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NICEATM Abstracts Published Since 2013

For each abstract, table lists presentation date, authors, title (link to abstract PDF), and presentation venue (link to meeting page on NICEATM site)
Year Presented Authors Title Presentation Venue
2018 Wynder J, Ovesen J, Maier A, Judson R, Kleinstreuer N, Krishnan M Evaluating the applicability of read-across tools and high-throughput screening data for food relevant chemicals Society of Toxicology
2018 Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K Evaluating perturbation of in vitro steroidogenesis using a high-throughput H295R assay Society of Toxicology
2018 Kleinstreuer N More than skin deep: when alternative approaches outperform animal tests Society of Toxicology
2018 Haggard DE, Karmaus AL, Martin MT, Judson RS, Setzer RW, Paul Friedman K Evaluating perturbation of in vitro steroidogenesis using a high-throughput H295R assay Society of Toxicology
2018 Shah I, Harrill J, Setzer RW, Haggard D, Karmaus A, Martin MT, Thomas RS Predicting chemical mechanisms-of-action using high-throughput transcriptomic data Society of Toxicology
2018 Mansouri K, Kleinstreuer N, Grulke C, Richard AM, Shah I, Williams AJ, Judson R Virtual screening of chemicals for estrogen and androgen activities Society of Toxicology
2018 Bell SM, Burgoon LD, Phillips J, Ceger P, Karmaus A, Allen D, Casey W, Kleinstreuer N ICE tools for aligning assay endpoints to adverse outcome pathways Society of Toxicology
2018 Casey W A roadmap to establishing new approaches for toxicity testing: improving human relevance and reducing animal use Society of Toxicology
2018 Karmaus A, Fitzpatrick J, Allen D, Patlewicz G, Kleinstreuer N, Casey W Variability of LD50 values from rat oral acute toxicity studies: implications for alternative model development Society of Toxicology
2018 Kleinstreuer N Current and future opportunities for U.S. regulatory application of read-across Society of Toxicology
2018 Ono A, Watanabe S, Sugawara t, Wakabayashi K, Tahara Y, Horle N, Fujimoto K, Kusakari K, Kurokawa Y, Sozu T, Nakayama T, Kusao T, Kawakami T, Kojima K, Kojima H, Richmond J, Kleinstreuer N, Bae-Hwa K, Yamamoto Y, Fujita M, Kasahara T A multi-centre validation study of amino acid derivative reactivity assay (ADRA): a novel in chemico alternative test method for skin sensitization Society of Toxicology
2018 Palmer J, Smith A, Burrier R, Donley E, Kirchner F, Kroese D, Stober R, Kleinstreuer N Valproate analogue developmental toxicity potency in a human pluripotent stem cell-based assay is concordant with in vivo potency Society of Toxicology
2018 Hamm J, Ceger P, Chang X, Maull E, Mahapatra D, Knuth M, Lingerfelt M, Ekins S, Xia M, Kullman SW Evaluation of FXR-active chemicals identified from Tox21 screening Society of Toxicology
2018 Choksi N, Daniel A, Lebrun S, Nguyen M, DeGeorge G, Willoughby JA, Casey W, Allen D Performance of the OptiSafe ocular irritation assay in a three-laboratory validation study Society of Toxicology
2017 Bell S, Burgoon L, Phillips J, Ceger P, Allen D, Casey W, Kleinstreuer N A new tool for aligning assay endpoints to adverse outcome pathways American Society for Cellular and Computational Toxicology
2017 Karmaus A, Allen D, Kleinstreuer N, Casey W Characterizing variability across rat oral acute toxicity studies: implications for alternative model evaluation American Society for Cellular and Computational Toxicology
2017 Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating QSAR and PK models American Society for Cellular and Computational Toxicology
2017 Allen D, Wilson D, Hotchkiss J, Morefield S, Casey W, Clippinger A Integrating alternative approaches to replace animals in inhalation toxicity testing Tenth World Congress
2017 Strickland J, Karmaus AL, Chang X, Paris M, Allen D, Kleinstreuer N, Casey W Correlation of in vitro cytotoxicity and acute toxicity Tenth World Congress
2017 Kleinstreuer N In vitro insights into chemical carcinogenesis Tenth World Congress
2017 Kleinstreuer N A Strategy to ensure relevant science for regulatory acceptance and industry adoption Tenth World Congress
