TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Benign Tumors Total 539/952(56.6%) 433/953(45.4%) Mean(sd) 56.6%(9.0) 45.4%(10.8) Range 20/50 - 38/50 12/50 - 31/50 Males 34/50 33/50 38/50 21/50 25/50 29/50 26/52 30/50 28/50 25/50 31/50 20/50 30/50 29/50 24/50 30/50 33/50 26/50 27/50 Females 26/50 14/50 21/51 22/50 12/50 31/50 27/50 26/52 29/50 20/49 19/49 22/50 27/51 26/50 21/50 29/50 22/51 26/50 13/50 --------------------------------------------------------------------------- Malignant Tumors Total 374/952(39.3%) 383/953(40.2%) Mean(sd) 39.3%(7.8) 40.2%(6.1) Range 14/50 - 31/50 14/49 - 25/50 Males 20/50 17/50 20/50 17/50 25/50 16/50 22/52 17/50 24/50 14/50 19/50 18/50 17/50 19/50 31/50 17/50 21/50 22/50 18/50 Females 15/50 21/50 23/51 20/50 23/50 20/50 22/50 16/52 17/50 14/49 22/49 23/50 23/51 25/50 22/50 18/50 18/51 20/50 21/50 --------------------------------------------------------------------------- Malignant and Benign Total 725/952(76.2%) 656/953(68.8%) Tumors Mean(sd) 76.2%(7.6) 68.8%(7.0) Range 31/50 - 46/50 28/50 - 40/50 Males 41/50 38/50 46/50 32/50 37/50 38/50 37/52 37/50 42/50 31/50 41/50 33/50 38/50 40/50 43/50 37/50 39/50 40/50 35/50 Females 34/50 31/50 37/51 34/50 29/50 39/50 40/50 35/52 35/50 29/49 34/49 36/50 38/51 40/50 34/50 37/50 32/51 34/50 28/50 --------------------------------------------------------------------------- Hemangioma Total 7/952(0.7%) 14/953(1.5%) Mean(sd) 0.7%(1.2) 1.5%(1.7) Range 0/50 - 2/50 0/50 - 2/49 Males 0/50 0/50 0/50 0/50 0/50 1/50 1/52 0/50 0/50 0/50 0/50 0/50 1/50 0/50 1/50 0/50 2/50 1/50 0/50 Females 0/50 0/50 1/51 0/50 0/50 2/50 0/50 1/52 2/50 1/49 2/49 0/50 2/51 2/50 0/50 0/50 0/51 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 53/952(5.6%) 31/953(3.3%) Mean(sd) 5.6%(3.5) 3.3%(2.4) Range 1/50 - 7/50 0/52 - 4/50 Males 2/50 2/50 1/50 1/50 4/50 3/50 5/52 2/50 2/50 1/50 4/50 6/50 1/50 3/50 3/50 1/50 7/50 3/50 2/50 Females 1/50 1/50 2/51 2/50 3/50 1/50 4/50 0/52 0/50 1/49 3/49 4/50 2/51 0/50 1/50 1/50 2/51 2/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 60/952(6.3%) 44/953(4.6%) Hemangioma Mean(sd) 6.3%(4.2) 4.6%(2.3) Range 1/50 - 9/50 1/52 - 4/49 Males 2/50 2/50 1/50 1/50 4/50 4/50 6/52 2/50 2/50 1/50 4/50 6/50 2/50 3/50 4/50 1/50 9/50 4/50 2/50 Females 1/50 1/50 3/51 2/50 3/50 3/50 4/50 1/52 2/50 2/49 4/49 4/50 4/51 2/50 1/50 1/50 2/51 3/50 1/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 4/952(0.4%) 16/953(1.7%) Mean(sd) 0.4%(0.8) 1.7%(1.7) Range 0/50 - 1/50 0/50 - 2/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 1/50 0/50 1/50 0/50 Females 2/50 0/50 0/51 0/50 0/50 2/50 1/50 1/52 0/50 0/49 2/49 1/50 1/51 0/50 1/50 1/50 2/51 0/50 2/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/952(0%) 0/953(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 71/952(7.5%) 167/953(17.5%) Histiocytic, Mean(sd) 7.5%(3.8) 17.5%(7.7) Lymphocytic, Mixed, NOS, Range 1/50 - 7/50 3/51 - 15/50 or Undifferentiated Cell Type Males 7/50 1/50 5/50 6/50 5/50 4/50 3/52 2/50 2/50 2/50 3/50 2/50 2/50 6/50 5/50 2/50 4/50 7/50 3/50 Females 7/50 9/50 15/51 12/50 9/50 5/50 4/50 5/52 8/50 7/49 12/49 9/50 13/51 15/50 9/50 3/50 3/51 8/50 14/50 --------------------------------------------------------------------------- Osteoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/952(0.1%) 3/953(0.3%) Mean(sd) 0.1%(0.5) 0.3%(1.0) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 2/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/952(0.1%) 3/953(0.3%) Mean(sd) 0.1%(0.5) 0.3%(1.0) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 2/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 38/945(4%) 9/951(0.9%) Mean(sd) 4.0%(6.0) 0.9%(2.0) Range 0/49 - 11/50 0/50 - 3/50 Males 0/49 1/50 0/49 0/50 0/50 7/50 2/52 1/48 4/50 0/50 2/49 0/50 11/50 1/49 1/50 6/49 1/50 1/50 0/50 Females 0/50 0/50 0/51 3/50 2/50 0/50 3/50 0/51 0/50 0/49 0/49 0/49 1/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/945(0%) 1/951(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/52 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/51 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/945(0%) 1/951(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/52 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 1/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/945(0%) 0/951(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/52 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 11/846(1.3%) 0/851(0%) Mean(sd) 1.2%(4.6) 0.0%(0.0) Range 0/49 - 10/50 0/50 - 0/50 Males 0/49 0/50 10/50 1/50 0/50 0/50 0/52 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/0 0/49 0/50 0/50 0/0 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/49 0/51 0/50 0/0 0/50 0/51 0/50 0/0 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Pheochromocytoma Benign Total 6/944(0.6%) 7/944(0.7%) Mean(sd) 0.6%(1.1) 0.7%(1.2) Range 0/49 - 2/52 0/49 - 2/50 Males 0/49 0/50 0/49 0/50 0/50 1/50 2/52 0/49 0/50 0/50 1/48 0/50 0/50 0/49 1/50 0/49 0/50 0/50 1/49 Females 0/49 0/50 1/51 0/47 0/49 1/50 2/50 0/51 1/50 0/49 0/49 1/49 0/49 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/944(0%) 0/944(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/49 Females 0/49 0/50 0/51 0/47 0/49 0/50 0/50 0/51 0/50 0/49 0/49 0/49 0/49 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 1/944(0.1%) 2/944(0.2%) Malignant Mean(sd) 0.1%(0.5) 0.2%(0.6) Range 0/49 - 1/50 0/49 - 1/50 Males 0/49 0/50 0/49 0/50 0/50 0/50 0/52 0/49 1/50 0/50 0/48 0/50 0/50 0/49 0/50 0/49 0/50 0/50 0/49 Females 0/49 1/50 0/51 0/47 0/49 0/50 0/50 0/51 