TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Benign Tumors Total 92/100(92%) 86/100(86%) Mean(sd) 92.0%(5.7) 86.0%(0.0) Range 44/50 - 48/50 43/50 - 43/50 Males 48/50 44/50 Females 43/50 43/50 --------------------------------------------------------------------------- Malignant Tumors Total 53/100(53%) 46/100(46%) Mean(sd) 53.0%(1.4) 46.0%(19.8) Range 26/50 - 27/50 16/50 - 30/50 Males 27/50 26/50 Females 30/50 16/50 --------------------------------------------------------------------------- Malignant and Benign Total 95/100(95%) 96/100(96%) Tumors Mean(sd) 95.0%(1.4) 96.0%(2.8) Range 47/50 - 48/50 47/50 - 49/50 Males 48/50 47/50 Females 49/50 47/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 0/100(0%) 1/100(1%) Hemangioma Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 49/100(49%) 35/100(35%) Monocytic, Mononuclear, Mean(sd) 49.0%(1.4) 35.0%(12.7) or Undifferentiated Range 24/50 - 25/50 13/50 - 22/50 Males 25/50 24/50 Females 22/50 13/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 0/100(0%) 0/100(0%) Histiocytic, Mean(sd) 0.0%(0.0) 0.0%(0.0) Lymphocytic, Mixed, NOS, Range 0/50 - 0/50 0/50 - 0/50 or Undifferentiated Cell Type Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 3/100(3%) 0/100(0%) Malignant, NOS Mean(sd) 3.0%(1.4) 0.0%(0.0) Range 1/50 - 2/50 0/50 - 0/50 Males 1/50 2/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Ganglioneuroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 8/100(8%) 4/100(4%) Mean(sd) 8.0%(2.8) 4.0%(5.7) Range 3/50 - 5/50 0/50 - 4/50 Males 5/50 3/50 Females 4/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 0/100(0%) 1/100(1%) Malignant Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 8/100(8%) 5/100(5%) Benign, Complex, Mean(sd) 8.0%(2.8) 5.0%(7.1) Malignant, NOS Range 3/50 - 5/50 0/50 - 5/50 Males 5/50 3/50 Females 5/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Chondroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/100(0%) 0/100(0%) Chondroma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Astrocytoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/100(0%) 0/100(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/100(0%) 0/100(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 1/100(1%) 0/100(0%) Glioma, or Astrocytoma Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 1/100(1%) 6/97(6.2%) Mean(sd) 1.0%(1.4) 6.2%(2.8) Range 0/50 - 1/50 2/48 - 4/49 Males 1/50 0/50 Females 4/49 2/48 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) 3/97(3.1%) Mean(sd) 1.0%(1.4) 3.1%(1.6) Range 0/50 - 1/50 1/49 - 2/48 Males 0/50 1/50 Females 1/49 2/48 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/100(2%) 9/97(9.3%) Mean(sd) 2.0%(0.0) 9.3%(1.3) Range 1/50 - 1/50 4/48 - 5/49 Males 1/50 1/50 Females 5/49 4/48 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/97(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 Females 0/49 0/48 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/97(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 Females 0/49 0/48 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Melanoma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 7/100(7%) 0/100(0%) Mean(sd) 7.0%(7.1) 0.0%(0.0) Range 1/50 - 6/50 0/50 - 0/50 Males 6/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/100(7%) 0/100(0%) Mean(sd) 7.0%(7.1) 0.0%(0.0) Range 1/50 - 6/50 0/50 - 0/50 Males 6/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 1/100(1%) 1/100(1%) Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/100(1%) 1/100(1%) Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Cholangiocarcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 3/100(3%) 0/100(0%) Mean(sd) 3.0%(4.2) 0.0%(0.0) Range 0/50 - 3/50 0/50 - 0/50 Males 0/50 3/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 1/100(1%) 0/100(0%) Carcinoma or Mean(sd) 1.0%(1.4) 0.0%(0.0) Hepatoblastoma Range 0/50 - 1/50 0/50 - 0/50 Males 