TOXICOLOGY DATA MANAGEMENT SYSTEM HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY =========================================================================== ALL ORGANS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Benign Tumors Total 1011/1055(95.8%) 878/1052(83.5%) Mean(sd) 95.8%(2.9) 83.5%(8.6) Range 49/54 - 50/50 35/53 - 48/50 Males 49/53 46/50 49/54 52/54 49/50 45/48 49/50 50/50 48/50 50/50 50/50 47/50 48/50 42/46 49/50 50/50 47/50 48/50 47/50 48/50 48/50 Females 37/53 44/50 35/53 39/53 46/50 38/48 43/50 44/49 45/50 45/50 48/50 42/50 42/50 32/46 42/50 44/50 48/50 37/50 44/50 41/50 42/50 --------------------------------------------------------------------------- Malignant Tumors Total 748/1055(70.9%) 562/1052(53.4%) Mean(sd) 70.9%(7.6) 53.4%(7.1) Range 28/50 - 41/50 20/50 - 35/53 Males 33/53 36/50 37/54 37/54 39/50 36/48 34/50 40/50 38/50 40/50 30/50 37/50 28/50 30/46 41/50 40/50 35/50 33/50 40/50 33/50 31/50 Females 24/53 29/50 35/53 32/53 21/50 29/48 28/50 26/49 25/50 28/50 28/50 27/50 27/50 21/46 26/50 28/50 31/50 20/50 21/50 26/50 30/50 --------------------------------------------------------------------------- Malignant and Benign Total 1046/1055(99.1%) 1000/1052(95.1%) Tumors Mean(sd) 99.2%(1.2) 95.0%(4.0) Range 48/50 - 50/50 42/50 - 50/50 Males 52/53 50/50 53/54 53/54 49/50 48/48 50/50 50/50 50/50 50/50 50/50 48/50 49/50 46/46 50/50 50/50 50/50 49/50 50/50 49/50 50/50 Females 48/53 47/50 49/53 52/53 49/50 47/48 49/50 47/49 48/50 48/50 48/50 46/50 49/50 40/46 47/50 49/50 49/50 42/50 48/50 48/50 50/50 --------------------------------------------------------------------------- Hemangioma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 3/1055(0.3%) 3/1052(0.3%) Mean(sd) 0.3%(0.7) 0.3%(0.7) Range 0/53 - 1/46 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma or Total 3/1055(0.3%) 4/1052(0.4%) Hemangioma Mean(sd) 0.3%(0.7) 0.4%(0.8) Range 0/53 - 1/46 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 1/50 1/50 1/50 --------------------------------------------------------------------------- Histiocytic Sarcoma Total 5/1055(0.5%) 4/1052(0.4%) Mean(sd) 0.5%(0.9) 0.4%(1.0) Range 0/50 - 1/50 0/53 - 2/50 Males 1/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/46 1/50 1/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 2/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Leukemia: Granulocytic Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leukemia: Lymphocytic, Total 602/1055(57.1%) 373/1052(35.5%) Monocytic, Mononuclear, Mean(sd) 57.1%(8.9) 35.4%(6.0) or Undifferentiated Range 19/50 - 35/50 12/50 - 25/53 Males 28/53 29/50 31/54 31/54 34/50 29/48 24/50 33/50 30/50 35/50 19/50 30/50 21/50 27/46 29/50 35/50 29/50 27/50 33/50 27/50 21/50 Females 19/53 16/50 25/53 22/53 16/50 18/48 14/50 18/49 15/50 18/50 22/50 17/50 18/50 14/46 18/50 22/50 21/50 13/50 12/50 17/50 18/50 --------------------------------------------------------------------------- Malignant Lymphoma: Total 2/1055(0.2%) 1/1052(0.1%) Histiocytic, Mean(sd) 0.2%(0.6) 0.1%(0.4) Lymphocytic, Mixed, NOS, Range 0/53 - 1/50 0/53 - 1/50 or Undifferentiated Cell Type Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign Total 7/1055(0.7%) 1/1052(0.1%) Mean(sd) 0.7%(1.6) 0.1%(0.4) Range 0/53 - 3/50 0/53 - 1/49 Males 0/53 0/50 0/54 0/54 0/50 0/48 2/50 0/50 0/50 3/50 1/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Benign, Total 39/1055(3.7%) 1/1052(0.1%) Malignant, NOS Mean(sd) 3.7%(3.1) 0.1%(0.4) Range 0/54 - 5/50 0/53 - 1/49 Males 1/53 1/50 0/54 0/54 5/50 3/48 5/50 0/50 3/50 3/50 2/50 2/50 2/50 0/46 1/50 1/50 3/50 0/50 2/50 2/50 3/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mesothelioma: Malignant Total 28/1055(2.7%) 0/1052(0%) Mean(sd) 2.7%(2.9) 0.0%(0.0) Range 0/53 - 5/50 0/53 - 0/53 Males 0/53 1/50 0/54 0/54 5/50 0/48 3/50 0/50 3/50 0/50 1/50 2/50 2/50 0/46 0/50 1/50 3/50 0/50 2/50 2/50 3/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 3/1055(0.3%) 0/1052(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/53 - 1/46 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/46 0/50 1/50 1/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 10/1055(0.9%) 6/1052(0.6%) Mean(sd) 0.9%(1.0) 0.6%(0.9) Range 0/50 - 1/48 0/53 - 1/49 Males 1/53 0/50 1/54 1/54 0/50 1/48 0/50 1/50 0/50 0/50 1/50 0/50 1/50 0/46 1/50 0/50 0/50 1/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 1/50 1/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 13/1055(1.2%) 6/1052(0.6%) Mean(sd) 1.2%(1.0) 0.6%(0.9) Range 0/50 - 1/46 0/53 - 1/49 Males 1/53 0/50 1/54 1/54 0/50 1/48 0/50 1/50 0/50 0/50 1/50 0/50 1/50 1/46 1/50 1/50 1/50 1/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 1/50 1/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL CORTEX FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 8/1053(0.8%) 10/1048(1%) Mean(sd) 0.8%(1.3) 1.0%(1.5) Range 0/53 - 2/50 0/53 - 2/49 Males 0/53 1/50 0/54 0/54 0/50 0/48 1/50 2/50 0/50 0/50 0/49 0/50 0/50 0/45 2/50 0/50 0/50 0/50 0/50 1/50 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 2/50 2/49 0/49 1/49 0/50 0/50 0/50 0/46 1/50 0/50 2/50 0/50 1/49 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 1/1053(0.1%) 2/1048(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 1/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 1/53 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ADRENAL MEDULLA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Ganglioneuroma Total 0/1051(0%) 0/1039(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/48 0/50 0/45 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/53 0/47 0/51 0/51 0/50 0/48 0/50 0/49 0/48 0/49 0/50 0/50 0/50 0/45 0/50 0/49 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma Benign Total 320/1051(30.4%) 54/1039(5.2%) Mean(sd) 30.3%(10.4) 5.2%(3.8) Range 4/50 - 27/54 0/50 - 6/47 Males 13/53 15/50 16/54 27/54 19/50 4/48 18/50 19/50 14/50 15/50 16/50 18/48 4/50 8/45 15/50 16/50 19/50 13/50 11/49 17/50 23/50 Females 2/53 6/47 2/51 4/51 4/50 1/48 1/50 3/49 2/48 5/49 4/50 0/50 0/50 0/45 3/50 1/49 4/50 2/50 1/49 6/50 3/50 --------------------------------------------------------------------------- Pheochromocytoma Complex Total 3/1051(0.3%) 5/1039(0.5%) Mean(sd) 0.3%(0.7) 0.5%(1.1) Range 0/50 - 1/50 0/53 - 2/45 Males 1/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 0/48 1/50 0/45 0/50 0/50 0/50 0/50 0/49 0/50 0/50 Females 0/53 0/47 0/51 0/51 0/50 0/48 0/50 0/49 0/48 1/49 0/50 0/50 0/50 2/45 0/50 1/49 0/50 0/50 0/49 0/50 1/50 --------------------------------------------------------------------------- Pheochromocytoma Total 20/1051(1.9%) 5/1039(0.5%) Malignant Mean(sd) 1.9%(2.1) 0.5%(1.1) Range 0/53 - 3/49 0/47 - 2/50 Males 0/53 2/50 0/54 0/54 2/50 0/48 3/50 1/50 0/50 2/50 2/50 0/48 1/50 1/45 0/50 1/50 1/50 0/50 3/49 1/50 0/50 Females 1/53 0/47 0/51 0/51 0/50 0/48 1/50 0/49 0/48 0/49 0/50 2/50 0/50 0/45 0/50 0/49 1/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Pheochromocytoma: Total 332/1051(31.6%) 64/1039(6.2%) Benign, Complex, Mean(sd) 31.4%(10.0) 6.2%(3.5) Malignant, NOS Range 4/48 - 27/54 0/50 - 6/47 Males 14/53 16/50 16/54 27/54 20/50 4/48 20/50 19/50 15/50 15/50 16/50 18/48 6/50 8/45 15/50 17/50 19/50 13/50 14/49 17/50 23/50 Females 3/53 6/47 2/51 4/51 4/50 1/48 2/50 3/49 2/48 6/49 4/50 2/50 0/50 2/45 3/50 2/49 5/50 2/50 1/49 6/50 4/50 --------------------------------------------------------------------------- =========================================================================== BONE MARROW FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1052(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/49 0/49 0/49 0/50 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== BONE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Chondroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma or Total 1/1055(0.1%) 0/1052(0%) Chondroma Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 2/1055(0.2%) 0/1052(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 