National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/alt-funding

Funding Opportunities for Test Method Developers


NICEATM and ICCVAM seek to facilitate development of test methods that replace, reduce, and refine the use of animals in testing and protect human health, animal health, and the environment. This page lists announcements of funding opportunities intended to support the development of alternative test methods. If you are aware of a funding opportunity that could be included on this page, please contact NICEATM.


Phase IIb SBIR Awards for Validation of Alternative Test Methods

NICEATM encourages U.S. small businesses involved in alternative methods development to apply for Small Business Innovation Research (SBIR) Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing offered by the National Institute of Environmental Health Sciences (NIEHS). These awards are intended to support the validation of promising alternative test methods that replace or reduce animal use in toxicity testing/screening and can be used to address current U.S. federal agency testing requirements. Priority areas for alternative test method development and validation include (but are not limited to) ocular toxicity testing, reproductive and developmental toxicity testing, carcinogenicity testing, and acute toxicity testing. Funding is available through November 2017; the next due date for letters of intent is October 13, 2017.

Presentation summarizing the funding opportunity (September 2015) 

Complete description of the funding opportunity on the National Institutes of Health website
An update to the funding opportunity was issued on August 29, 2016

For more information about this opportunity contact:
Dr. Daniel T. Shaughnessy [Send email]
NIEHS Division of Extramural Research and Training
POB 12233 (K3-12), Research Triangle Park, NC 27709
(919) 541-2506, Fax: (919) 541-4606


SBIR and STTR Omnibus Grant Solicitations of the National Institutes of Health, Centers for Disease Control and Prevention, Food and Drug Administration, and Administration for Children and Families

As part of a large Department of Health and Human Services solicitation of SBIR and Small Business Technology Transfer (STTR) grant applications, NIEHS is interested in technologies to improve predictivity in toxicology testing to support the goals and initiatives of Tox21. View more information on the NIEHS website.

SBIR/STTR Omnibus solicitations and accompanying resources:

Next due date: April 5, 2017

For more information about this opportunity contact: Dr. Daniel T. Shaughnessy [Send email], NIEHS Division of Extramural Research and Training


NIH Funding Resources

The NIEHS SBIR/STTR Program Staff encourages applicants to submit grants at least one week before the deadline and to take advantage of the following resources:


ARDF Offers Research Grants

The Alternatives Research & Development Foundation, which promotes alternatives to the use of laboratory animals in research, testing, and education, is currently soliciting research proposals for its 2017 Alternatives Research Grant Program. For over 20 years, this innovative program has created opportunities for scientists who have interest and expertise in alternatives research.

ARDF is offering up to $40,000 to support individual projects. Preference will be given to projects based in U.S. universities and research institutions using pathway-based “21st century toxicology” approaches. Proposals will be evaluated on their potential to significantly replace or reduce animal use and their scientific merit and feasibility. The application deadline for the grants is May 1. More information is available on the ARDF website.


PISC Accepting Proposals for In Vitro Inhalation Exposure Systems

The PETA International Science Consortium (PISC) is accepting proposals that will demonstrate application of the VITROCELL® in vitro exposure system to reduce and replace the use of animals in inhalation testing. The winning proposal will receive a VITROCELL exposure system valued at up to $100,000.

Proposals will be judged on scientific merit and the potential of the proposed approach to reduce and replace animal use. Detailed proposal requirements are available on the PISC website. Proposals must be submitted by March 30; winners will be announced in May.


NICEATM Areas of Special Emphasis

Identification of in vitro methods that can be used to assess the potential of environmental chemicals to interact with the human androgen receptor (hAR) with high specificity (i.e., the response is mediated via the AR receptor rather than non-specific “cross-over” activity) is a high priority area for NICEATM. Proposals for single-laboratory validation studies are especially encouraged.

Interested parties are encouraged to contact NICEATM for additional technical details and a list of suggested reference chemicals for demonstrating proof of concept.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.