Performance Standards for In Vitro Dermal Corrosivity Test Methods

Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion

Prepared by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

NIH Publication No: 04-4510

Complete Report

Front Matter

Main Body

  1. Purpose and Background of Performance Standards
    1. Introduction
    2. Elements of ICCVAM Performance Standards
    3. ICCVAM Process for the Development of Performance Standards
    4. ICCVAM Development of Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion
  2. In Vitro Membrane Barrier Test Systems for Skin Corrosion
    1. Background
    2. Principles of In Vitro Membrane Barrier Test Systems for Skin Corrosion
    3. Essential Test Method Components
    4. Reference Chemicals
    5. Accuracy and Reliability
  3. In Vitro Human Skin Model Systems for Skin Corrosion
    1. Background
    2. Principles of In Vitro Human Skin Model Systems for Skin Corrosion
    3. Essential Test Method Components
    4. Reference Chemicals
    5. Accuracy and Reliability
  4. In Vitro Skin Transcutaneous Electrical Resistance (TER) Test for Skin Corrosion
    1. Minimum Procedural Standards
    2. Principles of the In Vitro Skin TER Test for Skin Corrosion
    3. Essential Test Method Components
    4. Reference Chemicals
    5. Accuracy and Reliability
  5. References

Appendix A: Federal Register Notice [68 FR 39104; July 1, 2003]
Notice of Availability of Proposed Minimum Performance Standards (MPS) for Three Types of In Vitro Methods for Assessing the Dermal Corrosivity Hazard Potential of Chemicals; Request for Comments

Appendix B: Public Comments in Response to the Federal Register Notice (July 1, 2003)

Appendix C: Minutes of the EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) Scientific Advisory Panel (SAP) Meeting (October 28 and 29, 2003)