2017 Karmaus AL, Allen D, Kleinstreuer NC, Casey W Characterizing the variability of LD50 values in acute toxicity studies: implications for alternative methods development Tenth World Congress
2017 Chang X, Zang Q, Bell S, Allen D, Casey W, Kleinstreuer N An open-source IVIVE workflow integrating QSAR and PK models Tenth World Congress
2017 Bell S, Burgoon L, Phillips J, Allen D, Casey W, Kleinstreuer N A new tool for aligning assay endpoints to adverse outcome pathways Tenth World Congress
2017 Hamm J, Ceger P, Boyles R, Reif D, Burgoon L, Haendel M, Walker N,  Maull EA Implementation of zebrafish ontologies for toxicology screening Tenth World Congress
2017 Miller M, Goodson WH, Lowe L, Manjili MH, Kleinstreuer N, Bisson WH Integrating the low-dose mixture hypothesis of carcinogenesis into the future of cancer research Society of Toxicology
2017 Mansouri K, Kleinstreuer N, Watt E, Harris J, Judson R CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity Society of Toxicology
2017 Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Xia M Androgen receptor agonist identification and characterization by screening the Tox21 10K compound library Society of Toxicology
2017 Bone A, Xia M, Sakamuru S, Huang R, Houtman R, van Beuningen R, Watt E, Kleinstreuer N, Judson R, Houck K Identification of androgen receptor antagonists using Tox21 qHTS data and the MARCoNI assay Society of Toxicology
2017 Lowit A, Schlosser C, Myska A, Patlewicz G, Paris M, Karmaus A, Strickland J, Allen D, Kleinstreuer N, Casey W Replacing animals for acute systemic toxicity testing: a U.S. strategy and roadmap Society of Toxicology
2017 Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N Prediction of skin sensitization potency using machine learning approaches Society of Toxicology
2017 Bell S, Phillips J, Sedykh A, Sprankle C, Morefield S, Allen D, Casey W, Kleinstreuer N An Integrated Chemical Environment to support 21st century toxicology Society of Toxicology
2017 Kleinstreuer N Pathway-based models to predict developmental and reproductive toxicologies Society of Toxicology
2017 Ceger P, Choksi N, Hamm J, Truax J, Daniel A, Allen D, Sutherland V, McIntyre B, Foster P, Maull E, Casey W Development of a curated database of in vivo developmental toxicity data Society of Toxicology
2017 Kleinstreuer N, Strickland J, Zuang V, Lowit A, Matheson J, Allen D, Casey W, Whelan M Evaluating defined approaches to testing and assessment of skin sensitization potential Society of Toxicology
2017 Hamm J, Ceger P, Maull E, Padilla S, Perkins E, Planchart A, Stedman D, Tal T, Tanguay R, Volz D, Baker G, Stout M, Walker N SEAZIT: the National Toxicology Program’s Systematic Evaluation of the Application of Zebrafish in Toxicology Society of Toxicology
2017 Boyd WA, Pirone JR, Shaw MP, Kleinstreuer NC, Martin MT, Rashid A, Fostel JM, Thayer KA Identification of environmental chemicals with potential roles in obesity and diabetes using animal studies from U.S. EPA and NTP toxicological databases Society of Toxicology
2017 Chang X, Bell SM, Pirone JR, Allen D, Casey W, Kleinstreuer N Open-source workflows for in vitro to in vivo extrapolation Society of Toxicology
2015 Browne P, Judson R, Dixon A, Kleinstreuer N, Casey W, Bergfelt DR, Green TD, Kent R, Lynn SG, Touart L, Thomas RS Use of computational toxicology for integrated bioactivity-exposure prioritization of the EDSP chemical universe Society of Toxicology
2015 Bucher JR, Tice RR, Paules RS, Casey W, Rooney AA, Thayer K, DeVito M Assessing confidence in Tox21  Society of Toxicology
2014 Casey W A new vision and direction for ICCVAM and NICEATM Ninth World Congress
2015 Casey W Prioritization and predictive toxicology: estrogen receptor active compounds  Society of Toxicology
2015 Casey W Using reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity  Society of Toxicology
2015 Casey W, Allen D, Kleinstreuer N Using bioactivity based read-across (BaBRA) to characterize the ToxCast library Society of Toxicology
2014 Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Rinckel L, Ceger P Performance of the Tox21 BG1Luc and ER beta-lactamase estrogen receptor transactivation assays FutureTox II
