National Toxicology Program

National Toxicology Program

ICE: Integrated Chemical Environment

Integrated Testing Environment logo

In the course of its normal activities, NICEATM has collected and curated valuable data from the scientific literature, test method validation studies, government agencies, and other sources. As NICEATM reviews the data to ensure its quality, curated data sets will be released to the Integrated Chemical Environment or ICE.

Initially, ICE will let users view and download data from animal and non-animal tests measuring a variety of toxicity endpoints: acute dermal and oral toxicity, skin sensitization, and endocrine activity. It will also contain high throughput screening data from the Tox21 consortium and physicochemical property data such as solubility, melting point, and molecular weight. The data available in ICE will support evaluation of new non-animal toxicity tests and facilitate hypothesis generation and testing. In the future, ICE will be expanded to include workflows for tasks such as physicochemical property prediction and in vitro to in vivo extrapolation, and educational resources addressing the needs and challenges associated with developing new chemical evaluation methods.

Beta testing of ICE was conducted in December 2016. This effort focused on usability of the site: optimizing labeling and navigation, highlighting areas of potential confusion for users, and evaluating the quality of the documentation. ICE is currently being revised to address the testers’ comments. Formal launch of ICE is planned for March 2017, and information about the site will be presented at an exhibitor-hosted session at the Annual Meeting of the Society of Toxicology. The session, “ICCVAM Tools for Validation and Regulatory Application of Alternative Methods,” is on Wednesday, March 15, from 1:30-2:30 p.m. in Room 337.

For more information about ICE, please email

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.