TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Benign Tumors Total 255/340(75%) 236/340(69.4%) Mean(sd) 75.2%(4.9) 68.4%(15.3) Range 35/50 - 41/50 25/50 - 42/50 Males 39/50 36/51 57/79 47/60 41/50 35/50 Females 26/50 25/50 65/80 38/60 42/50 40/50 --------------------------------------------------------------------------- Malignant Tumors Total 174/340(51.2%) 174/340(51.2%) Mean(sd) 50.6%(13.8) 51.5%(9.7) Range 16/51 - 41/60 34/80 - 41/60 Males 22/50 16/51 41/79 41/60 32/50 22/50 Females 23/50 22/50 34/80 41/60 28/50 26/50 --------------------------------------------------------------------------- Malignant and Benign Total 305/340(89.7%) 289/340(85%) Tumors Mean(sd) 89.6%(4.5) 84.3%(11.2) Range 42/50 - 48/50 35/50 - 47/50 Males 42/50 45/51 71/79 56/60 48/50 43/50 Females 35/50 35/50 72/80 54/60 46/50 47/50 --------------------------------------------------------------------------- Hemangioma Total 5/340(1.5%) 8/340(2.4%) Mean(sd) 1.7%(2.7) 2.2%(2.7) Range 0/51 - 3/50 0/50 - 3/50 Males 3/50 0/51 0/79 0/60 2/50 0/50 Females 3/50 0/50 4/80 0/60 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 20/340(5.9%) 16/340(4.7%) Mean(sd) 6.1%(2.3) 4.7%(3.3) Range 3/79 - 5/50 0/50 - 5/60 Males 3/50 3/51 3/79 4/60 5/50 2/50 Females 3/50 1/50 3/80 5/60 4/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 25/340(7.4%) 23/340(6.8%) Hemangioma Mean(sd) 7.7%(4.3) 6.5%(4.4) Range 3/79 - 7/50 0/50 - 5/50 Males 6/50 3/51 3/79 4/60 7/50 2/50 Females 5/50 1/50 7/80 5/60 5/50 0/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 6/340(1.8%) 12/340(3.5%) Mean(sd) 1.8%(1.7) 3.2%(2.6) Range 0/50 - 2/50 0/50 - 5/80 Males 0/50 0/51 1/79 2/60 2/50 1/50 Females 0/50 0/50 5/80 3/60 2/50 2/50 --------------------------------------------------------------------------- Leukemia: Erythrocytic Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 0/340(0%) 0/340(0%) Monocytic, Mononuclear, Mean(sd) 0.0%(0.0) 0.0%(0.0) or Undifferentiated Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 23/340(6.8%) 68/340(20%) Histiocytic, Mean(sd) 6.8%(5.9) 20.4%(7.4) Lymphocytic, Mixed, NOS, Range 0/50 - 8/51 6/50 - 15/50 or Undifferentiated Cell Type Males 0/50 8/51 4/79 7/60 1/50 3/50 Females 9/50 15/50 11/80 17/60 10/50 6/50 --------------------------------------------------------------------------- Osteoma Total 1/340(0.3%) 1/340(0.3%) Mean(sd) 0.3%(0.7) 0.2%(0.5) Range 0/50 - 1/60 0/50 - 1/80 Males 0/50 0/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/340(0.3%) 3/340(0.9%) Mean(sd) 0.3%(0.8) 0.9%(1.0) Range 0/50 - 1/50 0/60 - 1/50 Males 0/50 0/51 0/79 0/60 1/50 0/50 Females 1/50 1/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 2/340(0.6%) 4/340(1.2%) Mean(sd) 0.6%(1.0) 1.1%(1.2) Range 0/50 - 1/50 0/60 - 2/80 Males 0/50 0/51 0/79 1/60 1/50 0/50 Females 1/50 1/50 2/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 21/337(6.2%) 3/338(0.9%) Mean(sd) 5.7%(4.8) 1.0%(1.7) Range 0/49 - 9/79 0/50 - 2/50 Males 5/50 0/49 9/79 4/60 0/50 3/49 Females 0/50 2/50 0/79 0/60 0/50 1/49 --------------------------------------------------------------------------- Carcinoma Total 0/337(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/49 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/79 0/60 0/50 1/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/337(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/79 0/60 0/50 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/337(0%) 0/338(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/79 0/60 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/337(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/49 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/79 0/60 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Pheochromocytoma Benign Total 1/331(0.3%) 0/334(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/48 - 1/49 0/50 - 0/50 Males 1/49 0/48 0/76 0/60 0/50 0/48 Females 0/50 0/49 0/76 0/60 0/50 0/49 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/331(0%) 0/334(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/48 0/76 0/60 0/50 0/48 Females 0/50 0/49 0/76 0/60 0/50 0/49 --------------------------------------------------------------------------- Pheochromocytoma Total 0/331(0%) 2/334(0.6%) Malignant Mean(sd) 