2014 Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Rinckel L, Ceger P, Allen D Performance of the BG1Luc and ER beta-lactamase estrogen receptor transactivation assays in Tox21 screening Ninth World Congress
2015 Ceger P, Kleinstreuer N, Allen D, Chang X, Strickland J, Zang Q, Hamm J, Philips E, Jones B, Casey W Curation and analysis of a rodent uterotrophic database: insights on data quality and reproducibility Society of Toxicology
2014 Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W Development of a curated database of in vivo estrogenic activity FutureTox II
2014 Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W Development of a curated database of in vivo estrogenic activity Society of Toxicology
2014 Ceger P, Kleinstreuer N, Chang X, Jones B, Hamm J, Rinckel L, Rotroff D, Casey W, Allen D Development of a curated database of in vivo estrogenic activity Ninth World Congress
2015 Chang X, Kleinstreuer N, Allen D, Casey W In vitro to in vivo extrapolation: optimizing parameters for improved predictions American Society for Cellular and Computational Toxicology
2015 Chang X, Kleinstreuer N, Allen D, Casey W In vitro to in vivo extrapolation: optimizing parameters for improved predictions FutureTox III
2015 Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, DeVito M, Allen D, Casey W Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity Society of Toxicology
2014 Chang X, Kleinstreuer N, Ceger P, Hamm J, Jones B, Rinckel L, Allen D, Casey W Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity FutureTox II
2014 Chang X, Kleinstreuer N, Ceger P, Hamm J, Jones B, Rinckel L, Casey W Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity Society of Toxicology
2014 Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Hamm J, Jones B, Choksi N, Rinckel L, Allen D, Casey W Development of reverse toxicokinetic models to correlate in vitro and in vivo estrogen receptor activity Ninth World Congress
2014 Ferguson S, Kleinstreuer N, Lawless M, Tice R Prioritization of the Tox21 10K library for xenobiotic metabolism and toxicity studies using in silico metabolism models  Society of Toxicology
2014 Franzosa J, Settivari RS, Ellis-Hutchings R, Kleinstreuer N, Houck K, Carney EW, Knudsen TB RNA-Seq analysis of the functional link between vascular disruption and adverse developmental consequences  Society of Toxicology
2014 Hamm J, Allen D, Casey W, Behl M, Hinton D, Kanungo J, Kullman S, Mattingly C, Planchart A, Tal T, Weis C Leveraging small aquarium fishes to advance understanding of environmentally influenced human disorders and diseases Ninth World Congress
2014 Hamm J, Casey W, Hsu C, Huang R, Xia M, Houck K, Chang X, Allen D, Kullman S Targeted testing of FXR Tox21 active compounds Ninth World Congress
2014 Hamm J, Kleinstreuer N, Casey W, Allen D, Padilla S Use of the zebrafish developmental screen and estimation of internal concentration to assess toxicity Ninth World Congress
2014 Hamm J, Kleinstreuer N, Padilla S, Casey W Use of the zebrafish developmental screen and estimation of internal concentration to assess toxicity Society of Toxicology
2014 Heinonen T, Toimela T, Knudsen TB, Kleinstreuer N, Sarkanen R Evaluation of environmental chemicals computationally predicted to disrupt angiogenesis  Society of Toxicology
2014 Hsu C, Zhao J, Huang R, Houck K, Hsieh J, Hamm J, Chang X, Xia M Quantitative profiling of environmental chemicals and drugs for farnesoid X receptor activity  Society of Toxicology
2014 Huang R, Sakamuru S, Martin MT, Reif D, Judson R, Houck K, Casey W, Hsieh J-H, Shockley K, Ceger P, Fostel J, Witt KL, Tong W, Rotroff D, Simeonov A, Dix DJ, Austin CP, Kavlock R, Tice, R, Xia M Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway  Society of Toxicology
2015 Kleinstreuer N Combining data streams and modeling approaches to develop skin sensitization ITS OpenTox USA 2015
2014 Kleinstreuer N Constructing AOPs for developmental toxicities Society of Toxicology
2014 Kleinstreuer N, Allen D, Ceger P, Chang X, Strickland J, Zang Q, Hamm J, Jones B, Casey W Using in vitro HTS methods to identify endocrine disruptors Ninth World Congress