1/50 1/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 8/1055(0.8%) 5/1052(0.5%) Mean(sd) 0.8%(1.0) 0.5%(0.9) Range 0/50 - 1/48 0/53 - 1/49 Males 1/53 0/50 1/54 0/54 0/50 1/48 0/50 1/50 0/50 0/50 1/50 0/50 1/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 1/50 1/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Osteosarcoma or Osteoma Total 10/1055(0.9%) 5/1052(0.5%) Mean(sd) 0.9%(1.0) 0.5%(0.9) Range 0/50 - 1/48 0/53 - 1/49 Males 1/53 0/50 1/54 0/54 0/50 1/48 0/50 1/50 0/50 0/50 1/50 0/50 1/50 0/46 1/50 1/50 1/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 1/50 1/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 2/1052(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== BRAIN FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Astrocytoma Benign Total 0/1055(0%) 2/1049(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/53 - 0/53 0/53 - 1/49 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 1/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 2/1055(0.2%) 1/1049(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 1/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma NOS Total 0/1055(0%) 1/1049(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/53 - 0/53 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant Total 4/1055(0.4%) 1/1049(0.1%) Mean(sd) 0.4%(1.0) 0.1%(0.5) Range 0/53 - 2/50 0/53 - 1/46 Males 0/53 0/50 0/54 0/54 0/50 1/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 2/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 1/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Glioma Malignant, Mixed Total 1/1055(0.1%) 0/1049(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Glioma NOS Total 1/1055(0.1%) 0/1049(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/54 0/53 - 0/53 Males 0/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/1055(0%) 1/1049(0.1%) Benign Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/49 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 1/49 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 0/1055(0%) 0/1049(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Meningioma Benign Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Meningioma Malignant Total 1/1055(0.1%) 0/1049(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Meningioma: Benign, Total 1/1055(0.1%) 0/1049(0%) Malignant, NOS Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Benign Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma Total 1/1055(0.1%) 0/1049(0%) Malignant Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma NOS Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Oligodendroglioma, Total 8/1055(0.8%) 5/1049(0.5%) Glioma, or Astrocytoma Mean(sd) 0.8%(1.3) 0.5%(0.9) Range 0/53 - 2/50 0/53 - 1/46 Males 0/53 0/50 1/54 0/54 0/50 1/48 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/46 2/50 0/50 0/50 0/50 0/50 1/50 2/50 Females 0/53 0/50 0/52 0/53 0/50 1/48 0/50 1/49 0/50 0/50 0/50 0/50 0/49 1/46 0/50 1/50 0/50 1/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1055(0%) 0/1049(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== CLITORAL/PREPUTIAL GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 37/1044(3.5%) 65/1003(6.5%) Mean(sd) 3.6%(2.8) 6.5%(4.9) Range 0/50 - 4/50 0/52 - 8/50 Males 1/53 0/50 2/54 1/54 1/50 0/47 2/50 3/50 0/50 2/50 0/50 2/49 1/50 3/44 3/46 4/50 2/49 3/49 0/50 3/49 4/50 Females 0/52 0/49 4/51 1/53 6/49 1/46 3/47 2/46 5/50 2/44 8/50 1/48 3/49 1/44 6/46 7/47 4/44 2/47 1/48 5/43 3/50 --------------------------------------------------------------------------- Carcinoma Total 48/1044(4.6%) 38/1003(3.8%) Mean(sd) 4.6%(3.8) 3.8%(3.1) Range 0/54 - 6/50 0/51 - 5/49 Males 2/53 6/50 1/54 0/54 3/50 5/47 3/50 3/50 3/50 3/50 4/50 3/49 0/50 0/44 5/46 0/50 3/49 0/49 2/50 1/49 1/50 Females 1/52 5/49 0/51 2/53 1/49 4/46 2/47 0/46 2/50 1/44 3/50 1/48 3/49 1/44 3/46 0/47 3/44 1/47 4/48 0/43 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 84/1044(8%) 103/1003(10.3%) Mean(sd) 8.1%(3.6) 10.3%(5.2) Range 1/54 - 8/46 1/52 - 11/50 Males 3/53 6/50 3/54 1/54 4/50 5/47 5/50 6/50 3/50 5/50 4/50 5/49 1/50 3/44 8/46 4/50 4/49 3/49 2/50 4/49 5/50 Females 1/52 5/49 4/51 3/53 7/49 5/46 5/47 2/46 7/50 3/44 11/50 2/48 6/49 2/44 9/46 7/47 7/44 3/47 5/48 5/43 4/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1044(0%) 0/1003(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/54 0/50 0/47 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/44 0/46 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/52 0/49 0/51 0/53 0/49 0/46 0/47 0/46 0/50 0/44 0/50 0/48 0/49 0/44 0/46 0/47 0/44 0/47 0/48 0/43 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1044(0%) 0/1003(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/54 0/50 0/47 0/50 0/50 0/50 0/50 0/50 0/49 0/50 0/44 0/46 0/50 0/49 0/49 0/50 0/49 0/50 Females 0/52 0/49 0/51 0/53 0/49 0/46 0/47 0/46 0/50 0/44 0/50 0/48 0/49 0/44 0/46 0/47 0/44 0/47 0/48 0/43 0/50 --------------------------------------------------------------------------- =========================================================================== EAR FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/53 - 1/48 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 1/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ESOPHAGUS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== EYE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Melanoma NOS Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HARDERIAN GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/955(0%) 1/952(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/955(0%) 1/952(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/955(0%) 0/952(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/0 0/50 0/50 0/46 0/50 0/0 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== HEART FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 1/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 2/1055(0.2%) 0/1052(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/46 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/1055(0%) 2/1052(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/53 - 0/53 0/50 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/53 0/50 0/53 0/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: CECUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangiosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE LARGE: COLON/RECTUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/1055(0.1%) 2/1052(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: DUODENUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: ILEUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: JEJUNUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 4/1055(0.4%) 1/1052(0.1%) Mean(sd) 0.4%(0.8) 0.1%(0.4) Range 0/53 - 1/46 0/53 - 1/50 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/53 - 1/48 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 1/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== INTESTINE SMALL: SITE UNSPECIFIED FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 5/1055(0.5%) 1/1052(0.1%) Mean(sd) 0.5%(0.9) 0.1%(0.4) Range 0/53 - 1/46 0/53 - 1/50 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 1/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/1055(0.5%) 1/1052(0.1%) Mean(sd) 0.5%(0.9) 0.1%(0.4) Range 0/53 - 1/46 0/53 - 1/50 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 1/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/53 - 1/48 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 1/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Mast Cell Tumor Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Adenomatous Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ISLETS, PANCREATIC FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 64/1050(6.1%) 25/1043(2.4%) Mean(sd) 6.1%(3.7) 2.4%(2.7) Range 1/50 - 8/50 0/53 - 5/46 Males 2/53 7/50 2/52 2/54 3/50 1/48 1/50 3/50 2/50 3/50 2/48 4/50 1/50 3/45 5/50 8/50 3/50 3/50 1/50 4/50 