National Toxicology Program

National Toxicology Program

Non-animal Methods and Strategies for Acute Systemic Toxicity

Request for Data and Information on Technologies Used to Identify Substances With the Potential To Cause Acute Systemic Toxicity

NICEATM requests available data and information on approaches and/or technologies currently used to identify substances with the potential to cause acute systemic toxicity when swallowed, inhaled, or absorbed through the skin.  Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce acute systemic toxicity.

Guidelines for Submission of Acute Toxicity Data

Acute systemic toxicity tests are conducted to determine the potential for a single or short-term dose of a substance to cause illness or death when inhaled (inhalation toxicity testing), swallowed (oral toxicity testing), or absorbed through the skin (dermal toxicity testing). These tests are required by multiple regulatory agencies and can use large numbers of animals. NICEATM, which fosters the evaluation and promotion of alternative test methods for regulatory use, supports efforts to develop, validate, and implement alternative approaches for acute systemic toxicity testing that replace, reduce, or refine animal use.

Respondents should provide information on any activities relevant to the development or validation of alternatives to in vivo tests currently required by regulatory agencies that assess acute oral, dermal, or inhalation toxicity. Of specific interest are chemical-specific data from non-animal tests for acute systemic toxicity hazard, as well as available data on the same chemicals from in vivo acute systemic toxicity tests, such as ethical human or animal studies or accidental human exposures. Respondents should include their name, affiliation (if applicable), mailing address, telephone, email, and sponsoring organization (if any) with their communications.

Responses to this notice will be posted on this page; therefore, no proprietary, classified, confidential, or sensitive information should be included in responses. View NTP guidelines for public comments.

Federal Register notice announcing data request (July 18, 2016) — View as a webpage

Responses to Federal Register Notice
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.