TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Benign Tumors Total 48/50(96%) 37/50(74%) Mean(sd) Range 48/50 - 48/50 37/50 - 37/50 Males 48/50 Females 37/50 --------------------------------------------------------------------------- Malignant Tumors Total 38/50(76%) 23/50(46%) Mean(sd) Range 38/50 - 38/50 23/50 - 23/50 Males 38/50 Females 23/50 --------------------------------------------------------------------------- Malignant and Benign Total 49/50(98%) 48/50(96%) Tumors Mean(sd) Range 49/50 - 49/50 48/50 - 48/50 Males 49/50 Females 48/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 0/50(0%) 0/50(0%) Hemangioma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 33/50(66%) 20/50(40%) Monocytic, Mononuclear, Mean(sd) or Undifferentiated Range 33/50 - 33/50 20/50 - 20/50 Males 33/50 Females 20/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 0/50(0%) 0/50(0%) Histiocytic, Mean(sd) Lymphocytic, Mixed, NOS, Range 0/50 - 0/50 0/50 - 0/50 or Undifferentiated Cell Type Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 1/50(2%) 0/50(0%) Malignant, NOS Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Ganglioneuroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 11/50(22%) 1/50(2%) Mean(sd) Range 11/50 - 11/50 1/50 - 1/50 Males 11/50 Females 1/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Pheochromocytoma Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 11/50(22%) 1/50(2%) Benign, Complex, Mean(sd) Malignant, NOS Range 11/50 - 11/50 1/50 - 1/50 Males 11/50 Females 1/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Chondroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 0/50(0%) 0/50(0%) Chondroma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chordoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/50(0%) 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 0/50(0%) 0/50(0%) Malignant, NOS Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 0/50(0%) 0/50(0%) Glioma, or Astrocytoma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 3/50(6%) 3/49(6.1%) Mean(sd) Range 3/50 - 3/50 3/49 - 3/49 Males 3/50 Females 3/49 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/49(0%) Mean(sd) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 Females 0/49 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/50(6%) 3/49(6.1%) Mean(sd) Range 3/50 - 3/50 3/49 - 3/49 Males 3/50 Females 3/49 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/49(0%) Mean(sd) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 Females 0/49 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/49(0%) Mean(sd) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 Females 0/49 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Melanoma NOS Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/50(0%) 1/50(2%) Mean(sd) Range 0/50 - 0/50 1/50 - 1/50 Males 0/50 Females 1/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 3/50(6%) 0/50(0%) Mean(sd) Range 3/50 - 3/50 0/50 - 0/50 Males 3/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 3/50(6%) 0/50(0%) Mean(sd) Range 3/50 - 3/50 0/50 - 0/50 Males 3/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/50(4%) 0/50(0%) Mean(sd) Range 2/50 - 2/50 0/50 - 0/50 Males 2/50 Females 0/50 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Cholangiocarcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 1/50(2%) 1/50(2%) Mean(sd) Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Total 1/50(2%) 0/50(0%) Carcinoma or Mean(sd) Hepatoblastoma Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Hepatocellular Total 2/50(4%) 1/50(2%) Carcinoma or Mean(sd) Hepatocellular Adenoma Range 2/50 - 2/50 1/50 - 1/50 Males 2/50 Females 1/50 --------------------------------------------------------------------------- Hepatocellular Total 2/50(4%) 1/50(2%) Carcinoma, Mean(sd) Hepatocellular Adenoma, Range 2/50 - 2/50 1/50 - 1/50 or Hepatoblastoma Males 2/50 Females 1/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Alveolar/Bronchiolar Total 0/50(0%) 0/50(0%) Adenoma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 1/50(2%) 0/50(0%) Carcinoma Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 1/50(2%) 0/50(0%) Carcinoma or Mean(sd) Alveolar/Bronchiolar Range 1/50 - 1/50 0/50 - 0/50 Adenoma Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Plasma Cell Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Plasma Cell Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoacanthoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 1/50(2%) Mean(sd) Range 0/50 - 0/50 1/50 - 1/50 Males 0/50 Females 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 1/50(2%) Mean(sd) Range 0/50 - 0/50 1/50 - 1/50 Males 0/50 Females 1/50 --------------------------------------------------------------------------- Fibroadenoma Total 3/50(6%) 29/50(58%) Mean(sd) Range 3/50 - 3/50 29/50 - 29/50 Males 3/50 Females 29/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 3/50(6%) 29/50(58%) or Adenoma Mean(sd) Range 3/50 - 3/50 29/50 - 29/50 Males 3/50 Females 29/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 3/50(6%) 29/50(58%) Carcinoma, or Adenoma Mean(sd) Range 3/50 - 3/50 29/50 - 29/50 Males 3/50 Females 29/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chondroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Papilloma Squamous or Total 0/50(0%) 0/50(0%) Papilloma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/50(0%) Carcinoma, Papilloma Mean(sd) Squamous, or Papilloma Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 0/50(0%) Benign, Malignant, NOS Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Luteoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 0/50(0%) Tumor, Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/46(0%) 0/41(0%) Mean(sd) Range 0/46 - 0/46 0/41 - 0/41 Males 0/46 Females 0/41 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Paraganglioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/50(0%) 0/50(0%) Malignant, NOS Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 19/49(38.8%) 20/50(40%) Mean(sd) Range 19/49 - 19/49 20/50 - 20/50 Males 19/49 Females 20/50 --------------------------------------------------------------------------- Carcinoma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 19/49(38.8%) 20/50(40%) Mean(sd) Range 19/49 - 19/49 20/50 - 20/50 Males 19/49 Females 20/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/49(0%) 0/50(0%) Mean(sd) Range 