1/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 4/100(4%) 0/100(0%) Carcinoma or Mean(sd) 4.0%(2.8) 0.0%(0.0) Hepatocellular Adenoma Range 1/50 - 3/50 0/50 - 0/50 Males 1/50 3/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 4/100(4%) 0/100(0%) Carcinoma, Mean(sd) 4.0%(2.8) 0.0%(0.0) Hepatocellular Adenoma, Range 1/50 - 3/50 0/50 - 0/50 or Hepatoblastoma Males 1/50 3/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Alveolar/Bronchiolar Total 0/100(0%) 0/100(0%) Adenoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 0/100(0%) 2/100(2%) Carcinoma Mean(sd) 0.0%(0.0) 2.0%(2.8) Range 0/50 - 0/50 0/50 - 2/50 Males 0/50 0/50 Females 2/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 0/100(0%) 2/100(2%) Carcinoma or Mean(sd) 0.0%(0.0) 2.0%(2.8) Alveolar/Bronchiolar Range 0/50 - 0/50 0/50 - 2/50 Adenoma Males 0/50 0/50 Females 2/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Plasma Cell Tumor Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Plasma Cell Tumor Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoacanthoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Adenoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) 3/100(3%) Mean(sd) 1.0%(1.4) 3.0%(4.2) Range 0/50 - 1/50 0/50 - 3/50 Males 0/50 1/50 Females 3/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/100(1%) 4/100(4%) Mean(sd) 1.0%(1.4) 4.0%(5.7) Range 0/50 - 1/50 0/50 - 4/50 Males 0/50 1/50 Females 4/50 0/50 --------------------------------------------------------------------------- Fibroadenoma Total 1/100(1%) 38/100(38%) Mean(sd) 1.0%(1.4) 38.0%(17.0) Range 0/50 - 1/50 13/50 - 25/50 Males 0/50 1/50 Females 25/50 13/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 1/100(1%) 39/100(39%) or Adenoma Mean(sd) 1.0%(1.4) 39.0%(18.4) Range 0/50 - 1/50 13/50 - 26/50 Males 0/50 1/50 Females 26/50 13/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 2/100(2%) 42/100(42%) Carcinoma, or Adenoma Mean(sd) 2.0%(2.8) 42.0%(22.6) Range 0/50 - 2/50 13/50 - 29/50 Males 0/50 2/50 Females 29/50 13/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chondroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Papilloma Squamous or Total 1/100(1%) 1/100(1%) Papilloma Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 Females 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/100(1%) 1/100(1%) Carcinoma, Papilloma Mean(sd) 1.0%(1.4) 1.0%(1.4) Squamous, or Papilloma Range 0/50 - 1/50 0/50 - 1/50 Males 0/50 1/50 Females 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/100(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 1/100(1%) Malignant Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 0/50 1/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 1/100(1%) Benign, Malignant, NOS Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 0/50 1/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/100(0%) Benign Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/100(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/100(0%) Tumor, Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 1/97(1%) 1/85(1.2%) Mean(sd) 1.1%(1.5) 1.2%(1.7) Range 0/49 - 1/48 0/44 - 1/41 Males 1/48 0/49 Females 0/44 1/41 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Paraganglioma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/100(0%) 0/100(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 60/99(60.6%) 63/99(63.6%) Mean(sd) 60.5%(13.4) 63.6%(3.4) Range 25/49 - 35/50 30/49 - 33/50 Males 25/49 35/50 Females 30/49 33/50 --------------------------------------------------------------------------- Carcinoma Total 0/99(0%) 2/99(2%) Mean(sd) 0.0%(0.0) 2.1%(2.9) Range 0/49 - 0/49 0/50 - 2/49 Males 0/49 0/50 Females 2/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 60/99(60.6%) 65/99(65.7%) Mean(sd) 60.5%(13.4) 65.7%(0.5) Range 25/49 - 35/50 32/49 - 33/50 Males 25/49 35/50 Females 32/49 33/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/49 - 0/49 Males 0/49 