4/50 Females 0/53 2/50 0/52 1/52 0/50 0/48 1/49 2/49 4/49 1/49 1/50 1/48 0/49 5/46 1/50 1/50 1/49 1/50 2/50 0/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 39/1050(3.7%) 6/1043(0.6%) Mean(sd) 3.7%(2.8) 0.6%(1.1) Range 0/53 - 4/50 0/50 - 2/49 Males 0/53 4/50 0/52 1/54 1/50 1/48 2/50 3/50 3/50 1/50 0/48 1/50 4/50 1/45 4/50 1/50 1/50 2/50 2/50 3/50 4/50 Females 1/53 0/50 0/52 0/52 0/50 0/48 0/49 1/49 2/49 0/49 0/50 1/48 0/49 0/46 0/50 0/50 0/49 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 103/1050(9.8%) 31/1043(3%) Mean(sd) 9.8%(5.2) 3.0%(3.2) Range 2/53 - 11/50 0/52 - 6/49 Males 2/53 11/50 2/52 3/54 4/50 2/48 3/50 6/50 5/50 4/50 2/48 5/50 5/50 4/45 9/50 9/50 4/50 5/50 3/50 7/50 8/50 Females 1/53 2/50 0/52 1/52 0/50 0/48 1/49 3/49 6/49 1/49 1/50 2/48 0/49 5/46 1/50 1/50 1/49 1/50 2/50 1/50 1/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1052(0%) 1/1048(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/52 - 0/52 0/53 - 1/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 1/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1052(0%) 1/1048(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/52 - 0/52 0/53 - 1/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 1/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 0/1052(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== KIDNEY: RENAL TUBULE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 13/1052(1.2%) 1/1048(0.1%) Mean(sd) 1.2%(1.5) 0.1%(0.4) Range 0/52 - 2/49 0/53 - 1/50 Males 0/52 0/50 1/54 0/54 0/50 1/48 0/50 0/50 1/50 1/50 2/49 1/50 0/50 0/45 1/50 0/50 1/50 0/50 0/50 2/50 2/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1052(0.1%) 5/1048(0.5%) Mean(sd) 0.1%(0.4) 0.5%(0.9) Range 0/52 - 1/50 0/53 - 1/50 Males 0/52 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 0/52 0/53 0/50 0/48 0/50 0/49 1/49 0/50 0/50 1/50 0/49 0/46 0/50 1/50 0/50 0/50 0/49 0/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 14/1052(1.3%) 6/1048(0.6%) Mean(sd) 1.3%(1.5) 0.6%(0.9) Range 0/52 - 2/49 0/53 - 1/50 Males 0/52 0/50 1/54 0/54 1/50 1/48 0/50 0/50 1/50 1/50 2/49 1/50 0/50 0/45 1/50 0/50 1/50 0/50 0/50 2/50 2/50 Females 0/53 1/50 0/52 0/53 0/50 0/48 0/50 0/49 1/49 0/50 0/50 1/50 0/49 0/46 0/50 1/50 0/50 0/50 0/49 1/50 1/50 --------------------------------------------------------------------------- Lipoma Total 2/1052(0.2%) 2/1048(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/52 - 1/50 0/53 - 1/49 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 1/50 0/50 1/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 1/49 0/50 0/50 1/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1052(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Mesenchymal Tumor Benign Total 0/1052(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Nephroblastoma Total 0/1052(0%) 1/1048(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/52 - 0/52 0/50 - 1/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Oncocytoma Benign Total 0/1052(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1052(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Stromal Nephroma Total 1/1052(0.1%) 0/1048(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/52 - 1/50 0/53 - 0/53 Males 0/52 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/49 0/50 0/50 0/50 0/49 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LACRIMAL GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LIVER FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Cholangiocarcinoma Total 2/1054(0.2%) 0/1050(0%) Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/50 1/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Cholangioma Total 0/1054(0%) 0/1050(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1054(0%) 0/1050(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Adenoma Total 20/1054(1.9%) 4/1050(0.4%) Mean(sd) 1.9%(2.2) 0.4%(0.8) Range 0/48 - 4/53 0/53 - 1/50 Males 4/53 1/50 1/54 3/54 3/50 0/48 0/50 0/50 1/50 0/50 1/50 0/50 0/50 1/45 1/50 1/50 1/50 0/50 0/50 2/50 0/50 Females 0/53 1/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 1/50 1/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Carcinoma Total 8/1054(0.8%) 0/1050(0%) Mean(sd) 0.7%(1.3) 0.0%(0.0) Range 0/53 - 2/50 0/53 - 0/53 Males 0/53 0/50 1/54 2/54 1/50 1/48 0/50 0/50 0/50 2/50 0/50 1/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 8/1054(0.8%) 0/1050(0%) Carcinoma or Mean(sd) 0.7%(1.3) 0.0%(0.0) Hepatoblastoma Range 0/53 - 2/50 0/53 - 0/53 Males 0/53 0/50 1/54 2/54 1/50 1/48 0/50 0/50 0/50 2/50 0/50 1/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 28/1054(2.7%) 4/1050(0.4%) Carcinoma or Mean(sd) 2.6%(2.7) 0.4%(0.8) Hepatocellular Adenoma Range 0/50 - 5/54 0/53 - 1/50 Males 4/53 1/50 2/54 5/54 4/50 1/48 0/50 0/50 1/50 2/50 1/50 1/50 0/50 1/45 1/50 1/50 1/50 0/50 0/50 2/50 0/50 Females 0/53 1/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 1/50 1/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Hepatocellular Total 28/1054(2.7%) 4/1050(0.4%) Carcinoma, Mean(sd) 2.6%(2.7) 0.4%(0.8) Hepatocellular Adenoma, Range 0/50 - 5/54 0/53 - 1/50 or Hepatoblastoma Males 4/53 1/50 2/54 5/54 4/50 1/48 0/50 0/50 1/50 2/50 1/50 1/50 0/50 1/45 1/50 1/50 1/50 0/50 0/50 2/50 0/50 Females 0/53 1/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 1/50 1/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LUNG FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Alveolar/Bronchiolar Total 18/1054(1.7%) 12/1050(1.1%) Adenoma Mean(sd) 1.7%(2.4) 1.1%(1.3) Range 0/53 - 5/50 0/52 - 2/50 Males 0/53 5/50 0/54 0/54 0/50 1/48 0/49 2/50 1/50 0/50 1/50 0/50 0/50 0/46 1/50 1/50 0/50 2/50 1/50 1/50 2/50 Females 2/53 1/50 0/52 1/53 0/50 0/48 1/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 1/50 1/50 1/49 0/50 2/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 8/1054(0.8%) 2/1050(0.2%) Carcinoma Mean(sd) 0.8%(1.2) 0.2%(0.6) Range 0/53 - 2/50 0/53 - 1/50 Males 0/53 0/50 1/54 0/54 0/50 1/48 1/49 0/50 0/50 0/50 2/50 0/50 0/50 1/46 0/50 0/50 0/50 1/50 0/50 1/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 1/50 0/50 0/50 1/49 0/50 0/50 --------------------------------------------------------------------------- Alveolar/Bronchiolar Total 26/1054(2.5%) 14/1050(1.3%) Carcinoma or Mean(sd) 2.5%(2.6) 1.3%(1.5) Alveolar/Bronchiolar Range 0/53 - 5/50 0/52 - 2/49 Adenoma Males 0/53 5/50 1/54 0/54 0/50 2/48 1/49 2/50 1/50 0/50 3/50 0/50 0/50 1/46 1/50 1/50 0/50 3/50 1/50 2/50 2/50 Females 2/53 1/50 0/52 1/53 0/50 0/48 1/50 1/49 0/50 0/50 0/50 1/50 0/50 0/46 0/50 1/50 1/50 1/50 2/49 0/50 2/50 --------------------------------------------------------------------------- Carcinoma Total 0/1054(0%) 0/1050(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1054(0%) 0/1050(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1054(0%) 0/1050(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/49 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 4/1054(0.4%) 1/1050(0.1%) Mean(sd) 0.4%(0.8) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 1/54 1/54 0/50 0/48 0/49 0/50 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, BRONCHIAL FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Plasma Cell Tumor Total 1/1055(0.1%) 0/1052(0%) Malignant Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MANDIBULAR FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangiosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MEDIASTINAL FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Plasma Cell Tumor Total 1/1055(0.1%) 1/1052(0.1%) Malignant Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE, MESENTERIC FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Hemangiosarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== LYMPH NODE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Sarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- =========================================================================== MAMMARY GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoacanthoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Adenoma Total 1/1055(0.1%) 13/1052(1.2%) Mean(sd) 0.1%(0.4) 1.2%(1.3) Range 0/50 - 1/53 0/50 - 2/50 Males 1/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 1/53 0/50 1/53 1/53 1/50 0/48 0/50 0/49 2/50 0/50 0/50 1/50 0/50 0/46 0/50 2/50 1/50 1/50 0/50 1/50 1/50 --------------------------------------------------------------------------- Carcinoma Total 4/1055(0.4%) 71/1052(6.7%) Mean(sd) 0.4%(0.8) 6.8%(4.2) Range 0/53 - 1/50 1/53 - 9/50 Males 0/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 1/50 Females 1/53 3/50 4/53 1/53 3/50 2/48 4/50 4/49 3/50 1/50 8/50 5/50 5/50 3/46 3/50 2/50 9/50 3/50 1/50 4/50 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/1055(0.5%) 83/1052(7.9%) Mean(sd) 0.5%(0.9) 7.9%(4.3) Range 0/50 - 1/50 1/50 - 10/50 Males 1/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 1/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 1/50 Females 2/53 3/50 5/53 2/53 4/50 2/48 4/50 4/49 5/50 1/50 8/50 5/50 5/50 3/46 3/50 4/50 10/50 4/50 1/50 5/50 3/50 --------------------------------------------------------------------------- Fibroadenoma Total 24/1055(2.3%) 421/1052(40%) Mean(sd) 2.3%(2.1) 40.0%(8.8) Range 0/53 - 3/50 12/53 - 27/50 Males 0/53 0/50 0/54 2/54 2/50 0/48 2/50 2/50 3/50 0/50 0/50 0/50 1/50 0/46 3/50 1/50 2/50 2/50 1/50 2/50 1/50 Females 22/53 12/50 17/53 12/53 22/50 16/48 19/50 24/49 22/50 22/50 26/50 23/50 24/50 11/46 23/50 19/50 19/50 19/50 27/50 20/50 22/50 --------------------------------------------------------------------------- Fibroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma Total 25/1055(2.4%) 431/1052(41%) or Adenoma Mean(sd) 2.4%(2.1) 41.0%(8.7) Range 0/50 - 3/50 11/46 - 27/50 Males 1/53 0/50 0/54 2/54 2/50 0/48 2/50 2/50 3/50 0/50 0/50 0/50 1/50 0/46 3/50 1/50 2/50 2/50 1/50 2/50 1/50 Females 23/53 12/50 18/53 13/53 23/50 16/48 19/50 24/49 23/50 22/50 26/50 24/50 24/50 11/46 23/50 20/50 20/50 20/50 27/50 21/50 22/50 --------------------------------------------------------------------------- Fibroma, Fibroadenoma, Total 29/1055(2.7%) 471/1052(44.8%) Carcinoma, or Adenoma Mean(sd) 2.7%(2.1) 44.8%(9.3) Range 0/50 - 3/50 13/53 - 29/50 Males 1/53 0/50 1/54 2/54 2/50 0/48 2/50 2/50 3/50 0/50 0/50 0/50 2/50 0/46 3/50 1/50 3/50 2/50 1/50 2/50 2/50 Females 24/53 14/50 22/53 13/53 24/50 17/48 20/50 28/49 25/50 23/50 29/50 27/50 26/50 13/46 25/50 21/50 25/50 22/50 27/50 23/50 23/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/53 - 0/53 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== MESENTERY FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1055(0.1%) 2/1052(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.9) Range 0/53 - 1/50 0/53 - 2/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 2/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Benign Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/54 0/53 - 0/53 Males 0/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== NOSE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Chondroma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Chondrosarcoma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Osteoma Total 1/1048(0.1%) 0/1044(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/53 - 1/45 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 1/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1048(0%) 0/1044(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/48 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/45 0/48 0/50 0/50 0/49 0/50 0/50 0/49 Females 0/53 0/50 0/51 0/53 0/50 0/47 0/50 0/49 0/50 0/48 0/50 0/49 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA) FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Papilloma Squamous or Total 14/1055(1.3%) 13/1052(1.2%) Papilloma Mean(sd) 1.3%(2.2) 1.2%(1.2) Range 0/50 - 4/50 0/53 - 2/50 Males 1/53 0/50 2/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/46 4/50 0/50 0/50 3/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 0/53 2/50 1/48 1/50 1/49 1/50 1/50 1/50 0/50 1/50 0/46 0/50 1/50 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 3/1055(0.3%) 7/1052(0.7%) Mean(sd) 0.3%(0.7) 0.7%(1.4) Range 0/53 - 1/50 0/53 - 3/53 Males 0/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 1/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 3/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 17/1055(1.6%) 20/1052(1.9%) Carcinoma, Papilloma Mean(sd) 1.6%(2.3) 1.9%(1.6) Squamous, or Papilloma Range 0/50 - 4/50 0/53 - 3/53 Males 1/53 0/50 2/54 0/54 2/50 0/48 0/50 0/50 0/50 1/50 2/50 1/50 0/50 0/46 4/50 0/50 0/50 3/50 0/50 1/50 0/50 Females 0/53 1/50 3/53 0/53 2/50 1/48 1/50 1/49 1/50 2/50 1/50 0/50 2/50 1/46 0/50 1/50 1/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== ORAL MUCOSA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Sarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1055(0.1%) 5/1052(0.5%) Mean(sd) 0.1%(0.4) 0.5%(1.3) Range 0/53 - 1/50 0/53 - 3/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 3/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 1/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 8/1055(0.8%) 5/1052(0.5%) Mean(sd) 0.7%(1.7) 0.5%(0.9) Range 0/53 - 3/50 0/53 - 1/49 Males 0/53 0/50 2/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 3/50 0/50 0/50 2/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 1/50 0/50 1/50 0/50 0/50 0/46 0/50 1/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== OVARY FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1050(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Arrhenoblastoma Benign Total 0/1050(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 7/1050(0.7%) Benign Mean(sd) 0.7%(1.1) Range 0/53 - 2/53 Females 2/53 1/50 1/52 0/53 0/50 0/48 1/50 0/49 1/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor Total 2/1050(0.2%) Malignant Mean(sd) 0.2%(0.6) Range 0/53 - 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 1/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa Cell Tumor: Total 9/1050(0.9%) Benign, Malignant, NOS Mean(sd) 0.8%(1.3) Range 0/53 - 2/50 Females 2/53 1/50 1/52 0/53 0/50 0/48 2/50 0/49 1/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 1/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 1/1050(0.1%) Benign Mean(sd) 0.1%(0.4) Range 0/53 - 1/53 Females 0/53 0/50 0/52 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Granulosa-Theca Tumor Total 2/1050(0.2%) Malignant Mean(sd) 0.2%(0.6) Range 0/53 - 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 1/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Luteoma Total 0/1050(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1050(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sex Cord Stromal Total 1/1050(0.1%) Tumor, Malignant Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Tubulostromal Adenoma Total 0/1050(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PANCREAS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 13/1052(1.2%) 0/1043(0%) Mean(sd) 1.2%(1.7) 0.0%(0.0) Range 0/50 - 3/50 0/53 - 0/53 Males 1/53 0/50 0/53 0/54 0/50 0/48 3/50 1/50 0/50 1/50 2/49 0/50 0/50 0/45 1/50 1/50 0/50 0/50 0/50 1/50 2/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1052(0.1%) 1/1043(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/52 Males 0/53 0/50 0/53 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 1/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 1/52 0/52 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 14/1052(1.3%) 1/1043(0.1%) Mean(sd) 1.3%(1.7) 0.1%(0.4) Range 0/50 - 3/50 0/53 - 1/52 Males 1/53 0/50 0/53 0/54 0/50 0/48 3/50 1/50 0/50 1/50 2/49 0/50 1/50 0/45 1/50 1/50 0/50 0/50 0/50 1/50 2/50 Females 0/53 0/50 1/52 0/52 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1052(0%) 0/1043(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/53 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Mixed Tumor Benign Total 1/1052(0.1%) 0/1043(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/53 