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Funding Opportunities for Test Method Developers

NICEATM and ICCVAM seek to facilitate development of test methods that replace, reduce, and refine the use of animals in testing and protect human health, animal health, and the environment. This page lists announcements of funding opportunities intended to support the development of alternative test methods. If you are aware of a funding opportunity that could be included on this page, please contact NICEATM.

SBIR and STTR Omnibus Grant Solicitations of the National Institutes of Health, Centers for Disease Control and Prevention, and Food and Drug Administration

The National Institute of Environmental Health Sciences (NIEHS) is offering funding for small businesses developing technologies of interest to the Tox21 program. These technologies include improved or expanded testing methods for toxicity screening, computational approaches for predictive toxicology, and other technologies such as alternative or improved methods for fixing and preserving tissues. The funding is being offered as part of the 2018 Omnibus Solicitation of the National Institutes of Health (NIH), Centers for Disease Control, and Food and Drug Administration for small business grant applications to support development and commercialization of innovative technologies. View more information on the NIEHS website.

SBIR/STTR Omnibus solicitations and accompanying resources:

Next due date: March 5, 2018

For more information about this opportunity contact:
Dr. Daniel T. Shaughnessy [Send email]
NIEHS Division of Extramural Research and Training
POB 12233 (K3-12), Research Triangle Park, NC 27709
(919) 541-2506, Fax: (919) 541-4606

NIH Funding Resources

The NIEHS SBIR/STTR Program Staff encourages applicants to submit grants at least one week before the deadline and to take advantage of the following resources:

NIH Grants Offer Support for Tissue Chip Development

The National Institutes of Health (NIH) has announced several funding opportunities for research and development of microphysiological systems (MPS; “tissue chips”) for studying human physiology and assessing toxicity and safety of new drugs and other substances. All of these funding opportunities are open to U.S.-based for-profit, non-profit, academic, and government institutions.

  • NIH is offering 1-2 year(s) of support for later stage research and development activities necessary support commercialization of MPS devices for drug efficacy and safety assessment prior to clinical trials. Details of this funding opportunity are available on the NIH Grants website. Applications are due March 21, 2018, and only one application will be accepted from an institution.
  • New and renewal cooperative agreement applications are invited for the Tissue Chip Testing Center MPS Data Center, which supports the NIH Tissue Chip Consortium. The MPS Data center will be the central clearinghouse for tissue chip data management and will incorporate novel approaches and technologies for data management, data mining, and data sharing across many organs and tissues, diseases, data types, and tissue chip platforms. Details of this funding opportunity are available on the NIH Grants website. Applications are due March 21, 2018, and only one application will be accepted from an institution.
NIDDK Offers Support for Development of Tissue Chips

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is establishing a new research consortium "Microphysiological Systems for Modeling Diabetes." This consortium will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue. An essential feature of this consortium will be a multidisciplinary approach that brings together basic science experts and physician scientists in stem cell biology, bioengineering, computational biology, pharmacology, liver biology, islet biology, adipose biology, metabolism and diabetes.

To establish the consortium, NIDDK intends to commit up to $3 million per year for Fiscal Years 2018 through 2019, and up to $6 million per year for Fiscal Years 2020 through 2022 to fund 2-3 awards. Eligible institutions include U.S.-based higher education institutions, nonprofits, for-profit organizations, and government entities.

Letters of intent are due February 20, 2018; applications are due March 20, 2018. Complete funding information is available on the NIH Grants website.

Grants Available From IFER

The International Foundation for Ethical Research (IFER) is accepting pre-proposal applications for its 2018-2019 graduate fellowships. These one-year grants of up to $12,500 will be awarded to projects that support the development, acceptance, and implementation of innovative scientific methodologies that advance science and replace the use of animals in research, testing or education. Projects will also be considered in fields such as education, psychology, humanities, journalism, and the law that show promise to increase public awareness or to promote changes in the legal system or public policy regarding the use of animals in research, testing, and education. Grants are renewable annually for up to three years, dependent on student progress and availability of funds. Proposals will be accepted through April 30; more information is available on the IFER website.

Grants Available from the Alternatives Research and Development Foundation

The Alternatives Research and Development Foundation (ARDF) Annual Open Grant Program funds research projects that develop alternative methods to advance science and replace or reduce animal use. Proposals are welcome from any nonprofit educational or research institution worldwide, although preference will be given to U.S. applications.

Expert reviewers will evaluate proposals based on scientific merit and feasibility and the potential to reduce or replace the use of animals in the near future. Proposals will be considered in fields of research, testing, or education. Pathway-based approaches that use in silico and in vitro methods with human cells or tissues are of particular interest. Proposals for projects that use intact, non-human vertebrate or invertebrate animals will not be considered.

Proposals will be accepted through May 1; awards up to $40,000 per project will be announced by July 17. More information is available on the ARDF website.