0.0%(0.0) 0.7%(1.0) Range 0/49 - 0/49 0/50 - 1/49 Males 0/49 0/48 0/76 0/60 0/50 0/48 Females 0/50 1/49 0/76 0/60 1/50 0/49 --------------------------------------------------------------------------- Pheochromocytoma: Total 1/331(0.3%) 2/334(0.6%) Benign, Complex, Mean(sd) 0.3%(0.8) 0.7%(1.0) Malignant, NOS Range 0/48 - 1/49 0/50 - 1/49 Males 1/49 0/48 0/76 0/60 0/50 0/48 Females 0/50 1/49 0/76 0/60 1/50 0/49 --------------------------------------------------------------------------- =========================================================================== BONE MARROW B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/338(0%) 1/337(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/49 - 1/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 1/50 0/49 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/338(0%) 0/337(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/49 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/338(0.9%) 1/337(0.3%) Mean(sd) 1.0%(1.0) 0.2%(0.5) Range 0/50 - 1/50 0/50 - 1/80 Males 1/50 0/50 0/79 1/60 1/50 0/49 Females 0/50 0/49 1/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/338(0%) 0/337(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/49 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor NOS Total 0/338(0%) 0/337(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/49 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/338(0%) 0/337(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/49 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== BONE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 1/340(0.3%) 1/340(0.3%) Mean(sd) 0.3%(0.7) 0.2%(0.5) Range 0/50 - 1/60 0/50 - 1/80 Males 0/50 0/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/340(0.3%) 3/340(0.9%) Mean(sd) 0.3%(0.8) 0.9%(1.0) Range 0/50 - 1/50 0/60 - 1/50 Males 0/50 0/51 0/79 0/60 1/50 0/50 Females 1/50 1/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 2/340(0.6%) 4/340(1.2%) Mean(sd) 0.6%(1.0) 1.1%(1.2) Range 0/50 - 1/50 0/60 - 2/80 Males 0/50 0/51 0/79 1/60 1/50 0/50 Females 1/50 1/50 2/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Astrocytoma Benign Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/340(0%) 1/339(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/49 - 1/60 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 1/60 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/340(0%) 1/339(0.3%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/50 - 0/50 0/49 - 1/60 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 1/60 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/340(0%) 0/339(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/340(0%) 0/339(0%) Glioma, or Astrocytoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/49 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EAR B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basosquamous Tumor Total 0/340(0%) 0/340(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EPIDIDYMIS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== GALLBLADDER B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/307(0%) 0/308(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/44 - 0/44 0/47 - 0/47 Males 0/44 0/44 0/76 0/55 0/45 0/43 Females 0/47 0/45 0/79 0/58 0/42 0/37 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 27/340(7.9%) 9/340(2.6%) Mean(sd) 7.7%(3.9) 2.5%(2.5) Range 1/50 - 8/60 0/50 - 3/50 Males 3/50 5/51 7/79 8/60 1/50 3/50 Females 1/50 0/50 4/80 1/60 3/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 7/340(2.1%) 5/340(1.5%) Mean(sd) 2.1%(1.4) 1.6%(1.5) Range 0/50 - 2/50 0/50 - 2/50 Males 0/50 1/51 1/79 2/60 1/50 2/50 Females 0/50 1/50 1/80 0/60 2/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 33/340(9.7%) 14/340(4.1%) Mean(sd) 9.4%(5.0) 4.0%(3.4) Range 1/50 - 10/60 1/60 - 5/50 Males 3/50 6/51 8/79 10/60 1/50 5/50 Females 1/50 1/50 5/80 1/60 5/50 1/50 --------------------------------------------------------------------------- =========================================================================== HEART B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/340(0.3%) 0/339(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/340(0.6%) 3/340(0.9%) Mean(sd) 0.6%(1.0) 0.9%(1.4) Range 0/50 - 1/51 0/50 - 