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/49 0/50 0/50 0/45 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PARATHYROID GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 3/992(0.3%) 1/980(0.1%) Mean(sd) 0.3%(0.7) 0.1%(0.5) Range 0/47 - 1/48 0/48 - 1/48 Males 1/50 0/47 0/49 1/50 0/50 0/47 0/48 1/48 0/48 0/47 0/47 0/46 0/42 0/39 0/47 0/47 0/49 0/45 0/48 0/49 0/49 Females 0/48 0/42 0/49 0/47 1/48 0/44 0/48 0/48 0/50 0/50 0/47 0/43 0/42 0/41 0/46 0/50 0/46 0/48 0/46 0/49 0/48 --------------------------------------------------------------------------- =========================================================================== PERIPHERAL NERVE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Paraganglioma Benign Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/54 0/53 - 0/53 Males 0/53 0/50 0/54 1/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma: Benign, Total 0/1055(0%) 0/1052(0%) Malignant, NOS Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PHARYNX FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Squamous Cell Carcinoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/53 - 0/53 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 662/1047(63.2%) 694/1043(66.5%) Mean(sd) 63.4%(18.3) 66.6%(14.0) Range 13/54 - 43/49 20/52 - 43/49 Males 20/53 23/50 13/54 24/53 39/50 25/48 39/50 40/50 43/49 37/49 21/49 33/49 32/50 25/45 24/49 38/50 36/50 25/49 41/50 41/50 43/50 Females 24/52 31/50 22/52 20/52 43/50 24/48 33/50 36/48 40/50 43/49 42/50 33/49 37/50 25/46 33/50 33/50 38/50 30/49 34/48 34/50 39/50 --------------------------------------------------------------------------- Carcinoma Total 0/1047(0%) 3/1043(0.3%) Mean(sd) 0.0%(0.0) 0.3%(0.7) Range 0/53 - 0/53 0/52 - 1/46 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 0/50 0/52 1/52 0/50 0/48 1/50 0/48 0/50 0/49 0/50 0/49 0/50 1/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 662/1047(63.2%) 697/1043(66.8%) Mean(sd) 63.4%(18.3) 66.9%(13.8) Range 13/54 - 43/49 21/52 - 43/49 Males 20/53 23/50 13/54 24/53 39/50 25/48 39/50 40/50 43/49 37/49 21/49 33/49 32/50 25/45 24/49 38/50 36/50 25/49 41/50 41/50 43/50 Females 24/52 31/50 22/52 21/52 43/50 24/48 34/50 36/48 40/50 43/49 42/50 33/49 37/50 26/46 33/50 33/50 38/50 30/49 34/48 34/50 39/50 --------------------------------------------------------------------------- Craniopharyngioma Total 0/1047(0%) 0/1043(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 0/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- Ganglioneuroma Total 0/1047(0%) 0/1043(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 0/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS INTERMEDIA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 2/1047(0.2%) 2/1043(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.9) Range 0/53 - 1/48 0/52 - 2/50 Males 0/53 0/50 0/54 0/53 1/50 1/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 2/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1047(0%) 0/1043(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 0/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 2/1047(0.2%) 2/1043(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.9) Range 0/53 - 1/48 0/52 - 2/50 Males 0/53 0/50 0/54 0/53 1/50 1/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 2/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PITUITARY GLAND: PARS NERVOSA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1047(0%) 0/1043(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/52 - 0/52 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 0/49 0/49 0/49 0/49 0/50 0/45 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/52 0/50 0/52 0/52 0/50 0/48 0/50 0/48 0/50 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/50 0/49 0/48 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== PROSTATE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 4/1052(0.4%) Mean(sd) 0.4%(0.8) Range 0/53 - 1/50 Males 0/53 0/50 0/54 0/53 0/50 0/48 0/50 0/50 1/50 1/50 0/50 0/50 0/50 0/46 1/49 0/50 1/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma Total 1/1052(0.1%) Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Males 0/53 0/50 0/54 0/53 0/50 0/48 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/49 0/50 0/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 5/1052(0.5%) Mean(sd) 0.5%(0.9) Range 0/53 - 1/50 Males 0/53 0/50 0/54 0/53 0/50 0/48 1/50 0/50 1/50 1/50 0/50 0/50 0/50 0/46 1/49 0/50 1/50 0/50 0/50 0/49 0/50 --------------------------------------------------------------------------- =========================================================================== SALIVARY GLANDS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1051(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/47 0/50 0/50 0/49 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 0/1051(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/47 0/50 0/50 0/49 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1051(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/47 0/50 0/50 0/49 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1051(0%) 0/1048(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/47 0/50 0/50 0/49 0/50 Females 0/53 0/50 0/52 0/52 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/50 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SEMINAL VESICLE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 1/1055(0.1%) Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKELETAL MUSCLE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Lipoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 1/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Rhabdomyosarcoma or Total 1/1055(0.1%) 1/1052(0.1%) Rhabdomyoma Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 1/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 1/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN1: SEBACEOUS GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 5/1055(0.5%) 0/1052(0%) Mean(sd) 0.5%(0.9) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 1/50 0/50 0/50 0/50 1/50 0/46 0/50 1/50 0/50 0/50 1/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 2/1055(0.2%) 1/1052(0.1%) Mean(sd) 0.2%(0.9) 0.1%(0.4) Range 0/53 - 2/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 7/1055(0.7%) 1/1052(0.1%) Mean(sd) 0.7%(1.2) 0.1%(0.4) Range 0/53 - 2/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 1/50 0/50 0/50 0/50 1/50 0/46 0/50 1/50 2/50 0/50 1/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 1/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN2 FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Basal Cell Adenoma Total 9/1055(0.9%) 1/1052(0.1%) Mean(sd) 0.8%(1.5) 0.1%(0.4) Range 0/53 - 2/50 0/53 - 1/53 Males 0/53 0/50 0/54 2/54 0/50 0/48 1/50 1/50 2/50 0/50 1/50 0/50 0/50 0/46 2/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma or Total 11/1055(1%) 1/1052(0.1%) Basosquamous Tumor Mean(sd) 1.0%(1.6) 0.1%(0.4) Benign Range 0/53 - 2/50 0/53 - 1/53 Males 0/53 0/50 0/54 2/54 2/50 0/48 1/50 1/50 2/50 0/50 1/50 0/50 0/50 0/46 2/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Adenoma, Total 13/1055(1.2%) 2/1052(0.2%) Basosquamous Tumor Mean(sd) 1.2%(1.6) 0.2%(0.6) Benign, or Range 0/53 - 2/50 0/53 - 1/48 Trichoepithelioma Males 0/53 0/50 0/54 2/54 2/50 0/48 1/50 1/50 2/50 0/50 1/50 1/50 1/50 0/46 2/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 4/1055(0.4%) 3/1052(0.3%) Mean(sd) 0.4%(1.2) 0.3%(0.7) Range 0/53 - 2/50 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 2/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma Total 4/1055(0.4%) 3/1052(0.3%) or Basosquamous Tumor Mean(sd) 0.4%(1.2) 0.3%(0.7) (malignant or NOS) Range 0/53 - 2/50 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 2/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal Cell Carcinoma, Total 17/1055(1.6%) 4/1052(0.4%) Basal Cell Adenoma, Mean(sd) 1.6%(2.1) 0.4%(0.8) Basosquamous Tumor Range 0/53 - 4/50 0/53 - 1/48 (benign, malignant or NOS), or Trichoepithelioma Males 0/53 0/50 0/54 2/54 2/50 0/48 1/50 1/50 2/50 0/50 1/50 1/50 1/50 0/46 4/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 1/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basal or Sq. Cell Total 81/1055(7.7%) 29/1052(2.8%) Carcinoma, Carcinoma, Mean(sd) 7.7%(4.4) 2.8%(2.2) Basosq. Tumor (M or B), Range 0/48 - 8/50 0/53 - 4/53 Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma Males 7/53 1/50 4/54 3/54 7/50 0/48 3/50 3/50 4/50 2/50 4/50 4/50 1/50 3/46 8/50 7/50 7/50 5/50 2/50 3/50 3/50 Females 0/53 0/50 1/53 4/53 2/50 2/48 2/50 0/49 1/50 2/50 0/50 2/50 3/50 1/46 3/50 1/50 1/50 0/50 1/50 2/50 1/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 2/1055(0.2%) 0/1052(0%) Benign Mean(sd) 0.2%(0.9) 0.0%(0.0) Range 0/53 - 2/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 2/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Basosquamous Tumor Total 0/1055(0%) 0/1052(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Hemangiopericytoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Keratoacanthoma Total 53/1055(5%) 11/1052(1%) Mean(sd) 5.0%(3.1) 1.0%(1.5) Range 0/50 - 6/50 0/53 - 2/50 Males 5/53 0/50 4/54 1/54 3/50 0/48 1/50 2/50 2/50 1/50 3/50 3/50 1/50 2/46 3/50 6/50 5/50 3/50 2/50 3/50 3/50 Females 0/53 0/50 0/53 1/53 2/50 0/48 0/50 0/49 0/50 0/50 0/50 1/50 2/50 0/46 2/50 0/50 1/50 0/50 1/50 0/50 1/50 --------------------------------------------------------------------------- Lipoma Total 8/1055(0.8%) 2/1052(0.2%) Mean(sd) 0.8%(1.2) 0.2%(0.9) Range 0/50 - 2/50 0/53 - 2/50 Males 1/53 0/50 0/54 0/54 0/50 0/48 1/50 2/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 1/50 1/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 2/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Liposarcoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Melanoma Malignant Total 0/1055(0%) 2/1052(0.2%) Mean(sd) 0.0%(0.0) 0.2%(0.6) Range 0/53 - 0/53 0/53 - 1/49 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Osteosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 7/1055(0.7%) 4/1052(0.4%) Mean(sd) 0.7%(1.0) 0.4%(0.8) Range 0/53 - 1/46 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 1/50 0/48 1/50 0/50 0/50 1/50 1/50 0/50 0/50 1/46 0/50 1/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 1/53 0/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 1/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 11/1055(1%) 7/1052(0.7%) Carcinoma, Basal Cell Mean(sd) 1.1%(1.4) 0.7%(1.2) Carcinoma, Basosquamous Range 0/53 - 2/50 0/53 - 2/48 Tumor (malignant or NOS), or Carcinoma Males 0/53 0/50 0/54 0/54 1/50 0/48 1/50 0/50 0/50 1/50 1/50 0/50 0/50 1/46 2/50 1/50 2/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 1/53 0/53 0/50 2/48 0/50 0/49 0/50 1/50 0/50 0/50 1/50 0/46 1/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 8/1055(0.8%) 10/1052(1%) Mean(sd) 0.8%(1.3) 1.0%(1.3) Range 0/54 - 2/50 0/53 - 2/50 Males 2/53 1/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 2/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 2/53 0/50 0/48 2/50 0/49 1/50 1/50 0/50 1/50 0/50 1/46 0/50 1/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 8/1055(0.8%) 10/1052(1%) Papilloma or Papilloma Mean(sd) 0.8%(1.3) 1.0%(1.3) Range 0/54 - 2/50 0/53 - 2/50 Males 2/53 1/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 2/50 0/50 1/50 0/50 Females 0/53 0/50 0/53 2/53 0/50 0/48 2/50 0/49 1/50 1/50 0/50 1/50 0/50 1/46 0/50 1/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 65/1055(6.2%) 25/1052(2.4%) Papilloma, Papilloma, Mean(sd) 6.1%(3.7) 2.4%(1.8) Squamous Cell Carcinoma Range 0/48 - 7/50 0/53 - 3/50 or Keratoacanthoma Males 7/53 1/50 4/54 1/54 5/50 0/48 2/50 2/50 2/50 2/50 3/50 3/50 1/50 3/46 4/50 7/50 5/50 5/50 2/50 3/50 3/50 Females 0/53 0/50 1/53 3/53 2/50 1/48 2/50 0/49 1/50 1/50 0/50 2/50 3/50 1/46 2/50 1/50 1/50 0/50 1/50 2/50 1/50 --------------------------------------------------------------------------- Squamous Cell Total 60/1055(5.7%) 21/1052(2%) Papilloma, Papilloma, or Mean(sd) 5.7%(3.6) 2.0%(1.8) Keratoacanthoma Range 0/48 - 7/53 0/53 - 3/53 Males 7/53 1/50 4/54 1/54 4/50 0/48 1/50 2/50 2/50 1/50 3/50 3/50 1/50 2/46 4/50 6/50 5/50 5/50 2/50 3/50 3/50 Females 0/53 0/50 0/53 3/53 2/50 0/48 2/50 0/49 1/50 1/50 0/50 2/50 2/50 1/46 2/50 1/50 1/50 0/50 1/50 1/50 1/50 --------------------------------------------------------------------------- Trichoepithelioma Total 2/1055(0.2%) 1/1052(0.1%) Mean(sd) 0.2%(0.6) 0.1%(0.5) Range 0/53 - 1/50 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 1/50 1/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SKIN3 FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibroma Total 41/1055(3.9%) 6/1052(0.6%) Mean(sd) 3.9%(2.8) 0.6%(0.9) Range 0/54 - 4/50 0/53 - 1/48 Males 3/53 2/50 0/54 3/54 3/50 3/48 0/50 0/50 0/50 3/50 3/50 2/50 4/50 0/46 2/50 3/50 4/50 1/50 3/50 1/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 1/48 0/50 0/49 0/50 0/50 1/50 0/50 0/50 0/46 0/50 1/50 0/50 1/50 0/50 1/50 1/50 --------------------------------------------------------------------------- Fibroma, Fibrosarcoma, Total 51/1055(4.8%) 20/1052(1.9%) Sarcoma, Myxoma, Mean(sd) 4.8%(3.0) 1.9%(1.7) Myxosarcoma, or Fibrous Range 0/54 - 6/50 0/53 - 3/50 Histiocytoma Males 4/53 3/50 0/54 3/54 3/50 3/48 0/50 2/50 0/50 3/50 3/50 2/50 4/50 1/46 3/50 6/50 4/50 1/50 3/50 1/50 2/50 Females 1/53 1/50 1/53 0/53 1/50 2/48 2/50 2/49 0/50 0/50 1/50 0/50 2/50 1/46 0/50 1/50 0/50 1/50 0/50 1/50 3/50 --------------------------------------------------------------------------- Fibrosarcoma Total 7/1055(0.7%) 6/1052(0.6%) Mean(sd) 0.7%(1.5) 0.6%(1.1) Range 0/54 - 3/50 0/50 - 2/49 Males 1/53 1/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/46 1/50 3/50 0/50 0/50 0/50 0/50 0/50 Females 1/53 0/50 0/53 0/53 0/50 0/48 1/50 2/49 0/50 0/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma, Sarcoma, Total 10/1055(0.9%) 14/1052(1.3%) Myxosarcoma, or Fibrous Mean(sd) 1.0%(1.6) 1.3%(1.6) Histiocytoma Range 0/54 - 3/50 0/53 - 2/49 Males 1/53 1/50 0/54 0/54 0/50 0/48 0/50 2/50 0/50 0/50 0/50 0/50 0/50 1/46 1/50 3/50 0/50 0/50 0/50 0/50 1/50 Females 1/53 1/50 1/53 0/53 1/50 1/48 2/50 2/49 0/50 0/50 0/50 0/50 2/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 2/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Neurofibroma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibroma or Total 2/1055(0.2%) 0/1052(0%) Schwannoma benign Mean(sd) 0.2%(0.6) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/54 0/53 - 0/53 Males 0/53 0/50 0/54 1/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma or Total 5/1055(0.5%) 2/1052(0.2%) Schwannoma (malignant or Mean(sd) 0.5%(1.1) 0.2%(0.6) NOS) Range 0/53 - 2/50 0/53 - 1/50 Males 0/53 0/50 0/54 1/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Neurofibrosarcoma, Total 7/1055(0.7%) 2/1052(0.2%) Neurofibroma, or Mean(sd) 0.7%(1.1) 0.2%(0.6) Schwannoma (benign, Range 0/53 - 2/50 0/53 - 1/50 malignant or NOS) Males 0/53 0/50 0/54 1/54 1/50 0/48 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 2/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 3/1055(0.3%) 7/1052(0.7%) Mean(sd) 0.3%(0.7) 0.7%(1.0) Range 0/53 - 1/46 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 1/50 1/53 0/53 1/50 1/48 1/50 0/49 0/50 0/50 0/50 0/50 1/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Schwannoma Benign Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 4/1055(0.4%) 2/1052(0.2%) Mean(sd) 0.4%(1.0) 0.2%(0.6) Range 0/53 - 2/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 2/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPINAL CORD FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Astrocytoma Benign Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/50 - 1/53 0/53 - 0/53 Males 1/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Astrocytoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chordoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Glioma Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== SPLEEN FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibroma Total 3/1055(0.3%) 0/1045(0%) Mean(sd) 0.3%(0.7) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 1/50 0/50 0/50 0/50 0/50 0/46 0/50 1/50 0/50 0/50 0/50 1/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1055(0%) 0/1045(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1055(0%) 0/1045(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 2/1055(0.2%) 2/1045(0.2%) Mean(sd) 0.2%(0.6) 0.2%(0.6) Range 0/53 - 1/46 0/53 - 1/49 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 1/49 0/49 1/49 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1045(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/1055(0.1%) 0/1045(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 0/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 0/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 1/1055(0.1%) 2/1045(0.2%) Mean(sd) 0.1%(0.4) 0.2%(0.6) Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 1/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/52 0/53 0/50 0/48 1/50 0/48 0/49 0/49 0/50 0/50 0/50 0/46 0/50 0/50 1/49 0/49 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, FORESTOMACH FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Basal Cell Adenoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 1/1055(0.1%) 1/1052(0.1%) Carcinoma or Papilloma Mean(sd) 0.1%(0.4) 0.1%(0.4) Squamous Range 0/53 - 1/50 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 1/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== STOMACH, GLANDULAR FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoid Tumor Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoid Tumor Total 0/1055(0%) 0/1052(0%) Malignant Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TESTES FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 740/1055(70.1%) Mean(sd) 70.1%(11.2) Range 23/50 - 45/50 Males 39/53 38/50 45/54 40/54 39/50 33/48 33/50 34/50 35/50 39/50 45/50 23/50 36/50 31/46 41/50 38/50 35/50 36/50 30/50 27/50 23/50 --------------------------------------------------------------------------- =========================================================================== THYMUS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Sarcoma Total 0/967(0%) 0/989(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 0/42 0/45 0/45 0/46 0/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 0/48 0/47 0/48 0/48 0/43 0/42 0/48 0/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/967(0%) 0/989(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 0/42 0/45 0/45 0/46 0/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 0/48 0/47 0/48 0/48 0/43 0/42 0/48 0/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- Thymoma Benign Total 2/967(0.2%) 1/989(0.1%) Mean(sd) 0.2%(0.7) 0.1%(0.5) Range 0/50 - 1/42 0/49 - 1/45 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 1/42 0/45 0/45 0/46 1/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 0/48 0/47 0/48 0/48 0/43 0/42 0/48 1/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- Thymoma Malignant Total 0/967(0%) 0/989(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/50 - 0/50 0/49 - 0/49 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 0/42 0/45 0/45 0/46 0/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 0/48 0/47 0/48 0/48 0/43 0/42 0/48 0/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- Thymoma NOS Total 0/967(0%) 1/989(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.5) Range 0/50 - 0/50 0/49 - 1/48 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 0/42 0/45 0/45 0/46 0/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 1/48 0/47 0/48 0/48 0/43 0/42 0/48 0/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- Thymoma: Benign, Total 2/967(0.2%) 2/989(0.2%) Malignant, NOS Mean(sd) 0.2%(0.7) 0.2%(0.6) Range 0/50 - 1/42 0/49 - 1/45 Males 0/50 0/48 0/49 0/44 0/49 0/48 0/47 1/42 0/45 0/45 0/46 1/50 0/50 0/41 0/45 0/45 0/43 0/46 0/50 0/44 0/40 Females 0/49 0/47 0/48 1/48 0/47 0/48 0/48 0/43 0/42 0/48 1/45 0/50 0/50 0/44 0/48 0/48 0/47 0/48 0/48 0/45 0/48 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1041(0%) 0/1038(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/52 - 0/52 0/51 - 0/51 Males 0/52 0/49 0/53 0/54 0/50 0/48 0/49 0/50 0/49 0/50 0/46 0/50 0/50 0/45 0/50 0/50 0/49 0/50 0/50 0/49 0/48 Females 0/51 0/50 0/52 0/52 0/50 0/48 0/48 0/49 0/49 0/49 0/50 0/48 0/50 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: C-CELL FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 88/1041(8.5%) 89/1038(8.6%) Mean(sd) 8.4%(4.4) 8.6%(4.9) Range 1/50 - 8/50 1/52 - 8/50 Males 4/52 5/49 8/53 6/54 7/50 6/48 3/49 3/50 4/49 3/50 3/46 4/50 1/50 1/45 7/50 8/50 5/49 3/50 1/50 1/49 5/48 Females 3/51 6/50 1/52 1/52 5/50 3/48 6/48 7/49 6/49 3/49 7/50 2/48 2/50 1/46 6/50 8/50 7/49 2/48 1/49 5/50 7/50 --------------------------------------------------------------------------- Carcinoma Total 28/1041(2.7%) 22/1038(2.1%) Mean(sd) 2.7%(2.5) 2.1%(2.2) Range 0/49 - 4/50 0/51 - 3/49 Males 2/52 0/49 0/53 1/54 2/50 3/48 1/49 2/50 3/49 4/50 0/46 2/50 0/50 1/45 1/50 0/50 0/49 2/50 3/50 1/49 0/48 Females 0/51 0/50 1/52 0/52 2/50 0/48 2/48 1/49 3/49 3/49 2/50 2/48 0/50 0/46 0/50 2/50 1/49 0/48 1/49 0/50 2/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 114/1041(11%) 111/1038(10.7%) Mean(sd) 10.9%(4.3) 10.7%(6.1) Range 1/50 - 9/48 1/52 - 10/50 Males 6/52 5/49 8/53 7/54 8/50 9/48 4/49 5/50 7/49 7/50 3/46 6/50 1/50 2/45 7/50 8/50 5/49 5/50 4/50 2/49 5/48 Females 3/51 6/50 2/52 1/52 7/50 3/48 8/48 8/49 9/49 6/49 9/50 4/48 2/50 1/46 6/50 10/50 8/49 2/48 2/49 5/50 9/50 --------------------------------------------------------------------------- =========================================================================== THYROID GLAND: FOLLICULAR CELL FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 9/1041(0.9%) 6/1038(0.6%) Mean(sd) 0.9%(1.2) 0.6%(1.1) Range 0/52 - 2/50 0/51 - 2/50 Males 0/52 0/49 0/53 1/54 1/50 0/48 1/49 0/50 0/49 1/50 1/46 2/50 1/50 0/45 1/50 0/50 0/49 0/50 0/50 0/49 0/48 Females 0/51 1/50 0/52 0/52 0/50 0/48 0/48 1/49 0/49 1/49 2/50 0/48 0/50 0/46 1/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 10/1041(1%) 5/1038(0.5%) Mean(sd) 1.0%(1.0) 0.5%(0.9) Range 0/52 - 1/45 0/51 - 1/48 Males 0/52 0/49 0/53 1/54 0/50 0/48 1/49 0/50 1/49 0/50 0/46 1/50 0/50 1/45 1/50 1/50 0/49 1/50 0/50 1/49 1/48 Females 0/51 0/50 0/52 0/52 0/50 1/48 0/48 0/49 0/49 0/49 0/50 0/48 0/50 0/46 1/50 0/50 0/49 0/48 1/49 1/50 1/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 19/1041(1.8%) 11/1038(1.1%) Mean(sd) 1.8%(1.7) 1.1%(1.4) Range 0/52 - 3/50 0/51 - 2/50 Males 0/52 0/49 0/53 2/54 1/50 0/48 2/49 0/50 1/49 1/50 1/46 3/50 1/50 1/45 2/50 1/50 0/49 1/50 0/50 1/49 1/48 Females 0/51 1/50 0/52 0/52 0/50 1/48 0/48 1/49 0/49 1/49 2/50 0/48 0/50 0/46 2/50 0/50 0/49 0/48 1/49 1/50 1/50 --------------------------------------------------------------------------- =========================================================================== TISSUE NOS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Chemodectoma Malignant Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 1/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/50 - 1/53 0/53 - 1/53 Males 1/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrous Histiocytoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Osteosarcoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.4) Range 0/53 - 1/54 0/53 - 1/53 Males 0/53 0/50 0/54 1/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Paraganglioma Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/54 0/53 - 0/53 Males 0/53 0/50 1/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 1/1055(0.1%) 0/1052(0%) Mean(sd) 0.1%(0.4) 0.0%(0.0) Range 0/53 - 1/50 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 1/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1055(0%) 3/1052(0.3%) Mean(sd) 0.0%(0.0) 0.3%(1.2) Range 