ICCVAM Agency Activities: 2014

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EPA: FIFRA Scientific Advisory Panel to Discuss Prioritization of EDSP Chemicals (November 2014)

The U.S. Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel will meet on December 2–5 at the EPA Conference Center in Arlington, Virginia. The panel will consider and review scientific issues related to endocrine activity and exposure-based prioritization and screening. NICEATM scientists will present their work on assessing bioactivity of chemicals tested in the ToxCast high-throughput screening assays. Read summary of the meeting and the NICEATM presentations in the January Environmental Factor newsletter. 

NIEHS: Grants Available for Development of Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (November 2014)

Small business concerns are invited to submit grant applications to develop medium- to high-throughput assays to evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. Assays will provide information on mechanisms of chemically-induced biological activity, help to prioritize chemicals for more extensive toxicological evaluation, support more predictive models of in vivo biological response, and potentially inform on the role of genetic diversity in toxicological effects. For more information, please visit the NIH website:

Applications are due February 13, 2015.

NLM: Update of Hazardous Substances Data Bank (August 2014)

The Hazardous Substances Data Bank (HSDB), a part of NLM's Toxicology Data Network (TOXNET®), has undergone numerous recent enhancements to its records for chemicals and substances. Examples include the creation of new subheadings in the human and non-human toxicity excerpts to allow users to more efficiently locate data from in vitro and other alternative methods. Coverage includes results from methods validated by ICCVAM and the European Union Reference Laboratory for Alternatives to Animal Testing.

USDA: Training Available on Searching for Alternatives (July 2014)

USDA’s Animal Welfare Information Center (AWIC) holds free workshops at the National Agricultural Library to help researchers explore alternatives to procedures that may cause pain or distress to their animals. Training is targeted to principal investigators, IACUC members, administrators of animal use programs, veterinarians, librarians, and other information specialists. The workshops provide an overview of relevant topics and resources, instruction on the use of existing databases and websites, and hands-on practice conducting online database searches.