2/60 Males 0/50 1/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 0/80 2/60 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 3/340(0.9%) 3/340(0.9%) Mean(sd) 1.0%(1.0) 0.9%(1.4) Range 0/79 - 1/50 0/50 - 2/60 Males 1/50 1/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 0/80 2/60 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/340(0.9%) 3/340(0.9%) Mean(sd) 1.0%(1.0) 0.9%(1.4) Range 0/79 - 1/50 0/50 - 2/60 Males 1/50 1/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 0/80 2/60 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 5/336(1.5%) 4/337(1.2%) Mean(sd) 1.6%(2.3) 1.2%(0.9) Range 0/50 - 3/50 0/50 - 1/50 Males 0/50 3/50 0/78 1/59 1/50 0/49 Females 0/50 0/50 1/79 1/59 1/50 1/49 --------------------------------------------------------------------------- Carcinoma Total 0/336(0%) 0/337(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/78 0/59 0/50 0/49 Females 0/50 0/50 0/79 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/336(1.5%) 4/337(1.2%) Mean(sd) 1.6%(2.3) 1.2%(0.9) Range 0/50 - 3/50 0/50 - 1/50 Males 0/50 3/50 0/78 1/59 1/50 0/49 Females 0/50 0/50 1/79 1/59 1/50 1/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/338(0.3%) 0/338(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/60 0/50 - 0/50 Males 0/50 0/50 0/79 1/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/338(0.3%) 0/338(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/60 0/50 - 0/50 Males 0/50 0/50 0/79 1/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/338(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 1/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/338(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 1/338(0.3%) 0/338(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LIVER B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Cholangiocarcinoma Total 1/339(0.3%) 1/338(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/50 - 1/59 0/50 - 1/59 Males 0/50 0/51 0/79 1/59 0/50 0/50 Females 0/50 0/50 0/80 1/59 0/50 0/49 --------------------------------------------------------------------------- Cholangioma Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/339(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 1/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/339(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 1/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 12/339(3.5%) 7/338(2.1%) Mean(sd) 3.6%(1.7) 2.0%(1.1) Range 1/50 - 3/50 0/49 - 2/59 Males 1/50 2/51 2/79 3/59 3/50 1/50 Females 1/50 1/50 2/80 2/59 1/50 0/49 --------------------------------------------------------------------------- Hepatoblastoma Total 11/339(3.2%) 1/338(0.3%) Mean(sd) 3.6%(4.5) 0.3%(0.8) Range 0/51 - 6/50 0/50 - 1/49 Males 1/50 0/51 0/79 2/59 6/50 2/50 Females 0/50 0/50 0/80 0/59 0/50 1/49 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 208/339(61.4%) 187/338(55.3%) Mean(sd) 61.0%(8.2) 55.0%(21.2) Range 24/51 - 35/50 13/50 - 40/50 Males 30/50 24/51 50/79 40/59 35/50 29/50 Females 19/50 13/50 49/80 29/59 40/50 37/49 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 95/339(28%) 68/338(20.1%) Mean(sd) 27.3%(10.7) 19.7%(12.8) Range 5/51 - 25/59 4/50 - 25/59 Males 12/50 5/51 25/79 25/59 13/50 15/50 Females 6/50 4/50 14/80 25/59 6/50 13/49 --------------------------------------------------------------------------- Hepatocellular Total 105/339(31%) 68/338(20.1%) Carcinoma or Mean(sd) 30.5%(12.1) 19.7%(12.8) Hepatoblastoma Range 5/51 - 27/59 4/50 - 25/59 Males 13/50 5/51 25/79 27/59 18/50 17/50 Females 6/50 4/50 14/80 25/59 6/50 13/49 --------------------------------------------------------------------------- Hepatocellular Total 247/339(72.9%) 214/338(63.3%) Carcinoma or Mean(sd) 72.2%(10.1) 62.7%(21.7) Hepatocellular Adenoma Range 27/51 - 47/59 16/50 - 41/49 Males 35/50 27/51 62/79 47/59 39/50 37/50 Females 20/50 16/50 55/80 41/59 41/50 41/49 --------------------------------------------------------------------------- Hepatocellular Total 250/339(73.7%) 214/338(63.3%) Carcinoma, Mean(sd) 73.1%(10.7) 62.7%(21.7) Hepatocellular Adenoma, Range 27/51 - 48/59 16/50 - 41/49 or Hepatoblastoma Males 35/50 27/51 62/79 48/59 40/50 38/50 Females 20/50 16/50 55/80 41/59 41/50 41/49 --------------------------------------------------------------------------- Hepatocholangiocarcinoma Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Ito Cell Tumor Benign Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Ito Cell Tumor Malignant Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Ito Cell Tumor NOS Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/339(0%) 0/338(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/339(0%) 0/338(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 1/339(0.3%) 0/338(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/59 0/50 0/50 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== LUNG B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/339(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 76/339(22.4%) 20/339(5.9%) Adenoma Mean(sd) 23.3%(5.7) 6.0%(1.9) Range 11/79 - 15/50 2/59 - 4/50 Males 15/50 14/51 11/79 12/60 12/50 12/49 Females 4/50 3/50 5/80 2/59 4/50 2/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 30/339(8.8%) 14/339(4.1%) Carcinoma Mean(sd) 8.3%(6.1) 4.2%(3.4) Range 1/51 - 8/50 0/50 - 5/50 Males 8/50 1/51 12/79 4/60 4/50 1/49 Females 1/50 0/50 3/80 3/59 5/50 2/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 103/339(30.4%) 33/339(9.7%) Carcinoma or Mean(sd) 30.7%(6.1) 9.8%(4.3) Alveolar/Bronchiolar Range 15/60 - 21/50 3/50 - 9/50 Adenoma Males 21/50 15/51 23/79 15/60 16/50 13/49 Females 5/50 3/50 8/80 4/59 9/50 4/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/339(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/339(0.3%) 0/339(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/339(0.3%) 0/339(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/60 0/50 - 0/50 Males 0/50 0/51 0/79 1/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/339(0%) 0/339(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/339(0.3%) 0/339(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/340(0%) 0/340(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/340(0%) 0/340(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE: MESENTERIC B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrous Histiocytoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 0/340(0%) 0/340(0%) or Adenoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 0/340(0%) 1/340(0.3%) Carcinoma, or Adenoma Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 1/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Myoepithelioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/60 0/50 - 0/50 Males 0/50 0/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/49 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/49 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/340(0.3%) 0/339(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 1/50 0/50 Females 0/50 0/49 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/339(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/49 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Papilloma Squamous or Total 0/340(0%) 0/340(0%) Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/340(0%) 0/340(0%) Carcinoma, Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous, or Papilloma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 2/328(0.6%) Mean(sd) 0.7%(1.8) Range 0/49 - 2/46 Females 2/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Arrhenoblastoma NOS Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Carcinoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Cystadenoma Total 10/328(3%) Mean(sd) 3.0%(3.2) Range 0/46 - 4/47 Females 0/46 0/49 3/78 2/58 1/50 4/47 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 4/328(1.2%) Benign Mean(sd) 1.2%(1.0) Range 0/46 - 1/47 Females 0/46 1/49 1/78 0/58 1/50 1/47 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/328(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 4/328(1.2%) Benign, Malignant, NOS Mean(sd) 1.2%(1.0) Range 0/46 - 1/47 Females 0/46 1/49 1/78 0/58 1/50 1/47 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/328(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Hemangioma Total 2/328(0.6%) Mean(sd) 0.7%(1.1) Range 0/49 - 1/46 Females 1/46 0/49 0/78 0/58 1/50 0/47 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Liposarcoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Luteoma Total 2/328(0.6%) Mean(sd) 