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Alternative Methods for Biologics & Vaccine Testing

Testing to ensure the effectiveness and safety of vaccines and other biologics often requires the use of large numbers of animals, many of which experience significant pain and distress during testing. NICEATM and ICCVAM work with stakeholders to identify methods for biologics and vaccine testing that can replace, reduce, or refine animal use.

Descriptions

Composite image of bottle with simulated chemical strands exiting lid

Detection & Measurement of Botulinum Neurotoxin

Tests to detect and measure BoNT are required by multiple federal agencies. NICEATM and ICCVAM work with stakeholders to identify alternatives to the standard mouse test. Learn more. Go
Petri dish with blue liquid surrounded by multiple petri dishes filled with pink liquid

Accepted Alternative Methods for Biologics & Vaccine Testing

ICCVAM agencies have published methods and guidance that can replace, reduce, or refine animal use for vaccine and biologics testing. Learn more. Go
Woman holding child during a doctor examination

Workshops on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines

NICEATM and international collaborators conducted workshops to discuss and review an international study of a non-animal alternative to the HIST. Read about the workshops. Go
Veterinarian holding stethescope to dog

International Workshop on Alternative Methods for Leptospira Vaccine Potency Testing (2012)

NICEATM and USDA organized a workshop to review advances in Leptospira vaccine testing and available alternatives to animal tests. Learn more about the workshop and actions later taken by USDA. Go
Black and white dog receiving vaccine

International Workshop on Alternative Methods for Human & Veterinary Rabies Vaccine Testing (2011)

A NICEATM-organized workshop reviewed alternative methods for rabies vaccine testing. Learn more about the workshop and actions later taken by USDA. Go
Doctor gives infant a vaccine while mother looks on

Workshop on Alternative Methods for Vaccine Potency & Safety Testing (2010)

NICEATM and ICCVAM organized a workshop to review the current status and use of alternative test methods for human and veterinary vaccines. Read about the workshop. Go