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Funding Opportunities for Test Method Developers

NICEATM and ICCVAM seek to facilitate development of test methods that replace, reduce, and refine the use of animals in testing. In addition, both organizations are committed to the protection of human health, animal health, and the environment. This page lists announcements of funding opportunities intended to support the development of alternative test methods. If you are aware of a funding opportunity that could be included on this page, please contact NICEATM.

SBIR and STTR Omnibus Grant Solicitations of the National Institutes of Health, Centers for Disease Control and Prevention, and Food and Drug Administration

NIEHS is offering funding for small businesses developing technologies of interest to the Tox21 program. These technologies include:

  • Improved or expanded testing methods for toxicity screening
  • Computational approaches for predictive toxicology
  • Technologies such as alternative or improved methods for fixing and preserving tissues

The funding is being offered as part of the 2018 Omnibus Solicitation of the NIH, CDC, and Food and Drug Administration. This funding is available for small business grant applications to support development and commercialization of innovative technologies. View more information on the NIEHS website.

SBIR/STTR Omnibus Solicitations and Accompanying Resources

Next due date: September 5, 2018

For more information about this opportunity, contact:

NIH Funding Resources

The NIEHS SBIR/STTR Program Staff encourages applicants to submit grants at least one week before the deadline and to take advantage of the following resources:

EPA Announces Funding Opportunity to Support Alternative Methods Development

EPA is funding research to promote the development and use of alternative test methods and strategies that reduce, refine, or replace vertebrate animal testing. Pertinent research includes approaches such as analog/read-across techniques, mathematical models, and tiered-testing approaches that integrate evidence from multiple sources to help accomplish these goals. Research activities should advance the science underpinning the use of non-vertebrate test methods and develop actionable alternative approaches for developmental toxicity, reproductive toxicity, or ecotoxicity testing.

This opportunity is expected to fund five grants of up to $850,000 each. Eligible institutions include U.S. state, local, and territory governments; federally recognized Indian tribal governments; and public and private nonprofits, hospitals, and academic institutions located in the U.S. Applications are due September 25.

Funding Available for Tissue Chip Models

NCATS has issued funding opportunities to support development of tissue chip technologies.

  • NIH and CDC are offering support to develop technologies and methodologies in the biomedical and behavioral sciences with potential to succeed as commercial products. As part of this opportunity, NCATS seeks proposals for novel media and materials to be used in microphysiological systems (MPS, or organs-on-chips). Applications are due October 22.
  • NCATS is also offering funding to support development of MPS models of nociception (detection of pain or potentially damaging stimuli), opioid addiction, and overdose. Eligibility for these funds is limited to investigators and institutions currently being funded through the Tissue Chip Consortium. Approximately $2,000,000 will be awarded in FY 2018 to fund 10-12 awards. Applications are due August 24.
Small Business Funding Available for Assessing Nanomaterials Toxicity

NIEHS has issued a funding opportunity to support development of technologies to assess exposure of engineered nanomaterials and characterize their effects on biological systems. In particular, this funding opportunity supports development of mid- to high-throughput assays or high-content assays for characterizing the effects of specific nanomaterials on biological pathways, including cytotoxicity, cellular uptake, inflammatory pathways, and oxidative stress in target tissues.

NIEHS intends to fund four or five awards totaling $1 million in 2019. This funding opportunity is open only to U.S. small business concerns. Applicant organizations may submit more than one application, provided that each application is scientifically distinct. Applications are due September 11. More information is available on the National Institutes of Health Grants website.

NEI Sponsors Competition to Develop In Vitro Retina Models

On February 13, NEI, which is part of NIH, announced the 3-D Retina Organoid Challenge. This $1 million federal prize competition is designed to support development of lab-grown human retinas from stem cells. Organoids developed for the competition will mimic the structure, organization, and function of the human retina, the light-sensitive tissue in the back of the eye.

In the current phase of the challenge, NEI will award up to $100,000 each to as many as six teams whose models best address the challenge's scientific criteria. Participating teams must designate a captain who is a U.S. citizen or permanent resident. Private entities participating must maintain a primary place of business in the U.S. Federal offices or employees are not eligible to participate, and federal funds may not be used to develop submissions. Submission deadline is October 1; winners will be announced in December. Challenge details are available on the NEI website.

Proposals Invited for New Applications for In Vitro Respiratory Toxicity Systems

The PETA International Science Consortium and Epithelix seek proposals for applications for MucilAirTM or SmallAirTM three-dimensional reconstructed human respiratory tissues from Epithelix. The winning proposal will receive $5,000 redeemable for a MucilAir or SmallAir system. Proposals will be evaluated based on their scientific merit and potential to replace animal testing. Researchers from any sector and geographical region are encouraged to apply. Proposals are due October 31.