0.5%(0.8) Range 0/46 - 1/58 Females 0/46 0/49 1/78 1/58 0/50 0/47 --------------------------------------------------------------------------- Teratoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Teratoma Benign Total 1/328(0.3%) Mean(sd) 0.4%(0.9) Range 0/49 - 1/46 Females 1/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Teratoma Malignant Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Teratoma NOS Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Thecoma Benign Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/328(0%) Mean(sd) 0.0%(0.0) Range 0/46 - 0/46 Females 0/46 0/49 0/78 0/58 0/50 0/47 --------------------------------------------------------------------------- =========================================================================== PANCREAS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/335(0.3%) 0/338(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma Total 0/335(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.2%(0.5) Range 0/50 - 0/50 0/50 - 1/80 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 1/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/335(0.3%) 1/338(0.3%) Mean(sd) 0.3%(0.8) 0.2%(0.5) Range 0/50 - 1/50 0/50 - 1/80 Males 0/50 1/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 1/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Fibrosarcoma Total 0/335(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/335(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 1/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangioma Total 0/335(0%) 1/338(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 1/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/335(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- Sarcoma Total 0/335(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 0/78 0/58 0/50 0/49 Females 0/50 0/50 0/80 0/59 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/288(0%) 0/277(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/47 - 0/47 Males 0/49 0/35 0/70 0/55 0/48 0/31 Females 0/47 0/29 0/73 0/48 0/49 0/31 --------------------------------------------------------------------------- =========================================================================== PHARYNX B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Papilloma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/314(0.3%) 64/328(19.5%) Mean(sd) 0.4%(0.9) 18.2%(7.4) Range 0/48 - 1/47 5/48 - 25/80 Males 0/48 1/47 0/71 0/52 0/50 0/46 Females 5/48 9/48 25/80 11/56 6/49 8/47 --------------------------------------------------------------------------- Carcinoma Total 0/314(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 0/47 0/71 0/52 0/50 0/46 Females 0/48 0/48 0/80 0/56 0/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/314(0.3%) 64/328(19.5%) Mean(sd) 0.4%(0.9) 18.2%(7.4) Range 0/48 - 1/47 5/48 - 25/80 Males 0/48 1/47 0/71 0/52 0/50 0/46 Females 5/48 9/48 25/80 11/56 6/49 8/47 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/314(0%) 1/328(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/48 - 0/48 0/48 - 1/48 Males 0/48 0/47 0/71 0/52 0/50 0/46 Females 1/48 0/48 0/80 0/56 0/49 0/47 --------------------------------------------------------------------------- Carcinoma Total 0/314(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/48 - 0/48 0/48 - 0/48 Males 0/48 0/47 0/71 0/52 0/50 0/46 Females 0/48 0/48 0/80 0/56 0/49 0/47 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/314(0%) 1/328(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/48 - 0/48 0/48 - 1/48 Males 0/48 0/47 0/71 0/52 0/50 0/46 Females 1/48 0/48 0/80 0/56 0/49 0/47 --------------------------------------------------------------------------- =========================================================================== PROSTATE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma Total 0/339(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/339(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/339(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Males 0/50 0/50 0/79 0/60 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangioma Total 0/337(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/51 0/78 0/60 0/50 0/48 Females 0/49 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/337(0.3%) 