May 5-6, 2014
James B. Hunt Jr. Library
North Carolina State University
Raleigh, North Carolina, USA
Read workshop report published in ALTEX
The workshop report was recognized as an NIEHS "Intramural Paper of the Month" in the September 2016 NIEHS Environmental Factor newsletter
The need to screen thousands of chemicals for their potential effects on human health has propelled the use of high-throughput cell-based screens to the forefront of toxicology. Key to the use of these screens is availability of model organisms that recapitulate human development, physiology and disease processes while avoiding the limitations of rodent-based models.
Small aquarium fish species have the potential to fill this need for such model organisms. However, they remain relatively modest contributors to understanding the effects of exposure to environmental contaminants on our health and wellbeing. Fully incorporating these model organisms into modern toxicological investigations could yield enormous scientific and economic benefits. To highlight the potential of these organisms, the National Toxicology Program and North Carolina State University are organizing this workshop, which will enable scientists in various fields to discuss strategies for leveraging aquatic models to advance understanding of the role of environmental exposures on human health.
The purpose of the workshop was to explore and discuss how aquatic models may be used to (i) screen and prioritize compounds for further in vivo testing (ii) to assess mechanisms of chemical toxicity and how this knowledge can impact the environment and human health. Discussions will focus on the application of these models for the field of environmental health while leveraging the techniques and knowledge of broad-based, interdisciplinary research.
Presentation abstracts and other workshop materials are posted below.
The objectives of the workshop were to: