National Toxicology Program

National Toxicology Program

ICCVAM Agency Activities

View activities from prior years:

NIEHS: NICEATM to Present Webinar Series on Zebrafish Screening (January 2017)

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins on February 2. This three-part webinar series will consider the issues of protocol variability in zebrafish screening studies and how some of these issues might be addressed by implementation of standardized nomenclature systems.

The webinars are free and open to the public, although registration is required to attend. The webinar series is being organized by NICEATM in support of the National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) program. A link to registration, details about all webinars, and more information about SEAZIT can be found on the NICEATM website.

EPA: Voluntary Pilot Program to Reduce Animal Testing (January 2017)

On December 20, 2016, the U.S. Environmental Protection Agency launched a voluntary pilot program to evaluate the usefulness and acceptability of a mathematical tool that estimates the toxicological classification of a chemical, and published guidance on how pesticide companies can submit data for the program. This program is another step toward EPA’s goal of reducing animal testing by adopting better testing methods, as described in the March 2016 Letter to Stakeholders issued by Office of Pesticide Programs Director Jack Housenger.

The mathematical tool, known as the GHS Mixtures Equation, is used in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Use of the GHS Mixtures Equation can reduce animal use for oral and inhalation toxicity studies of pesticide formulations.

To evaluate the GHS Mixtures Equation, EPA requests submission of acute oral and acute inhalation toxicity study data paired with mathematical calculations (GHS Mixtures Equation data) to support the evaluation of pesticide product formulations. EPA expects that the pilot will run for approximately six months but will begin data analysis sooner if enough data is received.

More information about the pilot program and instructions for submitting data are available on the EPA website.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.