0/338(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/49 - 0/49 Males 1/50 0/51 0/78 0/60 0/50 0/48 Females 0/49 0/50 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/340(0%) 0/340(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/51 - 1/50 0/50 - 0/50 Males 1/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Basal Cell Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/340(0%) 0/340(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/340(0%) 0/340(0%) Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) Benign, or Range 0/50 - 0/50 0/50 - 0/50 Trichoepithelioma Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/340(0%) 0/340(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/340(0%) 0/340(0%) Basal Cell Adenoma, Mean(sd) 0.0%(0.0) 0.0%(0.0) Basosquamous Tumor Range 0/50 - 0/50 0/50 - 0/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 1/340(0.3%) 1/340(0.3%) Carcinoma, Carcinoma, Mean(sd) 0.3%(0.8) 0.3%(0.8) Basosq. Tumor (M or B), Range 0/50 - 1/50 0/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 0/50 0/51 0/79 0/60 0/50 1/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/340(0%) 0/340(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/340(0%) 0/340(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 1/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/340(0.9%) 2/340(0.6%) Mean(sd) 0.9%(1.0) 0.6%(1.0) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/51 1/79 0/60 1/50 1/50 Females 0/50 0/50 0/80 1/60 1/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/340(0%) 0/340(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Benign Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 1/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/340(0.3%) 0/340(0%) Carcinoma, Basal Cell Mean(sd) 0.3%(0.8) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 1/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/51 0/79 0/60 0/50 1/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 0/340(0%) 1/340(0.3%) Papilloma or Papilloma Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 1/340(0.3%) 1/340(0.3%) Papilloma, Papilloma, Mean(sd) 0.3%(0.8) 0.3%(0.8) Squamous Cell Carcinoma Range 0/50 - 1/50 0/50 - 1/50 or Keratoacanthoma Males 0/50 0/51 0/79 0/60 0/50 1/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 0/340(0%) 1/340(0.3%) Papilloma, Papilloma, or Mean(sd) 0.0%(0.0) 0.3%(0.8) Keratoacanthoma Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibroma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/51 0/50 - 0/50 Males 0/50 1/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 3/340(0.9%) 10/340(2.9%) Sarcoma, Myxoma, Mean(sd) 1.0%(1.0) 3.1%(2.1) Myxosarcoma, or Fibrous Range 0/50 - 1/51 0/60 - 3/50 Histiocytoma Males 0/50 1/51 0/79 1/60 1/50 0/50 Females 2/50 3/50 2/80 0/60 1/50 2/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/340(0.3%) 7/340(2.1%) Mean(sd) 0.3%(0.7) 2.1%(2.2) Range 0/50 - 1/60 0/60 - 3/50 Males 0/50 0/51 0/79 1/60 0/50 0/50 Females 1/50 3/50 2/80 0/60 1/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 2/340(0.6%) 10/340(2.9%) Myxosarcoma, or Fibrous Mean(sd) 0.6%(1.0) 3.1%(2.1) Histiocytoma Range 0/50 - 1/50 0/60 - 3/50 Males 0/50 0/51 0/79 1/60 1/50 0/50 Females 2/50 3/50 2/80 0/60 1/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 1/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Myxosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/340(0%) 1/340(0.3%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 0.3%(0.8) NOS) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/340(0%) 1/340(0.3%) Neurofibroma, or Mean(sd) 0.0%(0.0) 0.3%(0.8) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 1/50 malignant or NOS) Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 3/340(0.9%) Mean(sd) 0.0%(0.0) 1.0%(1.7) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 2/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangiosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/337(0%) 0/335(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/79 0/59 0/50 0/49 Females 0/49 0/50 0/79 0/59 0/49 0/49 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/337(0%) 1/335(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/49 Males 0/50 0/50 0/79 0/59 0/50 0/49 