ICATM was originally established by an agreement signed by ICCVAM, EURL ECVAM, the Japanese Center for the Validation of Alternative Methods (JaCVAM), and Health Canada. ICATM's goals are:
ICATM works to promote consistent and enhanced voluntary international cooperation, collaboration, and communication among national validation organizations in order to:
The ICATM collaboration addresses three critical areas of cooperation: test method validation studies, independent peer review of the validation studies, and the development of formal recommendations on alternative testing methods.
An updated Memorandum of Cooperation (MOC) to add the Korean Center for the Validation of Alternative Methods (KoCVAM) to the ICATM agreement was signed in March 2011.
ICCVAM is an interagency committee of the U.S. government that coordinates technical reviews of alternative test methods and cross-agency activities relating to validation, acceptance, and harmonization of test methods.
EURL ECVAM is a unit within the Institute of Health and Consumer Protection in the European Union’s Joint Research Centre. EURL ECVAM coordinates the validation of alternative test methods at the European Union level.
JaCVAM is part of the Japanese National Institute of Health Sciences, for which it coordinates the evaluation of alternative test methods.
Health Canada’s Environmental Health Science and Research Bureau coordinates the evaluation of alternative test methods in Canada.
Health Canada is a permanent member of the Canadian Council on Animal Care, which oversees the ethical use of animals in science in Canada.
KoCVAM coordinates the evaluation of alternative test methods in South Korea. KoCVAM is part of the National Institute of Food and Drug Safety Evaluation of the South Korean Food and Drug Administration.
On behalf of the International Cooperation on Alternative Test Methods (ICATM), an "Alternative Test Method Validation and Regulatory Acceptance Status Report" was prepared for the International Cooperation on Cosmetics Regulation by the European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). The report includes a comprehensive listing of test method evaluation activities undertaken by the ICATM partner organizations and high-level summaries of ongoing validation studies, validation study peer review status, and harmonized recommendations.