2015 Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W Identifying reference chemicals for androgen receptor activity American Society for Cellular and Computational Toxicology
2015 Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W Identifying reference chemicals for androgen receptor activity FutureTox III
2014 Kleinstreuer N, Filer D, Martin M, Houck K, Zang Q, Allen D, Casey W, Judson R Integrating ToxCast assays into an androgen receptor (AR) pathway model ToxCast Data Summit
2014 Kleinstreuer N, Strickland J, Allen D, Casey W Predicting skin sensitization using ToxCast assays ToxCast Data Summit
2014 Kleinstreuer N, Strickland J, Casey W Predicting skin sensitization using 21st century toxicology Society of Toxicology
2014 Kleinstreuer N, Strickland J, Casey W Predicting skin sensitization using 21st century toxicology FutureTox II
2014 Kleinstreuer N, Strickland J, Casey W Predicting skin sensitization using 21st century toxicology Ninth World Congress
2014 Kleinstreuer N, Tal TL, Knudsen TB, Heinonen T, Franzosa J, Baker N, Padilla S, Carney E, Casey W Constructing, quantifying, and validating an outcome pathway for vascular developmental toxicity Ninth World Congress
2015 Kleinstreuer N, Zang Q, Filer D, Martin M, Houck K, Allen D, Casey W, Judson R Using ToxCast/Tox21 assays and QSAR modeling to predict androgen receptor pathway activity Society of Toxicology
2015 Mansouri K, Politi R, Farag S, Muratov E, Tropsha A, Judson R, Zang Q, Allen D, Casey W, Kleinstreuer N Domain-specific QSAR model for identifying potential estrogenic activity American Society for Cellular and Computational Toxicology
2015 Mansouri K, Politi R, Farag S, Muratov E, Tropsha A, Judson R, Zang Q, Allen D, Casey W, Kleinstreuer N QSAR models for identifying potential estrogenic activity of phenolic compounds FutureTox III
2015 Matheson J, Zang Q, Strickland J, Kleinstreuer N, Allen D, Lowit A, Jacobs A, Casey W ICCVAM integrated decision strategy for skin sensitization Society of Toxicology
2015 Paris M, Strickland J, Allen D, Casey W Using acute oral toxicity data to estimate acute dermal hazard classification and labeling of pesticides Society of Toxicology
2014 Pirone J, Smith M, Kleinstreuer N, Burns T, Strickland J, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J Development of an open-source integrated test strategy for skin sensitization potency Society of Toxicology
2014 Pirone J, Smith M, Kleinstreuer N, Burns T, Strickland J, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J Development of an open-source integrated test strategy for skin sensitization potency Ninth World Congress
2015 Pirone J, Smith M, Strickland J, Casey W, Jaworska J Impact of local lymph node assay uncertainty on predictions of a Bayesian network integrated testing strategy for skin sensitization potency Society of Toxicology
2014 Pirone J, Strickland J, Smith M, Kleinstreuer N, Jones B, Dancik Y, Morris R, Rinckel L, Casey W, Jaworska J Development of an open-source integrated test strategy for skin sensitization potency FutureTox II
2015 Polk W, Kleinstreuer N, Strickland J, Paris M, Allen D, Casey W Correlation of Tox21 and ToxCast in vitro and small model organism outcomes to rat oral toxicity Society of Toxicology
2014 Rinckel L, Casey W, Huang R, Hsieh J-H, Shockley K, Sakamuru S, Xia M, Tice R, Ceger P Performance of the Tox21 BG1Luc and ER beta-lactamase estrogen receptor transactivation assays in Tox21 Society of Toxicology
2015 Strickland J, Choksi N, Allen D, Casey W In silico predictions of skin sensitization using OECD QSAR Toolbox Society of Toxicology
2015 Strickland J, Zang Q, Paris M, Kleinstreuer N, Lehmann DM, Allen D, Matheson J, Jacobs A, Lowit A, Casey W Machine learning approaches for predicting human skin sensitization hazard American Society for Cellular and Computational Toxicology
2015 Strickland J, Zang Q, Paris M, Kleinstreuer N, Lehmann DM, Allen D, Matheson J, Jacobs A, Lowit A, Casey W Machine learning approaches for predicting human skin sensitization hazard FutureTox III
2014 Tal TL, Kleinstreuer N, Harris P, Olin J, Palekar A, Toimela T, Sarkanen R, Heinonen T, Knudsen TB, Padilla S Adverse outcome pathway for embryonic vascular disruption and alternative methods to identify chemical vascular disruptors during development  Society of Toxicology