0/50 0/49 0/49 0/49 0/49 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 7/944(0.7%) 9/944(1%) Benign, Complex, Mean(sd) 0.7%(1.2) 0.9%(1.2) Malignant, NOS Range 0/49 - 2/52 0/49 - 2/50 Males 0/49 0/50 0/49 0/50 0/50 1/50 2/52 0/49 1/50 0/50 1/48 0/50 0/50 0/49 1/50 0/49 0/50 0/50 1/49 Females 0/49 1/50 1/51 0/47 0/49 1/50 2/50 0/51 1/50 0/49 0/49 1/49 0/49 0/50 1/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/951(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/951(0%) 2/951(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 0/48 0/50 0/51 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 5/951(0.5%) 2/951(0.2%) Mean(sd) 0.5%(1.1) 0.2%(0.6) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 2/50 0/52 0/49 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 1/51 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 2/951(0.2%) 0/951(0%) Malignant Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/951(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/951(0%) 0/951(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrosarcoma Total 1/952(0.1%) 2/953(0.2%) Mean(sd) 0.1%(0.5) 0.2%(0.9) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 2/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/952(0.1%) 3/953(0.3%) Mean(sd) 0.1%(0.5) 0.3%(1.0) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 2/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/952(0.1%) 3/953(0.3%) Mean(sd) 0.1%(0.5) 0.3%(1.0) Range 0/50 - 1/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 2/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Astrocytoma Benign Total 0/951(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/951(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/951(0%) 0/951(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/951(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 1/951(0.1%) 0/951(0%) Malignant Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 1/951(0.1%) 0/951(0%) Glioma, or Astrocytoma Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/951(0%) 1/951(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/51 0/50 0/50 0/49 0/50 0/52 0/50 0/49 0/49 0/49 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Hemangiosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Basosquamous Tumor Total 0/952(0%) 0/953(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/951(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/951(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/951(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/951(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 2/889(0.2%) 0/914(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/34 - 1/48 0/43 - 0/43 Males 0/34 0/43 0/42 0/48 0/48 0/49 1/51 0/48 0/47 0/45 0/46 0/48 0/50 0/50 1/48 0/47 0/48 0/47 0/50 Females 0/43 0/45 0/51 0/48 0/50 0/48 0/49 0/49 0/50 0/47 0/44 0/50 0/50 0/45 0/47 0/50 0/50 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 45/902(5%) 29/903(3.2%) Mean(sd) 4.7%(2.9) 3.0%(2.9) Range 0/50 - 4/50 0/50 - 5/50 Males 3/50 4/50 4/50 0/50 1/50 0/0 0/52 3/50 4/50 3/50 4/50 1/50 1/50 3/50 4/50 2/50 3/50 2/50 3/50 Females 1/50 0/50 2/51 1/50 0/50 0/0 5/50 2/52 3/50 3/49 1/49 3/50 0/51 2/50 0/50 1/50 0/51 3/50 2/50 --------------------------------------------------------------------------- Carcinoma Total 8/902(0.9%) 9/903(1%) Mean(sd) 0.8%(1.2) 0.9%(1.4) Range 0/50 - 2/50 0/50 - 2/50 Males 0/50 0/50 1/50 1/50 0/50 0/0 1/52 1/50 0/50 0/50 1/50 0/50 2/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 0/50 0/0 0/50 1/52 0/50 0/49 0/49 0/50 1/51 2/50 1/50 1/50 0/51 2/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 53/902(5.9%) 38/903(4.2%) Mean(sd) 5.6%(2.9) 35.6%(136.7) Range 0/0 - 5/50 0/50 - 0/0 Males 3/50 4/50 5/50 1/50 1/50 0/0 1/52 4/50 4/50 3/50 5/50 1/50 3/50 3/50 4/50 3/50 3/50 2/50 3/50 Females 1/50 0/50 3/51 1/50 0/50 0/0 5/50 3/52 3/50 3/49 1/49 3/50 1/51 4/50 1/50 2/50 0/51 5/50 2/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/952(0%) 1/952(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/952(0.2%) 1/952(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 1/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 1/50 0/51 0/50 0/50 1/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 2/952(0.2%) 2/953(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 7/952(0.7%) 4/953(0.4%) Mean(sd) 0.7%(1.7) 0.4%(1.1) Range 0/50 - 3/50 0/50 - 2/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 2/50 1/50 0/50 3/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 1/50 0/50 2/50 0/50 0/52 1/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 8/952(0.8%) 6/953(0.6%) Mean(sd) 0.8%(1.7) 0.6%(1.5) Range 0/50 - 3/50 0/50 - 3/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 2/50 1/50 0/50 3/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 Females 0/50 1/50 0/51 1/50 0/50 3/50 0/50 0/52 1/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 8/952(0.8%) 6/953(0.6%) Mean(sd) 0.8%(1.7) 0.6%(1.5) Range 0/50 - 3/50 0/50 - 3/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 2/50 1/50 0/50 3/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 Females 0/50 1/50 0/51 1/50 0/50 3/50 0/50 0/52 1/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 2/952(0.2%) 2/953(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 1/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 12/940(1.3%) 11/945(1.2%) Mean(sd) 1.3%(1.4) 1.2%(1.7) Range 0/50 - 2/50 0/50 - 3/50 Males 2/50 1/50 0/50 0/50 0/47 2/50 1/52 1/49 0/50 0/49 1/50 0/50 0/50 1/50 0/49 0/49 1/50 1/45 1/50 Females 1/50 0/50 0/51 0/49 1/49 2/50 0/50 1/51 3/50 0/49 1/48 0/50 0/50 0/49 0/48 0/50 1/51 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 3/940(0.3%) 1/945(0.1%) Mean(sd) 0.3%(0.8) 0.1%(0.5) Range 0/50 - 1/47 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/47 0/50 0/52 0/49 0/50 0/49 0/50 0/50 1/50 0/50 0/49 0/49 0/50 0/45 1/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 1/50 0/51 0/50 0/49 0/48 0/50 0/50 0/49 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 15/940(1.6%) 12/945(1.3%) Mean(sd) 1.6%(1.4) 1.3%(1.7) Range 0/50 - 2/50 0/50 - 3/50 Males 2/50 1/50 0/50 0/50 1/47 2/50 1/52 1/49 0/50 0/49 1/50 0/50 1/50 1/50 0/49 0/49 1/50 1/45 2/50 Females 1/50 0/50 0/51 0/49 1/49 2/50 1/50 1/51 3/50 0/49 1/48 0/50 0/50 0/49 0/48 0/50 1/51 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 1/950(0.1%) 0/950(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/950(0.1%) 0/950(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/950(0%) 0/950(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/950(0%) 0/950(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/950(0.1%) 2/950(0.2%) Mean(sd) 0.1%(0.5) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/51 1/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 1/950(0.1%) 0/950(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/950(0.2%) 2/950(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 1/50 1/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/51 1/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/950(0%) 0/950(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/950(0%) 0/950(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/950(0%) 0/950(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/49 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Cholangiocarcinoma Total 2/950(0.2%) 0/951(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 1/49 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Cholangioma Total 0/950(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/950(0%) 1/951(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 2/950(0.2%) 2/951(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 1/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 23/950(2.4%) 7/951(0.7%) Mean(sd) 2.4%(2.1) 0.7%(1.0) Range 0/52 - 3/50 0/50 - 1/51 Males 1/50 1/50 1/50 1/50 2/50 2/50 0/52 1/49 0/50 0/50 3/50 0/50 0/50 1/50 3/50 1/49 3/50 2/50 1/50 Females 0/50 0/50 1/51 1/50 0/50 1/50 0/50 0/51 0/50 1/49 1/49 1/50 0/51 0/50 0/50 0/50 1/51 0/50 0/49 --------------------------------------------------------------------------- Hepatoblastoma Total 2/950(0.2%) 2/951(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/50 1/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 1/50 0/49 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 363/950(38.2%) 218/951(22.9%) Mean(sd) 38.2%(10.7) 22.9%(9.9) Range 9/50 - 30/50 6/50 - 25/50 Males 23/50 25/50 30/50 17/50 21/50 14/50 18/52 18/49 10/50 16/50 18/50 17/50 17/50 22/50 9/50 17/49 28/50 22/50 21/50 Females 12/50 7/50 12/51 10/50 7/50 14/50 12/50 16/51 6/50 7/49 6/49 11/50 17/51 17/50 9/50 25/50 9/51 15/50 6/49 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 194/950(20.4%) 104/951(10.9%) Mean(sd) 20.4%(6.7) 10.9%(4.6) Range 5/50 - 20/50 2/49 - 10/50 Males 13/50 12/50 9/50 5/50 9/50 7/50 15/52 11/49 12/50 7/50 10/50 8/50 11/50 8/50 20/50 9/49 8/50 12/50 8/50 Females 5/50 7/50 3/51 4/50 5/50 5/50 10/50 5/51 10/50 5/49 5/49 4/50 4/51 6/50 4/50 9/50 8/51 3/50 2/49 --------------------------------------------------------------------------- Hepatocellular Total 196/950(20.6%) 106/951(11.1%) Carcinoma or Mean(sd) 20.6%(7.0) 11.1%(4.5) Hepatoblastoma Range 5/50 - 21/50 2/49 - 10/50 Males 13/50 12/50 9/50 5/50 9/50 7/50 15/52 11/49 12/50 7/50 10/50 8/50 11/50 8/50 21/50 9/49 8/50 12/50 9/50 Females 5/50 7/50 3/51 4/50 5/50 6/50 10/50 5/51 10/50 5/49 5/49 4/50 4/51 6/50 4/50 9/50 8/51 4/50 2/49 --------------------------------------------------------------------------- Hepatocellular Total 493/950(51.9%) 292/951(30.7%) Carcinoma or Mean(sd) 51.9%(7.9) 30.6%(10.2) Hepatocellular Adenoma Range 20/50 - 34/50 6/49 - 28/50 Males 29/50 30/50 34/50 20/50 25/50 21/50 28/52 27/49 22/50 21/50 24/50 22/50 25/50 27/50 28/50 23/49 31/50 31/50 25/50 Females 16/50 13/50 13/51 13/50 10/50 17/50 21/50 20/51 14/50 10/49 9/49 15/50 20/51 21/50 13/50 28/50 17/51 16/50 6/49 --------------------------------------------------------------------------- Hepatocellular Total 495/950(52.1%) 292/951(30.7%) Carcinoma, Mean(sd) 52.1%(7.9) 30.6%(10.2) Hepatocellular Adenoma, Range 20/50 - 34/50 6/49 - 28/50 or Hepatoblastoma Males 29/50 30/50 34/50 20/50 25/50 21/50 28/52 27/49 22/50 21/50 24/50 22/50 25/50 27/50 29/50 23/49 31/50 31/50 26/50 Females 16/50 13/50 13/51 13/50 10/50 17/50 21/50 20/51 14/50 10/49 9/49 15/50 20/51 21/50 13/50 28/50 17/51 16/50 6/49 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/950(0%) 1/951(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/950(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 1/950(0.1%) 1/951(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 1/49 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/950(0%) 0/951(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/950(0%) 0/951(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/950(0%) 0/951(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 1/950(0.1%) 0/951(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 1/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 172/952(18.1%) 