Presentations at SOT 2016

55th Annual Meeting of the Society of Toxicology
March 13-17, 2016 - New Orleans, LA, USA

Ancillary Meeting: Discussion With NICEATM and ICCVAM Leadership

Priorities and Opportunities for Replacement of Animal Tests

NICEATM Director Warren Casey, NIEHS
ICCVAM Co-chair Anna Lowit, EPA
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Meeting co-sponsored by the Physicians Committee for Responsible Medicine, the PETA International Science Consortium, Ltd., and the Human Toxicology Project Consortium

NICEATM Presentations

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Poster Session: Bioinformatics and Toxicology

Abstract Number 1098: QSAR Modeling to Predict Androgen Receptor Pathway Activity
Authors: Zang Q, Allen D, Casey W, Judson R, Kleinstreuer N
Poster  Text version of poster

Symposium Session: The Promise and Reality of Alternative Methods in Inhalation Toxicology and the Development of Inhaled Therapeutics

Abstract Number 1705: Integrating Alternative Methods Within a Regulatory Framework and the Impact of AOPs in Designing an Integrated Testing Strategy to Replace Repeat Exposure Inhalation Toxicity
Presenter: Allen D
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Poster Session:  Alternative Models for Ocular and Skin Toxicity

Judy Strickland, ILS contractor supporting NICEATM, was a session co-chair

Abstract Number 2196: Bayesian Integrated Testing Strategy (ITS) for Skin Sensitization Potency Assessment – A Decision Support System for Quantitative Weight of Evidence and Adaptive Testing Strategy
Authors: Jaworska J, Natsch A, Ryan C, Strickland J, Ashikaga T, Miyazawa M

Abstract Number 2202: Multivariate Models for Prediction of Human Skin Sensitization Hazard
Authors: Strickland J, Zang Q, Paris M, Lehmann DM, Kleinstreuer N, Allen D, Choksi N, Matheson J, Jacobs A, Lowit A, Casey W
Poster  Text version of poster

Poster Session:  Biological Modeling

Abstract Number 2224: In Vitro to In Vivo Extrapolation for Estrogenic Activity of Environmental Chemicals
Authors: Chang X, Kleinstreuer N, Ceger P, Choksi N, Hsieh J-H, Wetmore BA, Ferguson S, DeVito MJ, Allen D, Casey W
Poster  Text version of poster

Workshop Session: Safety Assessment of Topically Exposed Cosmetic Ingredients: Lessons Learned

Abstract Number 2533: Skin Sensitization Testing Strategy Evaluation
Presenter: Kleinstreuer N

Poster Session:  Computational and Systems Toxicology II

Abstract Number 2651: Development and Application of a Reference Database for Androgen Receptor Activity  
Authors: Kleinstreuer N, Ceger P, Browne P, Allen D, Hamm J, Casey W
 Poster  Text version of poster

Specialty Section: In Vitro and Alternative Methods

Warren Casey, NICEATM Director, was Vice President-elect of the Specialty Section

Poster Session:  Regulation and Policy

Abstract Number 2990: Retrospective Analysis of Acute Toxicity Tests for Pesticides
Authors: Paris M, Strickland J, Allen D, Casey W
Poster  Text version of poster

Poster Session:  Late-breaking Abstracts

Abstract Number 3905: An In Vitro Test Method for Screening Potential Androgenic Agonists and Antagonists in MDA-kb2 Cells
Authors: Yang C, Casey W, Choksi N, Ceger P, Kleinstreuer N, Allen D, Dharshan P, Bittner G

ICCVAM Committee Activities

ICCVAM Committee member names are indicated in boldface in author lists.

Poster Session:  Systems Biology and Toxicology

Abstract Number 1110: Translational Biomarkers of Acetominophen-Induced Hepatotoxicity in Urine Samples
Authors: Schnackenberg LK, Sun J, Breenhaw J, Bhattacharyya S, Gill P, Salminen WF, Mendrick DL, James LP, Beger RD

Poster Session:  Bioinformatics and Toxicology

Abstract Number 1095: Real-Time Cell Viability Profiling of Tox21 10K Compounds
Authors: Hsieh J-H, Huang R, Tice R, Paules R, Xia M, Auerbach S

Poster Session:  Mixtures

Abstract Number 1453: Feasibility of Using Disability-Adjusted Life Years (DALYs) in Human Health Risk Assessment From Exposure to Hazardous Air Pollutant (HAP) Mixtures
Authors: Mumtaz M, Zhou Y

Workshop Session:  Quantitative Cumulative Risk Assessment: Is It Feasible Today?

