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Reports

Publication Date Title Category
Jul 18, 2018 ICCVAM Biennial Progress Report 2016-2017 General
Jan 30, 2018 A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States General
Aug 17, 2016 ICCVAM Biennial Progress Report 2014-2015 General
Jul 29, 2014 ICCVAM Biennial Progress Report 2012-2013 General
Oct 10, 2012 ICCVAM Test Method Evaluation Report: Identifying Chemical Eye Hazards with Fewer Animals Ocular
Jun 13, 2012 ICCVAM Biennial Progress Report 2010-2011 (NIH Publication No. 12-7873) General
Mar 06, 2012 Informational Brochure: "Nominations and Submissions to ICCVAM: A Guide for Test Method Developers and Sponsors" General
Feb 01, 2012 ICCVAM Test Method Evaluation Report - The LUMI-CELL® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals Endocrine
Jun 30, 2011 ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans (NIH Publication No. 11-7709) Immunotoxicity
May 01, 2011 Independent Scientific Peer Review Panel Report: Evaluation of the LUMI-CELL ER® (BG1Luc ER TA) Test Method Endocrine
Sep 13, 2010 ICCVAM Test Method Evaluation Report: Recommendation to Discontinue Use of the Low Volume Eye Test for Ocular Safety Testing (NIH Publication No. 10-7515) Ocular
Sep 13, 2010 ICCVAM Test Method Evaluation Report on a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products (NIH Publication No. 10-7513) Ocular
Sep 13, 2010 ICCVAM Test Method Evaluation Report: Recommendations for Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing (NIH Publication No. 10-7514) Ocular
Sep 13, 2010 ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553) Ocular
Jun 29, 2010 ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products (NIH Publication No. 10-7512) Immunotoxicity
Jun 29, 2010 ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA
A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7552)
Immunotoxicity
Jun 29, 2010 ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7551) Immunotoxicity
Jun 10, 2010 ICCVAM Biennial Progress Report 2008-2009 (NIH Publication No. 10-7612) General
Jul 13, 2009 Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches Ocular
Jun 01, 2009 Independent Scientific Peer Review Panel Report - Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products Immunotoxicity
Mar 01, 2009 Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations Acute Systemic Toxicity
Mar 01, 2009 ICCVAM Test Method Evaluation Report - The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 09-6439) Immunotoxicity
Jan 01, 2009 Recommended Performance Standards: Murine Local Lymph Node Assay (NIH Publication No. 09-7357) Immunotoxicity
Oct 23, 2008 Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 (NIH Publication No. 08-6529) General
May 20, 2008 Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products Immunotoxicity
May 01, 2008 ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6391) Pyrogenicity
May 01, 2008 ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6392) Pyrogenicity
Mar 28, 2008 Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing (NIH Publication No. 08-6416) Biologics
Feb 05, 2008 The NICEATM-ICCVAM Five-Year Plan (2008-2012) (NIH Publication No. 08-6410) General
Apr 30, 2007 Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products Pyrogenicity
Nov 26, 2006 Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516) General
Nov 01, 2006 Background Review Document: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518) Acute Systemic Toxicity
Nov 01, 2006 ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication No. 07-4517) Ocular
Nov 01, 2006 ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH Publication No. 07-4519) Acute Systemic Toxicity
Oct 16, 2006 NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) Endocrine
Sep 28, 2006 Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors Endocrine
Jun 01, 2006 Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing Acute Systemic Toxicity
Mar 12, 2006 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH Publication No. 06-4514) Ocular
Mar 12, 2006 Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512) Ocular
Mar 12, 2006 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH Publication No. 06-4513) Ocular
Mar 12, 2006 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test - Chrorioallantoic Membrane (Het-CAM) Test Method (NIH Publication No. 06-4515) Ocular
Nov 12, 2005 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUM Ocular
Mar 12, 2005 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants Ocular
May 10, 2004 Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH Publication No. 04-4510) Dermal
Feb 11, 2004 Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic Priorities General
Dec 19, 2003 ICCVAM Biennial Progress Report 2002-2003 (NIH Publication No. 04-4509) General
Sep 01, 2003 ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH Publication No. 03-4508) General
May 01, 2003 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503) Endocrine
Sep 01, 2002 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH Publication No. 03-4504) Endocrine
Sep 01, 2002 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4505) Endocrine
Sep 01, 2002 Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays Endocrine
Sep 01, 2002 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4507) Endocrine
Sep 01, 2002 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH Publication No. 03-4506) Endocrine
Jul 22, 2002 ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH Publication No. 02-4502) Dermal
Dec 19, 2001 Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) General
Nov 30, 2001 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH Publication No. 02-4501) Acute Systemic Toxicity
Aug 17, 2001 Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499) Acute Systemic Toxicity
Aug 12, 2001 Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals Dermal
Aug 01, 2001 Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATM Acute Systemic Toxicity
Dec 19, 2000 ICCVAM Authorization Act of 2000 (Public Law 106-545) General
Mar 10, 2000 Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX) Developmental/Reproductive
Jun 01, 1999 Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4495) Dermal
Mar 11, 1999 The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4494) Immunotoxicity
Mar 01, 1997 Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 97-3981) General