53/952(5.6%) Adenoma Mean(sd) 18.1%(6.7) 5.6%(2.6) Range 3/50 - 15/50 1/50 - 5/49 Males 15/50 11/50 7/50 3/50 6/50 5/50 7/52 12/50 9/50 13/50 14/50 6/50 6/50 8/50 9/50 11/50 12/50 7/50 11/50 Females 1/50 4/50 2/51 4/50 2/50 4/50 2/50 3/52 1/50 5/49 1/48 3/50 2/51 3/50 4/50 4/50 3/51 4/50 1/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 72/952(7.6%) 31/952(3.3%) Carcinoma Mean(sd) 7.6%(5.2) 3.2%(3.0) Range 1/52 - 10/50 0/50 - 4/50 Males 1/50 4/50 5/50 6/50 7/50 1/50 1/52 3/50 5/50 1/50 4/50 1/50 3/50 3/50 10/50 2/50 3/50 4/50 8/50 Females 1/50 1/50 4/51 0/50 1/50 2/50 4/50 2/52 0/50 0/49 0/48 0/50 0/51 4/50 2/50 1/50 2/51 4/50 3/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 236/952(24.8%) 81/952(8.5%) Carcinoma or Mean(sd) 24.8%(7.0) 8.5%(3.6) Alveolar/Bronchiolar Range 6/50 - 18/50 1/50 - 7/50 Adenoma Males 15/50 14/50 12/50 9/50 13/50 6/50 8/52 15/50 14/50 14/50 16/50 7/50 8/50 11/50 18/50 13/50 15/50 11/50 17/50 Females 2/50 5/50 6/51 4/50 3/50 6/50 5/50 5/52 1/50 5/49 1/48 3/50 2/51 6/50 6/50 5/50 5/51 7/50 4/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/952(0%) 1/952(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/952(0.1%) 0/952(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 1/952(0.1%) 0/952(0%) Malignant Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/48 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/952(0%) 0/953(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/952(0%) 0/953(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrous Histiocytoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 1/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 1/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/952(0%) 4/953(0.4%) Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 1/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 1/50 1/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/952(0%) 2/953(0.2%) or Adenoma Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 1/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/952(0%) 4/953(0.4%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 0.4%(0.8) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 1/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 1/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 1/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/952(0.1%) 1/953(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 1/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 1/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 1/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/952(0.1%) 2/953(0.2%) Mean(sd) 0.1%(0.5) 0.2%(0.6) Range 0/50 - 1/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 1/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/951(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/951(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/951(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/951(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Papilloma Squamous or Total 2/952(0.2%) 0/953(0%) Papilloma Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 3/952(0.3%) 0/953(0%) Carcinoma, Papilloma Mean(sd) 0.3%(0.7) 0.0%(0.0) Squamous, or Papilloma Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Squamous Cell Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 6/927(0.6%) Mean(sd) 0.6%(1.3) Range 0/50 - 2/49 Females 2/49 0/50 0/51 0/48 0/50 1/49 0/48 2/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 1/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Carcinoma Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Cystadenoma Total 18/927(1.9%) Mean(sd) 2.0%(1.9) Range 0/49 - 3/49 Females 0/49 1/50 2/51 1/48 0/50 1/49 0/48 0/51 0/49 2/47 1/46 1/50 0/50 0/50 1/45 1/50 2/50 3/49 2/45 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/927(0.1%) Mean(sd) 0.1%(0.5) Range 0/49 - 1/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 1/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 4/927(0.4%) Benign Mean(sd) 0.4%(0.8) Range 0/51 - 1/49 Females 1/49 1/50 0/51 0/48 0/50 0/49 0/48 0/51 1/49 0/47 0/46 0/50 0/50 1/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 2/927(0.2%) Malignant Mean(sd) 0.2%(0.6) Range 0/49 - 1/48 Females 0/49 0/50 0/51 0/48 0/50 0/49 1/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 1/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 6/927(0.6%) Benign, Malignant, NOS Mean(sd) 0.6%(1.0) Range 0/51 - 1/48 Females 1/49 1/50 0/51 0/48 0/50 0/49 1/48 0/51 1/49 0/47 0/46 0/50 0/50 1/50 0/45 1/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 1/927(0.1%) Malignant Mean(sd) 0.1%(0.5) Range 0/49 - 1/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 1/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Hemangioma Total 2/927(0.2%) Mean(sd) 0.2%(0.9) Range 0/49 - 2/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 2/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Liposarcoma Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Luteoma Total 3/927(0.3%) Mean(sd) 0.3%(1.0) Range 0/49 - 2/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 2/50 1/50 0/49 0/45 --------------------------------------------------------------------------- Teratoma Total 1/927(0.1%) Mean(sd) 0.1%(0.5) Range 0/49 - 1/48 Females 0/49 0/50 0/51 1/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Teratoma Benign Total 2/927(0.2%) Mean(sd) 0.2%(0.6) Range 0/49 - 1/47 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 1/47 0/46 0/50 0/50 1/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Teratoma Malignant Total 