Range 0/39 - 0/39 0/45 - 1/33 Males 0/39 0/54 0/31 0/48 0/36 0/39 0/39 0/35 0/19 0/36 0/34 0/39 0/21 0/29 0/26 0/41 0/32 0/22 0/43 0/47 0/41 Females 0/45 0/52 0/34 0/40 0/49 0/24 0/40 0/35 0/25 0/31 0/39 0/30 0/27 0/21 0/31 1/33 0/32 0/26 0/44 0/44 0/35 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Squamous Cell Papilloma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 5/1016(0.5%) 185/1052(17.6%) Mean(sd) 0.5%(0.9) 17.7%(8.8) Range 0/43 - 1/45 3/46 - 20/49 Males 0/43 0/56 0/49 0/52 0/54 0/46 1/50 1/49 0/48 0/47 0/48 1/45 1/46 0/47 0/49 1/47 0/50 0/44 0/49 0/47 0/50 Females 5/49 8/58 8/49 8/58 6/59 14/48 7/50 4/49 11/48 9/49 3/46 10/47 20/49 12/48 5/50 9/50 7/48 4/48 10/50 17/50 8/49 --------------------------------------------------------------------------- Carcinoma Total 1/1016(0.1%) 4/1052(0.4%) Mean(sd) 0.1%(0.4) 0.4%(0.8) Range 0/43 - 1/49 0/58 - 1/49 Males 0/43 0/56 1/49 0/52 0/54 0/46 0/50 0/49 0/48 0/47 0/48 0/45 0/46 0/47 0/49 0/47 0/50 0/44 0/49 0/47 0/50 Females 1/49 0/58 0/49 0/58 1/59 0/48 0/50 0/49 0/48 0/49 0/46 0/47 1/49 0/48 1/50 0/50 0/48 0/48 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 6/1016(0.6%) 189/1052(18%) Mean(sd) 0.6%(1.0) 18.1%(8.9) Range 0/43 - 1/45 3/46 - 21/49 Males 0/43 0/56 1/49 0/52 0/54 0/46 1/50 1/49 0/48 0/47 0/48 1/45 1/46 0/47 0/49 1/47 0/50 0/44 0/49 0/47 0/50 Females 6/49 8/58 8/49 8/58 7/59 14/48 7/50 4/49 11/48 9/49 3/46 10/47 21/49 12/48 6/50 9/50 7/48 4/48 10/50 17/50 8/49 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 3/1016(0.3%) 4/1052(0.4%) Mean(sd) 0.3%(0.8) 0.4%(1.1) Range 0/43 - 1/46 0/49 - 2/48 Males 0/43 0/56 0/49 0/52 0/54 1/46 0/50 0/49 0/48 0/47 0/48 0/45 1/46 0/47 0/49 0/47 0/50 0/44 0/49 1/47 0/50 Females 0/49 0/58 0/49 0/58 0/59 0/48 0/50 1/49 0/48 0/49 0/46 0/47 0/49 2/48 0/50 0/50 1/48 0/48 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/1016(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/49 - 0/49 Males 0/43 0/56 0/49 0/52 0/54 0/46 0/50 0/49 0/48 0/47 0/48 0/45 0/46 0/47 0/49 0/47 0/50 0/44 0/49 0/47 0/50 Females 0/49 0/58 0/49 0/58 0/59 0/48 0/50 0/49 0/48 0/49 0/46 0/47 0/49 0/48 0/50 0/50 0/48 0/48 0/50 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/1016(0.3%) 4/1052(0.4%) Mean(sd) 0.3%(0.8) 0.4%(1.1) Range 0/43 - 1/46 0/49 - 2/48 Males 0/43 0/56 0/49 0/52 0/54 1/46 0/50 0/49 0/48 0/47 0/48 0/45 1/46 0/47 0/49 0/47 0/50 0/44 0/49 1/47 0/50 Females 0/49 0/58 0/49 0/58 0/59 0/48 0/50 1/49 0/48 0/49 0/46 0/47 0/49 2/48 0/50 0/50 1/48 0/48 0/50 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1035(0%) Mean(sd) 0.0%(0.0) Range 0/45 - 0/45 Males 0/45 0/59 0/50 0/59 0/51 0/45 0/47 0/49 0/46 0/48 0/50 0/48 0/49 0/50 0/49 0/49 0/49 0/46 0/49 0/49 0/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1035(0%) Mean(sd) 0.0%(0.0) Range 0/45 - 0/45 Males 0/45 0/59 0/50 0/59 0/51 0/45 0/47 0/49 0/46 0/48 0/50 0/48 0/49 0/50 0/49 0/49 0/49 0/46 0/49 0/49 0/48 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1035(0%) Mean(sd) 0.0%(0.0) Range 0/45 - 0/45 Males 0/45 0/59 0/50 0/59 0/51 0/45 0/47 0/49 0/46 0/48 0/50 0/48 0/49 0/50 0/49 0/49 0/49 0/46 0/49 0/49 0/48 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangioma Total 0/1067(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/49 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/48 0/49 0/50 0/50 0/50 0/50 0/48 --------------------------------------------------------------------------- Sarcoma Total 0/1067(0%) 0/1071(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/59 0/49 0/60 0/55 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/49 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/48 0/49 0/50 0/50 0/50 0/50 0/48 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1074(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1074(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1074(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1074(0.1%) 