2014 Tropsha A, Alves V, Muratov E, Fourches E, Strickland J, Kleinstreuer N, Andrade C Identification of putative skin sensitizers using QSAR models enriched by in vitro data  Society of Toxicology
2014 Wang A, Franzosa J, Shah I, Filer DL, Kleinstreuer N, Marinakos S, Houck K Comparing bioactivity profiles of diverse nanomaterials based on high-throughput screening (HTS) in ToxCast™  Society of Toxicology
2015 Wetmore B, Casey W Incorporating in vitro pharmacokinetic data and tools into toxicity testing and risk assessment: state of the science  Society of Toxicology
2015 Zang Q, Kleinstreuer N, Allen D, Casey W, Judson R QSAR modeling for the prediction of androgen receptor pathway activity American Society for Cellular and Computational Toxicology
2015 Zang Q, Kleinstreuer N, Allen D, Casey W, Judson R QSAR modeling to predict androgen receptor pathway activity FutureTox III
2014 Zang Q, Mansouri K, Allen D, Casey W, Judson R Prediction of physicochemical properties of environmental chemicals using molecular fingerprints and machine learning methods Ninth World Congress
2015 Zang Q, Mansouri K, Allen D, Kleinstreuer N, Casey W, Judson R In silico prediction of physicochemical properties of environmental chemicals in combination of molecular fingerprints and machine learning approaches Society of Toxicology
2013 Casey W, Ceger P, Strickland J, Rinckel L, Grignard E, Bremer S, et al Regulatory acceptance of the BG1Luc estrogen receptor transactivation test method Society of Toxicology
2013 Ceger P, Strickland J, Rinckel L, Casey W Adaptation of the BG1Luc estrogen receptor transactivation test method to qHTS: comparison of results from both methods Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program
2016 Chang X, Pirone J, Bell SM, Allen D, Casey W, Kleinstreuer N An open-source workflow for in vitro to in vivo extrapolation American Society for Cellular and Computational Toxicology
2016 Kleinstreuer N, Ceger P, Allen D, Browne P, Houck K, Martin M, Thomas R, Dix D, Casey W, Judson R Development and validation of a computational model for androgen receptor activity American Society for Cellular and Computational Toxicology
2016 Casey W Strategy for implementing the vision of toxicity testing in the 21st century American Society for Cellular and Computational Toxicology
2016 Strickland J, Zang Q, Paris M, Lehmann DM, Bell S, Allen D, Matheson J, Jacobs A, Casey W, Kleinstreuer N Prediction of skin sensitization potency using machine learning approaches American Society for Cellular and Computational Toxicology
2016 Zang Q, Allen D, Casey W, Judson R, Kleinstreuer N QSAR modeling to predict androgen receptor pathway activity Society of Toxicology
2016 Allen D Integrating alternative methods within a regulatory framework and the impact of AOPs in designing an integrated testing strategy to replace repeat exposure inhalation toxicity Society of Toxicology
2016 Jaworska J, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment – a decision support system for quantitative weight of evidence and adaptive testing strategy Society of Toxicology
2016 Strickland J, Zang Q, Paris M, Lehmann DM, Kleinstreuer N, Allen D, Choksi N, Matheson J, Jacobs A, Lowit A, Casey W Multivariate models for prediction of human skin sensitization hazard Society of Toxicology
2016 Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, Wetmore BA, Ferguson S, DeVito MJ, Allen D, Casey W In vitro to in vivo extrapolation for estrogenic activity of environmental chemicals Society of Toxicology
2016 Kleinstreuer N Skin sensitization testing strategy evaluation Society of Toxicology
2016 Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W Development and application of a reference database for androgen receptor activity Society of Toxicology
2016 Paris M, Strickland J, Allen D, Casey W Retrospective analysis of acute toxicity tests for pesticides Society of Toxicology
2016 Yang C, Casey W, Choksi N, Ceger P, Kleinstreuer N, Allen D, Dharshan P, Bittner G An in vitro test method for screening potential androgenic agonists and antagonists in MDA-kb2 cells Society of Toxicology