Females 1/49 0/50 0/79 0/59 0/49 0/49 --------------------------------------------------------------------------- Hemangioma Total 1/337(0.3%) 0/335(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/49 - 0/49 Males 1/50 0/50 0/79 0/59 0/50 0/49 Females 0/49 0/50 0/79 0/59 0/49 0/49 --------------------------------------------------------------------------- Hemangiosarcoma Total 6/337(1.8%) 3/335(0.9%) Mean(sd) 2.0%(2.2) 1.0%(1.0) Range 0/79 - 3/50 0/50 - 1/49 Males 3/50 1/50 0/79 1/59 0/50 1/49 Females 1/49 0/50 0/79 1/59 1/49 0/49 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/337(0%) 0/335(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/79 0/59 0/50 0/49 Females 0/49 0/50 0/79 0/59 0/49 0/49 --------------------------------------------------------------------------- Plasma Cell Tumor Total 0/337(0%) 0/335(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 0/79 0/59 0/50 0/49 Females 0/49 0/50 0/79 0/59 0/49 0/49 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Hemangioma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/340(0.3%) 0/340(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/50 - 1/60 0/50 - 0/50 Males 0/50 0/51 0/79 1/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 4/340(1.2%) 5/340(1.5%) Carcinoma or Papilloma Mean(sd) 1.3%(1.0) 1.3%(1.6) Squamous Range 0/51 - 1/50 0/50 - 3/80 Males 1/50 0/51 0/79 1/60 1/50 1/50 Females 0/50 1/50 3/80 0/60 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 3/340(0.9%) 5/340(1.5%) Mean(sd) 1.0%(1.1) 1.3%(1.6) Range 0/51 - 1/50 0/50 - 3/80 Males 1/50 0/51 0/79 0/60 1/50 1/50 Females 0/50 1/50 3/80 0/60 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 2/339(0.6%) Mean(sd) 0.6%(1.0) Range 0/51 - 1/50 Males 1/50 0/51 0/78 1/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/339(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/51 0/78 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYMUS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/289(0%) 0/317(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/48 - 0/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/289(0%) 1/317(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/47 - 0/47 0/43 - 1/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 1/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Hemangioma Total 1/289(0.3%) 0/317(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/39 - 1/47 0/48 - 0/48 Males 1/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/289(0.3%) 0/317(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/47 - 1/53 0/48 - 0/48 Males 0/47 0/39 0/67 1/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Mast Cell Tumor Total 0/289(0%) 0/317(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/48 - 0/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Sarcoma Total 0/289(0%) 0/317(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/48 - 0/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Thymoma Benign Total 0/289(0%) 1/317(0.3%) Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/47 - 0/47 0/43 - 1/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 1/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Thymoma Malignant Total 0/289(0%) 0/317(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/48 - 0/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Thymoma NOS Total 0/289(0%) 0/317(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/47 - 0/47 0/48 - 0/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 0/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/289(0%) 1/317(0.3%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.4%(0.9) Range 0/47 - 0/47 0/43 - 1/48 Males 0/47 0/39 0/67 0/53 0/37 0/46 Females 1/48 0/43 0/76 0/57 0/48 0/45 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/339(0.3%) 1/338(0.3%) Mean(sd) 0.2%(0.5) 0.3%(0.8) Range 0/50 - 1/79 0/50 - 1/50 Males 0/50 0/51 1/79 0/60 0/50 0/49 Females 0/50 1/50 0/80 0/58 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/339(0.3%) 0/338(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 1/50 0/49 Females 0/50 0/50 0/80 0/58 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/339(0.6%) 1/338(0.3%) Mean(sd) 0.6%(0.9) 0.3%(0.8) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 0/51 1/79 