1/1077(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/1074(0%) 1/1077(0.1%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Basal Cell Adenoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/1074(0%) 1/1077(0.1%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.1%(0.4) Benign Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/1074(0%) 1/1077(0.1%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.1%(0.4) Benign, or Range 0/50 - 0/50 0/50 - 1/50 Trichoepithelioma Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/1074(0%) 1/1077(0.1%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.1%(0.4) (malignant or NOS) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 1/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/1074(0%) 2/1077(0.2%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.2%(0.6) Basosquamous Tumor Range 0/50 - 0/50 0/50 - 1/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 1/60 0/60 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 1/1074(0.1%) 6/1077(0.6%) Carcinoma, Carcinoma, Mean(sd) 0.1%(0.4) 0.6%(0.9) Basosq. Tumor (M or B), Range 0/50 - 1/50 0/58 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/58 0/49 1/60 0/60 0/49 0/50 1/50 1/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/1074(0%) 0/1077(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/1074(0%) 1/1077(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/60 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 1/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) 1/1077(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/1074(0.3%) 6/1077(0.6%) Mean(sd) 0.3%(0.7) 0.6%(1.1) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 1/50 2/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/58 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 2/1074(0.2%) 0/1077(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/59 - 1/50 0/50 - 0/50 Males 1/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/1074(0%) 0/1077(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1074(0.1%) 2/1077(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/1074(0.1%) 3/1077(0.3%) Carcinoma, Basal Cell Mean(sd) 0.1%(0.4) 0.3%(0.7) Carcinoma, Basosquamous Range 0/50 - 1/50 0/50 - 1/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 1/60 0/60 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/1074(0%) 1/1077(0.1%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/1074(0.1%) 4/1077(0.4%) Papilloma, Papilloma, Mean(sd) 0.1%(0.4) 0.4%(0.8) Squamous Cell Carcinoma Range 0/50 - 1/50 0/58 - 1/50 or Keratoacanthoma Males 0/50 0/59 0/50 0/60 0/55 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/1074(0%) 2/1077(0.2%) Papilloma, Papilloma, or Mean(sd) 0.0%(0.0) 0.2%(0.6) Keratoacanthoma Range 0/50 - 0/50 0/58 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibroma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 10/1074(0.9%) 32/1077(3%) Sarcoma, Myxoma, Mean(sd) 0.9%(1.2) 2.9%(3.3) Myxosarcoma, or Fibrous Range 0/50 - 2/50 0/60 - 6/50 Histiocytoma Males 0/50 1/59 0/50 0/60 0/55 1/50 1/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 1/50 2/50 1/50 0/50 Females 1/50 2/58 1/49 5/60 0/60 0/49 1/50 0/50 6/50 0/50 4/50 0/50 3/50 1/51 3/50 1/50 1/50 0/50 0/50 1/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma Total 4/1074(0.4%) 10/1077(0.9%) Mean(sd) 0.4%(0.8) 0.8%(2.0) Range 0/50 - 1/50 0/60 - 5/60 Males 0/50 1/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 Females 1/50 2/58 1/49 5/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 10/1074(0.9%) 32/1077(3%) Myxosarcoma, or Fibrous Mean(sd) 0.9%(1.2) 2.9%(3.3) Histiocytoma Range 0/50 - 2/50 0/60 - 6/50 Males 0/50 1/59 0/50 0/60 0/55 1/50 1/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 1/50 2/50 1/50 0/50 Females 1/50 2/58 1/49 5/60 0/60 0/49 1/50 0/50 6/50 0/50 