Test Method Evaluation Report: EPISKIN, EpiDerm, and Rat Skin Transcutaneous Electrical Resistance Assay

ICCVAM Evaluation of EPISKINTM, EpiDermTM (EPI-200),
and the Rat Skin Transcutaneous Electrical
Resistance (TER) Assay:
In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals

NIH Publication No: 02-4502

Complete Report

Front Matter

Main Body

Appendix 1: Federal Regulations and Guidelines for Corrosivity

  1. Summary Table of Guidelines and Regulations for Dermal Corrosivity
  2. OPPTS 870.2500 Acute Dermal Irritation - U.S. EPA (Health Effects Test Guidelines)
  3. Chapter 8 (Precautionary Labeling) - U.S. EPA. OPP

Appendix 2: European Commission (EC) Evaluations and Statements

  1. Statements by the ECVAM Scientific Advisory Committee (ESAC)
  2. Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP)
  3. EC Directive for Rat Skin TER and a Human Skin Model Assay

Appendix 3: OECD Test Guidelines and Documents

  • The OECD Test Guidelines referenced in this report have been superseded. Current OECD Test Guidelines can be obtained through the OECD iLibrary.

Appendix 4: Federal Register Notice (66 FR 49685, Sep. 28, 2001)

Appendix 5: Public Comments on 66 FR 49685