0/60 1/50 0/49 Females 0/50 1/50 0/80 0/58 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 7/339(2.1%) 12/338(3.6%) Mean(sd) 2.2%(1.0) 3.4%(2.2) Range 1/79 - 2/49 0/50 - 3/50 Males 1/50 1/51 1/79 1/60 1/50 2/49 Females 2/50 0/50 4/80 2/58 1/50 3/50 --------------------------------------------------------------------------- Carcinoma Total 0/339(0%) 0/338(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/49 Females 0/50 0/50 0/80 0/58 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/339(2.1%) 12/338(3.6%) Mean(sd) 2.2%(1.0) 3.4%(2.2) Range 1/79 - 2/49 0/50 - 3/50 Males 1/50 1/51 1/79 1/60 1/50 2/49 Females 2/50 0/50 4/80 2/58 1/50 3/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Fibrosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/340(0%) 1/340(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.8) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 1/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Squamous Cell Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/340(0%) 0/340(0%) Carcinoma or Papilloma Mean(sd) 0.0%(0.0) 0.0%(0.0) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adamantinoma Benign Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Carcinoma or Papilloma Total 1/334(0.3%) 0/328(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/50 - 1/48 0/49 - 0/49 Males 0/50 0/49 0/78 0/59 0/50 1/48 Females 0/49 0/47 0/80 0/59 0/48 0/45 --------------------------------------------------------------------------- Hemangioma Total 1/334(0.3%) 0/328(0%) Mean(sd) 0.3%(0.8) 0.0%(0.0) Range 0/50 - 1/50 0/49 - 0/49 Males 0/50 0/49 0/78 0/59 1/50 0/48 Females 0/49 0/47 0/80 0/59 0/48 0/45 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/334(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/49 0/78 0/59 0/50 0/48 Females 0/49 0/47 0/80 0/59 0/48 0/45 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/334(0%) 0/328(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/49 0/78 0/59 0/50 0/48 Females 0/49 0/47 0/80 0/59 0/48 0/45 --------------------------------------------------------------------------- Papilloma Total 1/334(0.3%) 0/328(0%) Mean(sd) 0.4%(0.9) 0.0%(0.0) Range 0/50 - 1/48 0/49 - 0/49 Males 0/50 0/49 0/78 0/59 0/50 1/48 Females 0/49 0/47 0/80 0/59 0/48 0/45 --------------------------------------------------------------------------- =========================================================================== UTERUS B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 1/340(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/80 0/60 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/340(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 2/340(0.6%) Mean(sd) 0.4%(1.0) Range 0/50 - 2/80 Females 0/50 0/50 2/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/340(0.6%) Mean(sd) 0.6%(1.0) Range 0/50 - 1/50 Females 0/50 0/50 0/80 1/60 1/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 1/340(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 9/340(2.6%) Mean(sd) 2.7%(2.1) Range 0/50 - 3/50 Females 0/50 3/50 2/80 1/60 1/50 2/50 --------------------------------------------------------------------------- Sarcoma Total 1/340(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 1/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 1/340(0.3%) Mean(sd) 0.3%(0.8) Range 0/50 - 1/50 Females 0/50 0/50 0/80 0/60 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 10/340(2.9%) Polyp Stromal Mean(sd) 3.0%(2.1) Range 0/50 - 3/50 Females 0/50 3/50 2/80 1/60 2/50 2/50 --------------------------------------------------------------------------- =========================================================================== VAGINA B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Leiomyosarcoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/340(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND B6C3F1 MICE ORAL WATER (Updated 12/99) Males(6 studies) Females(6 studies) =========================================================================== Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/340(0%) 0/340(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/51 0/79 0/60 0/50 0/50 Females 0/50 0/50 0/80 0/60 0/50 0/50 ---------------------------------------------------------------------------