4/50 0/50 3/50 1/51 3/50 1/50 1/50 0/50 0/50 1/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/1074(0%) 1/1077(0.1%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.1%(0.4) NOS) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/1074(0%) 1/1077(0.1%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.1%(0.4) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 1/51 malignant or NOS) Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 6/1074(0.6%) 22/1077(2%) Mean(sd) 0.6%(0.9) 2.1%(3.2) Range 0/50 - 1/50 0/50 - 6/50 Males 0/50 0/59 0/50 0/60 0/55 1/50 1/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 1/50 1/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 1/50 0/50 6/50 0/50 4/50 0/50 2/50 1/51 3/50 1/50 1/50 0/50 0/50 1/50 2/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1063(0%) 1/1073(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/58 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/47 0/50 0/50 0/48 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 1/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1063(0%) 0/1073(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/47 0/50 0/50 0/48 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Hemangioma Total 1/1063(0.1%) 0/1073(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/47 0/50 0/50 0/48 0/48 1/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 8/1063(0.8%) 16/1073(1.5%) Mean(sd) 0.8%(1.2) 1.5%(1.8) Range 0/50 - 2/50 0/50 - 3/49 Males 0/50 0/59 0/50 0/60 1/54 0/49 0/50 0/50 1/47 1/50 2/50 0/48 1/48 0/50 0/50 1/49 0/50 0/50 1/50 0/49 0/50 Females 0/50 0/58 0/49 1/60 2/60 2/49 2/49 1/50 0/50 0/50 0/50 1/49 1/50 1/51 1/50 0/50 0/50 0/50 0/50 1/49 3/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/1063(0%) 1/1073(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/47 0/50 0/50 0/48 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 1/50 0/50 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/1063(0%) 0/1073(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/54 0/49 0/50 0/50 0/47 0/50 0/50 0/48 0/48 0/50 0/50 0/49 0/50 0/50 0/50 0/49 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/49 0/50 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangioma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1074(0%) 2/1077(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 7/1074(0.7%) 10/1077(0.9%) Carcinoma or Papilloma Mean(sd) 0.7%(1.0) 0.9%(1.1) Squamous Range 0/50 - 1/50 0/50 - 2/60 Males 0/50 0/59 0/50 0/60 1/55 0/50 1/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 1/50 Females 0/50 1/58 0/49 0/60 2/60 1/49 0/50 1/50 1/50 0/50 0/50 1/50 1/50 0/51 0/50 1/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 7/1074(0.7%) 8/1077(0.7%) Mean(sd) 0.7%(1.0) 0.7%(1.0) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 1/55 0/50 1/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 1/50 Females 0/50 1/58 0/49 0/60 1/60 1/49 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/51 0/50 1/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/1074(0.2%) 0/1077(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 7/1070(0.7%) Mean(sd) 0.7%(1.1) Range 0/50 - 2/50 Males 1/50 1/59 0/50 0/60 0/55 0/50 1/50 1/50 0/49 0/50 0/50 0/50 0/48 0/50 0/50 2/50 0/50 1/49 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1070(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/49 0/50 0/50 1/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Hemangioma Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/838(0.1%) 0/963(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/41 - 1/44 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 1/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/838(0%) 1/963(0.1%) Malignant Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/41 - 0/41 0/45 - 1/43 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 