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Presentations: Workshop on Best Practices for Assessing the Potential for Chemically Induced Eye Injuries

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Please note:

  • The video files and some of the presentations are large files that may take several minutes to download or open, depending on your connection speed.
  • Some of the presentations may vary slightly in appearance from those presented at the workshop. However, no content has been changed.

Introduction and Public Health Impact of Chemically Induced Eye Injuries
RADM William Stokes, DVM, U.S. Public Health Service, NICEATM, NIEHS

Review of Alternative Test Methods and Integrated Strategies for Ocular Safety Assessments
Jill Merrill, PhD, Center for Drug Evaluation and Research, FDA

Study Director and IACUC Responsibilities: Consideration of Available Reduction, Refinement, and Replacement Alternative Test Methods (USDA)
Jodie Kulpa-Eddy, DVM, Animal and Plant Health Inspection Service, Department of Agriculture

Current Guidelines for Ocular Safety Testing
Deborah McCall, Office of Pesticide Programs, EPA

ICCVAM Evaluation and Recommendations on Best Practices for Incorporating Pain Management and Humane Endpoints in Ocular Safety Testing
RADM William Stokes, DVM, U.S. Public Health Service, NICEATM, NIEHS

The Bovine Corneal Opacity and Permeability (BCOP) Test Method: Validation Status
Elizabeth Lipscomb, PhD, ILS, Contractor Supporting NICEATM

Conducting and Interpreting the BCOP Test Method
Hans Raabe, Institute for In Vitro Sciences, Inc.

The Isolated Chicken Eye Test Method: Validation Status/Conducting and Interpreting the Method
David Allen, PhD, ILS, Contractor Supporting NICEATM
View video on application of liquid test substance to accompany slide 13 [AVI]
View video on application of solid test substance to accompany slide 13 [AVI]
Captioned and narrated versions of videos available on archived webcast: begin at 163 minutes

The Cytosensor Microphysiometer (CM) Test Method: Validation Status
Elizabeth Lipscomb, PhD, ILS, Contractor Supporting NICEATM

Conducting and Interpreting the CM Test Method
Rodger Curren, PhD, Institute for In Vitro Sciences, Inc.

Roundtable Discussion: Regulatory Agency Requirements and Acceptable Alternative Test Methods for Ocular Safety Testing

Alternative Test Methods for Ocular Safety Testing: Case Studies in Breakout Groups
View case study presentations and discussion summaries

New Models in the Validation Pipeline for Ocular Safety Testing