1/927(0.1%) Mean(sd) 0.1%(0.5) Range 0/49 - 1/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 1/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Teratoma NOS Total 2/927(0.2%) Mean(sd) 0.2%(0.7) Range 0/49 - 1/46 Females 0/49 0/50 0/51 0/48 0/50 0/49 1/48 0/51 0/49 0/47 1/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Thecoma Benign Total 1/927(0.1%) Mean(sd) 0.1%(0.5) Range 0/49 - 1/50 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 1/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/927(0%) Mean(sd) 0.0%(0.0) Range 0/49 - 0/49 Females 0/49 0/50 0/51 0/48 0/50 0/49 0/48 0/51 0/49 0/47 0/46 0/50 0/50 0/50 0/45 0/50 0/50 0/49 0/45 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/940(0%) 0/946(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/940(0%) 1/946(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 1/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/940(0%) 1/946(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 1/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/940(0%) 0/946(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/940(0%) 1/946(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/49 - 0/49 0/50 - 1/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 1/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/940(0.1%) 0/946(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/49 - 1/46 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 1/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/940(0%) 0/946(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/940(0%) 0/946(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 0/50 0/50 0/48 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/46 0/50 Females 0/50 0/50 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/49 0/48 0/50 0/50 0/50 0/48 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 0/840(0%) 0/816(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/36 - 0/36 0/36 - 0/36 Males 0/36 0/38 0/46 0/47 0/44 0/50 0/52 0/47 0/42 0/41 0/39 0/50 0/49 0/46 0/44 0/48 0/49 0/31 0/41 Females 0/36 0/33 0/47 0/41 0/47 0/50 0/46 0/44 0/48 0/33 0/39 0/40 0/46 0/46 0/44 0/46 0/46 0/45 0/39 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Squamous Cell Papilloma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 5/899(0.6%) 90/915(9.8%) Mean(sd) 0.6%(1.5) 9.8%(6.0) Range 0/46 - 3/48 0/46 - 11/48 Males 0/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 3/48 0/49 0/48 0/46 0/47 0/48 0/40 1/48 1/46 0/45 0/48 Females 11/48 0/46 2/48 7/49 1/49 7/49 6/46 4/50 9/48 2/48 7/48 7/48 6/48 3/49 4/46 2/50 5/49 3/49 4/47 --------------------------------------------------------------------------- Carcinoma Total 0/899(0%) 1/915(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/46 - 0/46 0/48 - 1/48 Males 0/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 0/48 0/49 0/48 0/46 0/47 0/48 0/40 0/48 0/46 0/45 0/48 Females 0/48 0/46 0/48 0/49 0/49 0/49 0/46 0/50 0/48 0/48 0/48 1/48 0/48 0/49 0/46 0/50 0/49 0/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/899(0.6%) 91/915(9.9%) Mean(sd) 0.6%(1.5) 10.0%(6.1) Range 0/46 - 3/48 0/46 - 11/48 Males 0/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 3/48 0/49 0/48 0/46 0/47 0/48 0/40 1/48 1/46 0/45 0/48 Females 11/48 0/46 2/48 7/49 1/49 7/49 6/46 4/50 9/48 2/48 7/48 8/48 6/48 3/49 4/46 2/50 5/49 3/49 4/47 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/899(0.1%) 4/915(0.4%) Mean(sd) 0.1%(0.5) 0.4%(0.9) Range 0/46 - 1/48 0/46 - 1/48 Males 0/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 0/48 0/49 0/48 0/46 0/47 1/48 0/40 0/48 0/46 0/45 0/48 Females 1/48 0/46 0/48 0/49 0/49 1/49 0/46 0/50 0/48 0/48 1/48 0/48 0/48 1/49 0/46 0/50 0/49 0/49 0/47 --------------------------------------------------------------------------- Carcinoma Total 1/899(0.1%) 2/915(0.2%) Mean(sd) 0.1%(0.5) 0.2%(0.7) Range 0/50 - 1/46 0/48 - 1/46 Males 1/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 0/48 0/49 0/48 0/46 0/47 0/48 0/40 0/48 0/46 0/45 0/48 Females 0/48 0/46 0/48 0/49 0/49 0/49 0/46 0/50 0/48 0/48 0/48 0/48 1/48 0/49 1/46 0/50 0/49 0/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/899(0.2%) 6/915(0.7%) Mean(sd) 0.2%(0.7) 0.7%(1.0) Range 0/50 - 1/46 0/46 - 1/46 Males 1/46 0/50 0/46 0/49 0/50 0/47 0/50 0/48 0/48 0/49 0/48 0/46 0/47 1/48 0/40 0/48 0/46 0/45 0/48 Females 1/48 0/46 0/48 0/49 0/49 1/49 0/46 0/50 0/48 0/48 1/48 0/48 1/48 1/49 1/46 0/50 0/49 0/49 0/47 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma Total 0/944(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Males 0/46 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/944(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Males 0/46 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/944(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Males 0/46 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/49 0/49 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Hemangioma Total 0/950(0%) 0/948(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/49 0/50 0/49 0/49 0/52 0/50 0/49 0/49 0/50 0/51 0/49 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/950(0%) 0/948(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/49 0/50 0/49 0/49 0/52 0/50 0/49 0/49 0/50 0/51 0/49 0/50 0/50 0/51 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/952(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/50 Males 1/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrosarcoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 1/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/952(0.2%) 