The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) is a permanent committee of the NIEHS under the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). ICCVAM is composed of representatives from 16 U.S. Federal regulatory and research agencies that require, use, generate, or disseminate toxicological and safety testing information.
ICCVAM coordinated development of “A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States,” published in January 2018.
ICCVAM was formally established in 2000 by the ICCVAM Authorization Act (42 U.S.C. 285l-3)
To establish, wherever feasible, guidelines, recommendations, and regulations that promote the regulatory acceptance of new or revised scientifically valid toxicological tests that protect human and animal health and the environment while reducing, refining, or replacing animal tests and ensuring human safety and product effectiveness.
Purposes of ICCVAM as defined by the ICCVAM Authorization Act
- Increase the efficiency and effectiveness of U.S. Federal agency test method review
- Eliminate unnecessary duplication of effort and share experience among U.S. Federal regulatory agencies
- Optimize utilization of scientific expertise outside the U.S. Federal government
- Ensure that new and revised test methods are validated to meet the needs of U.S. Federal agencies
- Reduce, refine, or replace the use of animals in testing where feasible
- Facilitating interagency and international collaborations promoting the development, regulatory acceptance, and use of alternative tests that encourage the reduction, refinement, or replacement of animal test methods
- Providing guidance to test method developers
- Evaluating recommendations from expert peer reviews of alternative toxicological test methods and making recommendations on the use of reviewed test methods to appropriate Federal agencies
ICCVAM relies on stakeholders to carry out alternative test method research, development, and validation studies.
- U.S. Federal agencies that generate, require, or use toxicological data
- Agencies within governments of other countries that use or generate toxicological data
- Researchers and Institutional Animal Care and Use Committee (IACUC) members in companies or research institutions that perform toxicological testing
- Companies that develop toxicological tests
- Animal welfare organizations
- Consumer protection organizations
- The public
ICCVAM facilitates international collaboration on the development of alternative test methods through its membership in the International Cooperation on Alternative Test Methods and ICCVAM agency participation in the Test Guidelines Programme of the Organisation for Economic Co-operation and Development.
ICCVAM receives advice from the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM), a standing NTP advisory committee. SACATM members include stakeholders from regulated industries, animal protection organizations, academia, U.S. state or international regulatory bodies, and companies or organizations that develop, market, or use test methods.