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Males 0/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Males 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/99(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Males 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/100(0%) 0/100(0%) Rhabdomyoma Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Basal Cell Adenoma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 1/100(1%) 0/100(0%) Basosquamous Tumor Mean(sd) 1.0%(1.4) 0.0%(0.0) Benign Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 1/100(1%) 0/100(0%) Basosquamous Tumor Mean(sd) 1.0%(1.4) 0.0%(0.0) Benign, or Range 0/50 - 1/50 0/50 - 0/50 Trichoepithelioma Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/100(0%) 0/100(0%) or Basosquamous Tumor Mean(sd) 0.0%(0.0) 0.0%(0.0) (malignant or NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 1/100(1%) 0/100(0%) Basal Cell Adenoma, Mean(sd) 1.0%(1.4) 0.0%(0.0) Basosquamous Tumor Range 0/50 - 1/50 0/50 - 0/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 11/100(11%) 1/100(1%) Carcinoma, Carcinoma, Mean(sd) 11.0%(7.1) 1.0%(1.4) Basosq. Tumor (M or B), Range 3/50 - 8/50 0/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 3/50 8/50 Females 0/50 1/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/100(0%) 0/100(0%) Benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 7/100(7%) 0/100(0%) Mean(sd) 7.0%(4.2) 0.0%(0.0) Range 2/50 - 5/50 0/50 - 0/50 Males 2/50 5/50 Females 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/100(0%) 0/100(0%) Carcinoma, Basal Cell Mean(sd) 0.0%(0.0) 0.0%(0.0) Carcinoma, Basosquamous Range 0/50 - 0/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 4/100(4%) 1/100(1%) Mean(sd) 4.0%(2.8) 1.0%(1.4) Range 1/50 - 3/50 0/50 - 1/50 Males 1/50 3/50 Females 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 4/100(4%) 1/100(1%) Papilloma or Papilloma Mean(sd) 4.0%(2.8) 1.0%(1.4) Range 1/50 - 3/50 0/50 - 1/50 Males 1/50 3/50 Females 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 10/100(10%) 1/100(1%) Papilloma, Papilloma, Mean(sd) 10.0%(5.7) 1.0%(1.4) Squamous Cell Carcinoma Range 3/50 - 7/50 0/50 - 1/50 or Keratoacanthoma Males 3/50 7/50 Females 0/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 10/100(10%) 1/100(1%) Papilloma, Papilloma, or Mean(sd) 10.0%(5.7) 1.0%(1.4) Keratoacanthoma Range 3/50 - 7/50 0/50 - 1/50 Males 3/50 7/50 Females 0/50 1/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 3/100(3%) 1/100(1%) Mean(sd) 3.0%(1.4) 1.0%(1.4) Range 1/50 - 2/50 0/50 - 1/50 Males 1/50 2/50 Females 1/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 5/100(5%) 1/100(1%) Sarcoma, Myxoma, Mean(sd) 5.0%(4.2) 1.0%(1.4) Myxosarcoma, or Fibrous Range 1/50 - 4/50 0/50 - 1/50 Histiocytoma Males 1/50 4/50 Females 1/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 2/100(2%) 0/100(0%) Myxosarcoma, or Fibrous Mean(sd) 2.0%(2.8) 0.0%(0.0) Histiocytoma Range 0/50 - 2/50 0/50 - 0/50 Males 0/50 2/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 0/100(0%) 0/100(0%) Schwannoma benign Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/100(0%) 1/100(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/100(0%) 1/100(1%) Schwannoma (malignant or Mean(sd) 0.0%(0.0) 1.0%(1.4) NOS) Range 0/50 - 0/50 0/50 - 1/50 Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/100(0%) 1/100(1%) Neurofibroma, or Mean(sd) 0.0%(0.0) 1.0%(1.4) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 1/50 malignant or NOS) Males 0/50 0/50 Females 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Astrocytoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Glioma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Basal Cell Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/100(1%) 0/100(0%) Carcinoma or Papilloma Mean(sd) 1.0%(1.4) 0.0%(0.0) Squamous Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoid Tumor Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/100(0%) 0/100(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 67/100(67%) Mean(sd) 67.0%(7.1) Range 31/50 - 36/50 Males 36/50 31/50 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Sarcoma Total 0/91(0%) 0/96(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/91(0%) 0/96(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- Thymoma Benign Total 0/91(0%) 0/96(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- Thymoma Malignant Total 0/91(0%) 0/96(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- Thymoma NOS Total 0/91(0%) 0/96(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/91(0%) 0/96(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/45 - 0/45 0/47 - 0/47 Males 0/45 0/46 Females 0/47 0/49 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 6/100(6%) 8/99(8.1%) Mean(sd) 6.0%(8.5) 8.2%(8.7) Range 0/50 - 6/50 1/50 - 7/49 Males 0/50 6/50 Females 7/49 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/50 Females 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 6/100(6%) 8/99(8.1%) Mean(sd) 6.0%(8.5) 8.2%(8.7) Range 0/50 - 6/50 1/50 - 7/49 Males 0/50 6/50 Females 7/49 1/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 3/99(3%) Mean(sd) 0.0%(0.0) 3.0%(1.4) Range 0/50 - 0/50 1/49 - 2/50 Males 0/50 0/50 Females 1/49 2/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) 1/99(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/50 - 0/50 0/49 - 1/50 Males 0/50 0/50 Females 0/49 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/100(0%) 4/99(4%) Mean(sd) 0.0%(0.0) 4.0%(2.8) Range 0/50 - 0/50 1/49 - 3/50 Males 0/50 0/50 Females 1/49 3/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/100(1%) 0/100(0%) Carcinoma or Papilloma Mean(sd) 1.0%(1.4) 0.0%(0.0) Squamous Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/100(1%) 0/100(0%) Mean(sd) 1.0%(1.4) 0.0%(0.0) Range 0/50 - 1/50 0/50 - 0/50 Males 0/50 1/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adamantinoma Benign Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Carcinoma Total 0/99(0%) 1/99(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/50 Females 1/50 0/49 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 0/99(0%) 1/99(1%) Mean(sd) 0.0%(0.0) 1.0%(1.4) Range 0/49 - 0/49 0/49 - 1/50 Males 0/49 0/50 Females 1/50 0/49 --------------------------------------------------------------------------- Leiomyoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- Papilloma Total 0/99(0%) 0/99(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 0/50 Females 0/50 0/49 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/100(0%) Malignant Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 0/50 1/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 6/100(6%) Mean(sd) 6.0%(2.8) Range 2/50 - 4/50 Females 4/50 2/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 6/100(6%) Polyp Stromal Mean(sd) 6.0%(2.8) Range 2/50 - 4/50 Females 4/50 2/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/100(1%) Mean(sd) 1.0%(1.4) Range 0/50 - 1/50 Females 1/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Fibrosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Polyp Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/100(0%) Mean(sd) 0.0%(0.0) Range 0/50 - 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS DERMAL ACETONE (Updated 12/99) Males(2 studies) Females(2 studies) =========================================================================== Adenoma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/100(1%) 1/100(1%) Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/100(1%) 1/100(1%) Mean(sd) 1.0%(1.4) 1.0%(1.4) Range 0/50 - 1/50 0/50 - 1/50 Males 1/50 0/50 Females 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/100(0%) 0/100(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 0/50 Females 0/50 0/50 ---------------------------------------------------------------------------