1/953(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/952(0%) 1/953(0.1%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/952(0.1%) 1/953(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 1/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/952(0.1%) 3/953(0.3%) Mean(sd) 0.1%(0.5) 0.3%(0.7) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 1/52 0/50 0/49 0/49 0/50 1/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Basal Cell Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/952(0%) 0/953(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/952(0%) 0/953(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign, or Range 0/50 - 0/50 0/50 - 0/50 Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 1/952(0.1%) 1/953(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 1/952(0.1%) 1/953(0.1%) or Basosquamous Tumor Mean(sd) 0.1%(0.5) 0.1%(0.5) (malignant or NOS) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 1/952(0.1%) 1/953(0.1%) Basal Cell Adenoma, Mean(sd) 0.1%(0.5) 0.1%(0.5) Basosquamous Tumor Range 0/50 - 1/50 0/50 - 1/51 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 2/952(0.2%) 2/953(0.2%) Carcinoma, Carcinoma, Mean(sd) 0.2%(0.6) 0.2%(0.6) Basosq. Tumor (M or B), Range 0/50 - 1/50 0/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/952(0%) 0/953(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/952(0%) 0/953(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 4/953(0.4%) Mean(sd) 0.0%(0.0) 0.4%(1.1) Range 0/50 - 0/50 0/50 - 2/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/52 1/50 0/49 0/49 0/50 2/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 8/952(0.8%) 3/953(0.3%) Mean(sd) 0.8%(1.2) 0.3%(0.7) Range 0/50 - 2/50 0/50 - 1/50 Males 0/50 1/50 0/50 0/50 0/50 1/50 1/52 0/50 1/50 0/50 0/50 1/50 0/50 1/50 0/50 0/50 2/50 0/50 0/50 Females 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 1/50 0/51 1/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 2/952(0.2%) 0/953(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 2/952(0.2%) 0/953(0%) Malignant Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/952(0.1%) 1/953(0.1%) Carcinoma, Basal Cell Mean(sd) 0.1%(0.5) 0.1%(0.5) Carcinoma, Basosquamous Range 0/50 - 1/50 0/50 - 1/51 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/952(0.1%) 1/953(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/952(0.1%) 1/953(0.1%) Papilloma or Papilloma Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/952(0.1%) 1/953(0.1%) Papilloma, Papilloma, Mean(sd) 0.1%(0.5) 0.1%(0.5) Squamous Cell Carcinoma Range 0/50 - 1/50 0/50 - 1/50 or Keratoacanthoma Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/952(0.1%) 1/953(0.1%) Papilloma, Papilloma, or Mean(sd) 0.1%(0.5) 0.1%(0.5) Keratoacanthoma Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 1/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibroma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 1/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 9/952(0.9%) 23/953(2.4%) Sarcoma, Myxoma, Mean(sd) 0.9%(1.4) 2.4%(2.2) Myxosarcoma, or Fibrous Range 0/50 - 2/50 0/50 - 3/50 Histiocytoma Males 2/50 1/50 0/50 1/50 0/50 0/50 0/52 0/50 0/50 0/50 2/50 0/50 0/50 1/50 1/50 0/50 0/50 1/50 0/50 Females 1/50 0/50 2/51 3/50 1/50 0/50 2/50 0/52 0/50 0/49 0/49 1/50 2/51 0/50 2/50 2/50 2/51 3/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma Total 2/952(0.2%) 18/953(1.9%) Mean(sd) 0.2%(0.6) 1.9%(2.3) Range 0/50 - 1/50 0/50 - 3/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 2/51 3/50 0/50 0/50 2/50 0/52 0/50 0/49 0/49 0/50 2/51 0/50 2/50 2/50 0/51 3/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 8/952(0.8%) 23/953(2.4%) Myxosarcoma, or Fibrous Mean(sd) 0.8%(1.4) 2.4%(2.2) Histiocytoma Range 0/50 - 2/50 0/50 - 3/50 Males 2/50 1/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 2/50 0/50 0/50 1/50 1/50 0/50 0/50 1/50 0/50 Females 1/50 0/50 2/51 3/50 1/50 0/50 2/50 0/52 0/50 0/49 0/49 1/50 2/51 0/50 2/50 2/50 2/51 3/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/952(0%) 2/953(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 1/952(0.1%) 3/953(0.3%) Schwannoma (malignant or Mean(sd) 0.1%(0.5) 0.3%(0.7) NOS) Range 0/50 - 1/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 1/952(0.1%) 3/953(0.3%) Neurofibroma, or Mean(sd) 0.1%(0.5) 0.3%(0.7) Schwannoma (benign, Range 0/50 - 1/50 0/50 - 1/51 malignant or NOS) Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 5/952(0.5%) 4/953(0.4%) Mean(sd) 0.5%(1.3) 0.4%(1.1) Range 0/50 - 2/50 0/50 - 2/51 Males 2/50 1/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 2/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 2/51 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/952(0.1%) 1/953(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Hemangiosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrosarcoma Total 0/944(0%) 1/940(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/51 Males 0/50 0/50 0/50 0/50 0/47 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/48 0/50 Females 0/50 0/49 1/51 0/49 0/49 0/50 0/50 0/51 0/50 0/48 0/48 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/944(0%) 0/940(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/47 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/48 0/50 Females 0/50 0/49 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/48 0/48 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Hemangioma Total 1/944(0.1%) 1/940(0.1%) Mean(sd) 0.1%(0.5) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/47 