ICCVAM member Moiz Mumtaz (ATSDR) was a session co-chair

Workshop Session:  Using 21st Century Approaches to Evaluate Endocrine-Active Compounds

Abstract Number 1726b: Screening Chemicals for Estrogen Bioactivity Using Computational Approaches
Author: Browne P

Workshop Session:  Bioactivity-Based Margin of Exposure Safety Assessment: The Next Stop Along the Road to 21st Century Safety Assessments

ICCVAM member Nigel Walker (NIEHS) was a session co-chair

Abstract Number 1767a: Bioactivity-Based Margin of Exposure Safety Assessment: The Next Stop Along the Road to 21st Century Safety Assessments
Rowlands JC, Walker N

Abstract Number 1767b: Biological Canaries in the Coal Mine: Strategic Implications for Utilizing Bioactivity-Based Margins of Exposure in Human Health Risk Assessments
Author: Walker N

Poster Session:  Alternative Models: Fish, Worms, and More

Abstract Number 1795: Strain-specific Changes in Locomotor Behavior in Larval Zebrafish Elicited by Cholinergic Challenge
Authors: Hedge JM, Jarema KA, Hunter DL, Padilla S

Abstract Number 1803: Toxicity Screening of a Subset of the ToxCast Phase III Chemical Library Using a Zebrafish Developmental Assay
Authors: Houck K, Mosher S, Judson R, Wambaugh J, Martin M, Padilla S

Poster Session:  3D Cell and Organ-on-a-Chip Models

Abstract Number 2179: Metabolically Competent HepaRG Spheroid Model for In Vitro Toxicology Studies
Authors: Ramaiahgari S, Waidyanatha S, Boyd W, DeVito M, Paules R, Ferguson S

Poster Session:  Non-Pharmaceutical Safety Assessment

Abstract Number 2456: Toxicity Profiling of Flame Retardants in Zebrafish Embryos Using a Battery of Assays
Authors: Alzualde A, Alday A, Behl M, Tice RR, Paules R, Muriana A, Quevedo C

Poster Session:  Biological Modeling

Abstract Number 2227: Applications of the PBPK Model of Dioxins to Evaluate Real Life Exposure Scenarios
Authors: Emond C, Ruiz P, Mumtaz M

Poster Session:  Particulate Matter Toxicology

Abstract Number 2252: Zebrafish Locomotor Responses Demonstrate Irritant Effect of Fine Particulate Matter Sources and a Role for TRPA1
Authors: Stevens J, DeMarini D, Hazari MS, Hunter DL, Padilla S, Farraj AK

Workshop Session:  Paradigm Change in Toxicology: What Will It Take to Bring Advances in the Science of Toxicology Into Regulatory Use?

Abstract Number 2574: CDER Acceptance of Alternative Assays
Author: Jacobs A

Poster Session:  Computational and Systems Toxicology 1

ICCVAM member Moiz Mumtaz (ATSDR) was a session co-chair

Poster Session:  Pharmacogenetics/Genetic Polymorphisms

Abstract Number 2750: FDALabel Database: A Rich Resource for Study of Pharmacogenomics Biomarkers in Advancing Drug Safety and Precision Medicine
Authors: Fang H, Xu J, Liu Z, Liu Y, Harris S, Thakkar S, Zhou G, Zhang G, Howard P, Tong W  

Poster Session:  Nanotoxicology: In Vitro

Abstract Number 2774: Size and Crystal Structure Dependent Inhibition of Human Mesenchymal Stem Cell Adipogenic Differentiation by Nanoscale Titanium Dioxide
Authors: Yao J, Jones Y, Monroe W, Collins J, Howard P, Patri AK, Zhang Y

Poster Session:  Risk Assessment 2

Abstract Number 2689: Development of a Screening Framework for Pesticide Cumulative Risk Assessment
Authors: Perron M, Lowit A, Smith C, Wilbur D

Abstract Number 2690: Implementation of the Screening Framework for Cumulative Risk Assessment of Pesticides
Authors: Craig E, Perron M, Pope-Varsalona H, Lowit A

Poster Session:  Pesticides

Abstract Number 2886: Esterase Detoxification of Acetylcholinesterase Inhibitors by Human Liver Samples In Vitro
Authors: Moser V, Padilla S

Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts

Invited Presentations and Open Microphone

Meeting co-sponsored by the Johns Hopkins Center for Alternatives to Animal Testing, the Human Toxicology Project Consortium, and the Human Toxome Project Consortium

ICCVAM member Richard Paules (NIEHS) gave an update on Tox21

NICEATM Director Warren Casey (NIEHS) gave an update on NICEATM activities