0/49 - 0/49 0/50 - 0/50 Males 0/49 Females 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Males 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 0/50(0%) 0/50(0%) Rhabdomyoma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 1/50(2%) Mean(sd) Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 1/50(2%) 1/50(2%) Mean(sd) Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 0/50(0%) 0/50(0%) Basosquamous Tumor Mean(sd) Benign Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 0/50(0%) 0/50(0%) Basosquamous Tumor Mean(sd) Benign, or Range 0/50 - 0/50 0/50 - 0/50 Trichoepithelioma Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 0/50(0%) 0/50(0%) or Basosquamous Tumor Mean(sd) (malignant or NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 0/50(0%) 0/50(0%) Basal Cell Adenoma, Mean(sd) Basosquamous Tumor Range 0/50 - 0/50 0/50 - 0/50 (benign, malignant or NOS), or Trichoepithelioma Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 4/50(8%) 1/50(2%) Carcinoma, Carcinoma, Mean(sd) Basosq. Tumor (M or B), Range 4/50 - 4/50 1/50 - 1/50 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 4/50 Females 1/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/50(0%) Benign Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 4/50(8%) 1/50(2%) Mean(sd) Range 4/50 - 4/50 1/50 - 1/50 Males 4/50 Females 1/50 --------------------------------------------------------------------------- Lipoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/50(2%) 0/50(0%) Carcinoma, Basal Cell Mean(sd) Carcinoma, Basosquamous Range 1/50 - 1/50 0/50 - 0/50 Tumor (malignant or NOS), or Carcinoma Males 1/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/50(0%) Papilloma or Papilloma Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 4/50(8%) 1/50(2%) Papilloma, Papilloma, Mean(sd) Squamous Cell Carcinoma Range 4/50 - 4/50 1/50 - 1/50 or Keratoacanthoma Males 4/50 Females 1/50 --------------------------------------------------------------------------- Squamous Cell Total 4/50(8%) 1/50(2%) Papilloma, Papilloma, or Mean(sd) Keratoacanthoma Range 4/50 - 4/50 1/50 - 1/50 Males 4/50 Females 1/50 --------------------------------------------------------------------------- Trichoepithelioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 5/50(10%) 0/50(0%) Mean(sd) Range 5/50 - 5/50 0/50 - 0/50 Males 5/50 Females 0/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 6/50(12%) 1/50(2%) Sarcoma, Myxoma, Mean(sd) Myxosarcoma, or Fibrous Range 6/50 - 6/50 1/50 - 1/50 Histiocytoma Males 6/50 Females 1/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 1/50(2%) 1/50(2%) Myxosarcoma, or Fibrous Mean(sd) Histiocytoma Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 0/50(0%) 0/50(0%) Schwannoma benign Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 0/50(0%) 0/50(0%) Schwannoma (malignant or Mean(sd) NOS) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 0/50(0%) 0/50(0%) Neurofibroma, or Mean(sd) Schwannoma (benign, Range 0/50 - 0/50 0/50 - 0/50 malignant or NOS) Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/50(2%) 1/50(2%) Mean(sd) Range 1/50 - 1/50 1/50 - 1/50 Males 1/50 Females 1/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Astrocytoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chordoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Glioma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Basal Cell Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/50(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoid Tumor Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/50(0%) 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 43/50(86%) Mean(sd) Range 43/50 - 43/50 Males 43/50 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Sarcoma Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- Thymoma Benign Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- Thymoma Malignant Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- Thymoma NOS Total 0/46(0%) 0/48(0%) Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- Thymoma: Benign, Total 0/46(0%) 0/48(0%) Malignant, NOS Mean(sd) Range 0/46 - 0/46 0/48 - 0/48 Males 0/46 Females 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 1/50(2%) 3/50(6%) Mean(sd) Range 1/50 - 1/50 3/50 - 3/50 Males 1/50 Females 3/50 --------------------------------------------------------------------------- Carcinoma Total 1/50(2%) 2/50(4%) Mean(sd) Range 1/50 - 1/50 2/50 - 2/50 Males 1/50 Females 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/50(4%) 5/50(10%) Mean(sd) Range 2/50 - 2/50 5/50 - 5/50 Males 2/50 Females 5/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 3/50(6%) 1/50(2%) Mean(sd) Range 3/50 - 3/50 1/50 - 1/50 Males 3/50 Females 1/50 --------------------------------------------------------------------------- Carcinoma Total 1/50(2%) 0/50(0%) Mean(sd) Range 1/50 - 1/50 0/50 - 0/50 Males 1/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 4/50(8%) 1/50(2%) Mean(sd) Range 4/50 - 4/50 1/50 - 1/50 Males 4/50 Females 1/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Paraganglioma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Total 0/50(0%) 0/50(0%) Carcinoma or Papilloma Mean(sd) Squamous Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adamantinoma Benign Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Odontoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Fibroma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/50(0%) Malignant Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 6/50(12%) Mean(sd) Range 6/50 - 6/50 Females 6/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 6/50(12%) Polyp Stromal Mean(sd) Range 6/50 - 6/50 Females 6/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 1/50(2%) Mean(sd) Range 1/50 - 1/50 Females 1/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Fibrosarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Polyp Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/50(0%) Mean(sd) Range 0/50 - 0/50 Females 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS GAVAGE WATER (Updated 12/99) Males(1 study) Females(1 study) =========================================================================== Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/50(0%) 0/50(0%) Mean(sd) Range 0/50 - 0/50 0/50 - 0/50 Males 0/50 Females 0/50 ---------------------------------------------------------------------------