0/50 0/52 0/49 0/50 0/49 0/50 0/50 1/50 0/50 0/50 0/49 0/50 0/48 0/50 Females 0/50 0/49 0/51 0/49 0/49 1/50 0/50 0/51 0/50 0/48 0/48 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Hemangiosarcoma Total 22/944(2.3%) 14/940(1.5%) Mean(sd) 2.3%(2.9) 1.5%(2.1) Range 0/50 - 4/50 0/50 - 3/49 Males 1/50 0/50 0/50 0/50 2/47 1/50 4/52 0/49 0/50 0/49 1/50 4/50 1/50 0/50 0/50 0/49 4/50 2/48 2/50 Females 0/50 1/49 0/51 1/49 3/49 0/50 3/50 0/51 0/50 0/48 2/48 1/50 2/51 0/50 0/48 0/50 0/51 1/50 0/45 --------------------------------------------------------------------------- Mast Cell Tumor Total 2/944(0.2%) 0/940(0%) Malignant Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/48 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/47 0/50 0/52 0/49 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 1/48 0/50 Females 0/50 0/49 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/48 0/48 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/944(0%) 0/940(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/47 0/50 0/52 0/49 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/48 0/50 Females 0/50 0/49 0/51 0/49 0/49 0/50 0/50 0/51 0/50 0/48 0/48 0/50 0/51 0/50 0/48 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Hemangioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 2/952(0.2%) 1/953(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.5) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 1/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 14/952(1.5%) 16/953(1.7%) Carcinoma or Papilloma Mean(sd) 1.5%(2.1) 1.7%(2.0) Squamous Range 0/50 - 3/50 0/50 - 3/50 Males 0/50 2/50 1/50 0/50 0/50 3/50 1/52 0/50 3/50 0/50 1/50 0/50 1/50 0/50 0/50 2/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 0/50 3/50 0/50 0/52 0/50 0/49 1/49 1/50 2/51 1/50 2/50 1/50 1/51 0/50 3/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 12/952(1.3%) 15/953(1.6%) Mean(sd) 1.3%(2.0) 1.6%(1.9) Range 0/50 - 3/50 0/50 - 3/50 Males 0/50 2/50 1/50 0/50 0/50 3/50 0/52 0/50 3/50 0/50 1/50 0/50 1/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/50 0/50 1/51 0/50 0/50 3/50 0/50 0/52 0/50 0/49 1/49 1/50 2/51 1/50 1/50 1/50 1/51 0/50 3/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 1/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 4/951(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 1/49 0/50 0/50 0/50 1/50 1/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/951(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrosarcoma Total 0/813(0%) 0/869(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/813(0%) 1/869(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/43 - 0/43 0/38 - 1/48 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 1/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Hemangioma Total 0/813(0%) 0/869(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/813(0%) 0/869(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/813(0%) 0/869(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Sarcoma Total 0/813(0%) 0/869(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Thymoma Benign Total 0/813(0%) 2/869(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.7) Range 0/43 - 0/43 0/38 - 1/45 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 1/49 0/38 0/47 0/47 0/45 0/46 1/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Thymoma Malignant Total 0/813(0%) 0/869(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/43 - 0/43 0/38 - 0/38 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 0/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Thymoma NOS Total 0/813(0%) 1/869(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/43 - 0/43 0/38 - 1/50 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 0/49 0/38 0/47 0/47 0/45 0/46 0/45 0/46 0/47 0/50 0/46 0/48 0/49 1/50 0/45 0/45 0/44 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/813(0%) 3/869(0.3%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/43 - 0/43 0/38 - 1/45 Males 0/43 0/39 0/39 0/36 0/40 0/47 0/45 0/44 0/42 0/49 0/38 0/45 0/47 0/43 0/42 0/43 0/44 0/42 0/45 Females 0/38 0/44 1/49 0/38 0/47 0/47 0/45 0/46 1/45 0/46 0/47 0/50 0/46 0/48 0/49 1/50 0/45 0/45 0/44 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/946(0.1%) 0/942(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/49 - 1/50 0/48 - 0/48 Males 0/49 0/50 0/50 0/50 0/50 0/49 0/52 0/49 0/50 0/50 0/50 0/50 1/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Carcinoma Total 1/946(0.1%) 0/942(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/49 - 1/50 0/48 - 0/48 Males 0/49 0/50 0/50 0/50 0/50 0/49 0/52 0/49 0/50 0/50 0/50 1/50 0/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/946(0.2%) 0/942(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/49 - 1/50 0/48 - 0/48 Males 0/49 0/50 0/50 0/50 0/50 0/49 0/52 0/49 0/50 0/50 0/50 1/50 1/50 0/49 0/50 0/49 0/50 0/49 0/50 Females 0/48 0/50 0/50 0/49 0/50 0/50 0/49 0/51 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 13/946(1.4%) 16/942(1.7%) Mean(sd) 1.4%(1.5) 1.7%(1.7) Range 0/50 - 2/49 0/48 - 3/51 Males 1/49 1/50 0/50 0/50 1/50 2/49 0/52 0/49 2/50 2/50 1/50 1/50 0/50 0/49 1/50 0/49 1/50 0/49 0/50 Females 0/48 1/50 2/50 1/49 0/50 1/50 1/49 3/51 1/50 0/49 0/49 0/50 0/51 1/50 2/50 0/50 1/51 1/50 1/45 --------------------------------------------------------------------------- Carcinoma Total 3/946(0.3%) 2/942(0.2%) Mean(sd) 0.3%(0.7) 0.2%(0.6) Range 0/49 - 1/49 0/48 - 1/49 Males 0/49 0/50 0/50 0/50 0/50 0/49 0/52 1/49 0/50 0/50 0/50 0/50 0/50 1/49 1/50 0/49 0/50 0/49 0/50 Females 0/48 0/50 0/50 