National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/40219

Presentations at 8th World Congress on Alternatives and Animal Use

Eighth World Congress on Alternatives and
Animal Use in the Life Sciences
August 21-25, 2011
Montreal, Canada

Printable list of NICEATM and ICCVAM activities, organized chronologically


Theme I: Safety and Efficacy Testing of Chemicals, Pharmaceuticals and Biologicals

Platform Presentations

Session I-18: Report on the ICCVAM International Workshop on Vaccines: ICCVAM Biologics Working Group
Dr. William Stokes, NICEATM Director, was chair of the session
ICCVAM Committee members Dr. Richard McFarland (U.S. FDA) and Dr. Jodie Kulpa-Eddy (USDA; ICCVAM Chair) presented

Session I-7: Potency and safety testing of veterinary vaccines
ICCVAM Committee member Dr. Jodie Kulpa-Eddy (USDA; ICCVAM Chair) presented

Session I-8: Safety testing for chemically-induced eye injuries: recent Three Rs advances
ICCVAM Committee member Dr. Jack Fowle (EPA) presented

Session I-3: Biological and biotechnology-based therapeutics
ICCVAM Committee member Dr. Ying Huang (FDA) presented

Session I-4: Validation of Alternative Test Methods for Detecting Estrogen Active Substances: Impact on the Three Rs
Dr. Warren Casey, NICEATM Deputy Director, was co-chair of the session
Dr. Casey and ICCVAM Committee member Dr. Jack Fowle (EPA) presented

Abstract: BG1Luc ER TA Test Method: Results of an International Validation Study and Proposed Performance Standards
Author: W Casey
Manuscript based on presentation, published in WC8 Proceedings (ALTEX Proceedings 2012)

Session I-13: Toxicity testing in the 21st century
ICCVAM working group member Dr. Ray Tice (NIEHS) presented

Session I-5: Nanotechnology and the Three Rs
ICCVAM Committee Member Dr. Abby Jacobs (FDA) presented

Session I-17: Update on New In Vitro Models for Detection and Potency Assessment of Botulinum Neurotoxin
Dr. Warren Casey, NICEATM Deputy Director, was co-chair of the session

Poster Presentations

Abstract I-11-575: International Acceptance of the Nonradioactive LLNA: DA for Evaluating Allergic Contact Dermatitis Hazards
Authors: P Brown, J Matheson, A Jacobs, R Ward, E Margosches, E Salicru, D Allen, F Stack, W Stokes
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Abstract I-11-574: International Acceptance of the Nonradioactive LLNA: BrdU-ELISA for Evaluating Allergic Contact Dermatitis Hazards
Authors: A Jacobs, J Matheson, V Malshet, J Toy, J Strickland, D Allen, T Burns, F Stack, W Stokes
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Abstract I-8-576:Usefulness and Limitations of the Cytosensor Microphysiometer Test Method for Ocular Safety Testing
Authors: W Stokes, D Lowther, A Layton, J Redden, E Lipscomb, J Truax, N Johnson, D Allen
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Abstract I-1-569: International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Human Vaccine Potency and Safety Testing
Authors: R McFarland, J Kulpa-Eddy, R Isbrucker, M Halder, H Kojima, D Verthelyi, M Schmitt, R Levis, N Johnson, B Jones, D Allen, W Casey, W Stokes
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Abstract I-1-570: International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Veterinary Vaccine Potency and Safety Testing
Authors: J Kulpa-Eddy, R McFarland, R Isbrucker, M Halder, H Kojima, G Srinivas, K Brown, B Jones, N Johnson, D Allen, W Casey, W Stokes
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Abstract I-11-567: Evaluation of the Murine Local Lymph Node Assay (LLNA) for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans
Authors: J Strickland, P Brown, J Matheson, A Jacobs, T McMahon, D Germolec, D Allen, E Salicru, T Burns, F Stack, W Stokes
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Abstract I-11-568: Evaluation of the Murine Local Lymph Node Assay (LLNA) for Assessing the Allergic Contact Dermatitis Hazard Potential of Pesticide Formulations
Authors: T McMahon, D McCall, J Matheson, A Jacobs, T Burns, D Allen, W Stokes
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Abstract I-11-446: Updated NICEATM Evaluation and International Acceptance of the Reduced Murine Local Lymph Node Assay
Authors: D Allen, T Burns, J Strickland, E Salicru, W Stokes
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Theme II: Policy/Law on Animal Use, Public Engagement and Ethics Review

Platform Presentations

Session II-1: Public accountability
ICCVAM Committee member Dr. Suzanne Fitzpatrick (FDA) was co-chair of the session

Session II-5: Validation of Three Rs Alternative Methods
Dr. William Stokes, NICEATM Director, was co-chair of the session

Abstract II-5-561: Validation of the 21st Century Toxicology Toolbox: Challenges, Opportunities, and the Way Forward
Author: W Stokes
Manuscript based on presentation, published in WC8 Proceedings (ALTEX Proceedings 2012)

Session II-11: The International cooperation on alternative test methods (ICATM) (updates from the National Validation Centers)
Dr. William Stokes, NICEATM Director, was chair of the session and also presented

Theme IV: Animal Welfare for Refinement and High Quality Science

Poster Presentation

Abstract IV-1-292: Eliminating Pain and Distress in Ocular Safety Testing: Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints
Authors: W Stokes, J Merrill, D Lowther, T McMahon, J Chen, M Hashim, M Lewis, B Jones, E Lipscomb, D Allen
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Theme V: Replacement and Reduction in Basic Research

Platform Presentations

Session II-1: Relevance, Reproducibility and Robustness – the other Three Rs important to science and animal welfare
ICCVAM working group member Dr. Myrtle Davis (NCI) was co-chair of the session

Session II-5: Validation of Three Rs Alternative Methods
Dr. William Stokes, NICEATM Director, was co-chair of the session

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