1/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Sarcoma Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Thymoma Benign Total 0/838(0%) 1/963(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/41 - 0/41 0/45 - 1/43 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 1/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Thymoma Malignant Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Thymoma NOS Total 0/838(0%) 0/963(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/41 - 0/41 0/45 - 0/45 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 0/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/838(0%) 1/963(0.1%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/41 - 0/41 0/45 - 1/43 Males 0/41 0/46 0/47 0/54 0/43 0/44 0/47 0/34 0/28 0/30 0/38 0/35 0/39 0/45 0/43 0/33 0/35 0/37 0/39 0/39 0/41 Females 0/45 0/58 0/49 0/57 0/56 0/44 0/46 0/44 0/41 0/40 0/43 0/40 0/45 0/47 0/46 1/43 0/42 0/42 0/41 0/47 0/47 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1063(0.1%) 1/1072(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/49 - 1/49 0/49 - 1/50 Males 0/49 0/59 0/48 0/60 0/53 1/49 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 Females 0/49 0/58 0/49 0/59 0/59 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/48 --------------------------------------------------------------------------- Carcinoma Total 0/1063(0%) 1/1072(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/59 0/48 0/60 0/53 0/49 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 Females 0/49 0/58 0/49 0/59 0/59 0/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1063(0.1%) 2/1072(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/49 - 1/49 0/49 - 1/50 Males 0/49 0/59 0/48 0/60 0/53 1/49 0/50 0/50 0/49 0/50 0/50 0/49 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 Females 0/49 0/58 0/49 0/59 0/59 0/49 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 31/1063(2.9%) 47/1072(4.4%) Mean(sd) 2.9%(2.3) 4.4%(2.5) Range 0/60 - 4/49 1/59 - 5/50 Males 1/49 4/59 1/48 0/60 2/53 2/49 2/50 1/50 0/49 1/50 1/50 4/49 1/48 1/50 2/50 1/50 1/50 3/50 3/50 0/49 0/50 Females 2/49 2/58 1/49 1/59 2/59 2/49 1/50 1/50 3/50 2/50 1/50 2/50 4/50 4/51 1/50 4/50 3/50 5/50 3/50 2/50 1/48 --------------------------------------------------------------------------- Carcinoma Total 4/1063(0.4%) 8/1072(0.7%) Mean(sd) 0.4%(0.8) 0.7%(1.5) Range 0/49 - 1/48 0/49 - 3/50 Males 0/49 0/59 0/48 0/60 0/53 0/49 0/50 0/50 0/49 1/50 1/50 0/49 1/48 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 Females 1/49 1/58 0/49 0/59 1/59 0/49 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 3/50 0/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 35/1063(3.3%) 55/1072(5.1%) Mean(sd) 3.3%(2.5) 5.1%(2.8) Range 0/60 - 4/49 1/59 - 5/50 Males 1/49 4/59 1/48 0/60 2/53 2/49 2/50 1/50 0/49 2/50 2/50 4/49 2/48 1/50 2/50 1/50 1/50 3/50 4/50 0/49 0/50 Females 3/49 3/58 1/49 1/59 3/59 2/49 1/50 1/50 4/50 2/50 1/50 3/50 4/50 4/51 1/50 4/50 3/50 5/50 3/50 5/50 1/48 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 1/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Squamous Cell Carcinoma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/1074(0%) 2/1077(0.2%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.2%(0.6) Squamous Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1074(0%) 1/1077(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adamantinoma Benign Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 4/1074(0.4%) 2/1077(0.2%) Mean(sd) 0.4%(0.8) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma or Papilloma Total 1/1053(0.1%) 0/1041(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/59 0/50 0/59 0/52 0/49 0/50 0/50 0/46 0/50 0/49 0/48 0/47 0/50 0/50 0/48 0/50 0/48 0/50 1/50 0/49 Females 0/50 0/56 0/48 0/59 0/60 0/48 0/47 0/50 0/48 0/48 0/48 0/47 0/48 0/49 0/47 0/49 0/49 0/47 0/49 0/49 0/45 --------------------------------------------------------------------------- Hemangioma Total 0/1053(0%) 0/1041(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/59 0/50 0/59 0/52 0/49 0/50 0/50 0/46 0/50 0/49 0/48 0/47 0/50 0/50 0/48 0/50 0/48 0/50 0/50 0/49 Females 0/50 0/56 0/48 0/59 0/60 0/48 0/47 0/50 0/48 0/48 0/48 0/47 0/48 0/49 0/47 0/49 0/49 0/47 0/49 0/49 0/45 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1053(0%) 0/1041(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/59 0/50 0/59 0/52 0/49 0/50 0/50 0/46 0/50 0/49 0/48 0/47 0/50 0/50 0/48 0/50 0/48 0/50 0/50 0/49 Females 0/50 0/56 0/48 0/59 0/60 0/48 0/47 0/50 0/48 0/48 0/48 0/47 0/48 0/49 0/47 0/49 0/49 0/47 0/49 0/49 0/45 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/1053(0.1%) 0/1041(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/49 - 1/59 0/50 - 0/50 Males 0/49 1/59 0/50 0/59 0/52 0/49 0/50 0/50 0/46 0/50 0/49 0/48 0/47 0/50 0/50 0/48 0/50 0/48 0/50 0/50 0/49 Females 0/50 0/56 0/48 0/59 0/60 0/48 0/47 0/50 0/48 0/48 0/48 0/47 0/48 0/49 0/47 0/49 0/49 0/47 0/49 0/49 0/45 --------------------------------------------------------------------------- Papilloma Total 1/1053(0.1%) 0/1041(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/49 - 1/50 0/50 - 0/50 Males 0/49 0/59 0/50 0/59 0/52 0/49 0/50 0/50 0/46 0/50 0/49 0/48 0/47 0/50 0/50 0/48 0/50 0/48 0/50 1/50 0/49 Females 0/50 0/56 0/48 0/59 0/60 0/48 0/47 0/50 0/48 0/48 0/48 0/47 0/48 0/49 0/47 0/49 0/49 0/47 0/49 0/49 0/45 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 3/1077(0.3%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/49 Females 0/50 0/58 1/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 1/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1077(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 1/1077(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 1/1077(0.1%) Benign Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 7/1077(0.6%) Mean(sd) 0.7%(1.1) Range 0/50 - 2/50 Females 0/50 1/58 1/49 0/60 0/60 1/49 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 2/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/1077(0.2%) Mean(sd) 0.2%(0.9) Range 0/50 - 2/49 Females 0/50 0/58 0/49 0/60 0/60 2/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 5/1077(0.5%) Mean(sd) 0.4%(0.8) Range 0/58 - 1/50 Females 1/50 0/58 0/49 1/60 1/60 0/49 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 3/1077(0.3%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/51 0/50 0/50 1/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 39/1077(3.6%) Mean(sd) 3.6%(2.2) Range 0/49 - 4/50 Females 1/50 1/58 0/49 2/60 2/60 2/49 2/50 2/50 0/50 4/50 1/50 1/50 3/50 3/51 1/50 4/50 2/50 2/50 2/50 1/50 3/50 --------------------------------------------------------------------------- Sarcoma Total 0/1077(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 4/1077(0.4%) Mean(sd) 0.4%(1.0) Range 0/50 - 2/50 Females 0/50 0/58 0/49 0/60 1/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/50 2/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 43/1077(4%) Polyp Stromal Mean(sd) 4.0%(2.4) Range 0/49 - 4/50 Females 1/50 1/58 0/49 2/60 3/60 2/49 2/50 2/50 0/50 4/50 1/50 1/50 3/50 4/51 1/50 4/50 2/50 2/50 2/50 3/50 3/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Leiomyosarcoma Total 1/1077(0.1%) Mean(sd) 0.1%(0.4) Range 0/50 - 1/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1077(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1077(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1074(0%) 0/1077(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/1074(0.1%) 0/1077(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/59 0/50 0/60 0/55 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/58 0/49 0/60 0/60 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/50 0/50 0/50 ---------------------------------------------------------------------------