1/49 0/50 0/50 0/49 0/51 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/45 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 16/946(1.7%) 18/942(1.9%) Mean(sd) 1.7%(1.5) 1.9%(1.7) Range 0/50 - 2/49 0/48 - 3/51 Males 1/49 1/50 0/50 0/50 1/50 2/49 0/52 1/49 2/50 2/50 1/50 1/50 0/50 1/49 2/50 0/49 1/50 0/49 0/50 Females 0/48 1/50 2/50 2/49 0/50 1/50 1/49 3/51 1/50 0/49 0/49 1/50 0/51 1/50 2/50 0/50 1/51 1/50 1/45 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Fibrosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 1/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/952(0%) 1/953(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Squamous Cell Carcinoma Total 1/952(0.1%) 0/953(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 3/952(0.3%) 0/953(0%) Carcinoma or Papilloma Mean(sd) 0.3%(0.7) 0.0%(0.0) Squamous Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 1/50 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 2/952(0.2%) 0/953(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adamantinoma Benign Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 2/952(0.2%) 0/953(0%) Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/50 - 2/52 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 2/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Carcinoma or Papilloma Total 1/944(0.1%) 0/934(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/48 0/50 0/50 1/50 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/51 0/48 0/50 0/50 0/49 0/51 0/50 0/48 0/43 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/44 --------------------------------------------------------------------------- Hemangioma Total 1/944(0.1%) 0/934(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/48 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/50 1/49 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/51 0/48 0/50 0/50 0/49 0/51 0/50 0/48 0/43 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/44 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/944(0.1%) 0/934(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/49 0/50 - 0/50 Males 0/50 0/50 0/48 0/50 0/50 0/50 0/52 1/49 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/51 0/48 0/50 0/50 0/49 0/51 0/50 0/48 0/43 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/44 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/944(0%) 0/934(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/48 0/50 0/50 0/50 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/51 0/48 0/50 0/50 0/49 0/51 0/50 0/48 0/43 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/44 --------------------------------------------------------------------------- Papilloma Total 1/944(0.1%) 0/934(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/50 0/48 0/50 0/50 1/50 0/52 0/49 0/50 0/50 0/48 0/50 0/50 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/50 0/50 0/51 0/48 0/50 0/50 0/49 0/51 0/50 0/48 0/43 0/50 0/50 0/50 0/49 0/50 0/51 0/50 0/44 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 1/953(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/51 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 4/953(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/51 0/50 1/50 1/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 1/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/953(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/953(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 2/953(0.2%) Mean(sd) 0.2%(0.6) Range 0/50 - 1/51 Females 0/50 0/50 1/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/953(0.3%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/51 Females 0/50 0/50 1/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 1/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 4/953(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/51 Females 0/50 0/50 1/51 0/50 0/50 1/50 0/50 0/52 0/50 1/49 1/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 3/953(0.3%) Mean(sd) 0.3%(0.7) Range 0/50 - 1/50 Females 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 1/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 31/953(3.3%) Mean(sd) 3.3%(3.9) Range 0/50 - 8/50 Females 4/50 1/50 1/51 0/50 0/50 3/50 2/50 3/52 8/50 0/49 2/49 0/50 2/51 1/50 2/50 1/50 0/51 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/953(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 4/953(0.4%) Mean(sd) 0.4%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/51 0/50 1/50 0/50 0/50 0/52 0/50 1/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 35/953(3.7%) Polyp Stromal Mean(sd) 3.7%(3.7) Range 0/50 - 8/50 Females 4/50 1/50 1/51 0/50 1/50 3/50 2/50 3/52 8/50 1/49 2/49 1/50 2/51 1/50 2/50 1/50 0/51 2/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Leiomyosarcoma Total 0/953(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/953(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/953(0.1%) Mean(sd) 0.1%(0.5) Range 0/50 - 1/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 1/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE ORAL FEED (Updated 12/99) Males(19 studies) Females(19 studies) =========================================================================== Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/952(0%) 0/953(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/50 0/50 0/50 0/50 0/52 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/50 0/50 0/51 0/50 0/50 0/50 0/50 0/52 0/50 0/49 0/49 0/50 0/51 0/50 0/50 0/50 0/51 0/50 0/50 ---------------------------------------------------------------------------