0/53 - 0/53 0/53 - 3/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 3/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Yolk Sac Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== TONGUE FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 1/1055(0.1%) 1/1052(0.1%) Mean(sd) 0.1%(0.4) 0.1%(0.5) Range 0/53 - 1/50 0/53 - 1/46 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 1/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 1/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Total 7/1055(0.7%) 8/1052(0.8%) Carcinoma or Papilloma Mean(sd) 0.7%(1.1) 0.8%(1.2) Squamous Range 0/50 - 2/50 0/53 - 2/50 Males 1/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 2/50 1/50 0/50 0/46 1/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 2/50 0/48 1/50 0/49 0/50 1/50 0/50 0/50 1/50 1/46 0/50 0/50 0/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 6/1055(0.6%) 7/1052(0.7%) Mean(sd) 0.6%(0.9) 0.7%(1.2) Range 0/50 - 1/50 0/53 - 2/50 Males 1/53 0/50 0/54 0/54 1/50 0/48 0/50 0/50 0/50 0/50 1/50 1/50 0/50 0/46 1/50 0/50 0/50 1/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 2/50 0/48 1/50 0/49 0/50 1/50 0/50 0/50 1/50 0/46 0/50 0/50 0/50 0/50 1/50 1/50 0/50 --------------------------------------------------------------------------- =========================================================================== TOOTH FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adamantinoma Benign Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Adamantinoma Malignant Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Odontoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 1/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URETHRA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== URINARY BLADDER FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Carcinoma Total 1/1050(0.1%) 0/1042(0%) Mean(sd) 0.1%(0.5) 0.0%(0.0) Range 0/53 - 1/46 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/49 0/48 0/50 0/50 0/50 0/50 0/48 0/50 0/50 1/46 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/52 0/49 0/48 0/50 0/49 0/49 0/49 0/50 0/49 0/49 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Papilloma Total 3/1050(0.3%) 1/1042(0.1%) Mean(sd) 0.3%(1.0) 0.1%(0.5) Range 0/53 - 2/49 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/49 0/48 0/50 0/50 0/50 0/50 0/48 0/50 0/50 1/46 2/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/52 0/49 1/48 0/50 0/49 0/49 0/49 0/50 0/49 0/49 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 0/1050(0%) 0/1042(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/49 0/48 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/46 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/52 0/49 0/48 0/50 0/49 0/49 0/49 0/50 0/49 0/49 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1050(0%) 0/1042(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/49 0/48 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/46 0/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/52 0/49 0/48 0/50 0/49 0/49 0/49 0/50 0/49 0/49 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- Papilloma Total 2/1050(0.2%) 1/1042(0.1%) Mean(sd) 0.2%(0.9) 0.1%(0.5) Range 0/53 - 2/49 0/53 - 1/48 Males 0/53 0/50 0/54 0/54 0/49 0/48 0/50 0/50 0/50 0/50 0/48 0/50 0/50 0/46 2/49 0/50 0/50 0/49 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/52 0/49 1/48 0/50 0/49 0/49 0/49 0/50 0/49 0/49 0/46 0/50 0/50 0/49 0/48 0/49 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== UTERUS FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 2/1052(0.2%) Mean(sd) 0.2%(0.6) Range 0/53 - 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 1/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 1/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma Benign Total 1/1052(0.1%) Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Deciduoma NOS Total 1/1052(0.1%) Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 1/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibroma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Fibrosarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Granular Cell Tumor Total 1/1052(0.1%) Malignant Mean(sd) 0.1%(0.4) Range 0/53 - 1/49 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangioma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Hemangiosarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyoma Total 1/1052(0.1%) Mean(sd) 0.1%(0.4) Range 0/53 - 1/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 2/1052(0.2%) Mean(sd) 0.2%(0.6) Range 0/53 - 1/50 Females 0/53 0/50 0/53 0/53 1/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Stromal Total 122/1052(11.6%) Mean(sd) 11.6%(4.8) Range 2/53 - 10/50 Females 2/53 4/50 4/53 9/53 6/50 7/48 8/50 6/49 8/50 6/50 7/50 5/50 8/50 2/46 6/50 6/50 6/50 2/50 2/50 10/50 8/50 --------------------------------------------------------------------------- Sarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal Total 6/1052(0.6%) Mean(sd) 0.6%(0.9) Range 0/53 - 1/46 Females 0/53 1/50 0/53 0/53 0/50 0/48 1/50 0/49 1/50 0/50 0/50 1/50 0/50 1/46 0/50 0/50 0/50 0/50 0/50 1/50 0/50 --------------------------------------------------------------------------- Sarcoma Stromal or Total 127/1052(12.1%) Polyp Stromal Mean(sd) 12.1%(4.8) Range 2/53 - 11/50 Females 2/53 5/50 4/53 9/53 6/50 7/48 8/50 6/49 9/50 6/50 7/50 6/50 8/50 3/46 6/50 6/50 6/50 2/50 2/50 11/50 8/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 3/1052(0.3%) Mean(sd) 0.3%(1.0) Range 0/53 - 2/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 1/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 2/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma NOS Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Carcinoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== VAGINA FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Fibrosarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Leiomyosarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Polyp Total 3/1052(0.3%) Mean(sd) 0.3%(0.7) Range 0/53 - 1/50 Females 0/53 0/50 0/53 1/53 1/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 1/50 --------------------------------------------------------------------------- Sarcoma Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Schwannoma Malignant Total 0/1052(0%) Mean(sd) 0.0%(0.0) Range 0/53 - 0/53 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- =========================================================================== ZYMBAL'S GLAND FISCHER344 RATS INHALATION AIR (Updated 12/99) Males(21 studies) Females(21 studies) =========================================================================== Adenoma Total 0/1055(0%) 1/1052(0.1%) Mean(sd) 0.0%(0.0) 0.1%(0.4) Range 0/53 - 0/53 0/53 - 1/50 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma Total 15/1055(1.4%) 5/1052(0.5%) Mean(sd) 1.4%(1.3) 0.5%(1.1) Range 0/53 - 2/50 0/53 - 2/48 Males 0/53 2/50 1/54 1/54 0/50 0/48 0/50 1/50 1/50 2/50 1/50 1/50 1/50 0/46 1/50 0/50 1/50 1/50 1/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 2/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 1/50 0/50 0/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Carcinoma or Adenoma Total 15/1055(1.4%) 6/1052(0.6%) Mean(sd) 1.4%(1.3) 0.6%(1.2) Range 0/53 - 2/50 0/53 - 2/48 Males 0/53 2/50 1/54 1/54 0/50 0/48 0/50 1/50 1/50 2/50 1/50 1/50 1/50 0/46 1/50 0/50 1/50 1/50 1/50 0/50 0/50 Females 0/53 1/50 0/53 0/53 0/50 2/48 0/50 0/49 0/50 1/50 0/50 0/50 0/50 0/46 0/50 1/50 0/50 1/50 0/50 0/50 0/50 --------------------------------------------------------------------------- Squamous Cell Papilloma Total 0/1055(0%) 0/1052(0%) Mean(sd) 0.0%(0.0) 0.0%(0.0) Range 0/53 - 0/53 0/53 - 0/53 Males 0/53 0/50 0/54 0/54 0/50 0/48 0/50 0/50 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 Females 0/53 0/50 0/53 0/53 0/50 0/48 0/50 0/49 0/50 0/50 0/50 0/50 0/50 0/46 0/50 0/50 0/50 0/50 0/50 0/50 0/50 ---------------------------------------------------------------------------