National Toxicology Program

National Toxicology Program

ICE: Integrated Chemical Environment

Integrated Testing Environment logo

The Integrated Chemical Environment (ICE) provides high-quality, curated data from NICEATM and its partners and other data resources, as well as tools to facilitate new approaches for assessing chemical safety. ICE was developed to address the needs frequently expressed by NICEATM stakeholders. The ICE Integrator allows users to easily query and integrate data streams; query results can be explored interactively in table and graphic views.

ICE version 1.0 launched in March at the 2017 annual meeting of the Society of Toxicology (SOT). Version 1.0 includes data from animal and non-animal tests that assess acute oral toxicity, skin and eye irritation, skin sensitization, and endocrine activity. It also contains high throughput screening data from the Tox21 consortium and physicochemical property data such as solubility, melting point, and molecular weight. 

Planned updates of ICE include:

  • July 2017 (v1.1): Data updates; launch of workflows section, including workflows for physicochemical property prediction and physiologically based pharmacokinetic models for in vitro to in vivo extrapolation
  • October 2017 (v1.2): Data updates
  • January 2018 (v 1.3): Data updates
  • April 2018 (v1.4): Data updates; interactive workflows

For more information about ICE, please email or visit the ICE FAQ page.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.