National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/iccvam-bien

ICCVAM Annual and Biennial Reports

The ICCVAM Authorization Act of 2000 directed ICCVAM to prepare a progress report on its first anniversary and biennially thereafter. The latest ICCVAM Biennial Progress Report describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015.

Home page of ICCVAM 2014-2015 Biennial Report

ICCVAM 2014-2015 Biennial Report
ICCVAM Authorization Act of 2000

The report highlights ICCVAM member agency research activities supporting toxicology innovation as well as regulatory agency initiatives to promote the 3Rs and provide information about use of in vitro methods. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized in the report include:

  • A computational approach developed by ICCVAM that integrates several types of data to predict human skin sensitization hazard without using animals
  • A U.S. Environmental Protection Agency (EPA) plan to adopt high throughput assays and computational models for detecting and measuring estrogen receptor bioactivity as an alternative for three Tier 1 tests, including the uterotrophic assay, currently used in the Endocrine Disruptor Screening Program to assess estrogen receptor activity
  • Establishment of the ICCVAM Communities of Practice webinar series
  • A NICEATM evaluation of acute oral and dermal toxicity data to determine if oral toxicity tests are sufficient to assign EPA dermal hazard classifications, eliminating the need for separate acute dermal toxicity tests
  • A series of workshops supported by NICEATM and ICCVAM agencies that drafted recommendations on use of an in vitro test with potential to replace animal use for pertussis vaccine testing
Past ICCVAM Reports (2001-2013)

ICCVAM 2012-2013 Biennial Report
Recognized as a Technical Communication of Excellence by the Society of Technical Communication
(Carolina Chapter, 2014)

ICCVAM 2010-2011 Biennial Report (NIH Publication Number 12-7873)
Recognized as a Distinguished Technical Communication by the Society of Technical Communication
(Carolina Chapter, 2013; STC International Summit Conference, 2014)

ICCVAM 2008-2009 Biennial Report (NIH Publication Number 10-7612)

ICCVAM 2006-2007 Biennial Report (NIH Publication Number 08-6529)

ICCVAM 2004-2005 Biennial Report (NIH Publication Number 06-4516)

ICCVAM Biennial Report (December 2003: NIH Publication Number 04-4509) 

ICCVAM Annual Progress Report (December 2001) 

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.